SI2780368T1 - Sestavki in postopki za povečanje mišične mase in mišične moči s specifičnim antagoniziranjem gdf8 in/ali aktivinom a - Google Patents
Sestavki in postopki za povečanje mišične mase in mišične moči s specifičnim antagoniziranjem gdf8 in/ali aktivinom a Download PDFInfo
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- SI2780368T1 SI2780368T1 SI201231245T SI201231245T SI2780368T1 SI 2780368 T1 SI2780368 T1 SI 2780368T1 SI 201231245 T SI201231245 T SI 201231245T SI 201231245 T SI201231245 T SI 201231245T SI 2780368 T1 SI2780368 T1 SI 2780368T1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/06—Anabolic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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Claims (11)
- SESTAVKI IN POSTOPKI ZA POVEČEVANJE MIŠIČNE MASE IN MIŠIČNE MOČI S SPECIFIČNIM ANTAGONIZIRANJEM GDF8 IN/ALI AKTIVINOM A Patentni zahtevki1. Sestavek, ki obsega protein s specifično vezavo GDF8 in protein s specifično vezavo aktivina A, pri čemer je protein s specifično vezavo GDF8 protitelo proti GDF-8 oziroma njegov fragment za vezavo antigena, ki inhibira GDF-8, ter pri čemer je protein s specifično vezavo aktivina A protitelo proti aktivinu A oziroma njegov fragment za vezavo antigena, ki inhibira aktivin A.
- 2. Sestavek, ki obsega protein s specifično vezavo GDF8 in protein s specifično vezavo aktivina A za uporabo pri postopku za zdravljenje bolezni ali motnje, označene s tem, da povzroča zmanjšano mišično maso ali moč, pri čemer je protein s specifično vezavo GDF8 protitelo proti GDF-8 oziroma njegov fragment za vezavo antigena, ki inhibira GDF-8, ter pri čemer je protein s specifično vezavo aktivina A protitelo proti aktivinu A oziroma njegov fragment za vezavo antigena, ki inhibira aktivin A.
- 3. Protein s specifično vezavo GDF8 za uporabo pri postopku za zdravljenje bolezni ali motnje, označene s tem, da povzroča zmanjšano mišično maso ali moč, pri čemer postopek obsega dajanje proteina s specifično vezavo GDF8 in proteina s specifično vezavo aktivina A subjektu, ter pri čemer je protein s specifično vezavo GDF8 protitelo proti GDF-8 oziroma njegov fragment za vezavo antigena, ki inhibira GDF-8, in pri čemer je protein s specifično vezavo aktivina A protitelo proti aktivinu A oziroma njegov fragment za vezavo antigena, ki inhibira aktivin A.
- 4. Protein s specifično vezavo aktivina A za uporabo pri postopku za zdravljenje bolezni ali motnje, označene s tem, da povzroča zmanjšano mišično maso ali moč, pri čemer postopek obsega dajanje proteina s specifično vezavo aktivina A in proteina s specifično vezavo GDF8 subjektu, ter pri čemer je protein s specifično vezavo GDF8 protitelo proti GDF-8 oziroma njegov fragment za vezavo antigena, ki inhibira GDF-8, in pri čemer je protein s specifično vezavo aktivina A protitelo proti aktivinu A oziroma njegov fragment za vezavo antigena, ki inhibira aktivin A.
- 5. Neterapevtski postopek za povečevanje mišične mase ali moči*pri siibjektij,. pri- čemer; • · · ·| postopek obsega dajanje subjektu (i) proteina s specifično vezavo aktivina A in proteina s specifično vezavo GDF8, pri čemer je protein s specifično vezavo GDF8 protitelo proti GDF-8 oziroma njegov fragment za vezavo antigena, ki inhibira GDF-8, in pri čemer je protein s specifično vezavo aktivina A protitelo proti aktivinu A oziroma njegov fragment za vezavo antigena, ki inhibira aktivin A, oziroma (ii) molekule za vezavo antigena, ki obsega specifično protitelo proti GDF-8 oziroma njegov fragment za vezavo antigena, ki inhibira GDF-8, in specifično protitelo proti aktivinu A oziroma njegov fragment za vezavo antigena, ki inhibira aktivin A.
