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WO2008108386A1 - 医薬組成物 - Google Patents

医薬組成物 Download PDF

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Publication number
WO2008108386A1
WO2008108386A1 PCT/JP2008/053908 JP2008053908W WO2008108386A1 WO 2008108386 A1 WO2008108386 A1 WO 2008108386A1 JP 2008053908 W JP2008053908 W JP 2008053908W WO 2008108386 A1 WO2008108386 A1 WO 2008108386A1
Authority
WO
WIPO (PCT)
Prior art keywords
substituted
hydrogen atom
lower alkyl
unsubstituted lower
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/053908
Other languages
English (en)
French (fr)
Inventor
Shiro Soga
Toshihiko Ishii
Takayuki Nakashima
Yukimasa Shiotsu
Shiro Akinaga
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Kyowa Kirin Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Kyowa Hakko Kirin Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd, Kyowa Hakko Kirin Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to US12/529,380 priority Critical patent/US20100098690A1/en
Priority to CN2008800071743A priority patent/CN101641117B/zh
Priority to CA002680161A priority patent/CA2680161A1/en
Priority to JP2009502597A priority patent/JPWO2008108386A1/ja
Priority to EP08721328A priority patent/EP2133094A4/en
Publication of WO2008108386A1 publication Critical patent/WO2008108386A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

　Hsp90ファミリー蛋白質阻害剤と、少なくとも1つの化合物とを組み合わせてなる医薬組成物、該Hsp90ファミリー蛋白質阻害剤が式(I) ［式中、nは1～5の整数を表し、R1は置換もしくは非置換の低級アルキル、CONR7R8（式中、R7及びR8は同一または異なって、水素原子、置換もしくは非置換の低級アルキル等を表す）等を表し、R2は置換もしくは非置換のアリール等を表し、R3及びR5は同一または異なって、水素原子、置換もしくは非置換の低級アルキル等を表し、R4は水素原子、ヒドロキシまたはハロゲンを表し、R6は水素原子、ハロゲン、置換もしくは非置換の低級アルキル等を表す]で表されるベンゾイル化合物もしくはそのプロドラッグまたはその薬理学的に許容される塩である前記医薬組成物等を提供する。 　
PCT/JP2008/053908 2007-03-05 2008-03-05 医薬組成物 Ceased WO2008108386A1 (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US12/529,380 US20100098690A1 (en) 2007-03-05 2008-03-05 Pharmaceutical composition
CN2008800071743A CN101641117B (zh) 2007-03-05 2008-03-05 药物组合物
CA002680161A CA2680161A1 (en) 2007-03-05 2008-03-05 Pharmaceutical composition
JP2009502597A JPWO2008108386A1 (ja) 2007-03-05 2008-03-05 医薬組成物
EP08721328A EP2133094A4 (en) 2007-03-05 2008-03-05 PHARMACEUTICAL COMPOSITION

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007053675 2007-03-05
JP2007-053675 2007-03-05

Publications (1)

Publication Number Publication Date
WO2008108386A1 true WO2008108386A1 (ja) 2008-09-12

Family

ID=39738259

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/053908 Ceased WO2008108386A1 (ja) 2007-03-05 2008-03-05 医薬組成物

Country Status (8)

