IL107092A - Renin inhibiting n-(2-amino- 2-oxoethyl) butanediamide derivatives, their preparation and pharmaceutical compositions containing them - Google Patents

Renin inhibiting n-(2-amino- 2-oxoethyl) butanediamide derivatives, their preparation and pharmaceutical compositions containing them

Info

Publication number: IL107092A
Authority: IL; Israel
Prior art keywords: alkyl; amino; oxoethyl; preparation; pharmaceutical compositions
Prior art date: 1992-09-25

Application number

IL107092A

Other languages

English (en)

Other versions

IL107092A0 (en

Inventor

Pierre Lavalle

Bruno Simoneau

Original Assignee

Bio Mega Boehringer Ingelheim

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-09-25

Filing date

1993-09-23

Publication date

1997-09-30

1993-09-23 Application filed by Bio Mega Boehringer Ingelheim filed Critical Bio Mega Boehringer Ingelheim

1993-12-28 Publication of IL107092A0 publication Critical patent/IL107092A0/xx

1997-09-30 Publication of IL107092A publication Critical patent/IL107092A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Thiazole And Isothizaole Compounds (AREA)
Pyridine Compounds (AREA)
Peptides Or Proteins (AREA)
Pyrrole Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)

IL107092A 1992-09-25 1993-09-23 Renin inhibiting n-(2-amino- 2-oxoethyl) butanediamide derivatives, their preparation and pharmaceutical compositions containing them IL107092A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US95147892A	1992-09-25	1992-09-25

Publications (2)

Publication Number	Publication Date
IL107092A0 IL107092A0 (en)	1993-12-28
IL107092A true IL107092A (en)	1997-09-30

Family

ID=25491725

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL107092A IL107092A (en)	1992-09-25	1993-09-23	Renin inhibiting n-(2-amino- 2-oxoethyl) butanediamide derivatives, their preparation and pharmaceutical compositions containing them

Country Status (29)

Country	Link
US (2)	US5541163A (xx)
EP (1)	EP0589445B1 (xx)
JP (1)	JP3490442B2 (xx)
KR (1)	KR950703520A (xx)
CN (1)	CN1090278A (xx)
AT (1)	ATE147720T1 (xx)
AU (1)	AU680829B2 (xx)
BG (1)	BG99542A (xx)
BR (1)	BR9307110A (xx)
CA (1)	CA2143300C (xx)
CO (1)	CO4560549A1 (xx)
CZ (1)	CZ74895A3 (xx)
DE (1)	DE69307446T2 (xx)
EE (1)	EE03083B1 (xx)
FI (1)	FI951398A7 (xx)
HU (2)	HUT70432A (xx)
IL (1)	IL107092A (xx)
LT (1)	LT3072B (xx)
LV (1)	LV10945B (xx)
MX (1)	MX9305918A (xx)
NO (1)	NO951133L (xx)
NZ (1)	NZ255301A (xx)
PH (1)	PH30881A (xx)
PL (1)	PL174454B1 (xx)
RU (1)	RU95113586A (xx)
SK (1)	SK37695A3 (xx)
TW (1)	TW239117B (xx)
WO (1)	WO1994007846A1 (xx)
ZA (1)	ZA937079B (xx)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CZ74795A3 (en) *	1992-09-25	1995-10-18	Bio Mega Boehringer Ingelheim	N-(hydroxyethyl) butanediamide derivatives, process of their preparation, their use for the preparation of pharmaceuticals and pharmaceutical preparations in which said derivatives are comprised
CA2165996C (en) *	1995-12-22	2002-01-29	Murray Douglas Bailey	Stereoselective preparation of 2-substituted succinic derivatives
US6096759A (en) *	1997-09-19	2000-08-01	Georgetown University	Method for treating essential hypertension
WO2005037317A2 (en) *	2003-10-17	2005-04-28	Cornell Research Foundation, Inc.	Mast cell-derived renin
US10517839B2 (en) *	2008-06-09	2019-12-31	Cornell University	Mast cell inhibition in diseases of the retina and vitreous

