SG151195A1 - Method for manufacture of escitalopram - Google Patents

Method for manufacture of escitalopram

Info

Publication number: SG151195A1
Authority: SG; Singapore
Prior art keywords: escitalopram; manufacture; benzonitrile; hydroxybutyl; hydroxymethyl
Prior art date: 2007-09-11

Application number

SG200806650-8A

Other languages

English (en)

Inventor

Carla De Faveri

Florian Anton Martin Huber

Robert James Dancer

Original Assignee

Lundbeck & Co As H

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-09-11

Filing date

2008-09-10

Publication date

2009-04-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39735675&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG151195(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2008-09-10 Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H

2009-04-30 Publication of SG151195A1 publication Critical patent/SG151195A1/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/32—Separation; Purification; Stabilisation; Use of additives
- C07C253/34—Separation; Purification
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/53—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and hydroxy groups bound to the carbon skeleton

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Epidemiology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

SG200806650-8A 2007-09-11 2008-09-10 Method for manufacture of escitalopram SG151195A1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DKPA200701314		2007-09-11

Publications (1)

Publication Number	Publication Date
SG151195A1 true SG151195A1 (en)	2009-04-30

Family

ID=39735675

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG200806650-8A SG151195A1 (en)	2007-09-11	2008-09-10	Method for manufacture of escitalopram

Country Status (52)

Country	Link
EP (2)	EP2061753B1 (es)
JP (1)	JP4966933B2 (es)
KR (1)	KR101054224B1 (es)
CN (1)	CN101386583A (es)
AR (2)	AR068174A1 (es)
AT (2)	ATE518829T1 (es)
AU (1)	AU2008212055C1 (es)
BE (1)	BE1017548A6 (es)
BG (1)	BG110206A (es)
BR (1)	BRPI0804121B1 (es)
CA (1)	CA2638499C (es)
CH (1)	CH697885B1 (es)
CL (1)	CL2008002686A1 (es)
CO (1)	CO6140012A1 (es)
CY (2)	CY2600B1 (es)
CZ (1)	CZ2008537A3 (es)
DE (1)	DE102008046530A1 (es)
DK (2)	DK177075B1 (es)
EA (1)	EA012787B1 (es)
EE (1)	EE00864U1 (es)
ES (2)	ES2334875B1 (es)
FI (1)	FI121570B (es)
FR (1)	FR2920766A1 (es)
GB (1)	GB2448848B (es)
GR (1)	GR1006595B (es)
HR (2)	HRP20080425A2 (es)
HU (1)	HUP0800549A2 (es)
IE (1)	IES20080708A2 (es)
IL (1)	IL193845A (es)
IS (1)	IS8758A (es)
LT (1)	LT5577B (es)
LU (1)	LU91479B1 (es)
LV (1)	LV13813B (es)
ME (1)	ME00176B (es)
MX (1)	MX2008011451A (es)
MY (1)	MY144210A (es)
NL (1)	NL2001953C2 (es)
NO (1)	NO20083756L (es)
NZ (1)	NZ570884A (es)
PL (2)	PL386026A1 (es)
PT (2)	PT104169A (es)
RO (1)	RO125301A2 (es)
RS (2)	RS20080401A (es)
SE (1)	SE533041C2 (es)
SG (1)	SG151195A1 (es)
SI (2)	SI22567A2 (es)
SK (1)	SK500302008A3 (es)
TR (2)	TR200907629A2 (es)
TW (1)	TWI391383B (es)
UA (2)	UA43461U (es)
WO (1)	WO2009033488A1 (es)
ZA (1)	ZA200807753B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7939680B2 (en)	2005-07-27	2011-05-10	Aurobindo Pharma Ltd.	Process for the preparation of Escitalopram
CN102796065A (zh) *	2011-05-27	2012-11-28	江苏豪森医药集团连云港宏创医药有限公司	一种制备光学纯度高的艾司西酞普兰的方法
CN104119240A (zh) *	2013-04-23	2014-10-29	中国人民解放军军事医学科学院毒物药物研究所	(S)-(-)-α-甲胺基苯丙酮的制备方法
CN103497145B (zh) *	2013-10-10	2016-01-27	南昌大学	一种光学纯多奈哌齐的制备工艺
CN104119248A (zh) *	2014-08-08	2014-10-29	广东东阳光药业有限公司	S-西酞普兰的制备方法
US10287240B2 (en)	2014-11-14	2019-05-14	Zhejiang Hushai Pharmaceuticals Co., Ltd.	Method for resolution of citalopram intermediate 5-cyano diol

