PL2780368T3 - Kompozycje i sposoby do zwiększania masy mięśni i siły mięśni poprzez swoiste antaganizowanie GDF8 i/lub aktywiny A - Google Patents
Kompozycje i sposoby do zwiększania masy mięśni i siły mięśni poprzez swoiste antaganizowanie GDF8 i/lub aktywiny AInfo
- Publication number
- PL2780368T3 PL2780368T3 PL12791657T PL12791657T PL2780368T3 PL 2780368 T3 PL2780368 T3 PL 2780368T3 PL 12791657 T PL12791657 T PL 12791657T PL 12791657 T PL12791657 T PL 12791657T PL 2780368 T3 PL2780368 T3 PL 2780368T3
- Authority
- PL
- Poland
- Prior art keywords
- activin
- compositions
- methods
- muscle
- increasing
- Prior art date
Links
- 210000003205 muscle Anatomy 0.000 title 2
- 102000005606 Activins Human genes 0.000 title 1
- 108010059616 Activins Proteins 0.000 title 1
- 101100228739 Danio rerio mstnb gene Proteins 0.000 title 1
- 239000000488 activin Substances 0.000 title 1
- 230000003042 antagnostic effect Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/06—Anabolic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161559175P | 2011-11-14 | 2011-11-14 | |
| US201261607024P | 2012-03-06 | 2012-03-06 | |
| US201261661451P | 2012-06-19 | 2012-06-19 | |
| PCT/US2012/064911 WO2013074557A1 (en) | 2011-11-14 | 2012-11-14 | Compositions and methods for increasing muscle mass and muscle strength by specifically antagonizing gdf8 and/or activin a |
| EP12791657.5A EP2780368B1 (en) | 2011-11-14 | 2012-11-14 | Compositions and methods for increasing muscle mass and muscle strength by specifically antagonizing gdf8 and/or activin a |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2780368T3 true PL2780368T3 (pl) | 2018-06-29 |
Family
ID=47228083
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL12791657T PL2780368T3 (pl) | 2011-11-14 | 2012-11-14 | Kompozycje i sposoby do zwiększania masy mięśni i siły mięśni poprzez swoiste antaganizowanie GDF8 i/lub aktywiny A |
Country Status (19)
| Country | Link |
|---|---|
| US (7) | US8871209B2 (pl) |
| EP (1) | EP2780368B1 (pl) |
| JP (1) | JP6177249B2 (pl) |
| KR (1) | KR102048189B1 (pl) |
| AU (1) | AU2012339722B2 (pl) |
| CA (1) | CA2855822C (pl) |
| CY (1) | CY1119994T1 (pl) |
| DK (1) | DK2780368T3 (pl) |
| ES (1) | ES2663946T3 (pl) |
| HR (1) | HRP20180201T1 (pl) |
| HU (1) | HUE038570T2 (pl) |
| LT (1) | LT2780368T (pl) |
| MX (1) | MX350355B (pl) |
| PL (1) | PL2780368T3 (pl) |
| PT (1) | PT2780368T (pl) |
| RS (1) | RS56796B1 (pl) |
| SI (1) | SI2780368T1 (pl) |
| SM (1) | SMT201800092T1 (pl) |
| WO (1) | WO2013074557A1 (pl) |
Families Citing this family (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3340B1 (ar) | 2010-05-26 | 2019-03-13 | Regeneron Pharma | مضادات حيوية لـعامل تمايز النمو 8 البشري |
| CN103221426B (zh) | 2010-08-16 | 2016-01-13 | 安姆根公司 | 结合肌肉生长抑制素的抗体、组合物和方法 |
| LT2780368T (lt) * | 2011-11-14 | 2018-03-12 | Regeneron Pharmaceuticals, Inc. | Kompozicijos ir būdai raumenų masės padidinimui ir raumenų sustiprinimui, specifiškai antagonizuojant gdf8 ir (arba) aktiviną a |
| AR095196A1 (es) | 2013-03-15 | 2015-09-30 | Regeneron Pharma | Medio de cultivo celular libre de suero |
| SMT202100008T1 (it) | 2013-05-06 | 2021-03-15 | Scholar Rock Inc | Composizioni e metodi per la modulazione di fattore di crescita |
| TWI655207B (zh) * | 2013-07-30 | 2019-04-01 | 再生元醫藥公司 | 抗活化素ａ之抗體及其用途 |
| WO2015195094A1 (en) * | 2014-06-17 | 2015-12-23 | Ember Therapeutics, Inc. | Anti-activin and nati-myostatin antibodies and methods of using the same |
| US20160075772A1 (en) | 2014-09-12 | 2016-03-17 | Regeneron Pharmaceuticals, Inc. | Treatment of Fibrodysplasia Ossificans Progressiva |
| AR102198A1 (es) | 2014-10-09 | 2017-02-08 | Regeneron Pharma | Proceso para reducir partículas subvisibles en una formulación farmacéutica |
| WO2016073853A1 (en) * | 2014-11-06 | 2016-05-12 | Scholar Rock, Inc. | Anti-pro/latent-myostatin antibodies and uses thereof |
| EA039118B1 (ru) * | 2015-04-01 | 2021-12-07 | Ридженерон Фармасьютикалз, Инк. | Способ лечения прогрессирующей оссифицирующей фибродисплазии |
| HK1250236A1 (zh) | 2015-04-15 | 2018-12-07 | Regeneron Pharmaceuticals, Inc. | 用gdf8抑制剂增加力量和功能的方法 |
| ES2856001T3 (es) | 2015-04-22 | 2021-09-27 | Biogen Ma Inc | Nuevas proteínas híbridas de bloqueo del ligando actriib para tratar enfermedades de atrofia muscular |
| TWI870789B (zh) | 2015-08-04 | 2025-01-21 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法 |
| JP2019504064A (ja) | 2016-01-08 | 2019-02-14 | スカラー ロック インコーポレイテッドＳｃｈｏｌａｒ Ｒｏｃｋ，Ｉｎｃ． | 抗プロ／潜在型ミオスタチン抗体およびその使用方法 |
| EA201891909A1 (ru) | 2016-03-11 | 2019-02-28 | Сколар Рок, Инк. | TGFβ1-СВЯЗЫВАЮЩИЕ ИММУНОГЛОБУЛИНЫ И ИХ ПРИМЕНЕНИЕ |
| CN119119244A (zh) | 2016-08-16 | 2024-12-13 | 里珍纳龙药品有限公司 | 用于对混合物中的个体抗体进行量化的方法 |
| EP3504328A1 (en) | 2016-08-24 | 2019-07-03 | Regeneron Pharmaceuticals, Inc. | Host cell protein modification |
| JOP20190085A1 (ar) | 2016-10-20 | 2019-04-17 | Biogen Ma Inc | طرق علاج الضمور العضلي ومرض العظام باستخدام بروتينات احتجاز مركب ترابطي actriib هجين حديثة |
| CN119492842A (zh) | 2016-10-25 | 2025-02-21 | 里珍纳龙药品有限公司 | 用于色谱数据分析的方法和系统 |
| CN110430890B (zh) | 2016-11-10 | 2024-09-10 | 科乐斯疗法公司 | 激活素受体iia型变体及其使用方法 |
| JP7157744B2 (ja) | 2017-01-06 | 2022-10-20 | スカラー ロック インコーポレイテッド | アイソフォーム特異的な、コンテクスト寛容ＴＧＦβ１阻害剤およびその使用 |
| WO2019010191A1 (en) | 2017-07-06 | 2019-01-10 | Regeneron Pharmaceuticals, Inc. | CELL CULTURE METHOD FOR PRODUCING GLYCOPROTEIN |
| CN118416215A (zh) | 2017-09-19 | 2024-08-02 | 里珍纳龙药品有限公司 | 减少粒子形成的方法以及由其形成的组合物 |
| AU2018364668B2 (en) | 2017-11-09 | 2024-05-30 | Keros Therapeutics, Inc. | Activin receptor type lla variants and methods of use thereof |
| EP3727629A1 (en) | 2017-12-22 | 2020-10-28 | Regeneron Pharmaceuticals, Inc. | System and method for characterizing drug product impurities |
| CA3087008A1 (en) | 2018-01-12 | 2019-07-18 | Keros Therapeutics, Inc. | Activin receptor type iib variants and methods of use thereof |
| KR20200115485A (ko) | 2018-01-31 | 2020-10-07 | 리제너론 파마슈티칼스 인코포레이티드 | 약물 생성물 불순물을 특성화하기 위한 시스템 및 방법 |
| TW202311746A (zh) | 2018-02-02 | 2023-03-16 | 美商再生元醫藥公司 | 用於表徵蛋白質二聚合之系統及方法 |
| WO2019168774A1 (en) | 2018-02-28 | 2019-09-06 | Regeneron Pharmaceuticals, Inc. | Systems and methods for identifying viral contaminants |
| EP3758800A1 (en) * | 2018-03-01 | 2021-01-06 | Regeneron Pharmaceuticals, Inc. | Methods for altering body composition |
| US12259355B2 (en) | 2018-03-19 | 2025-03-25 | Regeneron Pharmaceuticals, Inc. | Microchip capillary electrophoresis assays and reagents |
| DK3768709T3 (da) | 2018-03-19 | 2024-01-29 | Regeneron Pharma | Mikrochip-kapillærelektroforese-assays og reagenser |
| US12253490B2 (en) | 2018-03-19 | 2025-03-18 | Regeneron Pharmaceuticals, Inc. | Microchip capillary electrophoresis assays and reagents |
| ES3037632T3 (en) | 2018-04-06 | 2025-10-03 | Regeneron Pharma | A leptin receptor agonist antibody for use in increasing bone mass in a subject suffering from metabolic dysfunction or hypoleptinemia |
| AU2019266314B2 (en) | 2018-05-09 | 2025-05-15 | Keros Therapeutics, Inc. | Activin receptor type iia variants and methods of use thereof |
| TW202016125A (zh) | 2018-05-10 | 2020-05-01 | 美商再生元醫藥公司 | 用於定量及調節蛋白質黏度之系統與方法 |
| TW202448568A (zh) | 2018-07-02 | 2024-12-16 | 美商里珍納龍藥品有限公司 | 自混合物製備多肽之系統及方法 |
| EP3820896A1 (en) | 2018-07-11 | 2021-05-19 | Scholar Rock, Inc. | TGFbeta1 INHIBITORS AND USE THEREOF |
| TW202005981A (zh) | 2018-07-11 | 2020-02-01 | 美商供石公司 | 高親和性、異構體選擇性之TGFβ1抑制劑及其用途 |
| RS62914B1 (sr) | 2018-07-11 | 2022-03-31 | Scholar Rock Inc | Izoform selektivni inhibitori tgfbeta1 i njihova upotreba |
| CN120795059A (zh) | 2018-08-27 | 2025-10-17 | 瑞泽恩制药公司 | 拉曼光谱在下游纯化中的应用 |
| WO2020047067A1 (en) | 2018-08-30 | 2020-03-05 | Regeneron Pharmaceuticals, Inc. | Methods for characterizing protein complexes |
| US20240247071A2 (en) * | 2018-12-18 | 2024-07-25 | Regeneron Pharmaceuticals, Inc. | Compositions and Methods for Enhancing Body Weight and Lean Muscle Mass Using Antagonists Against Leptin Receptor, GDF8 and Activin A |
| CN113272651B (zh) | 2019-01-16 | 2023-06-16 | 瑞泽恩制药公司 | 鉴别蛋白质中的游离巯基的方法 |
| EP3969908A1 (en) | 2019-05-13 | 2022-03-23 | Regeneron Pharmaceuticals, Inc. | Improved competitive ligand binding assays |
| CN120334439A (zh) | 2019-09-24 | 2025-07-18 | 里珍纳龙药品有限公司 | 用于色谱介质的使用和再生的系统及方法 |
| US12297451B1 (en) | 2019-10-25 | 2025-05-13 | Regeneron Pharmaceuticals, Inc. | Cell culture medium |
| EP4065086A1 (en) | 2019-11-25 | 2022-10-05 | Regeneron Pharmaceuticals, Inc. | Sustained release formulations using non-aqueous emulsions |
| BR112022013733A2 (pt) | 2020-01-11 | 2022-11-01 | Scholar Rock Inc | Inibidores de tgfbeta e uso dos mesmos |
| EP4087659A2 (en) | 2020-01-11 | 2022-11-16 | Scholar Rock, Inc. | Tgf-beta inhibitors and use thereof |
