PL2370474T3 - Sposób wytwarzania funkcjonalizowanych pochodnych kwasu hialuronowego i wytwarzanie z nich hydrożeli - Google Patents
Sposób wytwarzania funkcjonalizowanych pochodnych kwasu hialuronowego i wytwarzanie z nich hydrożeliInfo
- Publication number
- PL2370474T3 PL2370474T3 PL09795949T PL09795949T PL2370474T3 PL 2370474 T3 PL2370474 T3 PL 2370474T3 PL 09795949 T PL09795949 T PL 09795949T PL 09795949 T PL09795949 T PL 09795949T PL 2370474 T3 PL2370474 T3 PL 2370474T3
- Authority
- PL
- Poland
- Prior art keywords
- hydrogels
- formation
- hyaluronic acid
- acid functionalized
- functionalized derivatives
- Prior art date
Links
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 229920002674 hyaluronan Polymers 0.000 title 1
- 229960003160 hyaluronic acid Drugs 0.000 title 1
- 239000000017 hydrogel Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
- B23K9/00—Arc welding or cutting
- B23K9/10—Other electric circuits therefor; Protective circuits; Remote controls
Landscapes
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Materials Engineering (AREA)
- Physics & Mathematics (AREA)
- Polymers & Plastics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Mechanical Engineering (AREA)
- Plasma & Fusion (AREA)
- Dermatology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Arc Welding Control (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000636A ITRM20080636A1 (it) | 2008-11-28 | 2008-11-28 | Procedimento per la produzione di derivati funzionalizzati dell acido ialuronico e relativi idrogeli. |
| EP09795949A EP2370474B1 (en) | 2008-11-28 | 2009-11-30 | Method to produce hyaluronic acid functionalized derivatives and formation of hydrogels thereof |
| PCT/EP2009/066060 WO2010061005A1 (en) | 2008-11-28 | 2009-11-30 | Method to produce hyaluronic acid functionalized derivatives and formation of hydrogels thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2370474T3 true PL2370474T3 (pl) | 2013-03-29 |
Family
ID=41210473
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL09795949T PL2370474T3 (pl) | 2008-11-28 | 2009-11-30 | Sposób wytwarzania funkcjonalizowanych pochodnych kwasu hialuronowego i wytwarzanie z nich hydrożeli |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US8858999B2 (pl) |
| EP (1) | EP2370474B1 (pl) |
| JP (1) | JP5607061B2 (pl) |
| CN (1) | CN102227448B (pl) |
| BR (1) | BRPI0920965B1 (pl) |
| CA (1) | CA2744892C (pl) |
| DK (1) | DK2370474T3 (pl) |
| ES (1) | ES2397987T3 (pl) |
| IT (1) | ITRM20080636A1 (pl) |
| MX (1) | MX2011005528A (pl) |
| PL (1) | PL2370474T3 (pl) |
| RU (1) | RU2523182C2 (pl) |
| SI (1) | SI2370474T1 (pl) |
| WO (1) | WO2010061005A1 (pl) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2861734B1 (fr) | 2003-04-10 | 2006-04-14 | Corneal Ind | Reticulation de polysaccharides de faible et forte masse moleculaire; preparation d'hydrogels monophasiques injectables; polysaccharides et hydrogels obtenus |
| EP2818184B1 (en) | 2007-11-16 | 2018-10-31 | Allergan, Inc. | Compositions and methods for treating Purpura |
| US8394782B2 (en) | 2007-11-30 | 2013-03-12 | Allergan, Inc. | Polysaccharide gel formulation having increased longevity |
| US8450475B2 (en) | 2008-08-04 | 2013-05-28 | Allergan, Inc. | Hyaluronic acid-based gels including lidocaine |