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5142056A (en)	1989-05-23	1992-08-25	Abbott Laboratories	Retroviral protease inhibiting compounds
US5006511A (en) *	1981-10-14	1991-04-09	Merck & Co., Inc.	Di- or tripeptide renin inhibitors containing lactam conformational restriction in achpa
EP0278158A3 (en)	1986-11-12	1990-05-23	Merck & Co. Inc.	Renin inhibitors containing phenylalanyl-histidine replacements
US4839357A (en)	1987-10-02	1989-06-13	Merck & Co., Inc.	Renin inhibitors containing phenylalanyl-histidine replacements
EP0312283A3 (en) *	1987-10-14	1990-05-09	Merck & Co. Inc.	Di-or tripeptide renin inhibitors containing lactam conformational restrictions in achpa
US5001113A (en)	1987-10-14	1991-03-19	Merck & Co., Inc.	Di- or tripeptide renin inhibitors containing lactam conformational restriction in ACHPA
US5055466A (en) *	1987-11-23	1991-10-08	E. R. Squibb & Sons, Inc.	N-morpholino derivatives and their use as anti-hypertensive agents
CA1329680C (en) *	1987-11-23	1994-05-17	Harold Norris Weller, Iii	N-heterocyclic alcohol derivatives
AU615313B2 (en) *	1988-07-01	1991-09-26	G.D. Searle & Co.	Aminoalkylaminocarbonyl aminodiol amino acid derivatives as anti-hypertensive agents
IE902446A1 (en) *	1989-07-26	1991-02-13	Abbott Lab	Peptidyl aminodiol renin inhibitors
US5063208A (en) *	1989-07-26	1991-11-05	Abbott Laboratories	Peptidyl aminodiol renin inhibitors
FI904441A7 (fi) *	1989-09-12	1991-03-13	Hoechst Ag	Aminohappojohdannaisia, joilla on reniiniä estäviä ominaisuuksia, menetelmiä niiden valmistamiseksi, näitä sisältäviä aineita ja niiden käyttö
JPH0532602A (ja) *	1991-07-26	1993-02-09	Terumo Corp	ナフチルメチルアミン誘導体及びこれを含有するレニン阻害剤

