CO4560549A1 - Derivados de n-[2-amino]-2-oxoetil] butanodiamida inhibido- res de la retina - Google Patents
Derivados de n-[2-amino]-2-oxoetil] butanodiamida inhibido- res de la retinaInfo
- Publication number
- CO4560549A1 CO4560549A1 CO93410100A CO93410100A CO4560549A1 CO 4560549 A1 CO4560549 A1 CO 4560549A1 CO 93410100 A CO93410100 A CO 93410100A CO 93410100 A CO93410100 A CO 93410100A CO 4560549 A1 CO4560549 A1 CO 4560549A1
- Authority
- CO
- Colombia
- Prior art keywords
- rent
- lower alkyl
- alkyl
- alcoxy
- cycloalkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyridine Compounds (AREA)
- Pyrrole Compounds (AREA)
- Peptides Or Proteins (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
1. UN COMPUESTO DE LA FORMULA 1. A-N(R^1)C(O)CH(R^ 2)C(O)-B(1) EN DONDE A ES R^3 R^4NC(O)CH2 EN DONDE (a)R^3 ES HIDROGENO AL ALQUILO INFERIOR MONOSUSTI- DO CON CICLOALQUILO INFERIOR O ALQUILO INFERIOR MONOSUSTITUIDO CON CICLOALQUILO INFERIOR, FENILO O UN ANILLOHETEROCICLICO ( DESIGNADO EN LO SUSCESIVO COMO " HET ") QUE ES UN ANILLO NO SUSTITUIDO, MONOSUSTITUIDO O DISTUTITUIDO, DE CINCO O SEIS MIEMBROS, QUE CONTIENE UNO O DOS HETEROATOMOS, ELEGIDOS ENTRE EL GRUPO FORMADO DE N.O H Y S Y DONDE CADA SUSTITUYENTE ES ELEGIDO INDEPOENDIENTE- MENTE ENTRE EL GRUPO FORMADO POR ALQUILO INFERIOR, ALCOXI INFERIOR,HALO, AMINO O ALQUILAMINO INFERIOR O (b)R^3 ES ALQUILO INFERIOR Y R^4 ES R^5 R^6 N-A1 K EN DONDE R^5 R^6 SON CADA UNO DE ELLOS HIDROGENO O ALQUILO INFERIOR Y ALK ES UN RADIAL ALQUILO DIVALENTE PROCEDENTE DE LA ELIMINACION DE DOS ATO- MOS DE HIDROGENO DE UN HIDROCARBURO DE CADENA LI- NEAL O RAMIFICAD QUE CONTIENE DE UNO A SEIS ATOMOS DE CARBONO; O (C) R^3 ES ALQUILO INFERIOR Y R^4 ES R^5AR^6ANCH2 CH2 EN DONDE R^5A ES ALQUILO INFERIOR Y R^GA ES PIPERIDINOCARBONILO, MORFOLINO- CARBONILO, TIONO- MORFOLINOCARBOLINO, PIPERAZINOCARBOLINO O 4-(ALQUI LO INFERIOR Y R^4 ES QC(O)CH^2(m EN DONDE Q ES PIPERDINO, MORFOLINO,TIMORFOLINO,PIPERAZINO O 4-( ALQUILO INFERIOR)-1-PIPERAZINILO Y m ES EL NUMERO DE 1O2;O (e) R^3 ES ALQUILO INFERIOR Y R^4 ES ALCOXI INFE- RIOR;O (f)R^3Y R^4, JUNTO CON ATOMO DE NITROGENO AL QUE ESTAN UNIDOS, FORMAN UN GRUPO PIRROLIDINO,PIPERI- NO, 4-HIDROXI-1-PIPERIDINO, 4-((ALCOXI INFERIOR)) -( ALCOXI INFERIOR)-1- PIPERIDINILO, MORFOLINO, TIOMORFOLINO, PIPERAZINO O 4 -(ALQUILO INFERIOR)-1 -PIPERAZINILO; R^1 ES ALQUILO (1-8C)O ALQUILO INFERIOR MONOSUSTI- TUIDO CON CICLOALQUILO INFERIOR, 1-( ALQUILO INFERIOR)-(CICLOALQUILO INFERIOR),BICICLO (2.2.1) HEP-2-ILO, FENILO, 2-(ALQUILO INFERIOR)FENILO, 2- (ALCOXI INFERIOR)FENILO,2-HALOFENILO. 4-(ALQUILO INFERIOR) FENILO,... * VER FIGURA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95147892A | 1992-09-25 | 1992-09-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO4560549A1 true CO4560549A1 (es) | 1998-02-10 |
Family
ID=25491725
