RU2015154275A - Комбинации антитела против pd-l1 и ингибитора mek и/или ингибитора braf - Google Patents
Комбинации антитела против pd-l1 и ингибитора mek и/или ингибитора braf Download PDFInfo
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- RU2015154275A RU2015154275A RU2015154275A RU2015154275A RU2015154275A RU 2015154275 A RU2015154275 A RU 2015154275A RU 2015154275 A RU2015154275 A RU 2015154275A RU 2015154275 A RU2015154275 A RU 2015154275A RU 2015154275 A RU2015154275 A RU 2015154275A
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- 102000008096 B7-H1 Antigen Human genes 0.000 title 1
- 108010074708 B7-H1 Antigen Proteins 0.000 title 1
- 229940125431 BRAF inhibitor Drugs 0.000 title 1
- 229940124647 MEK inhibitor Drugs 0.000 title 1
- 239000012271 PD-L1 inhibitor Substances 0.000 title 1
- 239000002829 mitogen activated protein kinase inhibitor Substances 0.000 title 1
- 229940121656 pd-l1 inhibitor Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 12
- 206010028980 Neoplasm Diseases 0.000 claims 7
- 201000011510 cancer Diseases 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 6
- 239000012453 solvate Substances 0.000 claims 5
- 238000000034 method Methods 0.000 claims 4
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 2
- 229940126062 Compound A Drugs 0.000 claims 2
- 206010051066 Gastrointestinal stromal tumour Diseases 0.000 claims 2
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims 2
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- 229920002678 cellulose Polymers 0.000 claims 2
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- YKGMKSIHIVVYKY-UHFFFAOYSA-N dabrafenib mesylate Chemical class CS(O)(=O)=O.S1C(C(C)(C)C)=NC(C=2C(=C(NS(=O)(=O)C=3C(=CC=CC=3F)F)C=CC=2)F)=C1C1=CC=NC(N)=N1 YKGMKSIHIVVYKY-UHFFFAOYSA-N 0.000 claims 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N dimethyl sulfoxide Natural products CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
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- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 1
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- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 208000007452 Plasmacytoma Diseases 0.000 claims 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000000389 T-cell leukemia Diseases 0.000 claims 1
- 208000028530 T-cell lymphoblastic leukemia/lymphoma Diseases 0.000 claims 1
- 206010042971 T-cell lymphoma Diseases 0.000 claims 1
- 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 claims 1
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- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 206010047741 Vulval cancer Diseases 0.000 claims 1
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- 208000008383 Wilms tumor Diseases 0.000 claims 1
- 208000021841 acute erythroid leukemia Diseases 0.000 claims 1
- 208000037833 acute lymphoblastic T-cell leukemia Diseases 0.000 claims 1
- 208000013593 acute megakaryoblastic leukemia Diseases 0.000 claims 1
- 208000020700 acute megakaryocytic leukemia Diseases 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Claims (37)
1. Комбинация, содержащая:
(i) соединение формулы (I)
или его фармацевтически приемлемую соль или сольват;
(ii) соединение формулы (II)
или его фармацевтически приемлемую соль;
и (iii) антитело против PD-L1.
2. Комбинация по п.1, где соединение (i) находится в форме диметилсульфоксидного сольвата, а соединение (ii) находится в форме метансульфонатной соли.
3. Комбинированный набор, содержащий комбинацию по п.1 или 2 вместе с фармацевтически приемлемым носителем или носителями.
4. Применение комбинации по п.1 или 2 для получения лекарственного средства для лечения рака.
5. Комбинация по п.1 или 2 для применения в терапии.
6. Комбинация по п.1 или 2, предназначенная для лечения рака.
7. Фармацевтическая композиция, содержащая комбинацию по п. 1 или 2 вместе с фармацевтически приемлемым разбавителем или носителем.
8 8. Способ лечения рака у нуждающегося в этом человека, включающий введение терапевтически эффективного количества
(i) соединения формулы (I)
или его фармацевтически приемлемой соли или сольвата;
и
(ii) соединения формулы (II)
или его фармацевтически приемлемой соли;
и (iii) антитела против PD-L1.
9 9. Способ по п.8, где рак выбран из рака головы и шеи, рака молочной железы, рака легкого, колоректального рака, рака яичников, рака предстательной железы, глиомы, глиобластомы, астроцитомы, мультиформной глиобластомы, синдрома Банаян-Зонана, болезни Коудена, болезни Лермитт-Дуклоса, воспалительного рака молочной железы, опухоли Вильмса, саркомы Юинга, рабдомиосаркомы, эпендимомы, медуллобластомы, рака почки, рака печени, меланомы, рака поджелудочной железы, саркомы, остеосаркомы, гигантоклеточной опухоли кости, рака щитовидной железы, лимфобластного Т-клеточного лейкоза, хронического миелогенного лейкоза, хронического лимфоцитарного лейкоза, волосатоклеточного лейкоза, острого лимфобластного лейкоза, острого миелогенного лейкоза (AML), хронического нейтрофильного лейкоза, острого лимфобластного Т-клеточного лейкоза, плазмацитомы, иммунобластного крупноклеточного лейкоза, мантийноклеточного лейкоза, множественной миеломы, мегакариобластного лейкоза, множественной миеломы, острого мегакариоцитарного лейкоза, промиелоцитарного лейкоза, эритролейкоза, злокачественной лимфомы, ходжкинской лимфомы, неходжкинской лимфомы, лимфобластной Т-клеточной лимфомы, лимфомы Беркитта, фоликулярной лимфомы, нейробластомы, рака мочевого пузыря, уротелиального рака, рака вульвы, рака шейки матки, рака эндометрия, ренального рака, мезотелиомы, эзофагеального рака, рака слюнной железы, печеночно-клеточного рака, рака желудка, рака носоглотки, рака щеки, рака ротовой полости, GIST (гастроинтестинальной стромальной опухоли) и рака яичка.