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8814057D0 (en) *	1988-06-14	1988-07-20	Lundbeck & Co As H	New enantiomers & their isolation
AR034612A1 (es)	2001-06-25	2004-03-03	Lundbeck & Co As H	Proceso para la preparacion del citalopram racemico y/o del s- o r-citalopram mediante la separacion de una mezcla de r- y s-citalopram
AR034759A1 (es) *	2001-07-13	2004-03-17	Lundbeck & Co As H	Metodo para la preparacion de escitalopram
IS7239A (is) *	2001-12-14	2004-04-29	H. Lundbeck A/S	Aðferð til framleiðslu á essítalóprami
JP4505335B2 (ja)	2002-12-23	2010-07-21	ハー・ルンドベック・アクチエゼルスカベット	ラセミ体シタロプラムジオール（ｒａｃｅｍｉｃｃｉｔａｌｏｐｒａｍｄｉｏｌ）および／またはＳ−もしくはＲ−シタロプラムジオールの製造方法、およびラセミ体シタロプラム、Ｒ−シタロプラムおよび／またはＳ−シタロプラムを製造するために、上記ジオールを使用する方法。
AU2003242990A1 (en) *	2003-01-17	2004-08-13	Pulla Reddy Muddasani	Processes for the preparation of escitalopram and its precursor
CA2575975A1 (en) *	2003-11-12	2005-05-26	Dr. Reddy's Laboratories, Inc.	Preparation of escitalopram
WO2006106531A1 (en) *	2005-04-04	2006-10-12	Jubilant Organosys Ltd	Process for the preparation of escitalopram or its acid addition salts
US7939680B2 (en) *	2005-07-27	2011-05-10	Aurobindo Pharma Ltd.	Process for the preparation of Escitalopram

