LV10945A - N-(2-amino-2-oksoetil) butandiamida atvasinajumi ka renina inhibitori - Google Patents

N-(2-amino-2-oksoetil) butandiamida atvasinajumi ka renina inhibitori

Info

Publication number: LV10945A
Authority: LV; Latvia
Prior art keywords: alkyl; amino; butandiamide; oxoethyl; derivatives
Prior art date: 1992-09-25

Application number

LV950107A

Other languages

English (en)

Other versions

LV10945B (en

Inventor

Pierre Lavallee

Bruno Simoneau

Original Assignee

Bio Mega Boehringer Ingelheim

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-09-25

Filing date

1995-04-25

Publication date

1995-12-20

1995-04-25 Application filed by Bio Mega Boehringer Ingelheim filed Critical Bio Mega Boehringer Ingelheim

1995-12-20 Publication of LV10945A publication Critical patent/LV10945A/lv

1996-06-20 Publication of LV10945B publication Critical patent/LV10945B/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Pyridine Compounds (AREA)
Peptides Or Proteins (AREA)
Pyrrole Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)

LVP-95-107A 1992-09-25 1995-04-25 Renin inhibiting n-(2-amino-2-oxoethyl)butanediamide derivatives LV10945B (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US95147892A	1992-09-25	1992-09-25
PCT/CA1993/000380 WO1994007846A1 (en)	1992-09-25	1993-09-15	Renin inhibiting n-(2-amino-2-oxoethyl)butanediamide derivatives

Publications (2)

Publication Number	Publication Date
LV10945A true LV10945A (lv)	1995-12-20
LV10945B LV10945B (en)	1996-06-20

Family

ID=25491725

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LVP-95-107A LV10945B (en)	1992-09-25	1995-04-25	Renin inhibiting n-(2-amino-2-oxoethyl)butanediamide derivatives

Country Status (29)

Country	Link
US (2)	US5541163A (lv)
EP (1)	EP0589445B1 (lv)
JP (1)	JP3490442B2 (lv)
KR (1)	KR950703520A (lv)
CN (1)	CN1090278A (lv)
AT (1)	ATE147720T1 (lv)
AU (1)	AU680829B2 (lv)
BG (1)	BG99542A (lv)
BR (1)	BR9307110A (lv)
CA (1)	CA2143300C (lv)
CO (1)	CO4560549A1 (lv)
CZ (1)	CZ74895A3 (lv)
DE (1)	DE69307446T2 (lv)
EE (1)	EE03083B1 (lv)
FI (1)	FI951398L (lv)
HU (2)	HUT70432A (lv)
IL (1)	IL107092A (lv)
LT (1)	LT3072B (lv)
LV (1)	LV10945B (lv)
MX (1)	MX9305918A (lv)
NO (1)	NO951133L (lv)
NZ (1)	NZ255301A (lv)
PH (1)	PH30881A (lv)
PL (1)	PL174454B1 (lv)
RU (1)	RU95113586A (lv)
SK (1)	SK37695A3 (lv)
TW (1)	TW239117B (lv)
WO (1)	WO1994007846A1 (lv)
ZA (1)	ZA937079B (lv)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU95113446A (ru) *	1992-09-25	1997-01-10	Био-Мега/Берингер Ингельхейм Рисерч Инк. (CA)	Производные n-/оксиэтил/бугандиамида или их кислотно-аддитивные соли и фармацевтическая композиция со свойствами ингибитора ренина
CA2165996C (en) *	1995-12-22	2002-01-29	Murray Douglas Bailey	Stereoselective preparation of 2-substituted succinic derivatives
US6096759A (en) *	1997-09-19	2000-08-01	Georgetown University	Method for treating essential hypertension
WO2005037317A2 (en) *	2003-10-17	2005-04-28	Cornell Research Foundation, Inc.	Mast cell-derived renin
US10517839B2 (en) *	2008-06-09	2019-12-31	Cornell University	Mast cell inhibition in diseases of the retina and vitreous

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5142056A (en)	1989-05-23	1992-08-25	Abbott Laboratories	Retroviral protease inhibiting compounds
US5006511A (en) *	1981-10-14	1991-04-09	Merck & Co., Inc.	Di- or tripeptide renin inhibitors containing lactam conformational restriction in achpa
EP0278158A3 (en)	1986-11-12	1990-05-23	Merck & Co. Inc.	Renin inhibitors containing phenylalanyl-histidine replacements
US4839357A (en)	1987-10-02	1989-06-13	Merck & Co., Inc.	Renin inhibitors containing phenylalanyl-histidine replacements
US5001113A (en)	1987-10-14	1991-03-19	Merck & Co., Inc.	Di- or tripeptide renin inhibitors containing lactam conformational restriction in ACHPA
EP0312283A3 (en) *	1987-10-14	1990-05-09	Merck & Co. Inc.	Di-or tripeptide renin inhibitors containing lactam conformational restrictions in achpa
CA1329680C (en) *	1987-11-23	1994-05-17	Harold Norris Weller, Iii	N-heterocyclic alcohol derivatives
US5055466A (en) *	1987-11-23	1991-10-08	E. R. Squibb & Sons, Inc.	N-morpholino derivatives and their use as anti-hypertensive agents
NZ229792A (en) *	1988-07-01	1991-07-26	Searle & Co	Aminoalkylaminocarbonylaminodiol derivatives and renin-inhibiting compositions thereof
IE902446A1 (en) *	1989-07-26	1991-02-13	Abbott Lab	Peptidyl aminodiol renin inhibitors
US5063208A (en) *	1989-07-26	1991-11-05	Abbott Laboratories	Peptidyl aminodiol renin inhibitors
ATE135368T1 (de) *	1989-09-12	1996-03-15	Hoechst Ag	Aminosäurederivate mit reninhemmenden eigenschaften, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung
JPH0532602A (ja) *	1991-07-26	1993-02-09	Terumo Corp	ナフチルメチルアミン誘導体及びこれを含有するレニン阻害剤

