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RU2018102078A - Комбинированная терапия противоопухолевым алкалоидом - Google Patents

Комбинированная терапия противоопухолевым алкалоидом Download PDF

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RU2018102078A
RU2018102078A RU2018102078A RU2018102078A RU2018102078A RU 2018102078 A RU2018102078 A RU 2018102078A RU 2018102078 A RU2018102078 A RU 2018102078A RU 2018102078 A RU2018102078 A RU 2018102078A RU 2018102078 A RU2018102078 A RU 2018102078A
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cancer
synergistic combination
combination according
pharmaceutically acceptable
acceptable salt
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RU2018102078A
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RU2018102078A3 (ru
RU2757373C2 (ru
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ОКАНЬЯ Виктория МОНЕО
НУНЬЕС Хема САНТАМАРИЯ
ФЕРНАНДЕС Луис Франсиско ГАРСИА
Карлос Мария ГАЛМАРИНИ
НАВАРРО Мария Хосе ГИЛЬЕН
МАРИН Пабло Мануэль АВИЛЕС
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Фарма Мар, С.А.
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Claims (12)

1. Фармацевтическая синергическая комбинация для лечения рака, содержащая терапевтически эффективное количество РМ01183 или его фармацевтически приемлемой соли и терапевтически эффективное количество ингибитора митоза.
2. Синергическая комбинация по п. 1, где рак, подлежащий лечению, выбран из рака легкого, саркомы, злокачественной меланомы, рака мочевого пузыря, рака предстательной железы, рака поджелудочной железы, рака щитовидной железы, рака желудка, рака яичника, гепатомы, рака молочной железы, колоректального рака, рака почки, рака пищевода, нейробластомы, рака головного мозга, рака шейки матки, анального рака, рака яичка, лейкоза, множественной миеломы и лимфомы.
3. Синергическая комбинация по п. 2, где рак, подлежащий лечению, выбран из рака легкого, саркомы, рака предстательной железы, рака поджелудочной железы, рака желудка, рака яичника, гепатомы, рака молочной железы, колоректального рака, рака почки и рака головного мозга.
4. Синергическая комбинация по п. 1, где РМ01183 или его фармацевтически приемлемая соль и ингибитор митоза
5. Синергическая комбинация по п. 1, где РМ01183 или его фармацевтически приемлемая соль и ингибитор митоза представлены в форме отдельных лекарственных средств для введения в одно и то же время или в разное время.
6. Синергическая комбинация по п. 5, где РМ01183 или его фармацевтически приемлемая соль и ингибитор митоза представлены в форме отдельных лекарственных средств для введения в разное время.
7. Синергическая комбинация по п. 1, где ингибитор митоза выбран из паклитаксела, доцетаксела, винбластина, винкристина, виндезина и винорелбина.
8. Синергическая комбинация по п. 7, где ингибитор митоза выбран из паклитаксела, доцетаксела, винкристина и винорелбина.
9. Синергическая комбинация по п. 8, где ингибитор митоза представляет собой паклитаксел.
10. Способ лечения рака, включающий введение пациенту, который нуждается в указанном лечении, синергической комбинации по любому из пп. 1-9.
11. Применение синергической комбинации по любому из пп. 1-9 для лечения рака.
12. Применение синергической комбинации по любому из пп. 1-9 в производстве лекарственного средства для лечения рака.
RU2018102078A 2010-11-12 2018-01-19 Комбинированная терапия противоопухолевым алкалоидом RU2757373C2 (ru)

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RU2016144668A RU2743643C2 (ru) 2010-11-12 2011-11-11 Комбинированная терапия противоопухолевым алкалоидом
RU2018102080A RU2767664C2 (ru) 2010-11-12 2018-01-19 Комбинированная терапия противоопухолевым алкалоидом
RU2018102078A RU2757373C2 (ru) 2010-11-12 2018-01-19 Комбинированная терапия противоопухолевым алкалоидом

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RU2018102080A RU2767664C2 (ru) 2010-11-12 2018-01-19 Комбинированная терапия противоопухолевым алкалоидом

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US (5) US20130266666A1 (ru)
EP (6) EP2786756B1 (ru)
JP (4) JP6382516B2 (ru)
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