SK287568B6 - Kompozícia s trvalým uvoľňovaním, spôsob jej výroby, jej použitie, farmaceutický prípravok a spôsob výroby polyméru - Google Patents
Kompozícia s trvalým uvoľňovaním, spôsob jej výroby, jej použitie, farmaceutický prípravok a spôsob výroby polyméru Download PDFInfo
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- SK287568B6 SK287568B6 SK1561-2003A SK15612003A SK287568B6 SK 287568 B6 SK287568 B6 SK 287568B6 SK 15612003 A SK15612003 A SK 15612003A SK 287568 B6 SK287568 B6 SK 287568B6
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- Slovakia
- Prior art keywords
- sustained release
- polymer
- salt
- release composition
- molecular weight
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- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- UQZIYBXSHAGNOE-XNSRJBNMSA-N stachyose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO[C@@H]3[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O3)O)O2)O)O1 UQZIYBXSHAGNOE-XNSRJBNMSA-N 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000010414 supernatant solution Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 150000004044 tetrasaccharides Chemical class 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229910052723 transition metal Inorganic materials 0.000 description 1
- 150000003624 transition metals Chemical class 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- FYGDTMLNYKFZSV-BYLHFPJWSA-N β-1,4-galactotrioside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@H](CO)O[C@@H](O[C@@H]2[C@@H](O[C@@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-BYLHFPJWSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurosurgery (AREA)
- Gynecology & Obstetrics (AREA)
- Neurology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Pregnancy & Childbirth (AREA)
- Hospice & Palliative Care (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001199462 | 2001-06-29 | ||
| JP2001340980 | 2001-11-06 | ||
| PCT/JP2002/006526 WO2003002091A2 (en) | 2001-06-29 | 2002-06-28 | Sustained-release composition comprising lactic acid-glycolic acid copolymer and process for producing the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK15612003A3 SK15612003A3 (sk) | 2004-07-07 |
| SK287568B6 true SK287568B6 (sk) | 2011-02-04 |
Family
ID=26617908
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1561-2003A SK287568B6 (sk) | 2001-06-29 | 2002-06-28 | Kompozícia s trvalým uvoľňovaním, spôsob jej výroby, jej použitie, farmaceutický prípravok a spôsob výroby polyméru |
Country Status (31)
| Country | Link |
|---|---|
| US (3) | US20040241229A1 (es) |
| EP (2) | EP1399133B2 (es) |
| JP (3) | JP5491318B2 (es) |
| KR (3) | KR20090096755A (es) |
| CN (1) | CN1535141B (es) |
| AR (1) | AR034640A1 (es) |
| AT (1) | ATE429903T1 (es) |
| AU (1) | AU2002311630B2 (es) |
| BR (1) | BR0210572A (es) |
| CA (1) | CA2451718C (es) |
| CO (1) | CO5540368A2 (es) |
| CY (1) | CY1109272T1 (es) |
| CZ (1) | CZ306388B6 (es) |
| DE (1) | DE60232147D1 (es) |
| DK (1) | DK1399133T4 (es) |
| ES (1) | ES2324156T5 (es) |
| HU (1) | HU230152B1 (es) |
| IL (1) | IL159060A0 (es) |
| MX (1) | MXPA03011440A (es) |
