BR9307110A - Derivados de n-(2-amido-2-oxoetil) butanodiamida inibidores de renina - Google Patents

Derivados de n-(2-amido-2-oxoetil) butanodiamida inibidores de renina

Info

Publication number: BR9307110A
Authority: BR; Brazil
Prior art keywords: alkyl; butanediamide; oxoethyl; starch; cyclohexylmethyl
Prior art date: 1992-09-25

Application number

BR9307110A

Other languages

English (en)

Inventor

Pierre Lavalee

Bruno Simoneau

Original Assignee

Boehringer Ingelheim Ca Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-09-25

Filing date

1993-09-15

Publication date

1999-03-30

1993-09-15 Application filed by Boehringer Ingelheim Ca Ltd filed Critical Boehringer Ingelheim Ca Ltd

1999-03-30 Publication of BR9307110A publication Critical patent/BR9307110A/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Pyridine Compounds (AREA)
Peptides Or Proteins (AREA)
Pyrrole Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)

BR9307110A 1992-09-25 1993-09-15 Derivados de n-(2-amido-2-oxoetil) butanodiamida inibidores de renina BR9307110A (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US95147892A	1992-09-25	1992-09-25
PCT/CA1993/000380 WO1994007846A1 (en)	1992-09-25	1993-09-15	Renin inhibiting n-(2-amino-2-oxoethyl)butanediamide derivatives

Publications (1)

Publication Number	Publication Date
BR9307110A true BR9307110A (pt)	1999-03-30

Family

ID=25491725

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR9307110A BR9307110A (pt)	1992-09-25	1993-09-15	Derivados de n-(2-amido-2-oxoetil) butanodiamida inibidores de renina

Country Status (29)

Country	Link
US (2)	US5541163A (pt)
EP (1)	EP0589445B1 (pt)
JP (1)	JP3490442B2 (pt)
KR (1)	KR950703520A (pt)
CN (1)	CN1090278A (pt)
AT (1)	ATE147720T1 (pt)
AU (1)	AU680829B2 (pt)
BG (1)	BG99542A (pt)
BR (1)	BR9307110A (pt)
CA (1)	CA2143300C (pt)
CO (1)	CO4560549A1 (pt)
CZ (1)	CZ74895A3 (pt)
DE (1)	DE69307446T2 (pt)
EE (1)	EE03083B1 (pt)
FI (1)	FI951398A7 (pt)
HU (2)	HUT70432A (pt)
IL (1)	IL107092A (pt)
LT (1)	LT3072B (pt)
LV (1)	LV10945B (pt)
MX (1)	MX9305918A (pt)
NO (1)	NO951133L (pt)
NZ (1)	NZ255301A (pt)
PH (1)	PH30881A (pt)
PL (1)	PL174454B1 (pt)
RU (1)	RU95113586A (pt)
SK (1)	SK37695A3 (pt)
TW (1)	TW239117B (pt)
WO (1)	WO1994007846A1 (pt)
ZA (1)	ZA937079B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ255300A (en) *	1992-09-25	1997-05-26	Bio Mega Boehringer Ingelheim	N-(hydroxyethyl)butane diamide derivatives, preparation and pharmaceutical compositions thereof
CA2165996C (en) *	1995-12-22	2002-01-29	Murray Douglas Bailey	Stereoselective preparation of 2-substituted succinic derivatives
US6096759A (en)	1997-09-19	2000-08-01	Georgetown University	Method for treating essential hypertension
US20050209141A1 (en) *	2003-10-17	2005-09-22	Silver Randi B	Mast cell-derived renin
US10517839B2 (en) *	2008-06-09	2019-12-31	Cornell University	Mast cell inhibition in diseases of the retina and vitreous

