SI0950657T1 - Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitors - Google Patents

Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitors

Info

Publication number: SI0950657T1
Authority: SI; Slovenia
Prior art keywords: preparation; spla2 inhibitors; substituted carbazoles; carbazoles; substituted
Prior art date: 1998-04-17

Application number

SI9930650T

Other languages

English (en)

Slovenian (sl)

Inventor

Nicholas James Bach

Jolie Anne Bastian

Gary Alan Hite

Michael Dean Kinnick

Edward David Mihelich

John Michael Morin Jr.

Daniel Jon Sall

Robert Theodore Vasileff

Original Assignee

Eli Lilly And Comapany

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-17

Filing date

1999-04-16

Publication date

2005-02-28

1999-04-16 Application filed by Eli Lilly And Comapany filed Critical Eli Lilly And Comapany

2005-02-28 Publication of SI0950657T1 publication Critical patent/SI0950657T1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Neurosurgery (AREA)
Orthopedic Medicine & Surgery (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Hematology (AREA)
Immunology (AREA)
Neurology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

SI9930650T 1998-04-17 1999-04-16 Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitors SI0950657T1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US6232898A	1998-04-17	1998-04-17
EP99302967A EP0950657B1 (en)	1998-04-17	1999-04-16	Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitors

Publications (1)

Publication Number	Publication Date
SI0950657T1 true SI0950657T1 (en)	2005-02-28

Family

ID=22041763

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI9930650T SI0950657T1 (en)	1998-04-17	1999-04-16	Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitors

Country Status (30)

Country	Link
EP (2)	EP0950657B1 (cs)
JP (2)	JPH11322713A (cs)
KR (2)	KR19990083232A (cs)
CN (1)	CN1149193C (cs)
AR (2)	AR018593A1 (cs)
AT (2)	ATE271037T1 (cs)
AU (2)	AU753436B2 (cs)
BR (2)	BR9902365A (cs)
CA (2)	CA2269262A1 (cs)
CO (2)	CO5031247A1 (cs)
CZ (2)	CZ136999A3 (cs)
DE (2)	DE69917833T2 (cs)
DK (1)	DK0950657T3 (cs)
DZ (1)	DZ2769A1 (cs)
EA (2)	EA002816B1 (cs)
ES (2)	ES2222663T3 (cs)
HU (2)	HUP9901220A3 (cs)
ID (2)	ID23761A (cs)
IL (2)	IL129483A0 (cs)
NO (2)	NO312240B1 (cs)
NZ (3)	NZ507564A (cs)
PE (2)	PE20000432A1 (cs)
PL (2)	PL332566A1 (cs)
PT (1)	PT950657E (cs)
SG (2)	SG81976A1 (cs)
SI (1)	SI0950657T1 (cs)
TR (2)	TR199900853A3 (cs)
TW (1)	TWI238160B (cs)
YU (2)	YU18999A (cs)
ZA (2)	ZA992772B (cs)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
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EP1011670A4 (en) *	1997-08-28	2004-10-27	Lilly Co Eli	PROCESS FOR TREATING NON-RHUMATOID POLYARTHRITIS
DZ2769A1 (fr) *	1998-04-17	2003-12-01	Lilly Co Eli	Composés tricycliques substitués.
EP1214041A2 (en) *	1998-12-21	2002-06-19	Eli Lilly And Company	Combination therapy for the treatment of sepsis
EP1202963B1 (en) *	1999-07-19	2007-01-03	Eli Lilly And Company	Spla2 inhibitors
US6706752B1 (en)	1999-07-19	2004-03-16	Eli Lilly And Company	sPLA2 inhibitors
WO2002000256A1 (fr) *	2000-06-29	2002-01-03	Shionogi & Co., Ltd.	Remedes contre la cirrhose
AU2001267824A1 (en) *	2000-06-29	2002-01-08	Shionogi And Co., Ltd.	Remedies for cancer
AU2001267826A1 (en) *	2000-06-29	2002-01-08	Shionogi And Co., Ltd.	Remedies for alzheimer's disease
EP1303262A2 (en) *	2000-07-14	2003-04-23	Eli Lilly And Company	Use of a spla2 inhibitor for the treatment of sepsis
CA2431028A1 (en) *	2000-12-18	2002-06-27	Ho-Shen Lin	Tetracyclic carbazole derivates and their use as spla2 inhibitors
ATE353876T1 (de)	2001-03-28	2007-03-15	Lilly Co Eli	Substituierte carbazole als inhibitoren von spla2
AUPS282602A0 (en)	2002-06-07	2002-06-27	Garvan Institute Of Medical Research	Method of inhibiting cell proliferation
DE10249055A1 (de)	2002-10-22	2004-05-06	Bayer Cropscience Ag	2-Phenyl-2-substituierte-1,3-diketone
JO3598B1 (ar)	2006-10-10	2020-07-05	Infinity Discovery Inc	الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني
EP1988098A1 (en) *	2007-04-27	2008-11-05	AEterna Zentaris GmbH	Novel Tetrahydrocarbazole Derivatives as Ligands of G-protein Coupled Receptors
RU2474575C2 (ru)	2008-03-26	2013-02-10	Дайити Санкио Компани, Лимитед	Новое производное тетрагидроизохинолина, фармацевтическая композиция на его основе, применение его и способ лечения и/или предотвращения заболевания
JP5637982B2 (ja)	2008-04-09	2014-12-10	インフィニティーファーマシューティカルズ，インコーポレイテッド	脂肪酸アミド加水分解酵素の阻害剤
WO2010084402A2 (en) *	2009-01-22	2010-07-29	Orchid Research Laboratories Ltd.	Heterocyclic compounds as phosphodiesterase inhibitors
JP2012523425A (ja)	2009-04-07	2012-10-04	インフイニトイプハルマセウトイカルスインコーポレイテッド	脂肪酸アミドヒドロラーゼの阻害薬
EP2416660B1 (en)	2009-04-07	2014-07-02	Infinity Pharmaceuticals, Inc.	Inhibitors of fatty acid amide hydrolase
KR101888026B1 (ko)	2010-02-03	2018-08-13	인피니티 파마슈티컬스, 인코포레이티드	지방산 아미드 하이드롤라제 저해제
AR088377A1 (es)	2011-10-20	2014-05-28	Siena Biotech Spa	Proceso para la preparacion de 6-cloro-2,3,4,9-tetrahidro-1h-carbazol-1-carboxamida y compuestos intermedios de esta
CN102816107B (zh) *	2012-08-20	2015-06-03	东南大学	咔唑衍生物及其制备方法与用途
CA2892485A1 (en)	2012-11-30	2014-06-05	Ge Healthcare Limited	Crystallization process of tricyclic indole derivatives
EP2925723A1 (en) *	2012-11-30	2015-10-07	GE Healthcare Limited	Zinc halide mediated cyclization process leading to tricyclic indoles
EP3248230B1 (de) *	2015-01-20	2020-05-06	cynora GmbH	Verwendung organischer moleküle in optoelektronischen bauelementen
CN108707104A (zh) *	2018-08-07	2018-10-26	北京恒信卓元科技有限公司	2-氯-1h-咔唑-1,4(9h)-二酮的合成方法