| IL303596B2 (en) | 2020-01-21 | 2025-04-01 | Regeneron Pharma | Deglycosylation methods for electrophoresis of glycosylated proteins |
| WO2021189010A1 (en) | 2020-03-20 | 2021-09-23 | Keros Therapeutics, Inc. | Methods of using activin receptor type iib variants |
| WO2022047108A1 (en) | 2020-08-31 | 2022-03-03 | Regeneron Pharmaceuticals, Inc. | Asparagine feed strategies to improve cell culture performance and mitigate asparagine sequence variants |
| EP4251128A1 (en) | 2020-11-25 | 2023-10-04 | Regeneron Pharmaceuticals, Inc. | Sustained release formulations using non-aqueous membrane emulsification |
| WO2022133135A1 (en) | 2020-12-17 | 2022-06-23 | Regeneron Pharmaceuticals, Inc. | Fabrication of protein-encapsulating microgels |
| WO2022159432A1 (en) | 2021-01-20 | 2022-07-28 | Regeneron Pharmaceuticals, Inc. | Methods of improving protein titer in cell culture |
| CA3207883A1 (en) | 2021-03-03 | 2022-09-09 | Xiaobin Xu | Systems and methods for quantifying and modifying protein viscosity |
| JP2024519407A (ja) | 2021-03-26 | 2024-05-13 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 混合プロトコルを作成するための方法およびシステム |
| WO2022204581A2 (en) | 2021-03-26 | 2022-09-29 | Scholar Rock, Inc. | Tgf-beta inhibitors and use thereof |
| CA3220848A1 (en) | 2021-06-01 | 2022-12-08 | Timothy Riehlman | Microchip capillary electrophoresis assays and reagents |
| WO2022256723A2 (en) | 2021-06-03 | 2022-12-08 | Scholar Rock, Inc. | Tgf-beta inhibitors and therapeutic use thereof |
| US20230077710A1 (en) | 2021-09-08 | 2023-03-16 | Regeneron Pharmaceuticals, Inc. | HIGH-THROUGHPUT AND MASS-SPECTROMETRY-BASED METHOD FOR QUANTITATING ANTIBODIES AND OTHER Fc-CONTAINING PROTEINS |
| KR20240058201A (ko) | 2021-09-20 | 2024-05-03 | 리제너론 파마슈티칼스 인코포레이티드 | 항체 이질성을 제어하는 방법 |
| EP4413359A1 (en) | 2021-10-07 | 2024-08-14 | Regeneron Pharmaceuticals, Inc. | Ph meter calibration and correction |
| CN118076894A (zh) | 2021-10-07 | 2024-05-24 | 里珍纳龙药品有限公司 | pH建模和控制的系统及方法 |
| KR20240097864A (ko) | 2021-10-26 | 2024-06-27 | 리제너론 파마슈티칼스 인코포레이티드 | 상이한 온도에서 실험실 용수를 생성하고 실험실 용수를 분배하는 시스템 및 방법 |
| KR20240164561A (ko) | 2022-03-18 | 2024-11-19 | 리제너론 파아마슈티컬스, 인크. | 폴리펩타이드 변종을 분석하기 위한 방법 및 시스템 |
| CN120187750A (zh) | 2022-09-21 | 2025-06-20 | 瑞泽恩制药公司 | 治疗肥胖、糖尿病和肝功能障碍的方法 |
| EP4634659A1 (en) | 2022-12-16 | 2025-10-22 | Regeneron Pharmaceuticals, Inc. | Methods and systems for assessing chromatographic column integrity |
| TW202430247A (zh) | 2022-12-22 | 2024-08-01 | 美商供石公司 | 肌肉生長抑制素活化之選擇性及強效抑制劑 |
| TW202445126A (zh) | 2023-01-25 | 2024-11-16 | 美商再生元醫藥公司 | 基於質譜法之體內共表現抗體之表徵 |
| WO2024158880A1 (en) | 2023-01-25 | 2024-08-02 | Regeneron Pharmaceuticals, Inc. | Methods of modeling liquid protein composition stability |
| TW202445138A (zh) | 2023-02-01 | 2024-11-16 | 美商再生元醫藥公司 | 用於生物巨分子分析之具質譜法的不對稱流場流分離 |