Country Link
US (1) US20100098690A1 (ja)
EP (2) EP2133094A4 (ja)
JP (2) JPWO2008108386A1 (ja)
KR (1) KR20090116794A (ja)
CN (1) CN101641117B (ja)
CA (1) CA2680161A1 (ja)
TW (1) TW200901960A (ja)
WO (1) WO2008108386A1 (ja)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011049946A1 (en) * 2009-10-19 2011-04-28 Synta Pharmaceuticals Corp. Combination cancer therapy with hsp90 inhibitory compounds
US9205086B2 (en) 2010-04-19 2015-12-08 Synta Pharmaceuticals Corp. Cancer therapy using a combination of a Hsp90 inhibitory compounds and a EGFR inhibitor
US9402831B2 (en) 2011-11-14 2016-08-02 Synta Pharmaceutical Corp. Combination therapy of HSP90 inhibitors with BRAF inhibitors
US9439899B2 (en) 2011-11-02 2016-09-13 Synta Pharmaceuticals Corp. Cancer therapy using a combination of HSP90 inhibitors with topoisomerase I inhibitors
JP2017505777A (ja) * 2014-01-29 2017-02-23 シンタ ファーマスーティカルズ コーポレーション 標的化治療薬
JP2017507150A (ja) * 2014-03-03 2017-03-16 シンタ ファーマスーティカルズ コーポレイションＳｙｎｔａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｃｏｒｐ． 標的治療薬
US10500193B2 (en) 2011-11-02 2019-12-10 Synta Pharmaceuticals Corporation Combination therapy of HSP90 inhibitors with platinum-containing agents
WO2025041853A1 (ja) * 2023-08-24 2025-02-27 大鵬薬品工業株式会社 アザ二環式化合物と抗アンドロゲン剤を用いたがん併用療法

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002032872A1 (fr) 2000-10-20 2002-04-25 Eisai Co., Ltd. Composes a noyau aromatique azote
ATE428421T1 (de) 2004-09-17 2009-05-15 Eisai R&D Man Co Ltd Medizinische zusammensetzung mit verbesserter stabilität und reduzierten gelierungseigenschaften
EP2281901B1 (en) 2005-08-02 2013-11-27 Eisai R&D Management Co., Ltd. Anti-tumour pharmaceutical composition with angiogenesis inhibitors
AU2006309551B2 (en) 2005-11-07 2012-04-19 Eisai R & D Management Co., Ltd. Use of combination of anti-angiogenic substance and c-kit kinase inhibitor
ES2556173T3 (es) 2006-05-18 2016-01-13 Eisai R&D Management Co., Ltd. Agente antitumoral para un cáncer de tiroides
CN101511793B (zh) 2006-08-28 2011-08-03 卫材R&D管理有限公司 针对未分化型胃癌的抗肿瘤剂
CN101600694A (zh) 2007-01-29 2009-12-09 卫材R&D管理有限公司 未分化型胃癌治疗用组合物
EP2218712B1 (en) 2007-11-09 2015-07-01 Eisai R&D Management Co., Ltd. Combination of anti-angiogenic substance and anti-tumor platinum complex
CA2795089A1 (en) * 2010-04-16 2011-10-20 Novartis Ag Combination of organic compounds
AU2011270165B2 (en) 2010-06-25 2015-12-24 Eisai R&D Management Co., Ltd. Antitumor agent using compounds having kinase inhibitory effect in combination
EP2678013A1 (en) * 2011-02-23 2014-01-01 Synta Pharmaceuticals Corp. Combination therapy of hsp90 inhibitory compounds with radiotherapy
KR101762999B1 (ko) 2011-04-18 2017-07-28 에자이 알앤드디 매니지먼트 가부시키가이샤 종양 치료제
US9945862B2 (en) 2011-06-03 2018-04-17 Eisai R&D Management Co., Ltd. Biomarkers for predicting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds
US20140079636A1 (en) 2012-04-16 2014-03-20 Dinesh U. Chimmanamada Targeted therapeutics
WO2014098176A1 (ja) 2012-12-21 2014-06-26 エーザイ・アール・アンド・ディー・マネジメント株式会社 キノリン誘導体のアモルファス及びその製造方法
SG11201509278XA (en) 2013-05-14 2015-12-30 Eisai R&D Man Co Ltd Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds
WO2015038649A1 (en) 2013-09-10 2015-03-19 Synta Pharmaceuticals Corp. Targeted therapeutics
WO2015066053A2 (en) 2013-10-28 2015-05-07 Synta Pharmaceuticals Corp. Targeted therapeutics
MA39483A (fr) 2014-03-18 2015-09-24 Synta Pharmaceuticals Corp Agents thérapeutiques cibles
PL3524595T3 (pl) 2014-08-28 2022-10-31 Eisai R&D Management Co., Ltd. Pochodna chinoliny o wysokiej czystości i sposób jej wytwarzania
HUE064614T2 (hu) 2015-02-25 2024-04-28 Eisai R&D Man Co Ltd Eljárás egy kinolin-származék keserû ízének elnyomására
WO2016140717A1 (en) 2015-03-04 2016-09-09 Merck Sharp & Dohme Corp. Combination of a pd-1 antagonist and a vegfr/fgfr/ret tyrosine kinase inhibitor for treating cancer
ES2886107T3 (es) 2015-06-16 2021-12-16 Prism Biolab Co Ltd Antineoplásico
FR3039401B1 (fr) * 2015-07-31 2018-07-13 Les Laboratoires Servier Nouvelle association entre le 3-[(3-{[4-(4-morpholinylmethyl)-1h-pyrrol-2-yl]methylene}-2-oxo-2,3-dihydro-1h-indol-5-yl)methyl]-1,3-thiazolidine-2,4-dione et un inhibiteur de la tyr kinase du egfr
US12220398B2 (en) 2015-08-20 2025-02-11 Eisai R&D Management Co., Ltd. Tumor therapeutic agent
KR102539920B1 (ko) 2017-02-08 2023-06-05 에자이 알앤드디 매니지먼트 가부시키가이샤 종양-치료용 약제학적 조성물
CA3061888A1 (en) 2017-05-16 2018-11-22 Eisai R&D Management Co., Ltd. Treatment of hepatocellular carcinoma
AU2018289339A1 (en) 2017-06-20 2020-01-02 Madrigal Pharmaceuticals, Inc. Targeted therapeutics
US11491145B2 (en) 2017-06-20 2022-11-08 Madrigal Pharmaceuticals, Inc. Combination therapies comprising targeted therapeutics

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002036075A2 (en) 2000-11-02 2002-05-10 Sloan-Kettering Institute For Cancer Research Small molecule compositions for binding to hsp90
WO2003055860A1 (en) 2001-12-21 2003-07-10 Vernalis (Cambridge) Limited 3,4-diarylpyrazoles and their use in the therapy of cancer
WO2005000778A1 (ja) 2003-06-27 2005-01-06 Kyowa Hakko Kogyo Co., Ltd. Hsp90ファミリー蛋白質阻害剤
WO2005012258A1 (ja) 2003-07-30 2005-02-10 Kyowa Hakko Kogyo Co., Ltd. タンパク質キナーゼ阻害剤
WO2005012257A1 (ja) 2003-07-30 2005-02-10 Kyowa Hakko Kogyo Co., Ltd. インダゾール誘導体
WO2005063222A1 (ja) 2003-12-26 2005-07-14 Kyowa Hakko Kogyo Co., Ltd. Hsp90ファミリー蛋白質阻害剤
WO2005095341A1 (ja) 2004-03-30 2005-10-13 Kyowa Hakko Kogyo Co., Ltd. 含窒素複素環化合物
WO2005095382A1 (ja) 2004-03-30 2005-10-13 Kyowa Hakko Kogyo Co., Ltd. 抗腫瘍剤
WO2005112952A2 (en) * 2004-05-20 2005-12-01 Kosan Biosciences Incorporated Geldanamycin compounds and method of use
WO2006010595A1 (en) * 2004-07-27 2006-02-02 Novartis Ag Inhibitors of hsp90
WO2006088193A1 (ja) 2005-02-21 2006-08-24 Kyowa Hakko Kogyo Co., Ltd. 抗腫瘍剤

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060252740A1 (en) * 2005-04-29 2006-11-09 Johnson Robert G Jr Method of treating multiple myeloma using 17-AAG or 17-AG or a prodrug of either in combination with a proteasome inhibitor
EP2133095A4 (en) * 2007-03-05 2012-09-26 Kyowa Hakko Kirin Co Ltd PHARMACEUTICAL COMPOSITION
JPWO2009028387A1 (ja) * 2007-08-24 2010-12-02 協和発酵キリン株式会社 プロテアーゼ阻害剤耐性を有する癌の治療薬

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002036075A2 (en) 2000-11-02 2002-05-10 Sloan-Kettering Institute For Cancer Research Small molecule compositions for binding to hsp90
WO2003055860A1 (en) 2001-12-21 2003-07-10 Vernalis (Cambridge) Limited 3,4-diarylpyrazoles and their use in the therapy of cancer
WO2005000778A1 (ja) 2003-06-27 2005-01-06 Kyowa Hakko Kogyo Co., Ltd. Hsp90ファミリー蛋白質阻害剤
WO2005012258A1 (ja) 2003-07-30 2005-02-10 Kyowa Hakko Kogyo Co., Ltd. タンパク質キナーゼ阻害剤
WO2005012257A1 (ja) 2003-07-30 2005-02-10 Kyowa Hakko Kogyo Co., Ltd. インダゾール誘導体
WO2005063222A1 (ja) 2003-12-26 2005-07-14 Kyowa Hakko Kogyo Co., Ltd. Hsp90ファミリー蛋白質阻害剤
WO2005095341A1 (ja) 2004-03-30 2005-10-13 Kyowa Hakko Kogyo Co., Ltd. 含窒素複素環化合物
WO2005095382A1 (ja) 2004-03-30 2005-10-13 Kyowa Hakko Kogyo Co., Ltd. 抗腫瘍剤
WO2005112952A2 (en) * 2004-05-20 2005-12-01 Kosan Biosciences Incorporated Geldanamycin compounds and method of use
WO2006010595A1 (en) * 2004-07-27 2006-02-02 Novartis Ag Inhibitors of hsp90
WO2006088193A1 (ja) 2005-02-21 2006-08-24 Kyowa Hakko Kogyo Co., Ltd. 抗腫瘍剤

Non-Patent Citations (35)

* Cited by examiner, † Cited by third party
Title
"International Journal of Radiation Oncology", BIOLOGY, PHYSICS, vol. 5, 1979, pages 85
"International Journal of Radiation Oncology", BIOLOGY, PHYSICS, vol. 5, 1979, pages 85 - 91
ADVANCES IN DRUG RES., vol. 13, 1984, pages 224 - 331
BIOCHEM. PHARMACOL, vol. 56, 1998, pages 675 - 682
BLOOD, vol. 107, 2006, pages 1092 - 1100
BLOOD, vol. 96, 2000, pages 2284 - 2291
BUNDGAARD: "Design of Prodrugs", 1985, ELSEVIER PRESS
CANCER CHEMOTHER. PHARMACOL., vol. 48, 2001, pages 435 - 445
CANCER RES., vol. 59, 1999, pages 2931 - 2938
CANCER RES., vol. 63, 2003, pages 2139 - 2144
CANCER RES., vol. 66, 2006, pages 1089 - 1095
CELL STRESS CHAPERONES, vol. 3, 1998, pages 100 - 108
CELL, vol. 89, 1997, pages 239 - 250
CLIN. CANCER RES., vol. 10, 2004, pages 8077 - 8084
CLIN. CANCER RES., vol. 12, 2006, pages 584 - 590
CLIN. CANCER RES., vol. 12, 2006, pages 6547 - 6556
CLIN. CANCER RES., vol. 9, 2003, pages 3749 - 3755
CURRENT MEDICINAL CHEMISTRY, vol. 14, 2007, pages 223 - 232
DRUG DEV. RES., vol. 34, 1995, pages 220 - 230
EMBO JOURNAL, vol. 21, 2002, pages 2407 - 2417
EXPERT OPINION ON BIOLOGICAL THERAPY, vol. 2, 2002, pages 3 - 24
IBID., vol. 5, 1979, pages 1145
INVEST. NEW DRUGS, vol. 17, 1999, pages 361 - 373
J. MED. CHEM., vol. 40, 1997, pages 2011 - 2016
J. MED. CHEM., vol. 42, 1999, pages 260 - 266
J. NATL. CANCER INST., vol. 92, 2000, pages 242 - 248
LEUKEMIA, vol. 20, 2006, pages 610 - 619
MERCK MANUAL, 10 December 1999 (1999-12-10), pages 983 - 992 *
MOL. CANCER THER., vol. 3, 2004, pages 551 - 566
MOL. CANCER THR., vol. 5, 2006, pages 1197 - 1208
MOL. CANCER THR., vol. 5, 2006, pages 179 - 186
NVEST. NEW DRUGS, vol. 17, 1999, pages 361 - 373
PHARMACOL. THER., vol. 79, 1997, pages 129 - 168
See also references of EP2133094A4 *
T.W. GREENE: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS INC.