| MY (1) | MY139606A (es) |
| NO (1) | NO333531B1 (es) |
| NZ (1) | NZ529968A (es) |
| PE (1) | PE20030069A1 (es) |
| PL (1) | PL212531B1 (es) |
| PT (1) | PT1399133E (es) |
| RU (2) | RU2297240C2 (es) |
| SI (1) | SI1399133T2 (es) |
| SK (1) | SK287568B6 (es) |
| TW (1) | TWI225416B (es) |
| WO (1) | WO2003002091A2 (es) |
| ZA (1) | ZA200309153B (es) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2490351C (en) | 2002-06-25 | 2011-11-01 | Takeda Pharmaceutical Company Limited | Process for producing sustained-release composition |
| DE60315472T2 (de) * | 2002-09-24 | 2008-04-30 | Asahi Kasei Chemicals Corp. | Glycolsaüre copolymer und verfahren zu dessen herstellung |
| TW200529890A (en) | 2004-02-10 | 2005-09-16 | Takeda Pharmaceutical | Sustained-release preparations |
| TW200613012A (en) * | 2004-07-02 | 2006-05-01 | Takeda Pharmaceuticals Co | Sustained-release composition, process for producing the same and use of the same |
| DE602006000381T2 (de) * | 2005-04-28 | 2008-12-18 | Nipro Corp., Osaka | Bioabsorbierbare pharmazeutische Zusammensetzung enthaltend einen PLGA-Copolymer |
| DK1984009T3 (da) | 2006-01-18 | 2013-01-28 | Qps Llc | Farmaceutiske sammensætninger med forbedret stabilitet |
| CN101563068B (zh) * | 2006-12-18 | 2013-03-20 | 武田药品工业株式会社 | 缓释组合物和其制备方法 |
| DK3660073T3 (da) | 2007-02-15 | 2023-09-18 | Tolmar International Ltd | Poly(lactid-co-glycolid) med lav sprængning |
| KR101008462B1 (ko) * | 2007-07-26 | 2011-01-14 | 조남열 | 치어류 이동용 어도 장치 |
| KR100969641B1 (ko) * | 2007-11-12 | 2010-07-14 | 민선영 | 저수지의 제방용 어도 |
| KR100969642B1 (ko) * | 2007-11-15 | 2010-07-12 | 민선영 | 하천의 보용 어도 |
| TWI477266B (zh) * | 2009-11-05 | 2015-03-21 | Taiwan Biotech Co Ltd | 連續製備微粒的方法、裝置及其收集單元 |
| US8641900B2 (en) | 2009-11-05 | 2014-02-04 | Taiwan Biotech Co., Ltd | Method and device for continuously preparing microspheres, and collection unit thereof |
| EP2697361A1 (en) * | 2011-04-11 | 2014-02-19 | Cellcura Asa | Protein-free culture media products for manufacturing viral-based vaccines |
| US9517210B2 (en) | 2012-07-12 | 2016-12-13 | Takeda Pharmaceutical Company Limited | Method for producing microcapsule powder |
| RU2572992C2 (ru) * | 2012-08-28 | 2016-01-20 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Курская государственная сельскохозяйственная академия имени И.И. Иванова" | Способ получения микрокапсул водорастворимых препаратов пестицидов |
| JP5959728B2 (ja) | 2013-04-11 | 2016-08-02 | 三井化学株式会社 | 乳酸―グリコール酸共重合体の製造法またはその塩の製造法 |
| RU2537173C1 (ru) * | 2013-05-24 | 2014-12-27 | Александр Александрович Кролевец | Способ получения микрокапсул гетероциклических соединений триазинового ряда |
| RU2537248C1 (ru) * | 2013-05-24 | 2014-12-27 | Екатерина Евгеньевна Быковская | Способ получения микрокапсул гетероциклических соединений триазинового ряда |
| CN105764491A (zh) | 2013-12-09 | 2016-07-13 | 度瑞公司 | 药物活性剂复合物、聚合物复合物,以及包括其的组合物和方法 |
| EP3131532A1 (de) | 2014-04-16 | 2017-02-22 | Veyx-Pharma GmbH | Veterinärpharmazeutische zusammensetzung und deren verwendung |
| TW201618783A (zh) | 2014-08-07 | 2016-06-01 | 艾森塔製藥公司 | 以布魯頓(Bruton)氏酪胺酸激酶(BTK)佔據和BTK再合成速率為基礎之治療癌症、免疫和自體免疫疾病及發炎性疾病之方法 |
