[go: up one dir, main page]

WO2003008588A3 - Verfahren zur herstellung von 2-keto-l-gulonsäure und vitamin c unter benutzung von l-sorbose-und l-sorbosondehydrogenase - Google Patents

Verfahren zur herstellung von 2-keto-l-gulonsäure und vitamin c unter benutzung von l-sorbose-und l-sorbosondehydrogenase Download PDF

Info

Publication number
WO2003008588A3
WO2003008588A3 PCT/EP2002/007484 EP0207484W WO03008588A3 WO 2003008588 A3 WO2003008588 A3 WO 2003008588A3 EP 0207484 W EP0207484 W EP 0207484W WO 03008588 A3 WO03008588 A3 WO 03008588A3
Authority
WO
WIPO (PCT)
Prior art keywords
dehydrogenase
keto
producing
vitamin
sorbosone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2002/007484
Other languages
English (en)
French (fr)
Other versions
WO2003008588A2 (de
Inventor
Knut Eichler
Christine Beck
Thomas Friedrich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE filed Critical BASF SE
Priority to AU2002328843A priority Critical patent/AU2002328843A1/en
Publication of WO2003008588A2 publication Critical patent/WO2003008588A2/de
Publication of WO2003008588A3 publication Critical patent/WO2003008588A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
    • A23K10/14—Pretreatment of feeding-stuffs with enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/58—Aldonic, ketoaldonic or saccharic acids
    • C12P7/60—2-Ketogulonic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/99—Oxidoreductases acting on the CH-OH group of donors (1.1) with other acceptors (1.1.99)
    • C12Y101/99012—Sorbose dehydrogenase (1.1.99.12)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Animal Husbandry (AREA)
  • Physiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Die vorliegende Erfindung betrifft Polypeptide mit L-Sorbosedehydrogenase (SDH) bzw. L-Sorbosondehydrogenase (SNDH) Aktivität sowie Nukleinsäuresequenzen kodierend für diese Polypeptide. Ferner betrifft die Erfindung transgene Expressionskonstrukte, Vektoren und transgene Organismen, die diese Nukleinsäuresequenzen enthalten sowie Verfahren zur Herstellung von 2-Keto-L-gulonsäure oder Ascorbinsäure unter Verwendung derselben.
PCT/EP2002/007484 2001-07-13 2002-07-05 Verfahren zur herstellung von 2-keto-l-gulonsäure und vitamin c unter benutzung von l-sorbose-und l-sorbosondehydrogenase Ceased WO2003008588A2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002328843A AU2002328843A1 (en) 2001-07-13 2002-07-05 Method for producing 2-keto-l-gulonic acid and vitamin c while using l-sorbose dehydrogenase and l-sorbosone dehydrogenase

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10133397 2001-07-13
DE10133397.8 2001-07-13

Publications (2)

Publication Number Publication Date
WO2003008588A2 WO2003008588A2 (de) 2003-01-30
WO2003008588A3 true WO2003008588A3 (de) 2003-11-06

Family

ID=7691222

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/007484 Ceased WO2003008588A2 (de) 2001-07-13 2002-07-05 Verfahren zur herstellung von 2-keto-l-gulonsäure und vitamin c unter benutzung von l-sorbose-und l-sorbosondehydrogenase

Country Status (2)

Country Link
AU (1) AU2002328843A1 (de)
WO (1) WO2003008588A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100395332C (zh) * 2003-11-28 2008-06-18 华北制药集团有限责任公司 一种l-山梨酮脱氢酶及其编码基因与应用
WO2006084720A2 (en) * 2005-02-11 2006-08-17 Dsm Ip Assets B.V. Hpr kinase from gluconobacter oxydan
ES2372879T3 (es) 2006-06-22 2012-01-27 Ikeda Food Research Co. Ltd. Procedimiento para determinar 1,5-anhidroglucitol y composición reactiva para determinar 1,5-anhidroglucitol.
CN102653767A (zh) * 2012-05-26 2012-09-05 江南大学 一种新型l-山梨糖/l-山梨酮脱氢酶的基因及其应用
CN103254159A (zh) * 2013-01-29 2013-08-21 南京凯通粮食生化研究设计有限公司 一种维生素c生产工艺的改进方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0276832A2 (de) * 1987-01-30 1988-08-03 F. Hoffmann-La Roche Ag Verfahren zur Herstellung von Ketogulonsäure
EP0753575A1 (de) * 1993-03-08 1997-01-15 Fujisawa Pharmaceutical Co., Ltd. NEUARTIGE L-SORBOSEDEHYDROGENASE UND NEUARTIGE LSORBOSEDEHYDROGENASE AUS $i(GLUCONOBACTER OXYDANS)
EP0758679A1 (de) * 1994-02-25 1997-02-19 Fujisawa Pharmaceutical Co., Ltd. Verfahren zur herstellung von 2-keto-l-gulonsäure