| WO2024178213A2 (en) | 2023-02-22 | 2024-08-29 | Regeneron Pharmaceuticals, Inc. | System suitability parameters and column aging |
| US20240366471A1 (en) | 2023-05-01 | 2024-11-07 | Regeneron Pharmaceuticals, Inc. | Multidose antibody drug products using phenol or benzyl alcohol |
| TW202528736A (zh) | 2023-09-08 | 2025-07-16 | 美商再生元醫藥公司 | 用於評估層析管柱完整性的方法及系統 |
| WO2025064403A2 (en) | 2023-09-18 | 2025-03-27 | Regeneron Pharmaceuticals, Inc. | Methods and systems for developing chromatography protocols |
| WO2025072597A2 (en) | 2023-09-29 | 2025-04-03 | Regeneron Pharmaceuticals, Inc. | Lyophilization using controlled nucleation |
| WO2025085594A1 (en) | 2023-10-18 | 2025-04-24 | Regeneron Pharmaceuticals, Inc. | Rapid purification of monoclonal antibody from in-process upstream cell culture material |
| US20250145662A1 (en) | 2023-11-02 | 2025-05-08 | Regeneron Pharmaceuticals, Inc. | Methods for reducing lipase activity using stress |
| WO2025166281A1 (en) | 2024-02-01 | 2025-08-07 | Regeneron Pharmaceuticals, Inc. | Platform for charge-detection mass spectrometry analysis of aavs |
| WO2025175164A1 (en) | 2024-02-16 | 2025-08-21 | Regeneron Pharmaceuticals, Inc. | Methods of producing concentrated formulated drug substances comprising proteins, and concentrated formulated drug substance made by the methods |
| WO2025194043A1 (en) | 2024-03-15 | 2025-09-18 | Regeneron Pharmaceuticals, Inc. | Polysorbate and polyoxyethylene sorbitan as excipients for stable protein formulations |
Family Cites Families (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| JP4124480B2 (ja) | 1991-06-14 | 2008-07-23 | ジェネンテック・インコーポレーテッド | 免疫グロブリン変異体 |
| ES2201076T3 (es) | 1993-03-19 | 2004-03-16 | The Johns Hopkins University School Of Medicine | Factor-8 de diferenciacion del crecimiento. |
| US5994618A (en) | 1997-02-05 | 1999-11-30 | Johns Hopkins University School Of Medicine | Growth differentiation factor-8 transgenic mice |
| DE69941116D1 (de) | 1998-05-06 | 2009-08-27 | Metamorphix Inc | G von gdf-8 |
| US6927044B2 (en) | 1998-09-25 | 2005-08-09 | Regeneron Pharmaceuticals, Inc. | IL-1 receptor based cytokine traps |
| IL146845A0 (en) | 1999-07-20 | 2002-07-25 | Pharmexa As | Method for down-regulating gdf-8 activity |
| US6670140B2 (en) * | 2001-03-06 | 2003-12-30 | The Procter & Gamble Company | Methods for identifying compounds for regulating muscle mass or function using corticotropin releasing factor receptors |
| US7320789B2 (en) | 2001-09-26 | 2008-01-22 | Wyeth | Antibody inhibitors of GDF-8 and uses thereof |
| US7241444B2 (en) * | 2002-01-18 | 2007-07-10 | Pierre Fabre Medicament | Anti-IGF-IR antibodies and uses thereof |
| US7261893B2 (en) | 2002-10-22 | 2007-08-28 | Wyeth | Neutralizing antibodies against GDF-8 and uses therefor |
| US20040101920A1 (en) | 2002-11-01 | 2004-05-27 | Czeslaw Radziejewski | Modification assisted profiling (MAP) methodology |