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US3579534A (en) *	1969-05-09	1971-05-18	American Cyanamid Co	Tetrahydrocarbazolecarboxylates
US3979391A (en) *	1972-11-22	1976-09-07	Sterling Drug Inc.	1,2,3,4-Tetrahydrocarbazoles
US3939177A (en) *	1972-11-22	1976-02-17	Sterling Drug Inc.	4-Aminomethyl-9-benzyl-1,2,3,4-tetrahydrocarbazoles
PT95692A (pt) *	1989-10-27	1991-09-13	American Home Prod	Processo para a preparacao de derivados de acidos indole-,indeno-,piranoindole- e tetra-hidrocarbazole-alcanoicos, ou quais sao uteis como inibidores de pla2 e da lipoxigenase
US5420289A (en) *	1989-10-27	1995-05-30	American Home Products Corporation	Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase
CA2110514A1 (en) *	1991-07-05	1993-01-21	Raymond Baker	Aromatic compounds, pharmaceutical compositions containing them and their use in therapy
MY110227A (en) *	1991-08-12	1998-03-31	Ciba Geigy Ag	1-acylpiperindine compounds.
IL109311A0 (en) *	1993-04-16	1994-07-31	Lilly Co Eli	1H-indole-3-acetamide sPla2 inhibitors
IL109309A (en) *	1993-04-16	2000-06-29	Lilly Co Eli	1-H-indole-3-acetic acid hydrazide SPLA2 inhibitors and pharmaceutical compositions containing them
CA2179678A1 (en) *	1995-06-23	1996-12-24	Michael Edward Flaugh	6-substituted-1,2,3,4-tetrahydro-9h-carbazoles and 7-substituted-10h-cyclohepta¬7,6-b\| indoles
BR9612347A (pt) *	1995-12-13	1999-07-13	Lilly Co Eli	Naftil acetamidas como inibidores de spla2
AU734096B2 (en) *	1996-10-30	2001-06-07	Eli Lilly And Company	Substituted tricyclics
JP2001517707A (ja) *	1997-09-26	2001-10-09	イーライ・リリー・アンド・カンパニー	嚢胞性繊維症の処置方法
EP1043991A4 (en) *	1997-11-14	2005-02-02	Lilly Co Eli	TREATMENT OF ALZHEIMER DISEASE
DZ2769A1 (fr) *	1998-04-17	2003-12-01	Lilly Co Eli	Composés tricycliques substitués.

