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RU95113586A - Производные n-/2-амино-2-оксоэтил/бугандиамида или их кислотноаддитивные соли и фармацевтическая композиция со свойствами ингибитора ренина - Google Patents

Производные n-/2-амино-2-оксоэтил/бугандиамида или их кислотноаддитивные соли и фармацевтическая композиция со свойствами ингибитора ренина

Info

Publication number
RU95113586A
RU95113586A RU95113586/04A RU95113586A RU95113586A RU 95113586 A RU95113586 A RU 95113586A RU 95113586/04 A RU95113586/04 A RU 95113586/04A RU 95113586 A RU95113586 A RU 95113586A RU 95113586 A RU95113586 A RU 95113586A
Authority
RU
Russia
Prior art keywords
butanediamide
oxoethyl
derivatives
amino
pharmaceutical composition
Prior art date
Application number
RU95113586/04A
Other languages
English (en)
Inventor
Лавале Пьер
Ca]
Симоно Брюно
Original Assignee
Био-Мега/Берингер Ингельхейм Рисерч Инк. (CA)
Био-Мега/Берингер Ингельхейм Рисерч Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Био-Мега/Берингер Ингельхейм Рисерч Инк. (CA), Био-Мега/Берингер Ингельхейм Рисерч Инк. filed Critical Био-Мега/Берингер Ингельхейм Рисерч Инк. (CA)
Publication of RU95113586A publication Critical patent/RU95113586A/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Pyrrole Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

Объектом изобретения являются производные N-(2-амино-2-оксоэтил)бутандиамида общей формулы, приведенной или их кислотно-аддитивные соли, которые можно применять в качестве активного начала в фармацевтической композиции со свойствами ингибитора ренина.

Claims (1)

  1. Объектом изобретения являются производные N-(2-амино-2-оксоэтил)бутандиамида общей формулы, приведенной или их кислотно-аддитивные соли, которые можно применять в качестве активного начала в фармацевтической композиции со свойствами ингибитора ренина.
RU95113586/04A 1992-09-25 1993-09-15 Производные n-/2-амино-2-оксоэтил/бугандиамида или их кислотноаддитивные соли и фармацевтическая композиция со свойствами ингибитора ренина RU95113586A (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95147892A 1992-09-25 1992-09-25
US951,478 1992-09-25

Publications (1)

Publication Number Publication Date
RU95113586A true RU95113586A (ru) 1997-01-10

Family

ID=25491725

Family Applications (1)

Application Number Title Priority Date Filing Date
RU95113586/04A RU95113586A (ru) 1992-09-25 1993-09-15 Производные n-/2-амино-2-оксоэтил/бугандиамида или их кислотноаддитивные соли и фармацевтическая композиция со свойствами ингибитора ренина

Country Status (29)

Country Link
US (2) US5541163A (ru)
EP (1) EP0589445B1 (ru)
JP (1) JP3490442B2 (ru)
KR (1) KR950703520A (ru)
CN (1) CN1090278A (ru)
AT (1) ATE147720T1 (ru)
AU (1) AU680829B2 (ru)
BG (1) BG99542A (ru)
BR (1) BR9307110A (ru)
CA (1) CA2143300C (ru)
CO (1) CO4560549A1 (ru)
CZ (1) CZ74895A3 (ru)
DE (1) DE69307446T2 (ru)
EE (1) EE03083B1 (ru)
FI (1) FI951398A7 (ru)
HU (2) HUT70432A (ru)
IL (1) IL107092A (ru)
LT (1) LT3072B (ru)
LV (1) LV10945B (ru)
MX (1) MX9305918A (ru)
NO (1) NO951133L (ru)
NZ (1) NZ255301A (ru)
PH (1) PH30881A (ru)
PL (1) PL174454B1 (ru)
RU (1) RU95113586A (ru)
SK (1) SK37695A3 (ru)
TW (1) TW239117B (ru)
WO (1) WO1994007846A1 (ru)
ZA (1) ZA937079B (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ74795A3 (en) * 1992-09-25 1995-10-18 Bio Mega Boehringer Ingelheim N-(hydroxyethyl) butanediamide derivatives, process of their preparation, their use for the preparation of pharmaceuticals and pharmaceutical preparations in which said derivatives are comprised
CA2165996C (en) * 1995-12-22 2002-01-29 Murray Douglas Bailey Stereoselective preparation of 2-substituted succinic derivatives
US6096759A (en) * 1997-09-19 2000-08-01 Georgetown University Method for treating essential hypertension
WO2005037317A2 (en) * 2003-10-17 2005-04-28 Cornell Research Foundation, Inc. Mast cell-derived renin
US10517839B2 (en) * 2008-06-09 2019-12-31 Cornell University Mast cell inhibition in diseases of the retina and vitreous