- 6. Sestavek, postopek in protein s specifično vezavo GDF8 za uporabo ter/ali protein s specifično vezavo aktivina A za uporabo po katerem koli izmed zahtevkov od 1 do 5, pri čemer protitelo proti GDF-8 oziroma njegov fragment za vezavo antigena obsega tri regije, ki določajo komplementarnost težke verige (HCDR), in sicer obsega SEQ ID NO:10, SEQ ID NO:11 in SEQ ID NO:12, ter tri regije, ki določajo komplementarnost lahke verige (LCDR), in sicer obsega SEQ ID NO:14, SEQ ID NO:15 in SEQ ID NO:16
- 7. Molekula za vezavo antigena, ki obsega protitelo proti GDF-8 oziroma njegov fragment za vezavo antigena, ki inhibira GDF-8, in protitelo proti aktivinu A oziroma njegov fragment za vezavo antigena, ki inhibira aktivin A.
- 8. Molekula za vezavo antigena, ki obsega protitelo proti GDF-8 oziroma njegov fragment za vezavo antigena, ki inhibira GDF-8, in protitelo proti aktivinu A oziroma njegov fragment za vezavo antigena, ki inhibira aktivin A, za uporabo pri postopku za zdravljenje bolezni ali motnje, označene s tem, da povzroča zmanjšano mišično maso ali moč.
- 9. Molekula za vezavo antigena po zahtevku 7 oziroma molekula za vezavo antigena za uporabo po zahtevku 8, pri čemer protitelo proti GDF-8 oziroma njegov fragment za vezavo antigena obsega variabilno regijo težke verige (HCVR) in variabilno regijo lahke verige (LCVR) ter/ali pri čemer protitelo proti aktivinu A oziroma njegov fragment za vezavo antigena obsega variabilno regijo težke verige (HCVR) in variabilno regijo lahke verige (LCVR)
- 10. Molekula za vezavo antigena oziroma molekula za vezavo anfigerfa za *yj&rabo* ρό· *.. ·*·· ·.. *„ zahtevku 9, pri čemer variabilna regija težke verige (HCVR) protitelesa proti GDF-8 oziroma njegovega fragmenta za vezavo antigena obsega tri regije, ki določajo komplementarnost težke verige (HCDR), in sicer obsega SEQ ID NO: 10, SEQ ID NO:11 in SEQ ID NO: 12, ter pri čemer variabilna regija lahke verige (LCVR) protitelesa proti GDF-8 oziroma njegovega fragmenta za vezavo antigena obsega tri regije, ki določajo komplementarnost lahke verige (LCDR), in sicer obsega SEQ ID NO: 14, SEQ ID NO: 15 in SEQ ID NO:16.
- 11. Molekula za vezavo antigena oziroma molekula za vezavo antigena za uporabo po zahtevku 9, pri čemer je molekula za vezavo antigena bispecifično protitelo.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161559175P | 2011-11-14 | 2011-11-14 | |
| US201261607024P | 2012-03-06 | 2012-03-06 | |
| US201261661451P | 2012-06-19 | 2012-06-19 | |
| PCT/US2012/064911 WO2013074557A1 (en) | 2011-11-14 | 2012-11-14 | Compositions and methods for increasing muscle mass and muscle strength by specifically antagonizing gdf8 and/or activin a |
| EP12791657.5A EP2780368B1 (en) | 2011-11-14 | 2012-11-14 | Compositions and methods for increasing muscle mass and muscle strength by specifically antagonizing gdf8 and/or activin a |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2780368T1 true SI2780368T1 (sl) | 2018-04-30 |
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ID=47228083
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201231245T SI2780368T1 (sl) | 2011-11-14 | 2012-11-14 | Sestavki in postopki za povečanje mišične mase in mišične moči s specifičnim antagoniziranjem gdf8 in/ali aktivinom a |
Country Status (19)
| Country | Link |
|---|---|
| US (7) | US8871209B2 (sl) |
| EP (1) | EP2780368B1 (sl) |
| JP (1) | JP6177249B2 (sl) |
| KR (1) | KR102048189B1 (sl) |
| AU (1) | AU2012339722B2 (sl) |
| CA (1) | CA2855822C (sl) |
| CY (1) | CY1119994T1 (sl) |
| DK (1) | DK2780368T3 (sl) |
| ES (1) | ES2663946T3 (sl) |
| HR (1) | HRP20180201T1 (sl) |
| HU (1) | HUE038570T2 (sl) |
| LT (1) | LT2780368T (sl) |
| MX (1) | MX350355B (sl) |
| PL (1) | PL2780368T3 (sl) |
| PT (1) | PT2780368T (sl) |
| RS (1) | RS56796B1 (sl) |
| SI (1) | SI2780368T1 (sl) |
| SM (1) | SMT201800092T1 (sl) |
| WO (1) | WO2013074557A1 (sl) |
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