RU2523182C2 - Способ получения функционализованных производных гиалуроновой кислоты и образования их гидрогелей - Google Patents

Способ получения функционализованных производных гиалуроновой кислоты и образования их гидрогелей Download PDF

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Publication number: RU2523182C2
Authority: RU; Russia
Prior art keywords: hyaluronic acid; derivative; group; functionalization; derivatives
Prior art date: 2008-11-28

Application number

RU2011126353/13A

Other languages

English (en)

Russian (ru)

Other versions

RU2011126353A (ru

Inventor

Гаэтано ДЖАММОНА

Фабио ПАЛУМБО

Джованна ПИТАРРЕЗИ

Original Assignee

Университа` Дельи Студи Ди Палермо

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-11-28

Filing date

2009-11-30

Publication date

2014-07-20

2009-11-30 Application filed by Университа` Дельи Студи Ди Палермо filed Critical Университа` Дельи Студи Ди Палермо

2013-01-10 Publication of RU2011126353A publication Critical patent/RU2011126353A/ru

2014-07-20 Application granted granted Critical

2014-07-20 Publication of RU2523182C2 publication Critical patent/RU2523182C2/ru

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KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical class CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title claims abstract description 126
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IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 46
DZLFLBLQUQXARW-UHFFFAOYSA-N tetrabutylammonium Chemical compound CCCC[N+](CCCC)(CCCC)CCCC DZLFLBLQUQXARW-UHFFFAOYSA-N 0.000 claims description 18
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
- B23K9/00—Arc welding or cutting
- B23K9/10—Other electric circuits therefor; Protective circuits; Remote controls

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Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
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Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Materials Engineering (AREA)
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Molecular Biology (AREA)
Mechanical Engineering (AREA)
Plasma & Fusion (AREA)
Dermatology (AREA)
Veterinary Medicine (AREA)
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Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Materials For Medical Uses (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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RU2011126353/13A 2008-11-28 2009-11-30 Способ получения функционализованных производных гиалуроновой кислоты и образования их гидрогелей RU2523182C2 (ru)

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ITRM2008A000636		2008-11-28
IT000636A ITRM20080636A1 (it)	2008-11-28	2008-11-28	Procedimento per la produzione di derivati funzionalizzati dell acido ialuronico e relativi idrogeli.
PCT/EP2009/066060 WO2010061005A1 (fr)	2008-11-28	2009-11-30	Procédé de production de dérivés fonctionnalisés d'acide hyaluronique et formation d'hydrogels à partir de ceux-ci

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US (2)	US8858999B2 (fr)
EP (1)	EP2370474B1 (fr)
JP (1)	JP5607061B2 (fr)
CN (1)	CN102227448B (fr)
BR (1)	BRPI0920965B1 (fr)
CA (1)	CA2744892C (fr)
DK (1)	DK2370474T3 (fr)
ES (1)	ES2397987T3 (fr)
IT (1)	ITRM20080636A1 (fr)
MX (1)	MX2011005528A (fr)
PL (1)	PL2370474T3 (fr)
RU (1)	RU2523182C2 (fr)
SI (1)	SI2370474T1 (fr)
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2008
- 2008-11-28 IT IT000636A patent/ITRM20080636A1/it unknown
2009
- 2009-01-30 US US13/131,098 patent/US8858999B2/en active Active
- 2009-11-30 ES ES09795949T patent/ES2397987T3/es active Active
- 2009-11-30 BR BRPI0920965-4A patent/BRPI0920965B1/pt not_active IP Right Cessation
- 2009-11-30 RU RU2011126353/13A patent/RU2523182C2/ru not_active IP Right Cessation
- 2009-11-30 SI SI200930470T patent/SI2370474T1/sl unknown
- 2009-11-30 WO PCT/EP2009/066060 patent/WO2010061005A1/fr not_active Ceased
- 2009-11-30 PL PL09795949T patent/PL2370474T3/pl unknown
- 2009-11-30 JP JP2011537999A patent/JP5607061B2/ja active Active
- 2009-11-30 MX MX2011005528A patent/MX2011005528A/es active IP Right Grant
- 2009-11-30 CA CA2744892A patent/CA2744892C/fr active Active
- 2009-11-30 EP EP09795949A patent/EP2370474B1/fr active Active
- 2009-11-30 CN CN200980147761.7A patent/CN102227448B/zh active Active
- 2009-11-30 DK DK09795949.8T patent/DK2370474T3/da active
2014
- 2014-11-13 US US14/507,474 patent/US9410000B2/en active Active

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Also Published As

Publication number	Publication date
BRPI0920965B1 (pt)	2019-07-09
ITRM20080636A1 (it)	2010-05-29
HK1162546A1 (en)	2012-08-31
ES2397987T3 (es)	2013-03-12
PL2370474T3 (pl)	2013-03-29
WO2010061005A1 (fr)	2010-06-03
CN102227448B (zh)	2014-04-02
CA2744892A1 (fr)	2010-06-03
EP2370474B1 (fr)	2012-10-24
CA2744892C (fr)	2016-10-25
DK2370474T3 (da)	2013-01-14
EP2370474A1 (fr)	2011-10-05
MX2011005528A (es)	2011-08-17
SI2370474T1 (sl)	2013-02-28
US9410000B2 (en)	2016-08-09
JP5607061B2 (ja)	2014-10-15
RU2011126353A (ru)	2013-01-10
JP2012510535A (ja)	2012-05-10
US20110236486A1 (en)	2011-09-29
US20150183891A1 (en)	2015-07-02
US8858999B2 (en)	2014-10-14
BRPI0920965A2 (pt)	2016-09-06
CN102227448A (zh)	2011-10-26

Publication	Publication Date	Title
RU2523182C2 (ru)	2014-07-20	Способ получения функционализованных производных гиалуроновой кислоты и образования их гидрогелей
US11337930B2 (en)	2022-05-24	Modified alginates for cell encapsulation and cell therapy
KR100674177B1 (ko)	2007-01-24	교차 결합된 히알루론산과 그것의 의학적 용도
US5874417A (en)	1999-02-23	Functionalized derivatives of hyaluronic acid
CN112812329B (zh)	2023-06-16	巯基改性高分子化合物的水凝胶及其制备方法和用途
WO2020240034A1 (fr)	2020-12-03	Hydrogel hybride à base d'acide hyaluronique
CN113929792A (zh)	2022-01-14	一种醛基化修饰的透明质酸（钠）及其合成方法和应用
HK1162546B (en)	2013-06-21	Method to produce hyaluronic acid functionalized derivatives and formation of hydrogels thereof
KR101242399B1 (ko)	2013-03-12	아미노살리실산이 결합된 고분자 화합물
Kuang et al.	2018	Polymeric hydrogels via click chemistry for regenerative engineering
Zerobin	2017	Two-Photon Structured Hydrogels based on Hyaluronic Acid for Applications in Tissue Engineering: by Elise Zerobin
HK1259279B (en)	2022-09-30	Modified alginates for cell encapsulation and cell therapy

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RU2523182C2 - Способ получения функционализованных производных гиалуроновой кислоты и образования их гидрогелей - Google Patents

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