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CY1106679T1 - Αζαδικυκλικες ετεροκυκλικες ενωσεις ως τροποποιητες κανναβινοειδους υποδοχεα - Google Patents

Αζαδικυκλικες ετεροκυκλικες ενωσεις ως τροποποιητες κανναβινοειδους υποδοχεα

Info

Publication number
CY1106679T1
CY1106679T1 CY20071100845T CY071100845T CY1106679T1 CY 1106679 T1 CY1106679 T1 CY 1106679T1 CY 20071100845 T CY20071100845 T CY 20071100845T CY 071100845 T CY071100845 T CY 071100845T CY 1106679 T1 CY1106679 T1 CY 1106679T1
Authority
CY
Cyprus
Prior art keywords
azadicyclic
heterocyclic compounds
formula
cannabinoid receptor
receptor modifiers
Prior art date
Application number
CY20071100845T
Other languages
English (en)
Inventor
Guixue Gu
William R. Ewing
Amarendra B. Mikkilineni
Annapurna Pendri
Bruce A. Ellsworth
Phillip M. SHER
Samuel Gerritz
Chongqing Sun
Natesan Murugesan
Ximao Wu
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of CY1106679T1 publication Critical patent/CY1106679T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
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    • A—HUMAN NECESSITIES
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A—HUMAN NECESSITIES
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    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Addiction (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)

Abstract

Στην παρούσα αίτηση περιγράφονται ενώσεις σύμφωνα με τον Τύπο Ι, φαρμακευτικές συνθέσεις που περιέχουν τουλάχιστον μία ένωση σύμφωνα με τον Τύπο Ι και προαιρετικά έναν ή περισσότερους θεραπευτικούς παράγοντες και μέθοδοι θεραπευτικής αγωγής με τη χρησιμοποίηση των ενώσεων σύμφωνα με τον Τύπο Ι και μεμονωμένα και σε συνδυασμό με έναν ή περισσότερους επιπρόσθετους θεραπευτικούς παράγοντες. Στην παρούσα περιγράφονται οι ενώσεις που έχουν το γενικό Τύπο Ι περιλαμβανομένων όλων των προφαρμάκων, των φαρμακευτικώς αποδεκτών αλάτων και στερεοϊσομερών, R1, R2, R3, R4, R5, m και n.
CY20071100845T 2003-12-19 2007-06-26 Αζαδικυκλικες ετεροκυκλικες ενωσεις ως τροποποιητες κανναβινοειδους υποδοχεα CY1106679T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US53145103P 2003-12-19 2003-12-19
US11/016,198 US7816357B2 (en) 2003-12-19 2004-12-17 Azabicyclic heterocycles as cannabinoid receptor modulators
PCT/US2004/042878 WO2005063762A1 (en) 2003-12-19 2004-12-17 Azabicyclic heterocycles as cannabinoid receptor modulators

Publications (1)

Publication Number Publication Date
CY1106679T1 true CY1106679T1 (el) 2012-05-23

Family

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Country Status (20)

Country Link
US (1) US7816357B2 (el)
EP (1) EP1697371B1 (el)
JP (1) JP2007514770A (el)
KR (1) KR20060103265A (el)
AT (1) ATE360631T1 (el)
AU (1) AU2004309368A1 (el)
BR (1) BRPI0417820A (el)
CA (1) CA2550375A1 (el)
CY (1) CY1106679T1 (el)
DE (1) DE602004006166T2 (el)
DK (1) DK1697371T3 (el)
ES (1) ES2284081T3 (el)
HR (1) HRP20070267T3 (el)
IL (1) IL176110A0 (el)
IS (1) IS8503A (el)
NO (1) NO20062691L (el)
PL (1) PL1697371T3 (el)
PT (1) PT1697371E (el)
RU (1) RU2006126123A (el)
WO (1) WO2005063762A1 (el)

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JP2006517958A (ja) 2003-02-19 2006-08-03 ニューロジェン・コーポレイション アリール酸ピリミジニルメチルアミド、ピリダジニルメチルアミドおよび関連化合物
DK1697371T3 (da) 2003-12-19 2007-09-17 Bristol Myers Squibb Co Azabicykliske heterocykliske forbindelser som cannabinoidreceptormodulatorer
TW200528455A (en) 2003-12-19 2005-09-01 Bristol Myers Squibb Co Azabicyclic heterocycles as cannabinoid receptor modulators

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JP2007514770A (ja) 2007-06-07
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PL1697371T3 (pl) 2007-09-28
KR20060103265A (ko) 2006-09-28
US20050171110A1 (en) 2005-08-04
DK1697371T3 (da) 2007-09-17
ATE360631T1 (de) 2007-05-15
EP1697371A1 (en) 2006-09-06
DE602004006166T2 (de) 2008-01-10
WO2005063762A1 (en) 2005-07-14
DE602004006166D1 (de) 2007-06-06
HRP20070267T3 (hr) 2007-08-31
AU2004309368A1 (en) 2005-07-14
US7816357B2 (en) 2010-10-19
RU2006126123A (ru) 2008-01-27
NO20062691L (no) 2006-09-14
EP1697371B1 (en) 2007-04-25
IS8503A (is) 2006-06-08
PT1697371E (pt) 2007-08-03
BRPI0417820A (pt) 2007-03-27
CA2550375A1 (en) 2005-07-14
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