1993
- 1993-09-15 CA CA002143300A patent/CA2143300C/en not_active Expired - Fee Related
- 1993-09-15 HU HU9500871A patent/HUT70432A/hu unknown
- 1993-09-15 CZ CZ95748A patent/CZ74895A3/cs unknown
- 1993-09-15 NZ NZ255301A patent/NZ255301A/en unknown
- 1993-09-15 KR KR1019950701149A patent/KR950703520A/ko not_active Withdrawn
- 1993-09-15 WO PCT/CA1993/000380 patent/WO1994007846A1/en not_active Ceased
- 1993-09-15 FI FI951398A patent/FI951398A7/fi not_active Application Discontinuation
- 1993-09-15 JP JP50854294A patent/JP3490442B2/ja not_active Expired - Fee Related
- 1993-09-15 AU AU49403/93A patent/AU680829B2/en not_active Ceased
- 1993-09-15 SK SK376-95A patent/SK37695A3/sk unknown
- 1993-09-15 RU RU95113586/04A patent/RU95113586A/ru unknown
- 1993-09-15 PL PL93308180A patent/PL174454B1/pl unknown
- 1993-09-15 BR BR9307110A patent/BR9307110A/pt not_active Application Discontinuation
- 1993-09-17 US US08/122,280 patent/US5541163A/en not_active Expired - Lifetime
- 1993-09-23 DE DE69307446T patent/DE69307446T2/de not_active Expired - Lifetime
- 1993-09-23 AT AT93115326T patent/ATE147720T1/de not_active IP Right Cessation
- 1993-09-23 EP EP93115326A patent/EP0589445B1/en not_active Expired - Lifetime
- 1993-09-23 LT LTIP1092A patent/LT3072B/lt not_active IP Right Cessation
- 1993-09-23 PH PH46946A patent/PH30881A/en unknown
- 1993-09-23 IL IL107092A patent/IL107092A/xx not_active IP Right Cessation
- 1993-09-24 MX MX9305918A patent/MX9305918A/es not_active IP Right Cessation
- 1993-09-24 CO CO93410100A patent/CO4560549A1/es unknown
- 1993-09-24 TW TW082107871A patent/TW239117B/zh active
- 1993-09-24 ZA ZA937079A patent/ZA937079B/xx unknown
- 1993-09-25 CN CN93117983A patent/CN1090278A/zh active Pending
1994
- 1994-11-23 EE EE9400334A patent/EE03083B1/xx unknown
1995
- 1995-03-24 NO NO951133A patent/NO951133L/no unknown
- 1995-04-03 BG BG99542A patent/BG99542A/bg unknown
- 1995-04-25 LV LVP-95-107A patent/LV10945B/en unknown
- 1995-06-23 HU HU95P/P00428P patent/HU211315A9/hu unknown
1996
- 1996-02-01 US US08/595,327 patent/US5693619A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
SK37695A3 (en)	1995-07-11
LT3072B (en)	1994-11-25
CO4560549A1 (es)	1998-02-10
LTIP1092A (en)	1994-05-15
EP0589445A1 (en)	1994-03-30
LV10945B (en)	1996-06-20
EE03083B1 (et)	1998-04-15
JP3490442B2 (ja)	2004-01-26
NO951133L (no)	1995-05-24
HUT70432A (en)	1995-10-30
KR950703520A (ko)	1995-09-20
JPH08501567A (ja)	1996-02-20
DE69307446T2 (de)	1997-05-15
US5693619A (en)	1997-12-02
HU211315A9 (en)	1995-11-28
CN1090278A (zh)	1994-08-03
NZ255301A (en)	1997-05-26
AU680829B2 (en)	1997-08-14
CA2143300A1 (en)	1994-04-14
FI951398L (fi)	1995-03-24
PL308180A1 (en)	1995-07-24
BG99542A (bg)	1995-12-29
CZ74895A3 (en)	1995-12-13
EP0589445B1 (en)	1997-01-15
RU95113586A (ru)	1997-01-10
BR9307110A (pt)	1999-03-30
US5541163A (en)	1996-07-30
HU9500871D0 (en)	1995-05-29
IL107092A0 (en)	1993-12-28
CA2143300C (en)	1998-04-21
PL174454B1 (pl)	1998-07-31
FI951398A0 (fi)	1995-03-24
AU4940393A (en)	1994-04-26
ATE147720T1 (de)	1997-02-15
DE69307446D1 (de)	1997-02-27
FI951398A7 (fi)	1995-03-24
WO1994007846A1 (en)	1994-04-14
LV10945A (lv)	1995-12-20
NO951133D0 (no)	1995-03-24
TW239117B (xx)	1995-01-21
MX9305918A (es)	1994-05-31
PH30881A (en)	1997-12-23
ZA937079B (en)	1994-06-06

Publication	Publication Date	Title
NO940737L (xx)	1994-05-03
EP0976748A4 (en)	2001-08-08	PYRROLIDINE DERIVATIVES HAVING PHOSPHOLIPASE A2 INHIBITING ACTIVITY
ATE173256T1 (de)	1998-11-15	Azolidindion-derivate und ihre anwendung als antihyperglykämika
DE69332259D1 (de)	2002-10-10	Kondensierte Thiadiazolderivate, Verfahren zu ihrer Herstellung und deren Verwendung
IL107092A (en)	1997-09-30	Renin inhibiting n-(2-amino- 2-oxoethyl) butanediamide derivatives, their preparation and pharmaceutical compositions containing them
TW221429B (xx)	1994-03-01
IL107093A (en)	1997-09-30	N-(hydroxyethyl) butanediamide derivatives, their preparation and pharmaceutical compositions containing them
AU657423B2 (en)	1995-03-09	Novel piperidine derivatives and process for preparation thereof
IL105140A (en)	1997-01-10	Pyridyloxy derivatives processes for the preparation for the preparation thereof and pharmaceutical compositions containing the same
AU653019B2 (en)	1994-09-15	New urea derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same

Legal Events

Date	Code	Title
1998-03-10	FF	Patent granted
1998-08-16	KB	Patent renewed
2000-12-06	RH	Patent void