1993
- 1993-09-15 CA CA002143300A patent/CA2143300C/en not_active Expired - Fee Related
- 1993-09-15 NZ NZ255301A patent/NZ255301A/en unknown
- 1993-09-15 FI FI951398A patent/FI951398L/fi not_active Application Discontinuation
- 1993-09-15 WO PCT/CA1993/000380 patent/WO1994007846A1/en not_active Ceased
- 1993-09-15 AU AU49403/93A patent/AU680829B2/en not_active Ceased
- 1993-09-15 BR BR9307110A patent/BR9307110A/pt not_active Application Discontinuation
- 1993-09-15 JP JP50854294A patent/JP3490442B2/ja not_active Expired - Fee Related
- 1993-09-15 HU HU9500871A patent/HUT70432A/hu unknown
- 1993-09-15 KR KR1019950701149A patent/KR950703520A/ko not_active Withdrawn
- 1993-09-15 SK SK376-95A patent/SK37695A3/sk unknown
- 1993-09-15 PL PL93308180A patent/PL174454B1/pl unknown
- 1993-09-15 RU RU95113586/04A patent/RU95113586A/ru unknown
- 1993-09-15 CZ CZ95748A patent/CZ74895A3/cs unknown
- 1993-09-17 US US08/122,280 patent/US5541163A/en not_active Expired - Lifetime
- 1993-09-23 IL IL107092A patent/IL107092A/xx not_active IP Right Cessation
- 1993-09-23 PH PH46946A patent/PH30881A/en unknown
- 1993-09-23 DE DE69307446T patent/DE69307446T2/de not_active Expired - Lifetime
- 1993-09-23 LT LTIP1092A patent/LT3072B/lt not_active IP Right Cessation
- 1993-09-23 EP EP93115326A patent/EP0589445B1/en not_active Expired - Lifetime
- 1993-09-23 AT AT93115326T patent/ATE147720T1/de not_active IP Right Cessation
- 1993-09-24 MX MX9305918A patent/MX9305918A/es not_active IP Right Cessation
- 1993-09-24 TW TW082107871A patent/TW239117B/zh active
- 1993-09-24 CO CO93410100A patent/CO4560549A1/es unknown
- 1993-09-24 ZA ZA937079A patent/ZA937079B/xx unknown
- 1993-09-25 CN CN93117983A patent/CN1090278A/zh active Pending
1994
- 1994-11-23 EE EE9400334A patent/EE03083B1/xx unknown
1995
- 1995-03-24 NO NO951133A patent/NO951133L/no unknown
- 1995-04-03 BG BG99542A patent/BG99542A/bg unknown
- 1995-04-25 LV LVP-95-107A patent/LV10945B/en unknown
- 1995-06-23 HU HU95P/P00428P patent/HU211315A9/hu unknown
1996
- 1996-02-01 US US08/595,327 patent/US5693619A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
ATE147720T1 (de)	1997-02-15
DE69307446T2 (de)	1997-05-15
EP0589445A1 (en)	1994-03-30
US5693619A (en)	1997-12-02
NO951133D0 (no)	1995-03-24
AU680829B2 (en)	1997-08-14
PL308180A1 (en)	1995-07-24
HU9500871D0 (en)	1995-05-29
LT3072B (en)	1994-11-25
FI951398A0 (fi)	1995-03-24
PL174454B1 (pl)	1998-07-31
FI951398A7 (fi)	1995-03-24
IL107092A0 (en)	1993-12-28
CN1090278A (zh)	1994-08-03
IL107092A (en)	1997-09-30
RU95113586A (ru)	1997-01-10
CZ74895A3 (en)	1995-12-13
BG99542A (bg)	1995-12-29
CA2143300C (en)	1998-04-21
NO951133L (no)	1995-05-24
CA2143300A1 (en)	1994-04-14
DE69307446D1 (de)	1997-02-27
EP0589445B1 (en)	1997-01-15
BR9307110A (pt)	1999-03-30
JP3490442B2 (ja)	2004-01-26
SK37695A3 (en)	1995-07-11
FI951398L (fi)	1995-03-24
MX9305918A (es)	1994-05-31
ZA937079B (en)	1994-06-06
WO1994007846A1 (en)	1994-04-14
HUT70432A (en)	1995-10-30
KR950703520A (ko)	1995-09-20
CO4560549A1 (es)	1998-02-10
TW239117B (lv)	1995-01-21
HU211315A9 (en)	1995-11-28
LTIP1092A (en)	1994-05-15
JPH08501567A (ja)	1996-02-20
NZ255301A (en)	1997-05-26
AU4940393A (en)	1994-04-26
PH30881A (en)	1997-12-23
US5541163A (en)	1996-07-30
EE03083B1 (et)	1998-04-15
LV10945B (en)	1996-06-20

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LV10945A (lv)	1995-12-20	N-(2-amino-2-oksoetil) butandiamida atvasinajumi ka renina inhibitori
NO982927L (no)	1998-06-23	Biologisk aktive benzotiazolon etanaminer
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FI953618A0 (fi)	1995-07-28	Kondensoituneita heterosyklisiä glutamiinijohdannaisia antiproliferatiivisina aineina
NO951134L (no)	1995-03-24	N-(hydroksyletyl) butandiamed-derivater som renin-inhibitorer