2008
- 2008-08-29 NZ NZ570884A patent/NZ570884A/en not_active IP Right Cessation
- 2008-08-29 FI FI20085807A patent/FI121570B/fi not_active IP Right Cessation
- 2008-09-01 IE IE20080708A patent/IES20080708A2/en not_active IP Right Cessation
- 2008-09-01 NO NO20083756A patent/NO20083756L/no unknown
- 2008-09-01 TW TW097133379A patent/TWI391383B/zh active
- 2008-09-01 GB GB0815773A patent/GB2448848B/en not_active Expired - Fee Related
- 2008-09-02 BG BG110206A patent/BG110206A/en unknown
- 2008-09-02 IS IS8758A patent/IS8758A/is unknown
- 2008-09-02 HR HR20080425A patent/HRP20080425A2/hr not_active Application Discontinuation
- 2008-09-02 IL IL193845A patent/IL193845A/en active IP Right Grant
- 2008-09-02 EA EA200801797A patent/EA012787B1/ru not_active IP Right Cessation
- 2008-09-02 LV LVP-08-154A patent/LV13813B/lv unknown
- 2008-09-02 JP JP2008224435A patent/JP4966933B2/ja active Active
- 2008-09-03 LT LT2008068A patent/LT5577B/lt not_active IP Right Cessation
- 2008-09-03 AR ARP080103832A patent/AR068174A1/es active IP Right Grant
- 2008-09-03 ME MEP-2008-101A patent/ME00176B/me unknown
- 2008-09-04 PL PL386026A patent/PL386026A1/pl unknown
- 2008-09-04 NL NL2001953A patent/NL2001953C2/en not_active IP Right Cessation
- 2008-09-04 RS RSP-2008/0401A patent/RS20080401A/sr unknown
- 2008-09-04 CZ CZ20080537A patent/CZ2008537A3/cs unknown
- 2008-09-04 MY MYPI20083415A patent/MY144210A/en unknown
- 2008-09-05 SI SI200800207A patent/SI22567A2/sl not_active IP Right Cessation
- 2008-09-05 HU HU0800549A patent/HUP0800549A2/hu unknown
- 2008-09-08 AU AU2008212055A patent/AU2008212055C1/en active Active
- 2008-09-08 MX MX2008011451A patent/MX2008011451A/es active IP Right Grant
- 2008-09-09 EE EEU200800091U patent/EE00864U1/xx not_active IP Right Cessation
- 2008-09-09 SE SE0801929A patent/SE533041C2/sv not_active IP Right Cessation
- 2008-09-09 ZA ZA200807753A patent/ZA200807753B/en unknown
- 2008-09-09 PT PT104169A patent/PT104169A/pt not_active IP Right Cessation
- 2008-09-10 RS RS20110394A patent/RS51909B/sr unknown
- 2008-09-10 GR GR20080100581A patent/GR1006595B/el not_active IP Right Cessation
- 2008-09-10 CL CL2008002686A patent/CL2008002686A1/es unknown
- 2008-09-10 UA UAU200811050U patent/UA43461U/uk unknown
- 2008-09-10 CA CA2638499A patent/CA2638499C/en not_active Expired - Fee Related
- 2008-09-10 AT AT08801398T patent/ATE518829T1/de active
- 2008-09-10 ES ES200802582A patent/ES2334875B1/es not_active Expired - Fee Related
- 2008-09-10 HR HR20110636T patent/HRP20110636T1/hr unknown
- 2008-09-10 DK DKPA200801265A patent/DK177075B1/da not_active IP Right Cessation
- 2008-09-10 UA UAU200901635U patent/UA41919U/uk unknown
- 2008-09-10 CN CNA2008101686272A patent/CN101386583A/zh active Pending
- 2008-09-10 EP EP08801398A patent/EP2061753B1/en active Active
- 2008-09-10 SK SK50030-2008A patent/SK500302008A3/sk unknown
- 2008-09-10 SI SI200830361T patent/SI2061753T1/sl unknown
- 2008-09-10 WO PCT/DK2008/050222 patent/WO2009033488A1/en not_active Ceased
- 2008-09-10 DE DE102008046530A patent/DE102008046530A1/de not_active Withdrawn
- 2008-09-10 CO CO08095718A patent/CO6140012A1/es not_active Application Discontinuation
- 2008-09-10 EP EP11172640A patent/EP2397461A1/en not_active Withdrawn
- 2008-09-10 FR FR0856077A patent/FR2920766A1/fr active Pending
- 2008-09-10 CY CY0800015A patent/CY2600B1/xx unknown
- 2008-09-10 PL PL08801398T patent/PL2061753T3/pl unknown
- 2008-09-10 DK DK08801398.2T patent/DK2061753T3/da active
- 2008-09-10 ES ES08801398T patent/ES2368294T3/es active Active
- 2008-09-10 SG SG200806650-8A patent/SG151195A1/en unknown
- 2008-09-10 PT PT08801398T patent/PT2061753E/pt unknown
- 2008-09-11 CH CH01450/08A patent/CH697885B1/de not_active IP Right Cessation
- 2008-09-11 AT AT0048708U patent/AT10984U1/de not_active IP Right Cessation
- 2008-09-11 BR BRPI0804121-0A patent/BRPI0804121B1/pt active IP Right Grant
- 2008-09-11 TR TR2009/07629A patent/TR200907629A2/xx unknown
- 2008-09-11 BE BE2008/0498A patent/BE1017548A6/fr not_active IP Right Cessation
- 2008-09-11 KR KR1020080090058A patent/KR101054224B1/ko active Active
- 2008-09-11 TR TR2008/06903A patent/TR200806903A2/xx unknown
- 2008-09-11 RO ROA200800706A patent/RO125301A2/ro unknown
- 2008-09-11 LU LU91479A patent/LU91479B1/fr active
2011
- 2011-10-07 CY CY20111100963T patent/CY1111924T1/el unknown
2017
- 2017-06-26 AR ARP170101761A patent/AR108885A2/es unknown