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0276832A2 (de) * 1987-01-30 1988-08-03 F. Hoffmann-La Roche Ag Verfahren zur Herstellung von Ketogulonsäure
EP0753575A1 (de) * 1993-03-08 1997-01-15 Fujisawa Pharmaceutical Co., Ltd. NEUARTIGE L-SORBOSEDEHYDROGENASE UND NEUARTIGE LSORBOSEDEHYDROGENASE AUS $i(GLUCONOBACTER OXYDANS)
EP0758679A1 (de) * 1994-02-25 1997-02-19 Fujisawa Pharmaceutical Co., Ltd. Verfahren zur herstellung von 2-keto-l-gulonsäure

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ASAKURA A ET AL: "ISOLATION AND CHARACTERIZATION OF A NEW QUINOPROTEIN DEHYDROGENASE, L-SORBOSE/L-SORBOSONE DEHYDROGENASE", BIOSCIENCE BIOTECHNOLOGY BIOCHEMISTRY, JAPAN SOC. FOR BIOSCIENCE, BIOTECHNOLOGY AND AGROCHEM. TOKYO, JP, vol. 63, no. 1, January 1999 (1999-01-01), pages 46 - 53, XP001085040, ISSN: 0916-8451 *
LEE H -W ET AL: "Screening for L-sorbose and L-sorbosone dehydrogenase producing microbes for 2-keto-L-gulonic acid production.", JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY, vol. 23, no. 2, August 1999 (1999-08-01), pages 106 - 111, XP002241676, ISSN: 1367-5435 *
SAITO Y ET AL: "CLONING OF GENES CODING FOR L-SORBOSE AND L-SORBOSONE DEHYDROGENASES FROM GLUCONOBACTER OXYDANS AND MICROBIAL PRODUCTION OF 2-KETO-L-GULONATE, A PRECURSOR OF L-ASCORBIC ACID, IN A RECOMBINANT G. OXYDANS STRAIN", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, WASHINGTON,DC, US, vol. 63, no. 2, 1997, pages 454 - 460, XP000886144, ISSN: 0099-2240 *

Also Published As

Publication number Publication date
WO2003008588A2 (de) 2003-01-30
AU2002328843A1 (en) 2003-03-03

Similar Documents

Publication Publication Date Title
ZA200201079B (en) Method of generating hoistway information to serve an elevator control.
AU6589094A (en) 7-deazapurine modified oligonucleotides
ATE551352T1 (de) Peptidakzeptorbindungsverfahren
WO2001007574A3 (de) Modifizierte cytochrom p450-monooxygenasen
WO2001061868A3 (en) Method, apparatus, and product for use in generating crc and other remainder based codes
ATE409235T1 (de) Verfahren zur herstellung von ascorbinsäurezwischenprodukten in wirtszellen
AU2003299104A1 (en) Aldehyde dehydrogenase gene
AU6438194A (en) Method for the oxidation of vicinal diols, including carbohydrates
MXPA00006539A (es) Metodo de procedimiento con laser, metodo para la fabricacion de cabeza de registro de chorros de tinta empleando dicho metodo, de fabricacion, y cabeza de registro de chorros de tinta fabricada por dicho metodo de fabricacion.
WO1995006764A3 (en) Oligonucleotides with rna cleavage activity
WO2003008588A3 (de) Verfahren zur herstellung von 2-keto-l-gulonsäure und vitamin c unter benutzung von l-sorbose-und l-sorbosondehydrogenase
MXPA01011077A (es) Metodo para mejorar la accion de insulina.
WO2001098469A3 (en) Polypeptides having peroxidase activity and nucleic acids encoding same
WO2001046455A3 (en) Survivin promotion of angiogenesis
GB2301700B (en) Laser writer having high speed, high current laser driver
WO2001016303A3 (de) Nucleinsäuren, die für enzymaktivitäten der spinosyn-biosynthese codieren
WO2000065036A3 (de) Überexpression einer dna-sequenz codierend für eine 1-desoxy-d-xylulose-5-phosphat reduktoisomerase in pflanzen
WO2001072974A3 (en) L-galactose dehydrogenase from arabidopsis thaliana, and uses thereof
WO2004090094A3 (de) L-carnitin dehydrogenasen, deren derivate und ein verfahren zur herstellung von substituierten (s)-alkanolen
WO2001012827A3 (de) Verfahren zur herstellung transgener pflanzen mit erhöhtem tocopherol-gehalt
PL348509A1 (en) Production of ascorbic acid using yeast
ZA200110146B (en) Method for producing peroxycarboxylic acid solutions, especially equilibrium peracetic acid and perpropionic acid.
WO1997029194A3 (de) Herstellung von l-ascorbinsäure
ATE396181T1 (de) Verfahren zur herstellung von lactonen oder epoxiden
EP0984066A3 (de) Methanoldehydrogenase-Aktivator und dafür kodierendes Gen

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LU MC NL PT SE SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP