SG161106A1 - Inhibitor proteins of a protease and use thereof - Google Patents

Inhibitor proteins of a protease and use thereof

Info

Publication number: SG161106A1
Authority: SG; Singapore
Prior art keywords: protease; inhibitor protein; chimeric inhibitor; purified; expression vector
Prior art date: 2003-04-04

Application number

SG200718462-5A

Other languages

English (en)

Inventor

David Deperthes

Sylvain Cloutier

Original Assignee

Univ Lausanne

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-04-04

Filing date

2004-04-05

Publication date

2010-05-27

2004-04-05 Application filed by Univ Lausanne filed Critical Univ Lausanne

2010-05-27 Publication of SG161106A1 publication Critical patent/SG161106A1/en

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biophysics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Microbiology (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Oncology (AREA)
Urology & Nephrology (AREA)
Transplantation (AREA)
Communicable Diseases (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

SG200718462-5A 2003-04-04 2004-04-05 Inhibitor proteins of a protease and use thereof SG161106A1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US46034503P	2003-04-04	2003-04-04

Publications (1)

Publication Number	Publication Date
SG161106A1 true SG161106A1 (en)	2010-05-27

Family

ID=33131923

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG200718462-5A SG161106A1 (en)	2003-04-04	2004-04-05	Inhibitor proteins of a protease and use thereof

Country Status (19)

Country	Link
US (1)	US8975370B2 (da)
EP (1)	EP1616007B1 (da)
JP (1)	JP4754478B2 (da)
KR (1)	KR101296367B1 (da)
CN (1)	CN1798838B (da)
AU (1)	AU2004225718B2 (da)
BR (1)	BRPI0409557B8 (da)
CA (1)	CA2521410C (da)
CY (1)	CY1114526T1 (da)
DK (1)	DK1616007T3 (da)
ES (1)	ES2431548T3 (da)
IL (1)	IL171158A (da)
MX (1)	MXPA05010574A (da)
NO (1)	NO334459B1 (da)
PL (1)	PL1616007T3 (da)
PT (1)	PT1616007E (da)
SG (1)	SG161106A1 (da)
SI (1)	SI1616007T1 (da)
WO (1)	WO2004087912A1 (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2163652B2 (en)	2002-01-28	2023-05-31	Life Technologies Corporation	Preparing crude biological extracts using protease, suitable for preparing cDNA
WO2006090282A2 (en) *	2005-02-28	2006-08-31	Universite De Lausanne	Recombinant inhibitor proteins of an hk14 protease and use thereof
US7964350B1 (en)	2007-05-18	2011-06-21	Applied Biosystems, Llc	Sample preparation for in situ nucleic acid analysis
US20110130338A1 (en) *	2008-01-21	2011-06-02	Dermadis Sa	Use of serine protease inhibitors in the treatment of skin diseases
WO2010071833A1 (en) *	2008-12-19	2010-06-24	Life Technologies Corporation	Proteinase k inhibitors, methods and compositions therefor
MX2011009272A (es)	2009-03-10	2012-09-07	Med Discovery S A	Uso de inhibidores de serina proteasa en el tratamiento de neutropenia.
BR112013030243A2 (pt) *	2011-05-26	2016-12-06	Baxter Healthcare Sa	método para a medição de inibidor de alfa1-proteinase ativo em uma amostra
CN103044542B (zh) *	2012-08-17	2015-08-19	常熟理工学院	鲫鱼卵中丝氨酸蛋白酶抑制剂及其基因和应用
CN117169519B (zh) *	2023-10-26	2024-01-30	艾康生物技术(杭州)有限公司	用于检测样本中tt3和/或tt4的解离剂和试剂盒

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3773919A (en)	1969-10-23	1973-11-20	Du Pont	Polylactide-drug mixtures
EP1029921B1 (en) *	1989-03-06	2002-10-23	The Board of Regents of The University of Texas System	Serpin resistant t-PA; mutants; genes
US5723316A (en) *	1989-06-23	1998-03-03	Trustees Of The University Of Pennsylvania	α-1-antichymotrypsin analogues having chymase inhibiting activity
US5612194A (en) *	1989-06-23	1997-03-18	Trustees Of The University Of Pennsylvania	Methods of producing effective recombinant serine protease inhibitors and uses of these inhibitors
US5827662A (en) *	1989-06-23	1998-10-27	The Trustees Of The University Of Pennsylvania	Methods for detecting genetic mutations resulting in protease inhibitor insufficiencies
US6057287A (en)	1994-01-11	2000-05-02	Dyax Corp.	Kallikrein-binding "Kunitz domain" proteins and analogues thereof
PT739355E (pt)	1994-01-11	2005-01-31	Dyax Corp	Proteinas de 'dominio de kunitz' inibidoras de calicreina e seus analogos
US6284873B1 (en)	1999-03-12	2001-09-04	Hybritech Incorporated	Complex of human kallikrein 2 (hK2) and protease inhibitor-6 (PI-6) in prostate tumor tissue and methods of using the complex

