BRPI0409557B8 - proteína recombinante inibidora de calicreína, sequência de dna, vetor de expressão, composição farmacêutica, uso da composição farmacêutica, método de produção da proteína recombinanete e kits de diagnóstico - Google Patents

proteína recombinante inibidora de calicreína, sequência de dna, vetor de expressão, composição farmacêutica, uso da composição farmacêutica, método de produção da proteína recombinanete e kits de diagnóstico

Info

Publication number: BRPI0409557B8
Authority: BR; Brazil
Prior art keywords: pharmaceutical composition; recombinant protein; expression vector; production method; dna sequence
Prior art date: 2003-04-04

Application number

Other languages

English (en)

Inventor

Deperthes David

Cloutier Sylvain

Original Assignee

Univ Lausanne

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-04-04

Filing date

2004-04-05

Publication date

2021-05-25

2004-04-05 Application filed by Univ Lausanne filed Critical Univ Lausanne

2006-04-18 Publication of BRPI0409557A publication Critical patent/BRPI0409557A/pt

2019-07-23 Publication of BRPI0409557B1 publication Critical patent/BRPI0409557B1/pt

2021-05-25 Publication of BRPI0409557B8 publication Critical patent/BRPI0409557B8/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biophysics (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Microbiology (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Oncology (AREA)
Transplantation (AREA)
Communicable Diseases (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

BRPI0409557-0 2003-04-04 2004-04-05 proteína recombinante inibidora de calicreína, sequência de dna, vetor de expressão, composição farmacêutica, uso da composição farmacêutica, método de produção da proteína recombinanete e kits de diagnóstico BRPI0409557B8 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US46034503P	2003-04-04	2003-04-04
US60/460,345		2003-04-04
PCT/IB2004/001040 WO2004087912A1 (en)	2003-04-04	2004-04-05	Inhibitor proteins of a protease and use thereof

Publications (3)

Publication Number	Publication Date
BRPI0409557A BRPI0409557A (pt)	2006-04-18
BRPI0409557B1 BRPI0409557B1 (pt)	2019-07-23
BRPI0409557B8 true BRPI0409557B8 (pt)	2021-05-25

Family

ID=33131923

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0409557-0 BRPI0409557B8 (pt)	2003-04-04	2004-04-05	proteína recombinante inibidora de calicreína, sequência de dna, vetor de expressão, composição farmacêutica, uso da composição farmacêutica, método de produção da proteína recombinanete e kits de diagnóstico

Country Status (19)

Country	Link
US (1)	US8975370B2 (pt)
EP (1)	EP1616007B1 (pt)
JP (1)	JP4754478B2 (pt)
KR (1)	KR101296367B1 (pt)
CN (1)	CN1798838B (pt)
AU (1)	AU2004225718B2 (pt)
BR (1)	BRPI0409557B8 (pt)
CA (1)	CA2521410C (pt)
CY (1)	CY1114526T1 (pt)
DK (1)	DK1616007T3 (pt)
ES (1)	ES2431548T3 (pt)
IL (1)	IL171158A (pt)
MX (1)	MXPA05010574A (pt)
NO (1)	NO334459B1 (pt)
PL (1)	PL1616007T3 (pt)
PT (1)	PT1616007E (pt)
SG (1)	SG161106A1 (pt)
SI (1)	SI1616007T1 (pt)
WO (1)	WO2004087912A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2290098A1 (en)	2002-01-28	2011-03-02	Ambion, Inc.	Preparing crude biological extracts using protease, suitable for preparing cDNA
WO2006090282A2 (en) *	2005-02-28	2006-08-31	Universite De Lausanne	Recombinant inhibitor proteins of an hk14 protease and use thereof
US7964350B1 (en)	2007-05-18	2011-06-21	Applied Biosystems, Llc	Sample preparation for in situ nucleic acid analysis
CA2712512C (en) *	2008-01-21	2018-08-28	Institut National De La Sante Et De La Recherche Medicale (Inserm)	Use of serine protease inhibitors in the treatment of skin diseases
US8211637B2 (en) *	2008-12-19	2012-07-03	Life Technologies Corporation	Proteinase K inhibitors, methods and compositions therefor
WO2010103475A2 (en)	2009-03-10	2010-09-16	Med Discovery Sa	Use of serine protease inhibitors in the treatment of neutropenia
US8652793B2 (en) *	2011-05-26	2014-02-18	Baxter International Inc.	Solid phase-bound elastase-binding assay for the measurement of alpha1-antitrypsin activity
CN103044542B (zh) *	2012-08-17	2015-08-19	常熟理工学院	鲫鱼卵中丝氨酸蛋白酶抑制剂及其基因和应用
CN117169519B (zh) *	2023-10-26	2024-01-30	艾康生物技术(杭州)有限公司	用于检测样本中tt3和/或tt4的解离剂和试剂盒

