IT201700122135A1 - Acido ialuronico funzionalizzato o suo derivato nel trattamento di stati infiammatori - Google Patents

Acido ialuronico funzionalizzato o suo derivato nel trattamento di stati infiammatori

Info

Publication number: IT201700122135A1
Authority: IT; Italy
Prior art keywords: derivative; treatment; hyaluronic acid; acid functionalized; inflammatory states
Prior art date: 2017-10-26

Application number

IT102017000122135A

Other languages

English (en)

Inventor

Giulio Bianchini

Lanfranco Callegaro

Original Assignee

Jointherapeutics S R L

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2017-10-26

Filing date

2017-10-26

Publication date

2019-04-26

2017-10-26 Application filed by Jointherapeutics S R L filed Critical Jointherapeutics S R L

2017-10-26 Priority to IT102017000122135A priority Critical patent/IT201700122135A1/it

2018-10-24 Priority to ES18804408T priority patent/ES2906599T3/es

2018-10-24 Priority to CA3078901A priority patent/CA3078901A1/en

2018-10-24 Priority to CN201880068662.9A priority patent/CN111247174B/zh

2018-10-24 Priority to DK18804408.5T priority patent/DK3700940T3/da

2018-10-24 Priority to KR1020207013301A priority patent/KR102688006B1/ko

2018-10-24 Priority to PL18804408T priority patent/PL3700940T3/pl

2018-10-24 Priority to RU2020113879A priority patent/RU2792001C2/ru

2018-10-24 Priority to PT188044085T priority patent/PT3700940T/pt

2018-10-24 Priority to IL274089A priority patent/IL274089B2/en

2018-10-24 Priority to PCT/IB2018/058297 priority patent/WO2019082097A1/en

2018-10-24 Priority to US16/757,864 priority patent/US11203649B2/en

2018-10-24 Priority to JP2020522074A priority patent/JP7277452B2/ja

2018-10-24 Priority to EP18804408.5A priority patent/EP3700940B1/en

2019-04-26 Publication of IT201700122135A1 publication Critical patent/IT201700122135A1/it

Links

KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title 1
229920002674 hyaluronan Polymers 0.000 title 1
229960003160 hyaluronic acid Drugs 0.000 title 1
230000002757 inflammatory effect Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Dermatology (AREA)
Epidemiology (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Transplantation (AREA)
Oral & Maxillofacial Surgery (AREA)
Biochemistry (AREA)
Materials Engineering (AREA)
Polymers & Plastics (AREA)
Rheumatology (AREA)
Dispersion Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Materials For Medical Uses (AREA)

IT102017000122135A 2017-10-26 2017-10-26 Acido ialuronico funzionalizzato o suo derivato nel trattamento di stati infiammatori IT201700122135A1 (it)

Priority Applications (14)

Application Number	Priority Date	Filing Date	Title
IT102017000122135A IT201700122135A1 (it)	2017-10-26	2017-10-26	Acido ialuronico funzionalizzato o suo derivato nel trattamento di stati infiammatori
ES18804408T ES2906599T3 (es)	2017-10-26	2018-10-24	Acido hialurónico funcionalizado o un derivado del mismo en el tratamiento de estados inflamatorios
CA3078901A CA3078901A1 (en)	2017-10-26	2018-10-24	Functionalized hyaluronic acid or a derivative thereof in the treatment of inflammatory states
CN201880068662.9A CN111247174B (zh)	2017-10-26	2018-10-24	在炎症状态的治疗中的官能化的透明质酸或其衍生物
DK18804408.5T DK3700940T3 (da)	2017-10-26	2018-10-24	Funktionaliseret hyaluronsyre eller et derivat deraf i behandling af inflammatoriske tilstande
KR1020207013301A KR102688006B1 (ko)	2017-10-26	2018-10-24	염증 상태의 치료에서의 작용화된 히알루론산 또는 이의 유도체
PL18804408T PL3700940T3 (pl)	2017-10-26	2018-10-24	Funkcjonalizowany kwas hialuronowy lub jego pochodna w leczeniu stanów zapalnych
RU2020113879A RU2792001C2 (ru)	2017-10-26	2018-10-24	Функционализированная гиалуроновая кислота или ее производное для лечения воспалительных состояний
PT188044085T PT3700940T (pt)	2017-10-26	2018-10-24	Ácido hialurónico funcionalizado ou um derivado do mesmo no tratamento de estados inflamatórios
IL274089A IL274089B2 (en)	2017-10-26	2018-10-24	Functionalized hyaluronic acid or a derivative thereof in the treatment of inflammatory states
PCT/IB2018/058297 WO2019082097A1 (en)	2017-10-26	2018-10-24	FUNCTIONALIZED HYALURONIC ACID OR A DERIVATIVE THEREOF IN THE TREATMENT OF INFLAMMATORY CONDITIONS
US16/757,864 US11203649B2 (en)	2017-10-26	2018-10-24	Functionalized hyaluronic acid or a derivative thereof in the treatment of inflammatory states
JP2020522074A JP7277452B2 (ja)	2017-10-26	2018-10-24	炎症症状の治療における官能化ヒアルロン酸またはその誘導体
EP18804408.5A EP3700940B1 (en)	2017-10-26	2018-10-24	Functionalized hyaluronic acid or a derivative thereof in the treatment of inflammatory states