2004
- 2004-04-05 US US10/552,786 patent/US8975370B2/en active Active
- 2004-04-05 SG SG200718462-5A patent/SG161106A1/en unknown
- 2004-04-05 CN CN2004800152687A patent/CN1798838B/zh not_active Expired - Lifetime
- 2004-04-05 WO PCT/IB2004/001040 patent/WO2004087912A1/en not_active Ceased
- 2004-04-05 AU AU2004225718A patent/AU2004225718B2/en not_active Expired
- 2004-04-05 MX MXPA05010574A patent/MXPA05010574A/es active IP Right Grant
- 2004-04-05 DK DK04725742.3T patent/DK1616007T3/da active
- 2004-04-05 JP JP2006506440A patent/JP4754478B2/ja not_active Expired - Lifetime
- 2004-04-05 EP EP04725742.3A patent/EP1616007B1/en not_active Expired - Lifetime
- 2004-04-05 SI SI200432098T patent/SI1616007T1/sl unknown
- 2004-04-05 PL PL04725742T patent/PL1616007T3/pl unknown
- 2004-04-05 KR KR1020057018938A patent/KR101296367B1/ko not_active Expired - Lifetime
- 2004-04-05 BR BRPI0409557-0 patent/BRPI0409557B8/pt not_active IP Right Cessation
- 2004-04-05 PT PT47257423T patent/PT1616007E/pt unknown
- 2004-04-05 ES ES04725742T patent/ES2431548T3/es not_active Expired - Lifetime
- 2004-04-05 CA CA2521410A patent/CA2521410C/en not_active Expired - Lifetime
2005
- 2005-09-28 IL IL171158A patent/IL171158A/en active IP Right Grant
- 2005-11-04 NO NO20055210A patent/NO334459B1/no unknown
2013
- 2013-10-23 CY CY20131100937T patent/CY1114526T1/el unknown

Also Published As

Publication number	Publication date
IL171158A (en)	2011-05-31
CN1798838A (zh)	2006-07-05
US8975370B2 (en)	2015-03-10
MXPA05010574A (es)	2006-03-09
AU2004225718B2 (en)	2009-11-05
JP4754478B2 (ja)	2011-08-24
NO20055210D0 (no)	2005-11-04
PL1616007T3 (pl)	2013-12-31
PT1616007E (pt)	2013-10-28
BRPI0409557A (pt)	2006-04-18
AU2004225718A1 (en)	2004-10-14
SI1616007T1 (sl)	2013-12-31
NO334459B1 (no)	2014-03-10
JP2006523097A (ja)	2006-10-12
CY1114526T1 (el)	2016-10-05
BRPI0409557B1 (pt)	2019-07-23
EP1616007A1 (en)	2006-01-18
EP1616007B1 (en)	2013-07-24
DK1616007T3 (da)	2013-10-28
WO2004087912A8 (en)	2005-01-20
ES2431548T3 (es)	2013-11-26
CA2521410C (en)	2014-06-03
CA2521410A1 (en)	2004-10-14
WO2004087912A1 (en)	2004-10-14
BRPI0409557B8 (pt)	2021-05-25
US20060269536A1 (en)	2006-11-30
CN1798838B (zh)	2012-01-04
KR101296367B1 (ko)	2013-08-14
NO20055210L (no)	2005-12-23
KR20060010740A (ko)	2006-02-02

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MY120693A (en)	2005-11-30	Human bikunin
WO2005121331A8 (en)	2006-03-09	Truncated galnact2 polypeptides and nucleic acids
DE60134786D1 (de)	2008-08-21	Mini-dystrophin nukleinsäure- und peptidsequenzen
MXPA03010433A (es)	2004-10-15	Metodos para produccion recombinante de peptidos antifusogenicos.
DE60323210D1 (en)	2008-10-09	Eukaryontische signalsequenzen für polypeptid-expr
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DK1697523T3 (da)	2008-02-04	Ekspressionsvektor til antibiotikafri ekspression
PL1675956T3 (pl)	2011-06-30	Minimalna sekwencja DNA działająca jako insulator chromatyny i jej zastosowanie do wyrażania białek
DE69840230D1 (de)	2009-01-02	Polypeptide mit prolyldipeptidylaminopeptidase-aktivität und dafür kodierende nukleinsäuren
CY1114526T1 (el)	2016-10-05	Κατασταλτικες πρωτεϊνες μιας πρωτεασης (protease) και χρησεις αυτων
ATE483810T1 (de)	2010-10-15	Entkopplung von dna-propagierung und proteinexpression für phagen-display
WO2004031210A3 (en)	2004-09-10	Optimized multi-epitope constructs and uses thereof
AU2003222717A8 (en)	2003-09-16	Streptavidin-binding peptide
WO2003076561A3 (en)	2004-01-22	Recombinase fusion protein with enhanced cellular uptake
MXPA02007752A (es)	2004-09-10	Celulas transgenicas que expresan acidos nucleicos de glucosiltransferasa.
ATE532861T1 (de)	2011-11-15	Expressionsvektor
WO2005078109A3 (en)	2005-11-10	Expression of plasminogen and microplasminogen in duckweed
WO2001066752A3 (en)	2002-07-11	Reproduction-specific genes
TW200604207A (en)	2006-02-01	A superantigen fusion protein and the use thereof
WO2006090282A3 (en)	2007-04-12	Recombinant inhibitor proteins of an hk14 protease and use thereof
WO2005057486A3 (en)	2005-08-11	Protein engineering with analogous contact environments
DE60225046D1 (de)	2008-03-27	Produktion eukaryontischer proteine und nukleinsäuremoleküle in c. elegans
TW200504218A (en)	2005-02-01	Methods for preventing gluconoylation of proteins