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PT739355E - Proteinas de 'dominio de kunitz' inibidoras de calicreina e seus analogos - Google Patents

Proteinas de 'dominio de kunitz' inibidoras de calicreina e seus analogos

Info

Publication number
PT739355E
PT739355E PT95909223T PT95909223T PT739355E PT 739355 E PT739355 E PT 739355E PT 95909223 T PT95909223 T PT 95909223T PT 95909223 T PT95909223 T PT 95909223T PT 739355 E PT739355 E PT 739355E
Authority
PT
Portugal
Prior art keywords
proteins
kunitz
domain
calicreina
analogs
Prior art date
Application number
PT95909223T
Other languages
English (en)
Inventor
Markland William
Ladner Robert Charles
Original Assignee
Dyax Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/208,264 external-priority patent/US6057287A/en
Application filed by Dyax Corp filed Critical Dyax Corp
Publication of PT739355E publication Critical patent/PT739355E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
PT95909223T 1994-01-11 1995-01-11 Proteinas de 'dominio de kunitz' inibidoras de calicreina e seus analogos PT739355E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17996494A 1994-01-11 1994-01-11
US08/208,264 US6057287A (en) 1994-01-11 1994-03-10 Kallikrein-binding "Kunitz domain" proteins and analogues thereof

Publications (1)

Publication Number Publication Date
PT739355E true PT739355E (pt) 2005-01-31

Family

ID=26875859

Family Applications (1)

Application Number Title Priority Date Filing Date
PT95909223T PT739355E (pt) 1994-01-11 1995-01-11 Proteinas de 'dominio de kunitz' inibidoras de calicreina e seus analogos

Country Status (10)

Country Link
US (3) US5795865A (pt)
EP (1) EP0739355B1 (pt)
JP (1) JP3805785B2 (pt)
AT (1) ATE275583T1 (pt)
CA (1) CA2180950C (pt)
DE (1) DE69533472T2 (pt)
DK (1) DK0739355T3 (pt)
ES (1) ES2227545T3 (pt)
PT (1) PT739355E (pt)
WO (1) WO1995021601A2 (pt)

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ES2375561T3 (es) * 1994-01-11 2012-03-02 Dyax Corporation Inhibidores de la plasmina humana derivados de dominios kunitz y �?cidos nucleicos que codifican los mismos.
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US6346510B1 (en) 1995-10-23 2002-02-12 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
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US5981471A (en) 1997-02-06 1999-11-09 Entremed, Inc. Compositions and methods for inhibiting cellular proliferation
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US6087473A (en) * 1999-05-26 2000-07-11 Zymogenetics, Inc. Kunitz domain polypeptide and materials and methods for making it
JP2002516102A (ja) * 1998-05-28 2002-06-04 ザイモジェネティクス，インコーポレイティド Ｋｕｎｉｔｚドメインポリペプチド並びにその製造のための材料及び方法
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ES2709103T3 (es) 2002-08-28 2019-04-15 Dyax Corp Métodos para conservar órganos y tejidos
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US6989369B2 (en) * 2003-02-07 2006-01-24 Dyax Corp. Kunitz domain peptides
US8975370B2 (en) 2003-04-04 2015-03-10 Universite De Lausanne Inhibitor proteins of a protease and use thereof
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JP7585193B2 (ja) 2018-08-30 2024-11-18 武田薬品工業株式会社 血漿カリクレイン阻害剤及び遺伝性血管浮腫発作を処置するためのその使用
JP2022525164A (ja) 2019-03-14 2022-05-11 武田薬品工業株式会社 遺伝性血管性浮腫の発作を処置するための血漿カリクレイン阻害剤およびその使用
JP2023510854A (ja) 2020-01-13 2023-03-15 武田薬品工業株式会社 小児遺伝性血管性浮腫発作を治療するための血漿カリクレイン阻害剤及びその使用
WO2021198534A1 (en) 2020-04-04 2021-10-07 Oxurion NV Plasma kallikrein inhibitors for use in the treatment of coronaviral disease
EP4126219A2 (en) 2020-04-04 2023-02-08 Takeda Pharmaceutical Company Limited Plasma kallikrein inhibitors and uses thereof for treating acute respiratory distress syndrome
WO2023144030A1 (en) 2022-01-31 2023-08-03 Oxurion NV Plasma kallikrein inhibitor therapy for anti-vegf sensitization
WO2023148016A1 (en) 2022-02-04 2023-08-10 Oxurion NV Biomarker for plasma kallikrein inhibitor therapy response
JP2025522757A (ja) 2022-06-30 2025-07-17 武田薬品工業株式会社 ラナデルマブ治療のためのタンパク質バイオマーカー
JP2025534392A (ja) 2022-09-29 2025-10-15 エヴォルヴェルタシュ バイオテクノロギアイ コルラートルト フェレレーシュシェーギュー タールシャシャーグ 足場タンパク質及びその使用

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Also Published As

Publication number Publication date
DE69533472D1 (de) 2004-10-14
EP0739355B1 (en) 2004-09-08
CA2180950A1 (en) 1995-08-17
DE69533472T2 (de) 2006-01-12
WO1995021601A3 (en) 1995-09-21
EP0739355A1 (en) 1996-10-30
US5994125A (en) 1999-11-30
ATE275583T1 (de) 2004-09-15
US5795865A (en) 1998-08-18
WO1995021601A2 (en) 1995-08-17
US6333402B1 (en) 2001-12-25
ES2227545T3 (es) 2005-04-01
JP3805785B2 (ja) 2006-08-09
DK0739355T3 (da) 2005-01-24
JPH09511131A (ja) 1997-11-11
CA2180950C (en) 2005-03-29

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