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3773919A (en)	1969-10-23	1973-11-20	Du Pont	Polylactide-drug mixtures
DK0462207T3 (da) *	1989-03-06	2001-06-18	Univ Texas	t-Pa mutanter resistente mod deres respektive inhibitorer
US5612194A (en) *	1989-06-23	1997-03-18	Trustees Of The University Of Pennsylvania	Methods of producing effective recombinant serine protease inhibitors and uses of these inhibitors
US5827662A (en)	1989-06-23	1998-10-27	The Trustees Of The University Of Pennsylvania	Methods for detecting genetic mutations resulting in protease inhibitor insufficiencies
US5723316A (en) *	1989-06-23	1998-03-03	Trustees Of The University Of Pennsylvania	α-1-antichymotrypsin analogues having chymase inhibiting activity
US6057287A (en)	1994-01-11	2000-05-02	Dyax Corp.	Kallikrein-binding "Kunitz domain" proteins and analogues thereof
DE69533472T2 (de)	1994-01-11	2006-01-12	Dyax Corp., Cambridge	Kallikreinhemmende "kunitz-domäne"-proteine und derivaten davon
US6284873B1 (en)	1999-03-12	2001-09-04	Hybritech Incorporated	Complex of human kallikrein 2 (hK2) and protease inhibitor-6 (PI-6) in prostate tumor tissue and methods of using the complex

2004
- 2004-04-05 MX MXPA05010574A patent/MXPA05010574A/es active IP Right Grant
- 2004-04-05 CN CN2004800152687A patent/CN1798838B/zh not_active Expired - Lifetime
- 2004-04-05 WO PCT/IB2004/001040 patent/WO2004087912A1/en not_active Ceased
- 2004-04-05 BR BRPI0409557-0 patent/BRPI0409557B8/pt not_active IP Right Cessation
- 2004-04-05 SG SG200718462-5A patent/SG161106A1/en unknown
- 2004-04-05 PT PT47257423T patent/PT1616007E/pt unknown
- 2004-04-05 ES ES04725742T patent/ES2431548T3/es not_active Expired - Lifetime
- 2004-04-05 DK DK04725742.3T patent/DK1616007T3/da active
- 2004-04-05 AU AU2004225718A patent/AU2004225718B2/en not_active Expired
- 2004-04-05 KR KR1020057018938A patent/KR101296367B1/ko not_active Expired - Lifetime
- 2004-04-05 CA CA2521410A patent/CA2521410C/en not_active Expired - Lifetime
- 2004-04-05 PL PL04725742T patent/PL1616007T3/pl unknown
- 2004-04-05 US US10/552,786 patent/US8975370B2/en active Active
- 2004-04-05 JP JP2006506440A patent/JP4754478B2/ja not_active Expired - Lifetime
- 2004-04-05 SI SI200432098T patent/SI1616007T1/sl unknown
- 2004-04-05 EP EP04725742.3A patent/EP1616007B1/en not_active Expired - Lifetime
2005
- 2005-09-28 IL IL171158A patent/IL171158A/en active IP Right Grant
- 2005-11-04 NO NO20055210A patent/NO334459B1/no unknown
2013
- 2013-10-23 CY CY20131100937T patent/CY1114526T1/el unknown

Also Published As

Publication number	Publication date
CA2521410A1 (en)	2004-10-14
CN1798838A (zh)	2006-07-05
AU2004225718B2 (en)	2009-11-05
NO20055210L (no)	2005-12-23
KR101296367B1 (ko)	2013-08-14
PL1616007T3 (pl)	2013-12-31
US8975370B2 (en)	2015-03-10
JP2006523097A (ja)	2006-10-12
EP1616007B1 (en)	2013-07-24
PT1616007E (pt)	2013-10-28
AU2004225718A1 (en)	2004-10-14
IL171158A (en)	2011-05-31
JP4754478B2 (ja)	2011-08-24
SI1616007T1 (sl)	2013-12-31
DK1616007T3 (da)	2013-10-28
SG161106A1 (en)	2010-05-27
EP1616007A1 (en)	2006-01-18
NO20055210D0 (no)	2005-11-04
WO2004087912A8 (en)	2005-01-20
US20060269536A1 (en)	2006-11-30
CA2521410C (en)	2014-06-03
BRPI0409557A (pt)	2006-04-18
BRPI0409557B1 (pt)	2019-07-23
WO2004087912A1 (en)	2004-10-14
MXPA05010574A (es)	2006-03-09
NO334459B1 (no)	2014-03-10
CY1114526T1 (el)	2016-10-05
ES2431548T3 (es)	2013-11-26
CN1798838B (zh)	2012-01-04
KR20060010740A (ko)	2006-02-02