| AU2009288118B2 (en) | 2008-09-02 | 2014-12-11 | Allergan, Inc. | Threads of hyaluronic acid and/or derivatives thereof, methods of making thereof and uses thereof |
| ITRM20080636A1 (it) | 2008-11-28 | 2010-05-29 | Univ Palermo | Procedimento per la produzione di derivati funzionalizzati dell acido ialuronico e relativi idrogeli. |
| CZ2009836A3 (cs) | 2009-12-11 | 2011-06-22 | Contipro C A.S. | Derivát kyseliny hyaluronové oxidovaný v poloze 6 glukosaminové cásti polysacharidu selektivne na aldehyd, zpusob jeho prípravy a zpusob jeho modifikace |
| CZ302503B6 (cs) | 2009-12-11 | 2011-06-22 | Contipro C A.S. | Zpusob prípravy derivátu kyseliny hyaluronové oxidovaného v poloze 6 glukosaminové cásti polysacharidu selektivne na aldehyd a zpusob jeho modifikace |
| US20110172180A1 (en) | 2010-01-13 | 2011-07-14 | Allergan Industrie. Sas | Heat stable hyaluronic acid compositions for dermatological use |
| US9114188B2 (en) | 2010-01-13 | 2015-08-25 | Allergan, Industrie, S.A.S. | Stable hydrogel compositions including additives |
| US8586562B2 (en) | 2010-03-12 | 2013-11-19 | Allergan Industrie, Sas | Fluid compositions for improving skin conditions |
| DK2550027T4 (da) | 2010-03-22 | 2019-05-13 | Allergan Inc | Tværbundne polysaccharid- og protein-polysaccharid-hydrogeler til blødvævsforøgelse |
| IT1401498B1 (it) | 2010-07-30 | 2013-07-26 | Mero Srl | Idrogelo a base di acido ialuronico e suo uso in ortopedia |
| US8889123B2 (en) | 2010-08-19 | 2014-11-18 | Allergan, Inc. | Compositions and soft tissue replacement methods |
| US9005605B2 (en) | 2010-08-19 | 2015-04-14 | Allergan, Inc. | Compositions and soft tissue replacement methods |
| US8883139B2 (en) | 2010-08-19 | 2014-11-11 | Allergan Inc. | Compositions and soft tissue replacement methods |
| CZ304072B6 (cs) * | 2011-04-26 | 2013-09-25 | Contipro Biotech S.R.O. | Amfoterní materiál na bázi sítované kyseliny hyaluronové, zpusob jeho prípravy, materiály obsahující aktivní cinidla uzavrené v síti hyaluronanu, zpusob jejich prípravy a jejich pouzití |
| US20130096081A1 (en) | 2011-06-03 | 2013-04-18 | Allergan, Inc. | Dermal filler compositions |
| US9393263B2 (en) | 2011-06-03 | 2016-07-19 | Allergan, Inc. | Dermal filler compositions including antioxidants |
| US9408797B2 (en) | 2011-06-03 | 2016-08-09 | Allergan, Inc. | Dermal filler compositions for fine line treatment |
| ES2738208T3 (es) | 2011-06-03 | 2020-01-20 | Allergan Ind Sas | Composiciones de relleno dérmico que incluyen antioxidantes |
| US20130244943A1 (en) | 2011-09-06 | 2013-09-19 | Allergan, Inc. | Hyaluronic acid-collagen matrices for dermal filling and volumizing applications |
| US9662422B2 (en) | 2011-09-06 | 2017-05-30 | Allergan, Inc. | Crosslinked hyaluronic acid-collagen gels for improving tissue graft viability and soft tissue augmentation |
| JP5714456B2 (ja) * | 2011-09-07 | 2015-05-07 | 株式会社シード | 重合性ヒアルロン酸誘導体、ならびにその重合体を含むヒアルロン酸ヒドロゲルおよびコンタクトレンズ |
| CZ303879B6 (cs) | 2012-02-28 | 2013-06-05 | Contipro Biotech S.R.O. | Deriváty na bázi kyseliny hyaluronové schopné tvorit hydrogely, zpusob jejich prípravy, hydrogely na bázi techto derivátu, zpusob jejich prípravy a pouzití |
| KR101240518B1 (ko) * | 2012-03-26 | 2013-03-11 | 주식회사 제네웰 | 생체 적합성 고분자를 이용한 이식용 재료 |