1999
- 1999-04-14 DZ DZ990069A patent/DZ2769A1/xx active
- 1999-04-15 ID IDP990341D patent/ID23761A/id unknown
- 1999-04-15 IL IL12948399A patent/IL129483A0/xx unknown
- 1999-04-15 ID IDP990340D patent/ID23287A/id unknown
- 1999-04-15 IL IL12948599A patent/IL129485A0/xx unknown
- 1999-04-16 CA CA002269262A patent/CA2269262A1/en not_active Abandoned
- 1999-04-16 KR KR1019990013436A patent/KR19990083232A/ko not_active Withdrawn
- 1999-04-16 PL PL99332566A patent/PL332566A1/xx not_active Application Discontinuation
- 1999-04-16 HU HU9901220A patent/HUP9901220A3/hu unknown
- 1999-04-16 CA CA002269246A patent/CA2269246C/en not_active Expired - Fee Related
- 1999-04-16 JP JP11109629A patent/JPH11322713A/ja not_active Withdrawn
- 1999-04-16 ES ES99302941T patent/ES2222663T3/es not_active Expired - Lifetime
- 1999-04-16 YU YU18999A patent/YU18999A/sh unknown
- 1999-04-16 YU YU19199A patent/YU19199A/sh unknown
- 1999-04-16 BR BR9902365-2A patent/BR9902365A/pt not_active IP Right Cessation
- 1999-04-16 NZ NZ507564A patent/NZ507564A/xx unknown
- 1999-04-16 DE DE69917833T patent/DE69917833T2/de not_active Expired - Lifetime
- 1999-04-16 SI SI9930650T patent/SI0950657T1/xx unknown
- 1999-04-16 CO CO99022884A patent/CO5031247A1/es unknown
- 1999-04-16 SG SG9901681A patent/SG81976A1/en unknown
- 1999-04-16 NO NO19991822A patent/NO312240B1/no not_active IP Right Cessation
- 1999-04-16 NZ NZ335253A patent/NZ335253A/xx unknown
- 1999-04-16 AT AT99302967T patent/ATE271037T1/de active
- 1999-04-16 EP EP99302967A patent/EP0950657B1/en not_active Expired - Lifetime
- 1999-04-16 NO NO19991821A patent/NO314400B1/no not_active IP Right Cessation
- 1999-04-16 AT AT99302941T patent/ATE268756T1/de not_active IP Right Cessation
- 1999-04-16 PL PL99332565A patent/PL332565A1/xx not_active Application Discontinuation
- 1999-04-16 AU AU23817/99A patent/AU753436B2/en not_active Ceased
- 1999-04-16 TR TR1999/00853A patent/TR199900853A3/tr unknown
- 1999-04-16 EP EP99302941A patent/EP0952149B1/en not_active Expired - Lifetime
- 1999-04-16 JP JP15240099A patent/JP4435330B2/ja not_active Expired - Fee Related
- 1999-04-16 DE DE69918590T patent/DE69918590T2/de not_active Expired - Lifetime
- 1999-04-16 EA EA199900303A patent/EA002816B1/ru not_active IP Right Cessation
- 1999-04-16 EA EA199900301A patent/EA002347B1/ru not_active IP Right Cessation
- 1999-04-16 PE PE1999000314A patent/PE20000432A1/es not_active Application Discontinuation
- 1999-04-16 AR ARP990101771A patent/AR018593A1/es active IP Right Grant
- 1999-04-16 BR BR9901279-0A patent/BR9901279A/pt not_active IP Right Cessation
- 1999-04-16 AU AU23819/99A patent/AU753547B2/en not_active Ceased
- 1999-04-16 KR KR1019990013438A patent/KR100586761B1/ko not_active Expired - Fee Related
- 1999-04-16 ES ES99302967T patent/ES2226286T3/es not_active Expired - Lifetime
- 1999-04-16 CZ CZ991369A patent/CZ136999A3/cs unknown
- 1999-04-16 TW TW088106130A patent/TWI238160B/zh not_active IP Right Cessation
- 1999-04-16 CZ CZ991370A patent/CZ137099A3/cs unknown
- 1999-04-16 PE PE1999000320A patent/PE20000476A1/es not_active Application Discontinuation
- 1999-04-16 HU HU9901221A patent/HUP9901221A3/hu unknown
- 1999-04-16 TR TR1999/00843A patent/TR199900843A2/xx unknown
- 1999-04-16 PT PT99302967T patent/PT950657E/pt unknown
- 1999-04-16 ZA ZA9902772A patent/ZA992772B/xx unknown
- 1999-04-16 ZA ZA9902771A patent/ZA992771B/xx unknown
- 1999-04-16 DK DK99302967T patent/DK0950657T3/da active
- 1999-04-16 NZ NZ335251A patent/NZ335251A/xx unknown
- 1999-04-16 AR ARP990101770A patent/AR018186A1/es not_active Application Discontinuation
- 1999-04-16 SG SG9901869A patent/SG81977A1/en unknown
- 1999-04-16 CO CO99022897A patent/CO5011054A1/es unknown
- 1999-04-16 CN CNB991079574A patent/CN1149193C/zh not_active Expired - Fee Related