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT102017000122135A IT201700122135A1 (it)	2017-10-26	2017-10-26	Acido ialuronico funzionalizzato o suo derivato nel trattamento di stati infiammatori

Publications (1)

Publication Number	Publication Date
IT201700122135A1 true IT201700122135A1 (it)	2019-04-26

Family

ID=61526960

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT102017000122135A IT201700122135A1 (it)	2017-10-26	2017-10-26	Acido ialuronico funzionalizzato o suo derivato nel trattamento di stati infiammatori

Country Status (13)

Country	Link
US (1)	US11203649B2 (it)
EP (1)	EP3700940B1 (it)
JP (1)	JP7277452B2 (it)
KR (1)	KR102688006B1 (it)
CN (1)	CN111247174B (it)
CA (1)	CA3078901A1 (it)
DK (1)	DK3700940T3 (it)
ES (1)	ES2906599T3 (it)
IL (1)	IL274089B2 (it)
IT (1)	IT201700122135A1 (it)
PL (1)	PL3700940T3 (it)
PT (1)	PT3700940T (it)
WO (1)	WO2019082097A1 (it)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN113906055B (zh) *	2019-04-19	2023-09-26	卓英医疗有限责任公司	官能化的透明质酸的交联的聚合物及其在炎症状态的治疗中的用途
WO2022236585A1 (zh) *	2021-05-10	2022-11-17	傅毓秀	玻尿酸用于制备治疗肺纤维化药剂的用途
CN113754795B (zh) *	2021-10-19	2023-03-10	澳门大学	磺酸化透明质酸类化合物、其制备方法及其应用

Citations (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4851521A (en) *	1985-07-08	1989-07-25	Fidia, S.P.A.	Esters of hyaluronic acid
EP0341745A1 (en) *	1988-05-13	1989-11-15	FIDIA S.p.A.	Crosslinked carboxy polysaccharides
WO1998045335A1 (en) *	1997-04-04	1998-10-15	Fidia Advanced Biopolymers, S.R.L.	N-sulphated hyaluronic acid compounds, derivatives thereof and a process for their preparation
WO2000001733A1 (en) *	1998-07-06	2000-01-13	Fidia Advanced Biopolymers S.R.L.	Amides of hyaluronic acid and the derivatives thereof and a process for their preparation
LU91414B1 (fr) *	2008-02-01	2009-08-03	Fidia Farmaceutici	Amides d'acide hyaluronique, derives de ce dernieret leurs procede de preparation
US20150231268A1 (en) *	2012-09-05	2015-08-20	Chugai Seiyaku Kabushiki Kaisha	Hyaluronic acid derivative having amino acid and steryl group introduced thereinto

