CY1115643T1 - Διεγερτης νευρογενεσης ή θεραπευτικος παραγων νευροπαθειας που περιλαμβανει παραγωγα αλκυλ αιθερα ή αλας αυτου - Google Patents
Διεγερτης νευρογενεσης ή θεραπευτικος παραγων νευροπαθειας που περιλαμβανει παραγωγα αλκυλ αιθερα ή αλας αυτουInfo
- Publication number
- CY1115643T1 CY1115643T1 CY20141100826T CY141100826T CY1115643T1 CY 1115643 T1 CY1115643 T1 CY 1115643T1 CY 20141100826 T CY20141100826 T CY 20141100826T CY 141100826 T CY141100826 T CY 141100826T CY 1115643 T1 CY1115643 T1 CY 1115643T1
- Authority
- CY
- Cyprus
- Prior art keywords
- group
- derivatives
- neurogenesis
- stimulant
- aryl
- Prior art date
Links
- 230000004766 neurogenesis Effects 0.000 title abstract 2
- 201000001119 neuropathy Diseases 0.000 title abstract 2
- 230000007823 neuropathy Effects 0.000 title abstract 2
- 208000033808 peripheral neuropathy Diseases 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- 150000005215 alkyl ethers Chemical class 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 abstract 5
- 125000003277 amino group Chemical group 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003302 alkenyloxy group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 abstract 1
- 125000005110 aryl thio group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- -1 benzothiophene alkyl ether Chemical class 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- FCEHBMOGCRZNNI-UHFFFAOYSA-N thianaphthalene Natural products C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Αποκαλύπτεται ένας παράγων που περιλαμβάνει παράγωγο αλκυλαιθέρα βενζοθειοφαινίου που αντιπροσωπεύεται με τον γενικό τύπο ανωτέρω ή άλας αυτού: όπου τα R1 και R2 ανεξαρτήτως αντιπροσωπεύουν τουλάχιστον μια ομάδα που επιλέγεται από άτομο υδρογόνου, άτομο αλογόνου, αλκύλ ομάδα, αρύλ ομάδα, αραλκύλ ομάδα, αλκόξυ ομάδα, αρυλόξυ ομάδα, αλκύλθειο ομάδα, αρύλθειο ομάδα, αλκενύλ ομάδα, αλκενυλόξυ ομάδα, άμινο ομάδα, αλκυλοσουλφονύλ ομάδα, αρυλσουλφονύλ ομάδα, καρβαμοΰλ ομάδα, ετεροκυκλική ομάδα, άμινο ομάδα, υδροξύλ ομάδα, καρβοξύλ ομάδα, νίτρο ομάδα, όξο ομάδα και τις παρόμοιες, το R3 αντιπροσωπεύει αλκυλάμινο ομάδα η οποία μπορεί να είναι υποκατεστημένη ή άμινο ή υδροξύλ ομάδα η οποία μπορεί να είναι προστατευμένη και τα m και n ανεξαρτήτως αντιπροσωπεύουν ακέραιο αριθμό που κυμαίνεται από 1 έως 6. Ο παράγων είναι χρήσιμος ως διεγέρτης νευρογένεσης ή ως θεραπευτικός παράγων για νευροπάθεια.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006122080 | 2006-04-26 | ||
| EP07742276.4A EP2011796B1 (en) | 2006-04-26 | 2007-04-24 | Neurogenesis inducer or neuropathy therapeutic agent comprising alkyl ether derivative or salt thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1115643T1 true CY1115643T1 (el) | 2017-01-04 |
Family
ID=38655439
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20141100826T CY1115643T1 (el) | 2006-04-26 | 2014-10-10 | Διεγερτης νευρογενεσης ή θεραπευτικος παραγων νευροπαθειας που περιλαμβανει παραγωγα αλκυλ αιθερα ή αλας αυτου |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20090093453A1 (el) |
| EP (1) | EP2011796B1 (el) |
| JP (2) | JP5695293B2 (el) |
| KR (1) | KR101374593B1 (el) |
| CN (1) | CN101432280B (el) |
| AU (1) | AU2007244409B2 (el) |
| BR (1) | BRPI0710239A2 (el) |
| CA (1) | CA2648898C (el) |
| CY (1) | CY1115643T1 (el) |
| DK (1) | DK2011796T3 (el) |
| ES (1) | ES2518371T3 (el) |
| IL (1) | IL194569A (el) |
| MX (1) | MX2008013728A (el) |
| NO (1) | NO342153B1 (el) |
| NZ (1) | NZ571975A (el) |
| PL (1) | PL2011796T3 (el) |
| PT (1) | PT2011796E (el) |