Also Published As

Publication number	Publication date
PL2061753T3 (pl)	2011-12-30
CY2600B1 (en)	2010-03-03
GB2448848B (en)	2011-01-26
JP2009149600A (ja)	2009-07-09
BRPI0804121B1 (pt)	2022-04-12
JP4966933B2 (ja)	2012-07-04
FI121570B (fi)	2011-01-14
EE00864U1 (et)	2009-10-15
DK200801265A (en)	2009-03-12
ES2334875A1 (es)	2010-03-16
TWI391383B (zh)	2013-04-01
AR108885A2 (es)	2018-10-03
AT10984U1 (de)	2010-02-15
NL2001953C2 (en)	2009-05-07
UA43461U (uk)	2009-08-25
BE1017548A6 (fr)	2008-11-04
RO125301A2 (ro)	2010-03-30
PT104169A (pt)	2009-02-02
NZ570884A (en)	2010-03-26
TW200906814A (en)	2009-02-16
NL2001953A1 (nl)	2008-12-22
AU2008212055B2 (en)	2010-08-12
FR2920766A1 (fr)	2009-03-13
RS20080401A (sr)	2010-03-02
EP2397461A1 (en)	2011-12-21
TR200907629A2 (tr)	2009-11-23
CO6140012A1 (es)	2010-03-19
GR20080100581A (el)	2009-04-30
ATE518829T1 (de)	2011-08-15
FI20085807L (fi)	2009-03-12
AR068174A1 (es)	2009-11-11
DK177075B1 (da)	2011-06-14
LU91479B1 (fr)	2010-03-11
CA2638499C (en)	2010-09-28
SK500302008A3 (sk)	2009-04-06
EP2061753A1 (en)	2009-05-27
SE0801929L (sv)	2009-03-12
CY1111924T1 (el)	2015-11-04
DK2061753T3 (da)	2011-09-26
DE102008046530A1 (de)	2009-03-19
SE533041C2 (sv)	2010-06-15
ES2334875B1 (es)	2010-10-27
EA200801797A2 (ru)	2008-12-30
CN101386583A (zh)	2009-03-18
NO20083756L (no)	2009-03-12
GR1006595B (el)	2009-11-16
MEP10108A (bs)	2010-10-10
ME00176B (me)	2011-02-10
CZ2008537A3 (cs)	2009-03-18
TR200806903A2 (tr)	2009-03-23
KR20090027185A (ko)	2009-03-16
IL193845A (en)	2011-03-31
HRP20110636T1 (hr)	2011-10-31
CL2008002686A1 (es)	2009-01-02
FI20085807A0 (fi)	2008-08-29
ZA200807753B (en)	2009-04-29
CA2638499A1 (en)	2008-11-21
HUP0800549A2 (en)	2009-03-02
MY144210A (en)	2011-08-15
LV13813B (en)	2008-11-20
IS8758A (is)	2009-03-12
BRPI0804121A2 (pt)	2009-09-29
EP2061753B1 (en)	2011-08-03
EA012787B1 (ru)	2009-12-30
AU2008212055C1 (en)	2011-06-02
RS51909B (sr)	2012-02-29
AU2008212055A1 (en)	2009-03-26
GB0815773D0 (en)	2008-10-08
SI22567A2 (sl)	2008-12-31
BG110206A (en)	2009-03-31
PL386026A1 (pl)	2009-02-16
GB2448848A (en)	2008-10-29
HRP20080425A2 (hr)	2010-04-30
LT2008068A (en)	2009-03-25
KR101054224B1 (ko)	2011-08-08
HU0800549D0 (en)	2008-10-28
IES20080708A2 (en)	2009-03-18
WO2009033488A1 (en)	2009-03-19
UA41919U (uk)	2009-06-10
EA200801797A3 (ru)	2009-02-27
SI2061753T1 (sl)	2011-10-28
PT2061753E (pt)	2011-09-14
BRPI0804121A8 (pt)	2021-04-13
CH697885B1 (de)	2009-03-13
LT5577B (lt)	2009-06-25
ES2368294T3 (es)	2011-11-16
MX2008011451A (es)	2009-03-10