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US6756363B1 (en) *	2000-11-17	2004-06-29	Wound Healing Of Oklahoma, Inc.	Solutions and films of glycated chitosan
EP1586325A1 (en) *	2003-01-24	2005-10-19	Galpharma Co., Ltd.	Drugs containing galectin 9
ES2417153T5 (es) *	2006-03-06	2024-04-04	Amunix Operating Inc	Polímeros recombinantes no estructurados y usos de los mismos
ITRM20080636A1 (it) *	2008-11-28	2010-05-29	Univ Palermo	Procedimento per la produzione di derivati funzionalizzati dell acido ialuronico e relativi idrogeli.
GB201214736D0 (en)	2012-08-17	2012-10-03	Isis Innovation	Inflammation imaging and therapy
FR3033498B1 (fr)	2015-03-12	2018-03-23	L'oreal	Procede de protection et de reparation des fibres keratiniques a partir de polysaccharide oxyde et de (poly)saccharide a groupe amine
CN106467563B (zh) *	2015-08-21	2019-08-06	北京大学	硫酸软骨素四糖的合成方法及其中间体化合物

2017
- 2017-10-26 IT IT102017000122135A patent/IT201700122135A1/it unknown
2018
- 2018-10-24 US US16/757,864 patent/US11203649B2/en active Active
- 2018-10-24 WO PCT/IB2018/058297 patent/WO2019082097A1/en not_active Ceased
- 2018-10-24 IL IL274089A patent/IL274089B2/en unknown
- 2018-10-24 CN CN201880068662.9A patent/CN111247174B/zh active Active
- 2018-10-24 PT PT188044085T patent/PT3700940T/pt unknown
- 2018-10-24 DK DK18804408.5T patent/DK3700940T3/da active
- 2018-10-24 EP EP18804408.5A patent/EP3700940B1/en active Active
- 2018-10-24 KR KR1020207013301A patent/KR102688006B1/ko active Active
- 2018-10-24 JP JP2020522074A patent/JP7277452B2/ja active Active
- 2018-10-24 ES ES18804408T patent/ES2906599T3/es active Active
- 2018-10-24 PL PL18804408T patent/PL3700940T3/pl unknown
- 2018-10-24 CA CA3078901A patent/CA3078901A1/en active Pending

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4851521A (en) *	1985-07-08	1989-07-25	Fidia, S.P.A.	Esters of hyaluronic acid
EP0341745A1 (en) *	1988-05-13	1989-11-15	FIDIA S.p.A.	Crosslinked carboxy polysaccharides
WO1998045335A1 (en) *	1997-04-04	1998-10-15	Fidia Advanced Biopolymers, S.R.L.	N-sulphated hyaluronic acid compounds, derivatives thereof and a process for their preparation
WO2000001733A1 (en) *	1998-07-06	2000-01-13	Fidia Advanced Biopolymers S.R.L.	Amides of hyaluronic acid and the derivatives thereof and a process for their preparation
LU91414B1 (fr) *	2008-02-01	2009-08-03	Fidia Farmaceutici	Amides d'acide hyaluronique, derives de ce dernieret leurs procede de preparation
US20150231268A1 (en) *	2012-09-05	2015-08-20	Chugai Seiyaku Kabushiki Kaisha	Hyaluronic acid derivative having amino acid and steryl group introduced thereinto

Also Published As

Publication number	Publication date
EP3700940A1 (en)	2020-09-02
JP2021500436A (ja)	2021-01-07
RU2020113879A (ru)	2021-11-26
WO2019082097A1 (en)	2019-05-02
ES2906599T3 (es)	2022-04-19
IL274089A (en)	2020-06-30
CN111247174A (zh)	2020-06-05
PL3700940T3 (pl)	2022-03-21
PT3700940T (pt)	2022-02-14
KR20200077528A (ko)	2020-06-30
DK3700940T3 (da)	2022-02-21
JP7277452B2 (ja)	2023-05-19
US11203649B2 (en)	2021-12-21
IL274089B1 (en)	2024-06-01
IL274089B2 (en)	2024-10-01
US20210189017A1 (en)	2021-06-24
CA3078901A1 (en)	2019-05-02
EP3700940B1 (en)	2021-12-15
KR102688006B1 (ko)	2024-07-25
CN111247174B (zh)	2022-07-22

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