| US7598227B2 (en) | 2003-04-16 | 2009-10-06 | Isis Pharmaceuticals Inc. | Modulation of apolipoprotein C-III expression |
| EP1635870A2 (en) | 2003-06-02 | 2006-03-22 | Wyeth | Use of myostatin (gdf8) inhibitors in conjunction with corticosteroids for treating neuromuscular disorders |
| KR20060120229A (ko) | 2003-12-31 | 2006-11-24 | 쉐링-프라우 리미티드 | 중화 에피토프계 성장 증진 백신 |
| AU2005219441A1 (en) | 2004-03-02 | 2005-09-15 | Acceleron Pharma Inc. | ALK7 and myostatin inhibitors and uses thereof |
| EP1733041B1 (en) | 2004-03-23 | 2012-05-09 | Eli Lilly & Company | Anti-myostatin antibodies |
| US7850962B2 (en) | 2004-04-20 | 2010-12-14 | Genmab A/S | Human monoclonal antibodies against CD20 |
| CN101001642A (zh) | 2004-08-12 | 2007-07-18 | 惠氏公司 | 使用gdf－8抑制剂对糖尿病、肥胖症和心血管病的联合治疗 |
| NZ538097A (en) | 2005-02-07 | 2006-07-28 | Ovita Ltd | Method and compositions for improving wound healing |
| KR20080011403A (ko) | 2005-04-25 | 2008-02-04 | 화이자 인크. | 미오스타틴에 대한 항체 |
| WO2006122079A1 (en) | 2005-05-06 | 2006-11-16 | Zymogenetics, Inc. | Il-31 monoclonal antibodies and methods of use |
| EP1773041A1 (en) | 2005-07-21 | 2007-04-11 | Chao-Hung Wu | Audio/video data transmission system using the internet to interconnect telephones |
| WO2007024535A2 (en) | 2005-08-19 | 2007-03-01 | Wyeth | Antagonist antibodies against gdf-8 and uses in treatment of als and other gdf-8-associated disorders |
| EA015589B1 (ru) | 2005-10-06 | 2011-10-31 | Эли Лилли Энд Компани | Антитела против миостатина и их применение |
| UA92504C2 (en) | 2005-10-12 | 2010-11-10 | Эли Лилли Энд Компани | Anti-myostatin monoclonal antibody |
| US8128933B2 (en) | 2005-11-23 | 2012-03-06 | Acceleron Pharma, Inc. | Method of promoting bone growth by an anti-activin B antibody |
| US20070149458A1 (en) | 2005-12-06 | 2007-06-28 | Amgen Inc. | Uses of myostatin antagonists |
| PL2374818T3 (pl) | 2006-06-02 | 2013-05-31 | Regeneron Pharma | Przeciwciała o wysokim powinowactwie przeciw ludzkiemu receptorowi IL 6 |
| US8309068B2 (en) | 2006-08-03 | 2012-11-13 | Myostin Therapeutics Pty Ltd. | Isolated polypeptides and methods of improving muscle strength |
| SI2066695T1 (sl) | 2006-09-05 | 2013-05-31 | Eli Lilly And Company | Protitelo proti miostatinu |
| CL2007002567A1 (es) * | 2006-09-08 | 2008-02-01 | Amgen Inc | Proteinas aisladas de enlace a activina a humana. |
| TWI454479B (zh) | 2007-03-06 | 2014-10-01 | Amgen Inc | 變異之活動素受體多肽及其用途 |
| PE20091163A1 (es) | 2007-11-01 | 2009-08-09 | Wyeth Corp | Anticuerpos para gdf8 |
| ATE550333T1 (de) | 2007-11-05 | 2012-04-15 | Novartis Ag | 4-benzylamino-1-carboxyacyl-piperidinderivate als cetp-hemmer zur behandlung von krankheiten wie hyperlipidämie oder arteriosklerose |
| JP5922928B2 (ja) | 2008-08-14 | 2016-05-24 | アクセルロン ファーマ， インコーポレイテッド | 赤血球レベルを高めるためのｇｄｆトラップの使用 |
| AR074777A1 (es) | 2008-12-19 | 2011-02-09 | Glaxo Group Ltd | Proteinas de union a antigeno |
| WO2010083034A1 (en) | 2009-01-13 | 2010-07-22 | Acceleron Pharma Inc. | Methods for increasing adiponectin |
