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WO2011016674A3 - Nouveaux composés organiques de germanium - Google Patents

Nouveaux composés organiques de germanium Download PDF

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Publication number
WO2011016674A3
WO2011016674A3 PCT/KR2010/005114 KR2010005114W WO2011016674A3 WO 2011016674 A3 WO2011016674 A3 WO 2011016674A3 KR 2010005114 W KR2010005114 W KR 2010005114W WO 2011016674 A3 WO2011016674 A3 WO 2011016674A3
Authority
WO
WIPO (PCT)
Prior art keywords
linear
ascorbic acid
group
aryl group
branched
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2010/005114
Other languages
English (en)
Korean (ko)
Other versions
WO2011016674A2 (fr
Inventor
함승욱
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Industry Academic Cooperation Foundation of Chung Ang University
Original Assignee
Industry Academic Cooperation Foundation of Chung Ang University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Industry Academic Cooperation Foundation of Chung Ang University filed Critical Industry Academic Cooperation Foundation of Chung Ang University
Publication of WO2011016674A2 publication Critical patent/WO2011016674A2/fr
Publication of WO2011016674A3 publication Critical patent/WO2011016674A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/30—Germanium compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52—Stabilizers
    • A61K2800/522—Antioxidants; Radical scavengers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne des composés organiques de germanium représentés par la formule (I), ou des sels de ces composés. [Formule I] Dans cette formule, R1, R2 et R3 sont identiques ou différents et sont indépendamment un groupe alcényle en C2-C6 linéaire ou ramifié, un groupe aryle, un groupe aryle substitué par un groupe alcényle en C2-C6 linéaire ou ramifié, ou un groupe aryle substitué par un groupe alkynyle en C2-C6 linéaire ou ramifié; R4 est un monosaccharide, un alcool, un acide L-ascorbique, des dérivés d'acide L-ascorbique ayant un groupe hydroxyle protégé au niveau de l'atome de carbone en position 2 dans un noyau de furane d'acide L-ascorbique, ou un dérivé d'amine de celui-ci; m est un entier compris entre 0 et 10; X est CO ou CH2 : et GE est germanium. Les nouveaux composés organiques de germanium de l'invention marquent un progrès remarquable en termes d'hydrosolubilité, ce qui facilite leur absorption in vivo, ne présentent pas d'accumulation dans les tissus, donc pas de toxicité pour le corps, et présentent suffisamment les effets du germanium. De plus, un composé combiné avec de l'acide L-ascorbique présente une forte activité anti-oxydante.
PCT/KR2010/005114 2009-08-05 2010-08-04 Nouveaux composés organiques de germanium Ceased WO2011016674A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020090072132A KR101200996B1 (ko) 2009-08-05 2009-08-05 신규 유기 게르마늄 화합물
KR10-2009-0072132 2009-08-05

Publications (2)

Publication Number Publication Date
WO2011016674A2 WO2011016674A2 (fr) 2011-02-10
WO2011016674A3 true WO2011016674A3 (fr) 2011-06-30

Family

ID=43544786

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2010/005114 Ceased WO2011016674A2 (fr) 2009-08-05 2010-08-04 Nouveaux composés organiques de germanium

Country Status (2)

Country Link
KR (1) KR101200996B1 (fr)
WO (1) WO2011016674A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101492811B1 (ko) * 2013-04-23 2015-02-13 김영민 게르마늄 부식산의 분리방법
KR20230062092A (ko) * 2021-10-29 2023-05-09 한국전자통신연구원 기지국 부하 제어 방법 및 장치

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009096737A2 (fr) * 2008-01-31 2009-08-06 Chung-Ang University Industry-Academy Cooperation Foundation Nouveaux composés de germanium organiques et compositions comprenant ceux-ci comme principes actifs

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009096737A2 (fr) * 2008-01-31 2009-08-06 Chung-Ang University Industry-Academy Cooperation Foundation Nouveaux composés de germanium organiques et compositions comprenant ceux-ci comme principes actifs

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ANDREA VASELLA.: "AN APPROACH TO THE SYNTHESIS OF POLYSACCHARIDE ANALOGUES", PURE & APPL. CHEM., vol. 70, no. 2, 1998, pages 425 - 430 *
CHISATO HIRAYAMA ET AL.: "Propagermanium: a nonspecific immune modulator for chronic hepatitis B", JOURNAL OF GASTROENTEROLOGY, vol. 38, no. 6, 2003, pages 525 - 532 *
YOKO IMAFUKU ET AL.: "Synthesis and characterization of some penicillins modified with germanium-containing moieties", APPLIED ORGANOMETALLIC CHEMISTRY, vol. 18, no. ISSUE, August 2004 (2004-08-01), pages 384 - 393 *
YOSHITO TAKEUCHI ET AL.: "Synthesis and characterization of several cephalothin derivatives modified with germanium-containing moieties", APPLIED ORGANOMETALLIC CHEMISTRY, SPECIAL ISSUE: DEDICATED TO THE MEMORY OF PROFESSOR COIN EABORN, vol. 19, no. ISSUE, April 2005 (2005-04-01), pages 473 - 478 *

Also Published As

Publication number Publication date
KR101200996B1 (ko) 2012-11-13
WO2011016674A2 (fr) 2011-02-10
KR20110014458A (ko) 2011-02-11

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