Publication	Publication Date	Title
DE60329983D1 (de)	2009-12-24	Wachsestersynthase-dna-sequenz, protein und verwendungen davon
DK1680507T3 (da)	2011-10-10	Bakterieekspression af proteaseinhibitorer og varianter deraf
ECSP034859A (es)	2004-01-28	Nuevos derivados de pirrol como agentes farmacéuticos
WO2006127899A3 (en)	2007-02-08	(r)-n-methylnaltrexone, processes for its synthesis and its pharmaceutical use
ATE466080T1 (de)	2010-05-15	Formulierungen und verfahren zum denaturieren von proteinen
ATE480567T1 (de)	2010-09-15	Hochkonzentrierter antikörper und proteinformulierungen
WO2004099231A3 (en)	2006-03-16	Glycopegylation methods and proteins/peptides produced by the methods
DK1448195T3 (da)	2007-02-12	N-adamantylmethylderivater og mellemprodukter som farmaceutiske præparater og fremgangsmåde til fremstilling deraf
EP2037737A4 (en)	2010-02-24	PROTEINS, NUCLEIC ACIDS FOR THEIR CODING AND CORRESPONDING USES.
EP1501532A4 (en)	2007-11-14	PEPTIDE INHIBITORS OF PROTEIN KINASE C
IS8282A (is)	2006-02-01	Kortlagning genamengja starfrænna DNA þátta og frumuprótína
NO20040356L (no)	2004-03-19	Indaneddiksyrederivater og deres andvendelse som farmasoytiske midler, intermediater og fremgangsmate for fremstilling.
WO2005107491A3 (en)	2005-12-22	Multi-lectin affinity chromatography and uses thereof
BRPI0607198A2 (pt)	2016-11-01	composição, uso da composição método de tratamento doenças, e, embalagem farmacêutica
CY1118930T1 (el)	2018-01-10	Ανασυνδυασμενες πρωτεϊνες ελαστασης και μεθοδοι βιομηχανικης κατασκευης και χρηση αυτων
EP1509226A4 (en)	2008-04-09	SMALL MOLECULAR INHIBITORS OF THE HER2 EXPRESSION
NO20062709L (no)	2006-08-11	Stamceller som er egnet for transplantasjon, fremstilling derav og farmasoytiske preperater omfattende nevnte stamceller
BRPI0409557B8 (pt)	2021-05-25	proteína recombinante inibidora de calicreína, sequência de dna, vetor de expressão, composição farmacêutica, uso da composição farmacêutica, método de produção da proteína recombinanete e kits de diagnóstico
FI20030771A7 (fi)	2004-11-22	Menetelmä toksisten syanobakteerien määrittämiseksi
WO2008054595A3 (en)	2008-12-04	Drug controlled molecular tags
AU2007310767A1 (en)	2008-05-02	New fluorene derivatives, compositions containing the same and use thereof as inhibitors of the protein chaperone HSP 90
ATE461453T1 (de)	2010-04-15	Nukleinsäuresequenz und protein, das eine rolle bei der zellulären alterung spielt
WO2004081033A3 (en)	2005-04-07	Synthesis of proteins by cell-free protein expression
ATE543833T1 (de)	2012-02-15	Bmp-7-varianten-zusammensetzungen, verfahren und verwendungen
EP1682572A4 (en)	2009-01-28	Protein Expression

Legal Events

Date	Code	Title	Description
2012-02-22	B06F	Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
2014-12-09	B15K	Others concerning applications: alteration of classification	Free format text: AS CLASSIFICACOES ANTERIORES ERAM: C12N 15/09 , C12N 15/15 , C12N 9/64 , C12P 21/02 Ipc: C12N 15/15 (2006.01), C12N 9/64 (2006.01), C12P 21
2015-06-30	B07D	Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
2018-03-13	B07E	Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
2019-02-05	B06A	Patent application procedure suspended [chapter 6.1 patent gazette]
2019-06-04	B09A	Decision: intention to grant [chapter 9.1 patent gazette]
2019-07-23	B16A	Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]	Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 23/07/2019, OBSERVADAS AS CONDICOES LEGAIS. (CO) 10 (DEZ) ANOS CONTADOS A PARTIR DE 23/07/2019, OBSERVADAS AS CONDICOES LEGAIS
2021-05-25	B16C	Correction of notification of the grant [chapter 16.3 patent gazette]	Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 05/04/2004 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF
2025-02-04	B21F	Lapse acc. art. 78, item iv - on non-payment of the annual fees in time	Free format text: REFERENTE A 21A ANUIDADE.
2025-02-18	B21H	Decision of lapse of a patent or of a certificate of addition of invention cancelled [chapter 21.8 patent gazette]	Free format text: ANULADA A PUBLICACAO CODIGO 21.6 NA RPI NO 2822 DE 04/02/2025 POR TER SIDO INDEVIDA.