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MX2013005179A - Derivado de pirazino[2,3-d]isoxazol. - Google Patents

Derivado de pirazino[2,3-d]isoxazol.

Info

Publication number
MX2013005179A
MX2013005179A MX2013005179A MX2013005179A MX2013005179A MX 2013005179 A MX2013005179 A MX 2013005179A MX 2013005179 A MX2013005179 A MX 2013005179A MX 2013005179 A MX2013005179 A MX 2013005179A MX 2013005179 A MX2013005179 A MX 2013005179A
Authority
MX
Mexico
Prior art keywords
group
pyrazino
derivative
pyrazinecarboxamide
hydroxy
Prior art date
Application number
MX2013005179A
Other languages
English (en)
Inventor
Takeshi Murakami
Kouki Nakamura
Hiroyuki Naitou
Naoyuki Hanaki
Katsuyuki Watanabe
Original Assignee
Fujifilm Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujifilm Corp filed Critical Fujifilm Corp
Publication of MX2013005179A publication Critical patent/MX2013005179A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C239/00—Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
    • C07C239/08—Hydroxylamino compounds or their ethers or esters
    • C07C239/18—Hydroxylamino compounds or their ethers or esters having nitrogen atoms of hydroxylamino groups further bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/36—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C251/38—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/23—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same unsaturated acyclic carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • C07C255/29—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton containing cyano groups and acylated amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/18—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

El objeto de la presente invención es proporcionar un compuesto que sea útil como intermediario de la producción del derivado de carboxamida de pirazina tal como carboxamida de 6-fluoro-3-hidroxi-2-pirazina. La presente invención proporciona un derivado de pirazino[2,3-d]isoxazol representado por la fórmula (I) (en donde X representa a un átomo de halógeno, un grupo hidroxi o un grupo sulfamoiloxi, y Y representa -C(=O)R o -CN; en donde R representa un átomo de hidrógeno, un grupo alcoxi, un grupo ariloxi, un grupo alquilo, un grupo arilo o un grupo amino.
MX2013005179A 2010-11-12 2011-11-11 Derivado de pirazino[2,3-d]isoxazol. MX2013005179A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2010253414 2010-11-12
JP2010256510 2010-11-17
JP2011025760 2011-02-09
PCT/JP2011/076029 WO2012063931A1 (ja) 2010-11-12 2011-11-11 ピラジノ〔２，３－ｄ〕イソオキサゾール誘導体

Publications (1)

Publication Number Publication Date
MX2013005179A true MX2013005179A (es) 2013-07-05

Family

ID=46051068

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013005179A MX2013005179A (es) 2010-11-12 2011-11-11 Derivado de pirazino[2,3-d]isoxazol.

Country Status (17)

Country Link
US (2) US8901302B2 (es)
EP (1) EP2639235B1 (es)
JP (1) JP5787727B2 (es)
KR (1) KR101902857B1 (es)
CN (1) CN103347884B (es)
AU (1) AU2011327111B2 (es)
BR (1) BR112013011418B1 (es)
CA (1) CA2816687C (es)
ES (1) ES2535341T3 (es)
IL (1) IL226228A (es)
MX (1) MX2013005179A (es)
NZ (1) NZ611498A (es)
RU (1) RU2570802C2 (es)
SG (1) SG190772A1 (es)
TW (1) TWI486350B (es)
WO (1) WO2012063931A1 (es)
ZA (1) ZA201304074B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104817511B (zh) * 2015-04-27 2017-04-19 济南大学 一种丁烯二酸酐制备法匹拉韦关键中间体的方法
CN113735784A (zh) * 2020-05-28 2021-12-03 南京桦冠生物技术有限公司 6-氟-3-羟基吡嗪-2-甲酰胺的制备方法
CN114478404A (zh) * 2022-03-17 2022-05-13 浙江海正药业股份有限公司 一种法维拉韦中间体羟基物的纯化方法
CN118930551B (zh) * 2024-10-15 2025-03-14 江苏恒瑞医药股份有限公司 制备β-氨基吡嗪乙酸酯的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ282939B6 (cs) * 1992-03-04 1997-11-12 Lonza A.G. Mikrobiologický způsob hydroxylace dusíkatých heterocyklických karboxylových kyselin
TW394760B (en) * 1993-09-07 2000-06-21 Hoffmann La Roche Novel Carboxamides, process for their preparation and pharmaceutical composition containing the same
JP3453362B2 (ja) * 1998-08-20 2003-10-06 富山化学工業株式会社 含窒素複素環カルボキサミド誘導体またはその塩並びにそれらを含有する抗ウイルス剤
CN1239511C (zh) 2000-02-16 2006-02-01 富山化学工业株式会社 新的吡嗪衍生物或其盐、以及含有该衍生物或盐的药物组合物
CN101809003A (zh) * 2007-09-27 2010-08-18 富山化学工业株式会社 6-氟-3-羟基-2-氰基吡嗪的有机胺盐及其制备方法
JP5364327B2 (ja) * 2008-09-26 2013-12-11 富士フイルム株式会社 ハロピラジンカルボキサミド化合物の製造方法

Also Published As

Publication number Publication date
AU2011327111A1 (en) 2013-05-02
RU2013126415A (ru) 2014-12-20
BR112013011418A8 (pt) 2018-08-14
NZ611498A (en) 2014-05-30
AU2011327111B2 (en) 2015-04-23
ZA201304074B (en) 2014-08-27
JP2012180336A (ja) 2012-09-20
EP2639235B1 (en) 2015-04-08
TW201226412A (en) 2012-07-01
IL226228A0 (en) 2013-07-31
IL226228A (en) 2017-11-30
US9181203B2 (en) 2015-11-10
KR20140082588A (ko) 2014-07-02
US8901302B2 (en) 2014-12-02
ES2535341T3 (es) 2015-05-08
WO2012063931A1 (ja) 2012-05-18
CA2816687A1 (en) 2012-05-18
RU2570802C2 (ru) 2015-12-10
TWI486350B (zh) 2015-06-01
CN103347884A (zh) 2013-10-09
HK1185882A1 (en) 2014-02-28
EP2639235A4 (en) 2014-07-30
BR112013011418B1 (pt) 2021-03-16
US20150051396A1 (en) 2015-02-19
CN103347884B (zh) 2015-12-02
BR112013011418A2 (pt) 2016-07-19
SG190772A1 (en) 2013-08-30
EP2639235A1 (en) 2013-09-18
CA2816687C (en) 2018-11-27
KR101902857B1 (ko) 2018-10-01
US20130245264A1 (en) 2013-09-19
JP5787727B2 (ja) 2015-09-30

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