| SI (1) | SI2011796T1 (el) |
| WO (1) | WO2007125913A1 (el) |
| ZA (1) | ZA200808728B (el) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60220694T2 (de) | 2001-10-19 | 2008-02-07 | Toyama Chemical Co. Ltd. | Alkyletherderivate oder deren salze |
| EP2389937B1 (en) | 2002-06-14 | 2018-08-15 | Toyama Chemical Co., Ltd. | Medicinal composition for improving brain function |
| CA2600381C (en) * | 2005-03-28 | 2013-11-12 | Toyama Chemical Co., Ltd. | Process for production of 1-(3-(2-(1-benzothiophen-5-yl)-ethoxy)propyl)azetidin-3-ol or salts thereof |
| AU2007279673B2 (en) * | 2006-08-04 | 2012-04-19 | Toyama Chemical Co., Ltd. | Protein kinase C activity enhancer containing alkyl ether derivative or salt thereof |
| MX2010012787A (es) * | 2008-05-28 | 2011-02-24 | Toyama Chemical Co Ltd | Nuevo derivado de oxido de benzotiofeno y sal del mismo. |
| CA2917628A1 (en) * | 2013-09-12 | 2015-03-19 | F. Hoffmann-La Roche Ag | Indol-carboxamide derivatives |
| SMT202000395T1 (it) | 2014-01-31 | 2020-09-10 | Fujifilm Toyama Chemical Co Ltd | Agente di potenziamento dell'effetto della riabilitazione dopo lesione di un nervo comprendente un derivato di alchiletere o un suo sale |
| US10238632B2 (en) | 2015-06-11 | 2019-03-26 | Fujifilm Toyama Chemical Co., Ltd. | Sigma receptor-binding agent |
| CN108366989B (zh) * | 2015-12-25 | 2020-11-03 | 富士胶片富山化学株式会社 | 含有1-(3-(2-(1-苯并噻吩-5-基-)乙氧基)丙基)氮杂环丁-3-醇或其盐的片剂 |
| JP7176957B2 (ja) * | 2016-12-28 | 2022-11-22 | 富士フイルム富山化学株式会社 | 外用組成物 |
| US11660287B2 (en) | 2017-06-02 | 2023-05-30 | Fujifilm Toyama Chemical Co., Ltd. | Agent for preventing or treating spinocerebellar ataxia |
| MX393052B (es) | 2017-06-02 | 2025-03-24 | Fujifilm Toyama Chemical Co Ltd | Agente para prevenir o tratar atrofia cerebral. |
| EP3636262A4 (en) | 2017-06-02 | 2020-06-10 | FUJIFILM Toyama Chemical Co., Ltd. | AGENT FOR PREVENTING OR TREATING ALZHEIMER-LIKE DEMENTIA |
| BR112019024983A2 (pt) | 2017-06-02 | 2020-06-23 | Fujifilm Toyama Chemical Co., Ltd. | Agente para reduzir a quantidade de proteína b amiloide |
| EP3705121B1 (en) | 2017-10-30 | 2023-08-30 | FUJIFILM Toyama Chemical Co., Ltd. | Emopamil binding protein binding agent and use thereof |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6294346B1 (en) | 1991-07-08 | 2001-09-25 | Neurospheres Holdings, Ltd. | Use of multipotent neural stem cells and their progeny for the screening of drugs and other biological agents |
| JPH05284992A (ja) * | 1992-04-14 | 1993-11-02 | Sagami Chem Res Center | 神経成長因子産生促進剤及びその製造法 |
| GB9309749D0 (en) * | 1993-05-12 | 1993-06-23 | Boots Co Plc | Therapeutic agents |
| JPH07285912A (ja) * | 1994-04-19 | 1995-10-31 | Asahi Chem Ind Co Ltd | 新規化合物ａｍ５２２１ |
| JP2733207B2 (ja) * | 1995-05-18 | 1998-03-30 | 工業技術院長 | 繊維芽細胞成長因子キメラ蛋白質を含有する医薬組成物 |
| WO1999031056A1 (en) * | 1997-12-12 | 1999-06-24 | Toyama Chemical Co., Ltd. | Alkyl ether derivatives or salts thereof and calcium antagonists containing the same |
| IL129178A0 (en) * | 1999-03-25 | 2000-02-17 | Yeda Res & Dev | Induction of nerve generation |
| US6797726B1 (en) * | 1999-06-11 | 2004-09-28 | Toyama Chemical Co., Ltd. | N-alkoxyalkyl-N,N-dialkylamine derivatives or salts thereof, and remedies for nerve degeneration diseases containing the same |
| GB2367554A (en) * | 2000-10-04 | 2002-04-10 | Lilly Co Eli | Pharmacologically active amines |
| US20040030131A1 (en) * | 2000-10-04 | 2004-02-12 | Martine Keenan | Pharmaceutical compounds |
| JP4303435B2 (ja) * | 2001-02-26 | 2009-07-29 | 富山化学工業株式会社 | ミトコンドリア機能賦活剤 |