| WO2013181566A1 (en) * | 2012-05-31 | 2013-12-05 | Cornell University | Polysaccharide-based hydrogels and hybrid hydrogels and precursors thereof, methods of making same, and uses thereof |
| CZ304512B6 (cs) | 2012-08-08 | 2014-06-11 | Contipro Biotech S.R.O. | Derivát kyseliny hyaluronové, způsob jeho přípravy, způsob jeho modifikace a použití |
| CZ304654B6 (cs) | 2012-11-27 | 2014-08-20 | Contipro Biotech S.R.O. | Nanomicelární kompozice na bázi C6-C18-acylovaného hyaluronanu, způsob přípravy C6-C18-acylovaného hyaluronanu, způsob přípravy nanomicelární kompozice a stabilizované nanomicelární kompozice a použití |
| CZ2012843A3 (cs) | 2012-11-27 | 2014-02-05 | Contipro Biotech S.R.O. | Nekonečná vlákna na bázi hyaluronanu, selektivně oxidovaného v poloze 6 N-acetyl-D-glukosaminové části, jejich příprava, použití, nitě, střiže, příze, textilie a způsob jejich úpravy |
| US20140275340A1 (en) * | 2013-03-15 | 2014-09-18 | Lake Region Manufacturing, Inc. d/b/a Lake Region Medical | Modified hyaluronate hydrophilic compositions, coatings and methods |
| KR20160032000A (ko) | 2013-03-15 | 2016-03-23 | 매튜 알. 드레허 | 이미지화 가능한 색전성 마이크로스피어 |
| US9623157B2 (en) | 2013-03-15 | 2017-04-18 | Lake Region Manufacturing, Inc. | Modified hyaluronate hydrophilic compositions, coatings and methods |
| CZ305153B6 (cs) | 2014-03-11 | 2015-05-20 | Contipro Biotech S.R.O. | Konjugáty oligomeru kyseliny hyaluronové nebo její soli, způsob jejich přípravy a použití |
| CN103910886B (zh) * | 2014-03-24 | 2016-04-06 | 海南大学 | 半胱氨酸功能化的透明质酸结合物及其合成方法以及在可注射原位形成的水凝胶中的应用 |
| CN106488772B (zh) * | 2014-05-07 | 2020-11-27 | 内米西斯有限公司 | 用于乳糜泄的口服酶疗法的甲基丙烯酸透明质酸衍生物的水凝胶 |
| CZ2014451A3 (cs) | 2014-06-30 | 2016-01-13 | Contipro Pharma A.S. | Protinádorová kompozice na bázi kyseliny hyaluronové a anorganických nanočástic, způsob její přípravy a použití |
| ES2761558T3 (es) | 2014-09-30 | 2020-05-20 | Allergan Ind Sas | Composiciones de hidrogel estables que incluyen aditivos |
| WO2016128783A1 (en) | 2015-02-09 | 2016-08-18 | Allergan Industrie Sas | Compositions and methods for improving skin appearance |
| PL3256179T3 (pl) | 2015-02-13 | 2020-05-18 | Allergan Industrie, Sas | Implanty do kształtowania, uwydatniania lub korygowania cech twarzy takich jak broda |
| CZ309295B6 (cs) | 2015-03-09 | 2022-08-10 | Contipro A.S. | Samonosný, biodegradabilní film na bázi hydrofobizované kyseliny hyaluronové, způsob jeho přípravy a použití |
| CN108136275A (zh) * | 2015-04-29 | 2018-06-08 | 沃特世科技公司 | 用于超临界流体色谱法的包含离子配对键合相的高纯度色谱材料 |
| CZ2015398A3 (cs) | 2015-06-15 | 2017-02-08 | Contipro A.S. | Způsob síťování polysacharidů s využitím fotolabilních chránicích skupin |
| CZ306662B6 (cs) | 2015-06-26 | 2017-04-26 | Contipro A.S. | Deriváty sulfatovaných polysacharidů, způsob jejich přípravy, způsob jejich modifikace a použití |
| CN114010640A (zh) * | 2015-08-19 | 2022-02-08 | 爱荷华大学研究基金会 | 创伤后骨关节炎的预防性治疗 |
| EP3156044A1 (en) * | 2015-10-16 | 2017-04-19 | Merz Pharma GmbH & Co. KGaA | In situ cross-linkable polysaccharide compositions and uses thereof |
| JP7009371B2 (ja) | 2015-12-29 | 2022-01-25 | ガルデルマ エス．エー． | バイオポリマーを脱アセチル化するための方法 |
| CN105770983B (zh) * | 2016-03-14 | 2019-02-19 | 武汉纺织大学 | 一种透明质酸生物粘合剂的制备方法 |
| JP6675247B2 (ja) * | 2016-03-28 | 2020-04-01 | 株式会社シード | フィブロイン−ヒアルロン酸ハイドロゲル複合体 |