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5142056A (en)	1989-05-23	1992-08-25	Abbott Laboratories	Retroviral protease inhibiting compounds
US5006511A (en) *	1981-10-14	1991-04-09	Merck & Co., Inc.	Di- or tripeptide renin inhibitors containing lactam conformational restriction in achpa
EP0278158A3 (en)	1986-11-12	1990-05-23	Merck & Co. Inc.	Renin inhibitors containing phenylalanyl-histidine replacements
US4839357A (en)	1987-10-02	1989-06-13	Merck & Co., Inc.	Renin inhibitors containing phenylalanyl-histidine replacements
EP0312283A3 (en) *	1987-10-14	1990-05-09	Merck & Co. Inc.	Di-or tripeptide renin inhibitors containing lactam conformational restrictions in achpa
US5001113A (en)	1987-10-14	1991-03-19	Merck & Co., Inc.	Di- or tripeptide renin inhibitors containing lactam conformational restriction in ACHPA
US5055466A (en) *	1987-11-23	1991-10-08	E. R. Squibb & Sons, Inc.	N-morpholino derivatives and their use as anti-hypertensive agents
CA1329680C (en) *	1987-11-23	1994-05-17	Harold Norris Weller, Iii	N-heterocyclic alcohol derivatives
AU615313B2 (en) *	1988-07-01	1991-09-26	G.D. Searle & Co.	Aminoalkylaminocarbonyl aminodiol amino acid derivatives as anti-hypertensive agents
US5063208A (en) *	1989-07-26	1991-11-05	Abbott Laboratories	Peptidyl aminodiol renin inhibitors
IE902446A1 (en) *	1989-07-26	1991-02-13	Abbott Lab	Peptidyl aminodiol renin inhibitors
DE59010189D1 (de) *	1989-09-12	1996-04-18	Hoechst Ag	Aminosäurederivate mit reninhemmenden Eigenschaften, Verfahren zu deren Herstellung, diese enthaltende Mittel und deren Verwendung
JPH0532602A (ja) *	1991-07-26	1993-02-09	Terumo Corp	ナフチルメチルアミン誘導体及びこれを含有するレニン阻害剤

1993
- 1993-09-15 JP JP50854294A patent/JP3490442B2/ja not_active Expired - Fee Related
- 1993-09-15 PL PL93308180A patent/PL174454B1/pl unknown
- 1993-09-15 AU AU49403/93A patent/AU680829B2/en not_active Ceased
- 1993-09-15 WO PCT/CA1993/000380 patent/WO1994007846A1/en not_active Ceased
- 1993-09-15 HU HU9500871A patent/HUT70432A/hu unknown
- 1993-09-15 FI FI951398A patent/FI951398A7/fi not_active Application Discontinuation
- 1993-09-15 CZ CZ95748A patent/CZ74895A3/cs unknown
- 1993-09-15 BR BR9307110A patent/BR9307110A/pt not_active Application Discontinuation
- 1993-09-15 RU RU95113586/04A patent/RU95113586A/ru unknown
- 1993-09-15 SK SK376-95A patent/SK37695A3/sk unknown
- 1993-09-15 NZ NZ255301A patent/NZ255301A/en unknown
- 1993-09-15 CA CA002143300A patent/CA2143300C/en not_active Expired - Fee Related
- 1993-09-15 KR KR1019950701149A patent/KR950703520A/ko not_active Withdrawn
- 1993-09-17 US US08/122,280 patent/US5541163A/en not_active Expired - Lifetime
- 1993-09-23 AT AT93115326T patent/ATE147720T1/de not_active IP Right Cessation
- 1993-09-23 LT LTIP1092A patent/LT3072B/lt not_active IP Right Cessation
- 1993-09-23 EP EP93115326A patent/EP0589445B1/en not_active Expired - Lifetime
- 1993-09-23 IL IL107092A patent/IL107092A/xx not_active IP Right Cessation
- 1993-09-23 DE DE69307446T patent/DE69307446T2/de not_active Expired - Lifetime
- 1993-09-23 PH PH46946A patent/PH30881A/en unknown
- 1993-09-24 ZA ZA937079A patent/ZA937079B/xx unknown
- 1993-09-24 MX MX9305918A patent/MX9305918A/es not_active IP Right Cessation
- 1993-09-24 TW TW082107871A patent/TW239117B/zh active
- 1993-09-24 CO CO93410100A patent/CO4560549A1/es unknown
- 1993-09-25 CN CN93117983A patent/CN1090278A/zh active Pending
1994
- 1994-11-23 EE EE9400334A patent/EE03083B1/xx unknown
1995
- 1995-03-24 NO NO951133A patent/NO951133L/no unknown
- 1995-04-03 BG BG99542A patent/BG99542A/bg unknown
- 1995-04-25 LV LVP-95-107A patent/LV10945B/en unknown
- 1995-06-23 HU HU95P/P00428P patent/HU211315A9/hu unknown
1996
- 1996-02-01 US US08/595,327 patent/US5693619A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EE03083B1 (et)	1998-04-15
JPH08501567A (ja)	1996-02-20
FI951398A0 (fi)	1995-03-24
PL174454B1 (pl)	1998-07-31
PL308180A1 (en)	1995-07-24
LTIP1092A (en)	1994-05-15
EP0589445B1 (en)	1997-01-15
SK37695A3 (en)	1995-07-11
DE69307446T2 (de)	1997-05-15
DE69307446D1 (de)	1997-02-27
PH30881A (en)	1997-12-23
CO4560549A1 (es)	1998-02-10
KR950703520A (ko)	1995-09-20
IL107092A0 (en)	1993-12-28
FI951398L (fi)	1995-03-24
NO951133D0 (no)	1995-03-24
CA2143300C (en)	1998-04-21
AU680829B2 (en)	1997-08-14
BG99542A (bg)	1995-12-29
LV10945A (lv)	1995-12-20
CA2143300A1 (en)	1994-04-14
LV10945B (en)	1996-06-20
US5693619A (en)	1997-12-02
ATE147720T1 (de)	1997-02-15
ZA937079B (en)	1994-06-06
AU4940393A (en)	1994-04-26
MX9305918A (es)	1994-05-31
TW239117B (pt)	1995-01-21
FI951398A7 (fi)	1995-03-24
NZ255301A (en)	1997-05-26
NO951133L (no)	1995-05-24
CN1090278A (zh)	1994-08-03
LT3072B (en)	1994-11-25
CZ74895A3 (en)	1995-12-13
HU211315A9 (en)	1995-11-28
US5541163A (en)	1996-07-30
RU95113586A (ru)	1997-01-10
JP3490442B2 (ja)	2004-01-26
IL107092A (en)	1997-09-30
HU9500871D0 (en)	1995-05-29
HUT70432A (en)	1995-10-30
EP0589445A1 (en)	1994-03-30
WO1994007846A1 (en)	1994-04-14