| CN104224731A (zh) * | 2014-09-11 | 2014-12-24 | 北京天晟泰丰医药科技有限公司 | 一种不含致敏性辅料的九肽微球的制备方法 |
| JP5938762B1 (ja) | 2015-09-01 | 2016-06-22 | 日揮株式会社 | マイクロカプセル製剤及びその製造方法 |
| CN110856690B (zh) * | 2018-08-22 | 2024-07-02 | 深圳善康医药科技股份有限公司 | 一种植入剂包膜及干燥装置 |
| WO2021234731A1 (en) * | 2020-05-18 | 2021-11-25 | Dr Reddy's Institute Of Life Sciences | Sustained release compositions |
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| JPS60100516A (ja) | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
| JPH0678425B2 (ja) | 1984-07-06 | 1994-10-05 | 和光純薬工業株式会社 | 重合体の新規製造法 |
| CA1256638A (en) | 1984-07-06 | 1989-06-27 | Motoaki Tanaka | Polymer and its production |
| JPH0720859B2 (ja) | 1985-02-07 | 1995-03-08 | 武田薬品工業株式会社 | マイクロカプセルの製造法 |
| EP0190833B1 (en) | 1985-02-07 | 1991-03-27 | Takeda Chemical Industries, Ltd. | Method for producing microcapsule |
| JP2551756B2 (ja) | 1985-05-07 | 1996-11-06 | 武田薬品工業株式会社 | ポリオキシカルボン酸エステルおよびその製造法 |
| EP0480918A1 (en) | 1988-02-10 | 1992-04-22 | Abbott Laboratories | Reduced size lhrh analogs |
| US5110904A (en) | 1989-08-07 | 1992-05-05 | Abbott Laboratories | Lhrh analogs |
| JP2653255B2 (ja) * | 1990-02-13 | 1997-09-17 | 武田薬品工業株式会社 | 長期徐放型マイクロカプセル |
| JP3200706B2 (ja) | 1990-04-13 | 2001-08-20 | 武田薬品工業株式会社 | 生体内分解型高分子重合物 |
| DE69129770T2 (de) * | 1990-04-13 | 1998-11-19 | Takeda Chemical Industries Ltd | Biologisch abbaubare hochmolekulare Polymere, ihre Herstellung und ihre Verwendung |
| CA2079509C (en) * | 1991-10-01 | 2002-05-14 | Shigeyuki Takada | Prolonged release microparticle preparation and production of the same |
| JP3277342B2 (ja) * | 1992-09-02 | 2002-04-22 | 武田薬品工業株式会社 | 徐放性マイクロカプセルの製造法 |
| TW333456B (en) | 1992-12-07 | 1998-06-11 | Takeda Pharm Ind Co Ltd | A pharmaceutical composition of sustained-release preparation the invention relates to a pharmaceutical composition of sustained-release preparation which comprises a physiologically active peptide. |
| NZ260909A (en) * | 1993-07-05 | 1995-04-27 | Takeda Chemical Industries Ltd | Production of sustained release preparation by allowing a water-soluble polypeptide to permeate into a biodegradable matrix in an aqueous solution |
| JP3761594B2 (ja) * | 1993-07-05 | 2006-03-29 | 武田薬品工業株式会社 | 徐放性製剤の製造法 |
| JPH08259460A (ja) | 1995-01-23 | 1996-10-08 | Takeda Chem Ind Ltd | 徐放性製剤の製造法 |
| CA2192782C (en) * | 1995-12-15 | 2008-10-14 | Nobuyuki Takechi | Production of microspheres |
| JPH11269094A (ja) | 1998-01-16 | 1999-10-05 | Takeda Chem Ind Ltd | 徐放性組成物、その製造法および用途 |
| US6740634B1 (en) * | 1998-01-16 | 2004-05-25 | Takeda Chemical Industries, Ltd. | Sustained release compositions, process for producing the same and utilization thereof |
| CN1134479C (zh) † | 1998-12-15 | 2004-01-14 | 武田药品工业株式会社 | 制备聚合物的方法 |
| JP3716146B2 (ja) * | 1998-12-15 | 2005-11-16 | 武田薬品工業株式会社 | ポリマーの製造方法 |
| JP2002114667A (ja) | 2000-10-11 | 2002-04-16 | Ltt Institute Co Ltd | 徐放性製剤用組成物、その製造法および徐放性マイクロカプセル製剤 |
| TW200526267A (en) * | 2001-06-29 | 2005-08-16 | Takeda Chemical Industries Ltd | Controlled release composition and method of producing the same |