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO93410100A CO4560549A1 (es) | 1992-09-25 | 1993-09-24 | Derivados de n-[2-amino]-2-oxoetil] butanodiamida inhibido- res de la retina |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US5541163A (es) |
| EP (1) | EP0589445B1 (es) |
| JP (1) | JP3490442B2 (es) |
| KR (1) | KR950703520A (es) |
| CN (1) | CN1090278A (es) |
| AT (1) | ATE147720T1 (es) |
| AU (1) | AU680829B2 (es) |
| BG (1) | BG99542A (es) |
| BR (1) | BR9307110A (es) |
| CA (1) | CA2143300C (es) |
| CO (1) | CO4560549A1 (es) |
| CZ (1) | CZ74895A3 (es) |
| DE (1) | DE69307446T2 (es) |
| EE (1) | EE03083B1 (es) |
| FI (1) | FI951398L (es) |
| HU (2) | HUT70432A (es) |
| IL (1) | IL107092A (es) |
| LT (1) | LT3072B (es) |
| LV (1) | LV10945B (es) |
| MX (1) | MX9305918A (es) |
| NO (1) | NO951133L (es) |
| NZ (1) | NZ255301A (es) |
| PH (1) | PH30881A (es) |
| PL (1) | PL174454B1 (es) |
| RU (1) | RU95113586A (es) |
| SK (1) | SK37695A3 (es) |
| TW (1) | TW239117B (es) |
| WO (1) | WO1994007846A1 (es) |
| ZA (1) | ZA937079B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU95113446A (ru) * | 1992-09-25 | 1997-01-10 | Био-Мега/Берингер Ингельхейм Рисерч Инк. (CA) | Производные n-/оксиэтил/бугандиамида или их кислотно-аддитивные соли и фармацевтическая композиция со свойствами ингибитора ренина |
| CA2165996C (en) * | 1995-12-22 | 2002-01-29 | Murray Douglas Bailey | Stereoselective preparation of 2-substituted succinic derivatives |
| US6096759A (en) | 1997-09-19 | 2000-08-01 | Georgetown University | Method for treating essential hypertension |
| WO2005037317A2 (en) * | 2003-10-17 | 2005-04-28 | Cornell Research Foundation, Inc. | Mast cell-derived renin |
| US10517839B2 (en) * | 2008-06-09 | 2019-12-31 | Cornell University | Mast cell inhibition in diseases of the retina and vitreous |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5142056A (en) | 1989-05-23 | 1992-08-25 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| US5006511A (en) * | 1981-10-14 | 1991-04-09 | Merck & Co., Inc. | Di- or tripeptide renin inhibitors containing lactam conformational restriction in achpa |
| EP0278158A3 (en) | 1986-11-12 | 1990-05-23 | Merck & Co. Inc. | Renin inhibitors containing phenylalanyl-histidine replacements |
| US4839357A (en) | 1987-10-02 | 1989-06-13 | Merck & Co., Inc. | Renin inhibitors containing phenylalanyl-histidine replacements |
| US5001113A (en) | 1987-10-14 | 1991-03-19 | Merck & Co., Inc. | Di- or tripeptide renin inhibitors containing lactam conformational restriction in ACHPA |
| EP0312283A3 (en) * | 1987-10-14 | 1990-05-09 | Merck & Co. Inc. | Di-or tripeptide renin inhibitors containing lactam conformational restrictions in achpa |
| US5055466A (en) * | 1987-11-23 | 1991-10-08 | E. R. Squibb & Sons, Inc. | N-morpholino derivatives and their use as anti-hypertensive agents |
| CA1329680C (en) * | 1987-11-23 | 1994-05-17 | Harold Norris Weller, Iii | N-heterocyclic alcohol derivatives |