| JP5766179B2 (ja) | 2009-04-27 | 2015-08-19 | ノバルティス アーゲー | 筋肉増殖を増加させるための組成物および方法 |
| RU2522002C2 (ru) | 2009-06-26 | 2014-07-10 | Ридженерон Фармасьютикалз, Инк. | Легковыделяемые биспецифические антитела с природным иммуноглобулиновым форматом |
| US8710016B2 (en) * | 2009-11-17 | 2014-04-29 | Acceleron Pharma, Inc. | ActRIIB proteins and variants and uses therefore relating to utrophin induction for muscular dystrophy therapy |
| WO2014121221A1 (en) | 2013-02-01 | 2014-08-07 | Santa Maria Biotherapeutics, Inc. | Administration of an anti-activin-a compound to a subject |
| JO3340B1 (ar) * | 2010-05-26 | 2019-03-13 | Regeneron Pharma | مضادات حيوية لـعامل تمايز النمو 8 البشري |
| AR081556A1 (es) | 2010-06-03 | 2012-10-03 | Glaxo Group Ltd | Proteinas de union al antigeno humanizadas |
| CN103221426B (zh) | 2010-08-16 | 2016-01-13 | 安姆根公司 | 结合肌肉生长抑制素的抗体、组合物和方法 |
| EP2638065A4 (en) | 2010-11-08 | 2014-04-09 | Acceleron Pharma Inc | ACTRIIA-BINDING SUBSTANCES AND ITS USES |
| LT2780368T (lt) | 2011-11-14 | 2018-03-12 | Regeneron Pharmaceuticals, Inc. | Kompozicijos ir būdai raumenų masės padidinimui ir raumenų sustiprinimui, specifiškai antagonizuojant gdf8 ir (arba) aktiviną a |
| GR1007832B (el) | 2011-11-21 | 2013-02-14 | Ιδρυμα Ιατροβιολογικων Ερευνων Ακαδημιας Αθηνων, | Αδρανοποιητες της ακτιβινης και χρηση τους για την θεραπεια ασθενειων που σχετιζονται με παρεκκλινουσα ενεργοποιηση της "αμυντικης αποκρισης του ξενιστη" |
| JP6433889B2 (ja) | 2012-06-15 | 2018-12-05 | ファイザー・インク | Ｇｄｆ−８に対する改善された拮抗抗体およびその使用 |
| WO2014022540A1 (en) | 2012-08-02 | 2014-02-06 | Regeneron Pharmaceuticals, Inc. | Multivalent antigen-binding proteins |
| TWI655207B (zh) | 2013-07-30 | 2019-04-01 | 再生元醫藥公司 | 抗活化素ａ之抗體及其用途 |
| EP3033358A2 (en) | 2013-08-14 | 2016-06-22 | Novartis AG | Methods of treating sporadic inclusion body myositis |
| US20160075772A1 (en) | 2014-09-12 | 2016-03-17 | Regeneron Pharmaceuticals, Inc. | Treatment of Fibrodysplasia Ossificans Progressiva |
| HK1250236A1 (zh) | 2015-04-15 | 2018-12-07 | Regeneron Pharmaceuticals, Inc. | 用gdf8抑制剂增加力量和功能的方法 |
| WO2018009732A1 (en) | 2016-07-08 | 2018-01-11 | Regeneron Pharmaceuticals, Inc. | Anti-activin a antibodies and methods of use thereof for treating pulmonary arterial hypertension |
| EP3758800A1 (en) | 2018-03-01 | 2021-01-06 | Regeneron Pharmaceuticals, Inc. | Methods for altering body composition |
-
2012
- 2012-11-14 LT LTEP12791657.5T patent/LT2780368T/lt unknown
- 2012-11-14 HR HRP20180201TT patent/HRP20180201T1/hr unknown
- 2012-11-14 JP JP2014541413A patent/JP6177249B2/ja active Active
- 2012-11-14 DK DK12791657.5T patent/DK2780368T3/en active
- 2012-11-14 SM SM20180092T patent/SMT201800092T1/it unknown
- 2012-11-14 EP EP12791657.5A patent/EP2780368B1/en active Active
- 2012-11-14 US US13/676,233 patent/US8871209B2/en active Active