| CZ308106B6 (cs) | 2016-06-27 | 2020-01-08 | Contipro A.S. | Nenasycené deriváty polysacharidů, způsob jejich přípravy a jejich použití |
| CN106279729A (zh) * | 2016-08-26 | 2017-01-04 | 北京大清生物技术有限公司 | 一种透明质酸交联凝胶及其制备方法与应用 |
| FR3060239A1 (fr) * | 2016-12-14 | 2018-06-15 | Ge Energy Products France Snc | Procede de determination d'un profil de reponse en statisme d'une machine electrique reliee a un reseau electrique |
| JP2018153296A (ja) * | 2017-03-16 | 2018-10-04 | Jsr株式会社 | 不飽和化合物を含有する組成物 |
| CA3055985A1 (en) | 2017-03-22 | 2018-09-27 | Genentech, Inc. | Hydrogel cross-linked hyaluronic acid prodrug compositions and methods |
| US10263552B2 (en) * | 2017-08-08 | 2019-04-16 | Rolls-Royce North American Technologies Inc. | Anticipatory control using output shaft speed |
| CN108187130B (zh) * | 2017-09-15 | 2020-08-18 | 海宁侏罗纪生物科技有限公司 | 一种用于生物损伤修复或止血的试剂及其应用 |
| IT201700122135A1 (it) * | 2017-10-26 | 2019-04-26 | Jointherapeutics S R L | Acido ialuronico funzionalizzato o suo derivato nel trattamento di stati infiammatori |
| US20210015967A1 (en) * | 2018-03-23 | 2021-01-21 | Kaohsiung Medical University | Method for preparing hyaluronic acid hydrogel microparticles and use thereof in repairing articular cartilage defects |
| EP3659632A1 (en) | 2018-11-29 | 2020-06-03 | Nestlé Skin Health SA | Post-crosslinking partial degradation of amide crosslinked hydrogels |
| CN110384822B (zh) * | 2019-08-19 | 2021-11-16 | 江苏人冠医疗科技有限公司 | 眼用粘合封闭胶及其制备方法 |
| CN110433320A (zh) * | 2019-09-12 | 2019-11-12 | 深圳刚华健医疗有限公司 | 一种医用敷料的制备方法 |
| CN112812200B (zh) * | 2019-11-18 | 2023-06-16 | 孛朗孚(杭州)生物科技有限公司 | 巯基改性高分子化合物及其制备方法和用途 |
| JP7730323B2 (ja) | 2019-12-02 | 2025-08-27 | ガルデルマ ホールディング エスエー | 高分子量美容組成物 |
| US11904006B2 (en) | 2019-12-11 | 2024-02-20 | University Of Iowa Research Foundation | Poly(diaminosulfide) particle-based vaccine |
| CN114269813B (zh) * | 2020-06-01 | 2024-01-02 | 株式会社Lg化学 | 制备聚合物微粒的方法，聚合物微粒，使用其的医用组合物、美容组合物、医用制品和美容制品 |
| IT202000028445A1 (it) | 2020-11-25 | 2022-05-25 | Univ Degli Studi Di Palermo | Nanosistema per la diagnosi ed il trattamento fototermico di tumori |
| TR202022151A2 (tr) * | 2020-12-29 | 2022-07-21 | Vsy Biyoteknoloji Ve Ilac Sanayi Anonim Sirketi | Enjekte edi̇lebi̇li̇r fotoçapraz bağli hi̇yaluroni̇k asi̇t hi̇drojeller, bunlarin üreti̇m yöntemi̇ ve osteoartri̇t tedavi̇si̇ i̇çi̇n kullanimi |
| WO2023148619A1 (en) | 2022-02-01 | 2023-08-10 | Galderma Holding SA | Methods of producing crosslinked hyaluronic acid hydrogels |
| CN115636884B (zh) * | 2022-12-23 | 2023-03-28 | 北京格林意锐医药科技有限责任公司 | 一种透明质酸钠衍生物制备方法及交联透明质酸钠和用途 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06279502A (ja) * | 1993-03-29 | 1994-10-04 | Asahi Chem Ind Co Ltd | カーボネート化セルロース誘導体の製法 |
| JPH06279501A (ja) * | 1993-03-29 | 1994-10-04 | Asahi Chem Ind Co Ltd | カーボネート化セルロース誘導体及びその製造方法 |
| IT1268955B1 (it) * | 1994-03-11 | 1997-03-18 | Fidia Advanced Biopolymers Srl | Esteri attivi di polisaccaridi carbossilici |
| AU722250B2 (en) * | 1995-11-15 | 2000-07-27 | Seikagaku Corporation | Photocured crosslinked-hyaluronic acid gel and method of preparation thereof |
| RU2191782C2 (ru) * | 2000-09-21 | 2002-10-27 | Институт нефтехимии и катализа АН РБ и УНЦ РАН | Способ получения модифицированной гиалуроновой кислоты |