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013508378A (ja) * 2009-10-19 2013-03-07 シンタ ファーマシューティカルズ コーポレーション Ｈｓｐ９０阻害化合物を用いる併用がん療法
EA022119B1 (ru) * 2009-10-19 2015-11-30 Синта Фармасьютиклз Корп. Комбинированная терапия раковых заболеваний с помощью соединений - ингибиторов hsp90
WO2011049946A1 (en) * 2009-10-19 2011-04-28 Synta Pharmaceuticals Corp. Combination cancer therapy with hsp90 inhibitory compounds
US9205086B2 (en) 2010-04-19 2015-12-08 Synta Pharmaceuticals Corp. Cancer therapy using a combination of a Hsp90 inhibitory compounds and a EGFR inhibitor
US10500193B2 (en) 2011-11-02 2019-12-10 Synta Pharmaceuticals Corporation Combination therapy of HSP90 inhibitors with platinum-containing agents
US9439899B2 (en) 2011-11-02 2016-09-13 Synta Pharmaceuticals Corp. Cancer therapy using a combination of HSP90 inhibitors with topoisomerase I inhibitors
US9402831B2 (en) 2011-11-14 2016-08-02 Synta Pharmaceutical Corp. Combination therapy of HSP90 inhibitors with BRAF inhibitors
JP2017505777A (ja) * 2014-01-29 2017-02-23 シンタ ファーマスーティカルズ コーポレーション 標的化治療薬
US10232049B2 (en) 2014-03-03 2019-03-19 Madrigal Pharmaceuticals, Inc. Targeted therapeutics
JP2019196406A (ja) * 2014-03-03 2019-11-14 マドリガル ファーマシューティカルズ インコーポレイテッドＭａｄｒｉｇａｌ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． 標的治療薬
JP2017507150A (ja) * 2014-03-03 2017-03-16 シンタ ファーマスーティカルズ コーポレイションＳｙｎｔａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｃｏｒｐ． 標的治療薬
US10675360B2 (en) 2014-03-03 2020-06-09 Madrigal Pharmaceuticals, Inc. Targeted therapeutics
WO2025041853A1 (ja) * 2023-08-24 2025-02-27 大鵬薬品工業株式会社 アザ二環式化合物と抗アンドロゲン剤を用いたがん併用療法

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US20100098690A1 (en) 2010-04-22
EP2543390A1 (en) 2013-01-09
TW200901960A (en) 2009-01-16
EP2133094A1 (en) 2009-12-16
JPWO2008108386A1 (ja) 2010-06-17
EP2133094A4 (en) 2010-10-13
JP2013121987A (ja) 2013-06-20
CA2680161A1 (en) 2008-09-12
CN101641117B (zh) 2012-06-13

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