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DK0976748T3 (da)	2004-03-22	Pyrrolidinderivater med phospholispase A2-hæmmende aktivitet
NO177677C (no)	1995-11-01	Analogifremgangsmåte for fremstilling av terapeutisk aktive forbindelser
EP0749966A4 (en)	1997-07-02	5-HT 3 RECEPTOR AGONIST, NEW THIAZOLE DERIVATIVE AND INTERMEDIATE FOR OBTAINING IT
BR9307110A (pt)	1999-03-30	Derivados de n-(2-amido-2-oxoetil) butanodiamida inibidores de renina
NO982927L (no)	1998-06-23	Biologisk aktive benzotiazolon etanaminer
ATE116974T1 (de)	1995-01-15	5- piperazinylalkyl-1,5-benzothiazepinone verwendbar als calciumantagonisten.
EP0798298A4 (en)	1998-03-25	THIAZOLIDINONE COMPOUNDS OR MEDICAMENT FOR PREVENTING OR CURING ANGINA OF CHEST CONTAINING THESE COMPOUNDS AS ACTIVE INGREDIENT
LV10944A (lv)	1995-12-20	N-(hidroksietil)butandiamida atvasinajumi ka renina inhibitori
ATE201877T1 (de)	2001-06-15	Kondensierte heterocyclische glutaminsäurederivate als antiproliferative mittel
IE900585L (en)	1990-08-16	Peptides having renin inhibitory activity, their preparation¹and use

Legal Events

Date	Code	Title	Description
1999-01-19	PC	Transfer	Free format text: BOEHRINGER INGELHEIM (CANADA) LTD./BOEHRINGER INGELHEIM LTEE (CA)
1999-05-04	EG	Technical examination (opinion): publication of technical examination (opinion)
2000-04-25	FC	Decision: refusal