CY1119994T1 - Συνθεσεις και μεθοδοι για αυξηση της μυϊκης μαζας και της μυϊκης δυναμης ανταγωνιζοντας ειδικα ton gdf8 και/ή την ακτιβινη α - Google Patents
Συνθεσεις και μεθοδοι για αυξηση της μυϊκης μαζας και της μυϊκης δυναμης ανταγωνιζοντας ειδικα ton gdf8 και/ή την ακτιβινη αInfo
- Publication number
- CY1119994T1 CY1119994T1 CY20181100259T CY181100259T CY1119994T1 CY 1119994 T1 CY1119994 T1 CY 1119994T1 CY 20181100259 T CY20181100259 T CY 20181100259T CY 181100259 T CY181100259 T CY 181100259T CY 1119994 T1 CY1119994 T1 CY 1119994T1
- Authority
- CY
- Cyprus
- Prior art keywords
- gdf8
- compositions
- activin
- muscle
- activity
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 5
- 102100039939 Growth/differentiation factor 8 Human genes 0.000 title abstract 4
- 101000886562 Homo sapiens Growth/differentiation factor 8 Proteins 0.000 title abstract 4
- 210000003205 muscle Anatomy 0.000 title abstract 3
- 230000000694 effects Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 230000002860 competitive effect Effects 0.000 title 1
- 108010023082 activin A Proteins 0.000 abstract 4
- 230000009870 specific binding Effects 0.000 abstract 3
- 239000000488 activin Substances 0.000 abstract 2
- 230000003042 antagnostic effect Effects 0.000 abstract 2
- 230000027455 binding Effects 0.000 abstract 2
- 102000023732 binding proteins Human genes 0.000 abstract 2
- 108091008324 binding proteins Proteins 0.000 abstract 2
- 108010059616 Activins Proteins 0.000 abstract 1
- 102100026818 Inhibin beta E chain Human genes 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/06—Anabolic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physical Education & Sports Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Η παρούσα εφεύρεση παρέχει συνθέσεις και μεθόδους που εμπλέκουν ειδικά τον ανταγωνισμό των GDFS και της Ακτιβίνης Α. Σε ορισμένες ενσωματώσεις, παρέχονται συνθέσεις οι οποίες περιλαμβάνουν μια πρωτεΐνη πρόσδεσης ειδική του GDF8 και μια πρωτεΐνη πρόσδεσης ειδική της Ακτιβίνης Α. Για παράδειγμα, η εφεύρεση περιλαμβάνει συνθέσεις που περιλαμβάνουν ένα αντίσωμα αντι-GDF8 και ένα αντίσωμα αντι-Ακτιβίνης Α, σε άλλες ενσωματώσεις, παρέχονται μόρια πρόσδεσης αντιγόνου τα οποία περιλαμβάνουν έναν τομέα πρόσδεσης ειδικό του GDFB και έναν τομέα πρόσδεσης ειδικό της Ακτιβίνης Α. Για παράδειγμα, η εφεύρεση περιλαμβάνει διειδικά αντισώματα που προσδένονται στον GDF8 και στην Ακτιβίνη Α. Οι συνθέσεις της παρούσας εφεύρεσης είναι χρήσιμες για τη θεραπεία νόσων και καταστάσεων που χαρακτηρίζονται από μειωμένη μυϊκή μάζα ή δύναμη, καθώς και άλλες καταστάσεις που θεραπεύονται με ανταγωνισμό της δραστικότητας του GDF8 και/ή της Ακτιβίνης Α.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161559175P | 2011-11-14 | 2011-11-14 | |
| US201261607024P | 2012-03-06 | 2012-03-06 | |
| US201261661451P | 2012-06-19 | 2012-06-19 | |
| PCT/US2012/064911 WO2013074557A1 (en) | 2011-11-14 | 2012-11-14 | Compositions and methods for increasing muscle mass and muscle strength by specifically antagonizing gdf8 and/or activin a |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1119994T1 true CY1119994T1 (el) | 2018-12-12 |
Family
ID=47228083
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20181100259T CY1119994T1 (el) | 2011-11-14 | 2018-03-01 | Συνθεσεις και μεθοδοι για αυξηση της μυϊκης μαζας και της μυϊκης δυναμης ανταγωνιζοντας ειδικα ton gdf8 και/ή την ακτιβινη α |
Country Status (19)
| Country | Link |
|---|---|
| US (7) | US8871209B2 (el) |
| EP (1) | EP2780368B1 (el) |
| JP (1) | JP6177249B2 (el) |
| KR (1) | KR102048189B1 (el) |
| AU (1) | AU2012339722B2 (el) |
| CA (1) | CA2855822C (el) |
| CY (1) | CY1119994T1 (el) |
| DK (1) | DK2780368T3 (el) |
| ES (1) | ES2663946T3 (el) |
| HR (1) | HRP20180201T1 (el) |
| HU (1) | HUE038570T2 (el) |
| LT (1) | LT2780368T (el) |
| MX (1) | MX350355B (el) |
| PL (1) | PL2780368T3 (el) |
| PT (1) | PT2780368T (el) |
| RS (1) | RS56796B1 (el) |
| SI (1) | SI2780368T1 (el) |
| SM (1) | SMT201800092T1 (el) |
| WO (1) | WO2013074557A1 (el) |
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