| CA2490351C (en) * | 2002-06-25 | 2011-11-01 | Takeda Pharmaceutical Company Limited | Process for producing sustained-release composition |
-
2002
- 2002-06-25 TW TW091113853A patent/TWI225416B/zh not_active IP Right Cessation
- 2002-06-26 AR ARP020102405A patent/AR034640A1/es not_active Application Discontinuation
- 2002-06-27 PE PE2002000577A patent/PE20030069A1/es not_active Application Discontinuation
- 2002-06-27 MY MYPI20022432A patent/MY139606A/en unknown
- 2002-06-28 PL PL367491A patent/PL212531B1/pl not_active IP Right Cessation
- 2002-06-28 DK DK02738837.0T patent/DK1399133T4/da active
- 2002-06-28 CZ CZ2003-3492A patent/CZ306388B6/cs not_active IP Right Cessation
- 2002-06-28 WO PCT/JP2002/006526 patent/WO2003002091A2/en not_active Ceased
- 2002-06-28 KR KR1020097017748A patent/KR20090096755A/ko not_active Ceased
- 2002-06-28 KR KR1020097017747A patent/KR100988178B1/ko not_active Expired - Lifetime
- 2002-06-28 CN CN028130413A patent/CN1535141B/zh not_active Expired - Lifetime
- 2002-06-28 PT PT02738837T patent/PT1399133E/pt unknown
- 2002-06-28 BR BR0210572-1A patent/BR0210572A/pt not_active Application Discontinuation
- 2002-06-28 EP EP02738837A patent/EP1399133B2/en not_active Expired - Lifetime
- 2002-06-28 RU RU2004102503/15A patent/RU2297240C2/ru active
- 2002-06-28 HU HU0400382A patent/HU230152B1/hu unknown
- 2002-06-28 EP EP09155256A patent/EP2108363A1/en not_active Withdrawn
- 2002-06-28 MX MXPA03011440A patent/MXPA03011440A/es active IP Right Grant
- 2002-06-28 ES ES02738837T patent/ES2324156T5/es not_active Expired - Lifetime
- 2002-06-28 DE DE60232147T patent/DE60232147D1/de not_active Expired - Lifetime
- 2002-06-28 AT AT02738837T patent/ATE429903T1/de active
- 2002-06-28 SK SK1561-2003A patent/SK287568B6/sk unknown
- 2002-06-28 NZ NZ529968A patent/NZ529968A/en not_active IP Right Cessation
- 2002-06-28 KR KR10-2003-7017111A patent/KR20040018401A/ko not_active Ceased
- 2002-06-28 SI SI200230837T patent/SI1399133T2/sl unknown
- 2002-06-28 CA CA2451718A patent/CA2451718C/en not_active Expired - Fee Related
- 2002-06-28 US US10/479,516 patent/US20040241229A1/en not_active Abandoned
- 2002-06-28 IL IL15906002A patent/IL159060A0/xx active IP Right Grant
- 2002-06-28 AU AU2002311630A patent/AU2002311630B2/en not_active Expired
-
2003
- 2003-11-25 ZA ZA2003/09153A patent/ZA200309153B/en unknown
- 2003-12-19 NO NO20035737A patent/NO333531B1/no not_active IP Right Cessation
- 2003-12-22 CO CO03111730A patent/CO5540368A2/es not_active Application Discontinuation
-
2006
- 2006-12-05 RU RU2006143104/15A patent/RU2434644C2/ru active
-
2007
- 2007-12-19 US US11/960,114 patent/US8258252B2/en not_active Expired - Fee Related
-
2009
- 2009-07-29 CY CY20091100808T patent/CY1109272T1/el unknown
-
2010
- 2010-08-11 JP JP2010180145A patent/JP5491318B2/ja not_active Expired - Lifetime
-
2012
- 2012-02-15 JP JP2012030788A patent/JP5860300B2/ja not_active Expired - Lifetime
- 2012-08-02 US US13/564,928 patent/US20120295848A1/en not_active Abandoned
-
2014
- 2014-09-10 JP JP2014184482A patent/JP5931147B2/ja not_active Expired - Lifetime
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