| CA2452596C (en) * | 2001-07-05 | 2010-12-21 | Takeda Chemical Industries, Ltd. | Benzo-fused 5-membered heterocyclic compounds, their production and use |
| JP4357802B2 (ja) * | 2001-07-05 | 2009-11-04 | 武田薬品工業株式会社 | ベンゼン環縮合５員複素環式化合物、その製造法および用途 |
| JP4905752B2 (ja) * | 2001-07-24 | 2012-03-28 | エスティー・ラボ株式会社 | 揮発性有機塩素化合物センサ |
| DE60220694T2 (de) * | 2001-10-19 | 2008-02-07 | Toyama Chemical Co. Ltd. | Alkyletherderivate oder deren salze |
| JP4537011B2 (ja) * | 2002-03-01 | 2010-09-01 | 武田薬品工業株式会社 | 抗うつ剤 |
| EP2389937B1 (en) * | 2002-06-14 | 2018-08-15 | Toyama Chemical Co., Ltd. | Medicinal composition for improving brain function |
| JP2004256428A (ja) * | 2003-02-25 | 2004-09-16 | Science Univ Of Tokyo | 神経栄養因子様プリン系化合物含有作用剤 |
| AU2004229283B2 (en) * | 2003-04-17 | 2009-02-05 | Toyama Chemical Co., Ltd. | Preventive/remedy for retinal nerve diseases containing alkyl ether derivatives or salts thereof |
| JP4715514B2 (ja) * | 2003-10-03 | 2011-07-06 | 小野薬品工業株式会社 | 神経再生促進剤 |
-
2007
- 2007-04-24 NZ NZ571975A patent/NZ571975A/en unknown
- 2007-04-24 ES ES07742276.4T patent/ES2518371T3/es active Active
- 2007-04-24 US US12/298,656 patent/US20090093453A1/en not_active Abandoned
- 2007-04-24 JP JP2008513218A patent/JP5695293B2/ja not_active Expired - Fee Related
- 2007-04-24 BR BRPI0710239-9A patent/BRPI0710239A2/pt not_active Application Discontinuation
- 2007-04-24 CA CA2648898A patent/CA2648898C/en active Active
- 2007-04-24 EP EP07742276.4A patent/EP2011796B1/en active Active
- 2007-04-24 DK DK07742276.4T patent/DK2011796T3/da active
- 2007-04-24 PL PL07742276T patent/PL2011796T3/pl unknown
- 2007-04-24 SI SI200731584T patent/SI2011796T1/sl unknown
- 2007-04-24 WO PCT/JP2007/058841 patent/WO2007125913A1/ja not_active Ceased
- 2007-04-24 CN CN2007800147663A patent/CN101432280B/zh not_active Expired - Fee Related
- 2007-04-24 KR KR1020087027617A patent/KR101374593B1/ko active Active
- 2007-04-24 ZA ZA200808728A patent/ZA200808728B/xx unknown
- 2007-04-24 MX MX2008013728A patent/MX2008013728A/es active IP Right Grant
- 2007-04-24 AU AU2007244409A patent/AU2007244409B2/en not_active Ceased
- 2007-04-24 PT PT77422764T patent/PT2011796E/pt unknown
-
2008
- 2008-10-06 IL IL194569A patent/IL194569A/en active IP Right Grant
- 2008-10-16 NO NO20084338A patent/NO342153B1/no unknown
-
2013
- 2013-05-07 JP JP2013097429A patent/JP2013177410A/ja active Pending
-
2014
- 2014-10-10 CY CY20141100826T patent/CY1115643T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101432280B (zh) | 2012-11-21 |
| KR20080111131A (ko) | 2008-12-22 |
| CA2648898A1 (en) | 2007-11-08 |
| CN101432280A (zh) | 2009-05-13 |
| JPWO2007125913A1 (ja) | 2009-09-10 |
| CA2648898C (en) | 2015-01-20 |
| EP2011796A1 (en) | 2009-01-07 |
| ZA200808728B (en) | 2010-01-27 |
| JP5695293B2 (ja) | 2015-04-01 |
| DK2011796T3 (da) | 2014-10-27 |
| EP2011796A4 (en) | 2010-07-07 |
| PT2011796E (pt) | 2014-11-26 |
| AU2007244409B2 (en) | 2011-12-01 |
| KR101374593B1 (ko) | 2014-03-17 |
| BRPI0710239A2 (pt) | 2011-08-09 |
| NZ571975A (en) | 2011-04-29 |
| AU2007244409A1 (en) | 2007-11-08 |
| EP2011796B1 (en) | 2014-10-08 |
| SI2011796T1 (sl) | 2015-02-27 |
| IL194569A0 (en) | 2009-08-03 |
| MX2008013728A (es) | 2009-01-07 |
| NO20084338L (no) | 2008-11-19 |
| JP2013177410A (ja) | 2013-09-09 |
| IL194569A (en) | 2014-09-30 |
| US20090093453A1 (en) | 2009-04-09 |
| WO2007125913A1 (ja) | 2007-11-08 |
| NO342153B1 (no) | 2018-04-03 |
| PL2011796T3 (pl) | 2015-03-31 |
| ES2518371T3 (es) | 2014-11-05 |
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