- 2012-11-14 WO PCT/US2012/064911 patent/WO2013074557A1/en not_active Ceased
- 2012-11-14 HU HUE12791657A patent/HUE038570T2/hu unknown
- 2012-11-14 MX MX2014005865A patent/MX350355B/es active IP Right Grant
- 2012-11-14 ES ES12791657.5T patent/ES2663946T3/es active Active
- 2012-11-14 PL PL12791657T patent/PL2780368T3/pl unknown
- 2012-11-14 SI SI201231245T patent/SI2780368T1/en unknown
- 2012-11-14 KR KR1020147016067A patent/KR102048189B1/ko active Active
- 2012-11-14 PT PT127916575T patent/PT2780368T/pt unknown
- 2012-11-14 RS RS20180105A patent/RS56796B1/sr unknown
- 2012-11-14 AU AU2012339722A patent/AU2012339722B2/en active Active
- 2012-11-14 CA CA2855822A patent/CA2855822C/en active Active
-
2014
- 2014-09-25 US US14/496,941 patent/US20150010568A1/en not_active Abandoned
-
2016
- 2016-03-22 US US15/077,662 patent/US20170008956A1/en not_active Abandoned
- 2016-09-30 US US15/282,489 patent/US20170226197A1/en not_active Abandoned
-
2018
- 2018-02-09 US US15/893,480 patent/US10400036B2/en active Active
- 2018-03-01 CY CY20181100259T patent/CY1119994T1/el unknown
-
2019
- 2019-07-17 US US16/514,858 patent/US11655291B2/en active Active
-
2023
- 2023-04-17 US US18/135,608 patent/US20240117027A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUE038570T2 (hu) | Készítmények és eljárások izomtömeg és izomerõ növelésére GDF8 és/vagy aktivin A specifikus antagonizálásával | |
| IL251796A0 (en) | Methods to suppress muscle atrophy | |
| IL269489A (en) | Compounds, compositions and methods useful for cholesterol mobilization | |
| GB2494937B (en) | Mass estimator | |
| ZA201306316B (en) | Methods and compositions for preparing noribogaine from voacangine | |
| PT2731451T (pt) | Métodos e composições para produtos de consumo | |
| ZA201401923B (en) | Adhesive acrylate-olefin copolymers, method for producing same and compositions utilizing same | |
| GB201122195D0 (en) | Composition and method | |
| GB201408236D0 (en) | Composition and method | |
| ZA201403538B (en) | Blasting compositions | |
| AP3469A (en) | Methods and compositions for inhibiting hiv transmission | |
| EP2621268A4 (en) | MODEL FOR MUSCLE ATROPHY | |
| GB201106433D0 (en) | Composition and method | |
| ZA201308892B (en) | Compositions and methods | |
| IL232085A0 (en) | Methods and preparations for neuroprotection | |
| GB201113315D0 (en) | Composition amd method | |
| HK1194382A (en) | Methods and compositions for preparing noribogaine from voacangine | |
| GB201013909D0 (en) | A method of balancing a component | |
| GB201013911D0 (en) | A method of balancing a component | |
| GB201110658D0 (en) | Improved process and compositions | |
| GB201116340D0 (en) | Compositions and methods | |
| GB201101937D0 (en) | Method of preparing a composition | |
| GB201116421D0 (en) | Composition and method | |
| GB201102040D0 (en) | Composition and method | |
| GB201117620D0 (en) | Method and composition |