Publication	Publication Date	Title
SG151195A1 (en)	2009-04-30	Method for manufacture of escitalopram
UY35850A (es)	2016-06-30	Proceso para la preparación del citalopram racemico y/o del s-ó r-citalopram mediante la separación de una mezcla de r-y s-citalopram
NZ765535A (en)	2024-03-22	Enantiomeric separation of racemic nicotine by addition of an o,o’-disubstituted tartaric acid enantiomer
ATE327972T1 (de)	2006-06-15	Verfahren zur herstellung von optisch-reinen (r)- und (s)- didesmethylsibutramin
WO2010056633A8 (en)	2011-01-13	7-amino alkylidenyl-heterocyclic quinolones and naphthyridones
MX2007011774A (es)	2008-03-10	Quinolonas y naftiridonas 7-amino alquildenil heterociclicas.
UA92354C2 (en)	2010-10-25	Amino acid salts of rosiglitazone
ATE368661T1 (de)	2007-08-15	Verfahren zur herstellung von 5-(4-fluorphenyl)-1- 2-((2r,4r)-4-hydroxy-6-oxo etrahydropyran-2- yl)ethylö-2-isopropyl-4-phenyl-1h-pyrrol-3- carbonsäurephenylamid
WO2006015716A3 (de)	2006-06-22	Verfahren zur herstellung der enantiomeren formen von cis-konfigurierten 3-hydroxycyclohexancarbonsäure-derivaten unter verwendung von hydrolasen
EA200601513A1 (ru)	2007-02-27	Способ получения энантиомерно чистых 1-замещённых 3-аминоспиртов
DE602005017194D1 (de)	2009-11-26	Verfahren zur herstellung von carvedilol und seinen enantiomeren
EA201071025A1 (ru)	2011-02-28	Способ получения [фенилсульфанилфенил]пиперидинов
MXPA05009053A (es)	2005-10-19	Metodo para producir las formas enantiomericas de derivados de 1,3-ciclohexanodiol en configuracion cis.
WO2008029257A3 (en)	2008-05-22	Improved method for preparing 1,3-disubstituted pyrrolidine compounds
WO2006127331A3 (en)	2007-11-29	Conversion process for 2,3-benzodiazepine enantiomers
GB0328871D0 (en)	2004-01-14	Resolution process
ATE534639T1 (de)	2011-12-15	Verfahren zur lösung von citalopram
BRPI0508808A (pt)	2007-08-07	processo quimio-enzimático para preparar escitalopram
ES2285972T1 (es)	2007-12-01	Procedimiento de fabricacion de citalopram y enantiomeros.
ATE513840T1 (de)	2011-07-15	Verfahren zur herstellung optisch aktiver diphosphane
ATE550422T1 (de)	2012-04-15	Verfahren zur herstellung von mycophenolsäure mit penicillium arenicola bicc7673
ATE387423T1 (de)	2008-03-15	Verfahren zur herstellung der enantiomeren formen von 2,3-diaminopropionsäurederivaten
ATE415388T1 (de)	2008-12-15	Verfahren zur herstellung von enantiomerenreinen 4-pyrrolidinophenyl- benzyletherderivaten
DE602005025912D1 (de)	2011-02-24	Neues verfahren zur herstellung von 3-ä5'-(3,4-bis-hydroxymethyl-benzyloxy)-2'- ethyl-2-propyl-biphenyl-4-ylü-penta-3-ol
NO20030876L (no)	2003-02-25	Fremgangsmåte for racemisering av 1-benzyl-4-(4-fluorfenyl)-3- hydroksymetyl-1,2,3,6-tetrahydropyridin for bruk som mellomprodukt i syntese avparoxetin