| JP2004292465A (ja) * | 2000-11-30 | 2004-10-21 | Denki Kagaku Kogyo Kk | ヒドロキサム酸誘導体とヒアルロン酸の結合体 |
| ITTS20010013A1 (it) * | 2001-06-04 | 2002-12-04 | Ct Ricerche Poly Tec H A R L S | Nuovi derivati di ialuronano. |
| WO2003002125A2 (en) * | 2001-06-29 | 2003-01-09 | Astion A/S | Combination of aminosugars and cysteine or cysteine derivatives |
| TW200524959A (en) * | 2003-09-08 | 2005-08-01 | Chugai Pharmaceutical Co Ltd | Hyaluronic acid modification product and drug carrier therefrom |
| GB2408741B (en) * | 2003-12-04 | 2008-06-18 | Ind Tech Res Inst | Hyaluronic acid derivative with urethane linkage |
| JP5001645B2 (ja) * | 2004-04-02 | 2012-08-15 | 電気化学工業株式会社 | ヒアルロン酸−メトトレキサート結合体 |
| EP1790665B1 (en) * | 2004-09-07 | 2014-11-05 | Chugai Seiyaku Kabushiki Kaisha | Process for producing water-soluble modified hyaluronic acid |
| US7879818B2 (en) * | 2005-12-23 | 2011-02-01 | Janos Borbely | Hyaluronic acid-based cross-linked nanoparticles |
| KR100849185B1 (ko) * | 2006-01-19 | 2008-07-30 | 서울산업대학교 산학협력단 | 키토산 또는 히알루론산-폴리에틸렌옥사이드 및키토산-히알루론산-폴리에틸렌옥사이드를 기저로 하는하이드로젤과 이의 제조방법 |
| ITRM20080636A1 (it) | 2008-11-28 | 2010-05-29 | Univ Palermo | Procedimento per la produzione di derivati funzionalizzati dell acido ialuronico e relativi idrogeli. |
-
2008
- 2008-11-28 IT IT000636A patent/ITRM20080636A1/it unknown
-
2009
- 2009-01-30 US US13/131,098 patent/US8858999B2/en active Active
- 2009-11-30 ES ES09795949T patent/ES2397987T3/es active Active
- 2009-11-30 BR BRPI0920965-4A patent/BRPI0920965B1/pt not_active IP Right Cessation
- 2009-11-30 RU RU2011126353/13A patent/RU2523182C2/ru not_active IP Right Cessation
- 2009-11-30 SI SI200930470T patent/SI2370474T1/sl unknown
- 2009-11-30 WO PCT/EP2009/066060 patent/WO2010061005A1/en not_active Ceased
- 2009-11-30 PL PL09795949T patent/PL2370474T3/pl unknown
- 2009-11-30 JP JP2011537999A patent/JP5607061B2/ja active Active
- 2009-11-30 MX MX2011005528A patent/MX2011005528A/es active IP Right Grant
- 2009-11-30 CA CA2744892A patent/CA2744892C/en active Active
- 2009-11-30 EP EP09795949A patent/EP2370474B1/en active Active
- 2009-11-30 CN CN200980147761.7A patent/CN102227448B/zh active Active
- 2009-11-30 DK DK09795949.8T patent/DK2370474T3/da active
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2014
- 2014-11-13 US US14/507,474 patent/US9410000B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0920965B1 (pt) | 2019-07-09 |
| ITRM20080636A1 (it) | 2010-05-29 |
| HK1162546A1 (en) | 2012-08-31 |
| ES2397987T3 (es) | 2013-03-12 |
| WO2010061005A1 (en) | 2010-06-03 |
| RU2523182C2 (ru) | 2014-07-20 |
| CN102227448B (zh) | 2014-04-02 |
| CA2744892A1 (en) | 2010-06-03 |
| EP2370474B1 (en) | 2012-10-24 |
| CA2744892C (en) | 2016-10-25 |
| DK2370474T3 (da) | 2013-01-14 |
| EP2370474A1 (en) | 2011-10-05 |
| MX2011005528A (es) | 2011-08-17 |
| SI2370474T1 (sl) | 2013-02-28 |
| US9410000B2 (en) | 2016-08-09 |
| JP5607061B2 (ja) | 2014-10-15 |
| RU2011126353A (ru) | 2013-01-10 |
| JP2012510535A (ja) | 2012-05-10 |
| US20110236486A1 (en) | 2011-09-29 |
| US20150183891A1 (en) | 2015-07-02 |
| US8858999B2 (en) | 2014-10-14 |
| BRPI0920965A2 (pt) | 2016-09-06 |
| CN102227448A (zh) | 2011-10-26 |
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