Also Published As

Publication number	Publication date
PE20000432A1 (es)	2000-05-23
AR018593A1 (es)	2001-11-28
EA199900301A3 (ru)	2000-04-24
HUP9901221A3 (en)	2001-11-28
HU9901220D0 (en)	1999-06-28
EA199900301A2 (ru)	1999-10-28
BR9901279A (pt)	2000-05-02
NZ335251A (en)	2000-11-24
CO5011054A1 (es)	2001-02-28
CZ136999A3 (cs)	1999-11-17
YU18999A (sh)	2002-08-12
DE69918590T2 (de)	2005-07-21
NZ335253A (en)	2000-11-24
EP0950657A3 (en)	2001-08-16
AU2381799A (en)	1999-10-28
DE69917833D1 (de)	2004-07-15
DE69918590D1 (de)	2004-08-19
NO991821L (no)	1999-10-18
DE69917833T2 (de)	2005-07-14
NO314400B1 (no)	2003-03-17
IL129485A0 (en)	2000-02-29
DZ2769A1 (fr)	2003-12-01
KR100586761B1 (ko)	2006-06-08
JP2000026416A (ja)	2000-01-25
BR9902365A (pt)	2001-04-24
HU9901221A (hu)	2000-04-28
KR19990083232A (ko)	1999-11-25
JP4435330B2 (ja)	2010-03-17
EP0952149A3 (en)	2001-08-16
EA002816B1 (ru)	2002-10-31
HUP9901220A3 (en)	2001-11-28
ES2222663T3 (es)	2005-02-01
EA199900303A3 (ru)	2000-04-24
YU19199A (sh)	2002-08-12
ID23761A (id)	2000-05-11
TWI238160B (en)	2005-08-21
EP0952149A2 (en)	1999-10-27
CN1149193C (zh)	2004-05-12
ZA992772B (en)	2002-07-16
IL129483A0 (en)	2000-02-29
JPH11322713A (ja)	1999-11-24
AU2381999A (en)	1999-10-28
PE20000476A1 (es)	2000-06-02
CA2269246A1 (en)	1999-10-17
EP0950657B1 (en)	2004-07-14
ID23287A (id)	2000-04-05
AU753436B2 (en)	2002-10-17
AR018186A1 (es)	2001-10-31
HU9901220A (hu)	2000-04-28
NO312240B1 (no)	2002-04-15
EA199900303A2 (ru)	1999-10-28
EP0952149B1 (en)	2004-06-09
PL332565A1 (en)	1999-10-25
HU9901221D0 (en)	1999-06-28
NO991822D0 (no)	1999-04-16
TR199900843A2 (xx)	2000-02-21
CZ137099A3 (cs)	1999-11-17
CO5031247A1 (es)	2001-04-27
AU753547B2 (en)	2002-10-24
SG81976A1 (en)	2001-07-24
ZA992771B (en)	2002-04-18
ES2226286T3 (es)	2005-03-16
NZ507564A (en)	2002-10-25
NO991822L (no)	1999-10-18
CA2269246C (en)	2009-08-25
EA002347B1 (ru)	2002-04-25
CN1253948A (zh)	2000-05-24
NO991821D0 (no)	1999-04-16
TR199900853A2 (xx)	1999-11-22
KR19990083233A (ko)	1999-11-25
CA2269262A1 (en)	1999-10-17
ATE268756T1 (de)	2004-06-15
PL332566A1 (en)	1999-10-25
ATE271037T1 (de)	2004-07-15
EP0950657A2 (en)	1999-10-20
PT950657E (pt)	2004-11-30
SG81977A1 (en)	2001-07-24
TR199900853A3 (tr)	1999-11-22
DK0950657T3 (da)	2004-11-22

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