10 10. Способ по п.п.8-9, где соединение (i) находится в форме диметилсульфоксидного сольвата и соединение (ii) находится в форме метансульфонатной соли.
11 11. Комбинация, содержащая соединение A, соединение B и антитело против PD-L1.
12 12. Способ лечения рака у нуждающегося в этом человека, включающий введение терапевтически эффективного количества комбинации соединения А, соединения В и антитела против PD-1.
13 13. Комбинация, содержащая:
(i) соединение формулы (I)
или его фармацевтически приемлемую соль или сольват; и
(ii) антитело против PD-L1.
14 14. Комбинация, содержащая:
(i) соединение формулы (II)
или его фармацевтически приемлемую соль; и
(ii) антитело против PD-L1.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361830220P | 2013-06-03 | 2013-06-03 | |
| US61/830,220 | 2013-06-03 | ||
| PCT/IB2014/061895 WO2014195852A1 (en) | 2013-06-03 | 2014-06-02 | Combinations of an anti-pd-l1 antibody and a mek inhibitor and/or a braf inhibitor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2015154275A true RU2015154275A (ru) | 2017-07-17 |
| RU2015154275A3 RU2015154275A3 (ru) | 2018-05-11 |
Family
ID=50943361
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015154275A RU2015154275A (ru) | 2013-06-03 | 2014-06-02 | Комбинации антитела против pd-l1 и ингибитора mek и/или ингибитора braf |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20160089434A1 (ru) |
| EP (1) | EP3003282A1 (ru) |
| JP (1) | JP2016520643A (ru) |
| KR (1) | KR20160013049A (ru) |
| CN (1) | CN105658206A (ru) |
| AU (3) | AU2014276440A1 (ru) |
| BR (1) | BR112015028326A8 (ru) |
| CA (1) | CA2909052A1 (ru) |
| CL (1) | CL2015003522A1 (ru) |
| HK (1) | HK1216231A1 (ru) |
| MA (1) | MA38643A1 (ru) |
| MX (1) | MX2015016592A (ru) |
| PH (1) | PH12015502415A1 (ru) |
| RU (1) | RU2015154275A (ru) |
| SG (1) | SG11201509742QA (ru) |
| TN (1) | TN2015000444A1 (ru) |
| WO (1) | WO2014195852A1 (ru) |
Families Citing this family (94)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2625292B1 (en) | 2010-10-07 | 2018-12-05 | The General Hospital Corporation | Biomarkers of cancer |
| BR122022000334B1 (pt) | 2011-08-01 | 2023-03-21 | Genentech, Inc | Composição farmacêutica compreendendo um antagonista de ligação ao eixo pd-1 e um inibidor de mek |
| US10570204B2 (en) | 2013-09-26 | 2020-02-25 | The Medical College Of Wisconsin, Inc. | Methods for treating hematologic cancers |
| LT3049441T (lt) | 2013-09-27 | 2020-02-10 | F. Hoffmann-La Roche Ag | Anti-pdl1 antikūnų kompozicija |
| PL3081576T3 (pl) | 2013-12-12 | 2020-03-31 | Shanghai Hengrui Pharmaceutical Co., Ltd. | Przeciwciało anty pd-1, jego fragment wiążący antygen i ich zastosowanie medyczne |
| MY189089A (en) * | 2013-12-17 | 2022-01-25 | Genentech Inc | Methods of treating cancers using pd-1 axis binding antagonists and taxanes |
| JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
| JOP20200096A1 (ar) | 2014-01-31 | 2017-06-16 | Children’S Medical Center Corp | جزيئات جسم مضاد لـ tim-3 واستخداماتها |
| EP3660050A1 (en) | 2014-03-14 | 2020-06-03 | Novartis AG | Antibody molecules to lag-3 and uses thereof |
| EP3760208B1 (en) | 2014-06-25 | 2024-05-29 | The General Hospital Corporation | Targeting human satellite ii (hsatii) |
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2014
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- 2014-06-02 WO PCT/IB2014/061895 patent/WO2014195852A1/en not_active Ceased
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- 2014-06-02 US US14/891,984 patent/US20160089434A1/en not_active Abandoned
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| CA2909052A1 (en) | 2014-12-11 |
| KR20160013049A (ko) | 2016-02-03 |
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| SG11201509742QA (en) | 2015-12-30 |
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| BR112015028326A2 (pt) | 2017-07-25 |
| CL2015003522A1 (es) | 2016-09-16 |
| TN2015000444A1 (en) | 2017-04-06 |
| EP3003282A1 (en) | 2016-04-13 |
| RU2015154275A3 (ru) | 2018-05-11 |
| AU2017202926A1 (en) | 2017-05-25 |
| US20160089434A1 (en) | 2016-03-31 |
| HK1216231A1 (zh) | 2016-10-28 |
| BR112015028326A8 (pt) | 2018-01-23 |
| AU2014276440A1 (en) | 2015-11-05 |
| JP2016520643A (ja) | 2016-07-14 |
| AU2019201366A1 (en) | 2019-03-21 |
| PH12015502415A1 (en) | 2016-02-22 |
| MA38643A1 (fr) | 2017-10-31 |
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