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5142056A (en) 1989-05-23 1992-08-25 Abbott Laboratories Retroviral protease inhibiting compounds
US5006511A (en) * 1981-10-14 1991-04-09 Merck & Co., Inc. Di- or tripeptide renin inhibitors containing lactam conformational restriction in achpa
EP0278158A3 (en) 1986-11-12 1990-05-23 Merck & Co. Inc. Renin inhibitors containing phenylalanyl-histidine replacements
US4839357A (en) 1987-10-02 1989-06-13 Merck & Co., Inc. Renin inhibitors containing phenylalanyl-histidine replacements
EP0312283A3 (en) * 1987-10-14 1990-05-09 Merck & Co. Inc. Di-or tripeptide renin inhibitors containing lactam conformational restrictions in achpa
US5001113A (en) 1987-10-14 1991-03-19 Merck & Co., Inc. Di- or tripeptide renin inhibitors containing lactam conformational restriction in ACHPA
US5055466A (en) * 1987-11-23 1991-10-08 E. R. Squibb & Sons, Inc. N-morpholino derivatives and their use as anti-hypertensive agents
CA1329680C (en) * 1987-11-23 1994-05-17 Harold Norris Weller, Iii N-heterocyclic alcohol derivatives
AU615313B2 (en) * 1988-07-01 1991-09-26 G.D. Searle & Co. Aminoalkylaminocarbonyl aminodiol amino acid derivatives as anti-hypertensive agents
IE902446A1 (en) * 1989-07-26 1991-02-13 Abbott Lab Peptidyl aminodiol renin inhibitors
US5063208A (en) * 1989-07-26 1991-11-05 Abbott Laboratories Peptidyl aminodiol renin inhibitors
FI904441A7 (fi) * 1989-09-12 1991-03-13 Hoechst Ag Aminohappojohdannaisia, joilla on reniiniä estäviä ominaisuuksia, menetelmiä niiden valmistamiseksi, näitä sisältäviä aineita ja niiden käyttö
JPH0532602A (ja) * 1991-07-26 1993-02-09 Terumo Corp ナフチルメチルアミン誘導体及びこれを含有するレニン阻害剤

Also Published As

Publication number Publication date
SK37695A3 (en) 1995-07-11
LT3072B (en) 1994-11-25
CO4560549A1 (es) 1998-02-10
LTIP1092A (en) 1994-05-15
EP0589445A1 (en) 1994-03-30
LV10945B (en) 1996-06-20
EE03083B1 (et) 1998-04-15
JP3490442B2 (ja) 2004-01-26
NO951133L (no) 1995-05-24
IL107092A (en) 1997-09-30
HUT70432A (en) 1995-10-30
KR950703520A (ko) 1995-09-20
JPH08501567A (ja) 1996-02-20
DE69307446T2 (de) 1997-05-15
US5693619A (en) 1997-12-02
HU211315A9 (en) 1995-11-28
CN1090278A (zh) 1994-08-03
NZ255301A (en) 1997-05-26
AU680829B2 (en) 1997-08-14
CA2143300A1 (en) 1994-04-14
FI951398L (fi) 1995-03-24
PL308180A1 (en) 1995-07-24
BG99542A (bg) 1995-12-29
CZ74895A3 (en) 1995-12-13
EP0589445B1 (en) 1997-01-15
BR9307110A (pt) 1999-03-30
US5541163A (en) 1996-07-30
HU9500871D0 (en) 1995-05-29
IL107092A0 (en) 1993-12-28
CA2143300C (en) 1998-04-21
PL174454B1 (pl) 1998-07-31
FI951398A0 (fi) 1995-03-24
AU4940393A (en) 1994-04-26
ATE147720T1 (de) 1997-02-15
DE69307446D1 (de) 1997-02-27
FI951398A7 (fi) 1995-03-24
WO1994007846A1 (en) 1994-04-14
LV10945A (lv) 1995-12-20
NO951133D0 (no) 1995-03-24
TW239117B (ru) 1995-01-21
MX9305918A (es) 1994-05-31
PH30881A (en) 1997-12-23
ZA937079B (en) 1994-06-06

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