| EP0349922A3 (en) * | 1988-07-01 | 1991-08-21 | G.D. Searle & Co. | Aminoalkylaminocarbonyl aminodiol amino acid derivatives as anti-hypertensive agents |
| IE902446A1 (en) * | 1989-07-26 | 1991-02-13 | Abbott Lab | Peptidyl aminodiol renin inhibitors |
| US5063208A (en) * | 1989-07-26 | 1991-11-05 | Abbott Laboratories | Peptidyl aminodiol renin inhibitors |
| US5374731A (en) * | 1989-09-12 | 1994-12-20 | Hoechst Aktiengesellschaft | Amino acid derivatives with renin-inhibiting properties, a process for the preparation thereof, agents containing these, and the use thereof |
| JPH0532602A (ja) * | 1991-07-26 | 1993-02-09 | Terumo Corp | ナフチルメチルアミン誘導体及びこれを含有するレニン阻害剤 |
-
1993
- 1993-09-15 CZ CZ95748A patent/CZ74895A3/cs unknown
- 1993-09-15 FI FI951398A patent/FI951398L/fi not_active Application Discontinuation
- 1993-09-15 WO PCT/CA1993/000380 patent/WO1994007846A1/en not_active Ceased
- 1993-09-15 JP JP50854294A patent/JP3490442B2/ja not_active Expired - Fee Related
- 1993-09-15 HU HU9500871A patent/HUT70432A/hu unknown
- 1993-09-15 CA CA002143300A patent/CA2143300C/en not_active Expired - Fee Related
- 1993-09-15 AU AU49403/93A patent/AU680829B2/en not_active Ceased
- 1993-09-15 NZ NZ255301A patent/NZ255301A/en unknown
- 1993-09-15 PL PL93308180A patent/PL174454B1/pl unknown
- 1993-09-15 BR BR9307110A patent/BR9307110A/pt not_active Application Discontinuation
- 1993-09-15 KR KR1019950701149A patent/KR950703520A/ko not_active Withdrawn
- 1993-09-15 RU RU95113586/04A patent/RU95113586A/ru unknown
- 1993-09-15 SK SK376-95A patent/SK37695A3/sk unknown
- 1993-09-17 US US08/122,280 patent/US5541163A/en not_active Expired - Lifetime
- 1993-09-23 EP EP93115326A patent/EP0589445B1/en not_active Expired - Lifetime
- 1993-09-23 PH PH46946A patent/PH30881A/en unknown
- 1993-09-23 LT LTIP1092A patent/LT3072B/lt not_active IP Right Cessation
- 1993-09-23 AT AT93115326T patent/ATE147720T1/de not_active IP Right Cessation
- 1993-09-23 IL IL107092A patent/IL107092A/xx not_active IP Right Cessation
- 1993-09-23 DE DE69307446T patent/DE69307446T2/de not_active Expired - Lifetime
- 1993-09-24 MX MX9305918A patent/MX9305918A/es not_active IP Right Cessation
- 1993-09-24 CO CO93410100A patent/CO4560549A1/es unknown
- 1993-09-24 ZA ZA937079A patent/ZA937079B/xx unknown
- 1993-09-24 TW TW082107871A patent/TW239117B/zh active
- 1993-09-25 CN CN93117983A patent/CN1090278A/zh active Pending
-
1994
- 1994-11-23 EE EE9400334A patent/EE03083B1/xx unknown
-
1995
- 1995-03-24 NO NO951133A patent/NO951133L/no unknown
- 1995-04-03 BG BG99542A patent/BG99542A/bg unknown
- 1995-04-25 LV LVP-95-107A patent/LV10945B/en unknown
- 1995-06-23 HU HU95P/P00428P patent/HU211315A9/hu unknown
-
1996
- 1996-02-01 US US08/595,327 patent/US5693619A/en not_active Expired - Lifetime
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