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MX2011009423A - Compuesto de piperazina capaz de inhibir prostaglandina d sintasa. - Google Patents

Compuesto de piperazina capaz de inhibir prostaglandina d sintasa.

Info

Publication number
MX2011009423A
MX2011009423A MX2011009423A MX2011009423A MX2011009423A MX 2011009423 A MX2011009423 A MX 2011009423A MX 2011009423 A MX2011009423 A MX 2011009423A MX 2011009423 A MX2011009423 A MX 2011009423A MX 2011009423 A MX2011009423 A MX 2011009423A
Authority
MX
Mexico
Prior art keywords
group
carbon atoms
piperazine compound
alkyl group
synthase
Prior art date
Application number
MX2011009423A
Other languages
English (en)
Inventor
Yoshihiro Urade
Makoto Kitade
Kazuhiko Shigeno
Keiko Yamane
Katsunao Tanaka
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Publication of MX2011009423A publication Critical patent/MX2011009423A/es

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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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Abstract

Esta invención se refiere a un compuesto de piperazina representado por la fórmula (I, (ver fórmula (I)) en donde R1 es alquilo de C1-6 R2 es hidroxi, alquilo de C1-6 que puede tener uno o más sustituyentes, -(C=O)-N(R3)(R4), o -(C=O)-OR5; R3 y R4 son los mismos o diferentes, y cada uno representa hidrógeno o alquilo de C1-6 que puede tener uno o más sustituyentes, o R3 y R4, tomados junto con un átomo de nitrógeno al cual R3 y R4 están unidos, pueden formar un grupo heterocíclico saturado; R5 es hidrógeno o alquilo de C1-6 que puede tener uno o más sustituyentes; y n es 1 ó 2; o una sal del mismo.
MX2011009423A 2009-03-09 2010-03-08 Compuesto de piperazina capaz de inhibir prostaglandina d sintasa. MX2011009423A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2009055721 2009-03-09
PCT/JP2010/053760 WO2010104024A1 (ja) 2009-03-09 2010-03-08 プロスタグランジンd合成酵素を阻害するピペラジン化合物

Publications (1)

Publication Number Publication Date
MX2011009423A true MX2011009423A (es) 2011-09-28

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MX2011009423A MX2011009423A (es) 2009-03-09 2010-03-08 Compuesto de piperazina capaz de inhibir prostaglandina d sintasa.

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US (2) US8865714B2 (es)
EP (1) EP2407466B1 (es)
JP (1) JP5111657B2 (es)
KR (1) KR101421785B1 (es)
CN (1) CN102341385B (es)
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PL2407466T3 (pl) 2016-06-30
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WO2010104024A1 (ja) 2010-09-16
JP5111657B2 (ja) 2013-01-09
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US8865714B2 (en) 2014-10-21
US20110319413A1 (en) 2011-12-29
CA2754613A1 (en) 2010-09-16
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KR20110133040A (ko) 2011-12-09
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BRPI1009212B8 (pt) 2024-03-12
HK1165419A1 (en) 2012-10-05
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CN102341385B (zh) 2014-01-15
SG173865A1 (en) 2011-09-29
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MY159870A (en) 2017-02-15
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CN102341385A (zh) 2012-02-01
JPWO2010104024A1 (ja) 2012-09-13
CA2754613C (en) 2016-07-12
DK2407466T3 (en) 2016-03-07
KR101421785B1 (ko) 2014-07-22
EP2407466A4 (en) 2012-09-05
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HUE027702T2 (en) 2016-11-28
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