SI2488033T1 - Kombinacija, ki vsebuje inhibitor MEK in inhibitor B-RAF - Google Patents

Kombinacija, ki vsebuje inhibitor MEK in inhibitor B-RAF

Info

Publication number: SI2488033T1
Authority: SI; Slovenia
Prior art keywords: inhibitor; combination containing; raf; containing mek; mek inhibitor
Prior art date: 2009-10-16

Application number

SI201031933T

Other languages

English (en)

Inventor

Melissa Dumble

Rakesh Kumar

Sylvie Laquerre

Peter Lebowitz

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-10-16

Filing date

2010-10-15

Publication date

2019-10-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43876568&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI2488033(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2010-10-15 Application filed by Novartis Ag filed Critical Novartis Ag

2019-10-30 Publication of SI2488033T1 publication Critical patent/SI2488033T1/sl

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

SI201031933T 2009-10-16 2010-10-15 Kombinacija, ki vsebuje inhibitor MEK in inhibitor B-RAF SI2488033T1 (sl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US25221309P	2009-10-16	2009-10-16
EP10824148.0A EP2488033B1 (en)	2009-10-16	2010-10-15	Combination comprising an MEK inhibitor and a B-raf inhibitor
PCT/US2010/052808 WO2011047238A1 (en)	2009-10-16	2010-10-15	Combination

Publications (1)

Publication Number	Publication Date
SI2488033T1 true SI2488033T1 (sl)	2019-10-30

Family

ID=43876568

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
SI201031933T SI2488033T1 (sl)	2009-10-16	2010-10-15	Kombinacija, ki vsebuje inhibitor MEK in inhibitor B-RAF
SI201032148T SI4159217T1 (sl)	2009-10-16	2010-10-15	Kombinacija, ki vsebuje zaviralec MEK in zaviralec B-RAF

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
SI201032148T SI4159217T1 (sl)	2009-10-16	2010-10-15	Kombinacija, ki vsebuje zaviralec MEK in zaviralec B-RAF

Country Status (35)

Country	Link
US (3)	US8703781B2 (sl)
EP (4)	EP4159217B1 (sl)
JP (1)	JP5718929B2 (sl)
KR (1)	KR101729116B1 (sl)
CN (1)	CN102655753B (sl)
AU (1)	AU2010306653B2 (sl)
BR (1)	BR112012008854B8 (sl)
CA (1)	CA2775803C (sl)
CL (1)	CL2012000964A1 (sl)
CO (1)	CO6531498A2 (sl)
CR (1)	CR20120155A (sl)
CY (1)	CY1122013T1 (sl)
DK (3)	DK2488033T3 (sl)
DO (1)	DOP2012000091A (sl)
EA (1)	EA020589B1 (sl)
ES (3)	ES2986037T3 (sl)
FI (1)	FI4159217T3 (sl)
HR (2)	HRP20221304T1 (sl)
HU (3)	HUE067723T2 (sl)
IL (1)	IL219073A (sl)
LT (3)	LT3560498T (sl)
MA (1)	MA33746B1 (sl)
ME (1)	ME03497B (sl)
MX (1)	MX2012004413A (sl)
MY (1)	MY174759A (sl)
NZ (1)	NZ598913A (sl)
PE (1)	PE20121093A1 (sl)
PH (1)	PH12012500742A1 (sl)
PL (3)	PL3560498T3 (sl)
PT (3)	PT2488033T (sl)
RS (3)	RS63702B1 (sl)
SI (2)	SI2488033T1 (sl)
UA (1)	UA105064C2 (sl)
WO (1)	WO2011047238A1 (sl)
ZA (1)	ZA201202612B (sl)

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CN103965170A (zh) *	2013-01-24	2014-08-06	通化济达医药有限公司	苯磺酰胺吡唑激酶抑制剂
CA2904338C (en) *	2013-03-05	2022-07-05	University Of Tennessee Research Foundation	Use of imidazole derivatives in combination with a braf inhibitor or mek inhibitor in the treatment of cancer
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WO2015105822A1 (en) *	2014-01-07	2015-07-16	Glaxosmithkline Llc	Cancer treatment method
KR20170013891A (ko)	2014-05-06	2017-02-07	지티엑스, 인코포레이티드	암 치료용 화합물
KR101629184B1 (ko)	2014-12-10	2016-06-13	현대오트론 주식회사	Autosar 플랫폼에서의 eeprom 처리속도 향상을 위한 주기함수 호출 방법
WO2017033113A1 (en)	2015-08-21	2017-03-02	Acerta Pharma B.V.	Therapeutic combinations of a mek inhibitor and a btk inhibitor
EP3534905A4 (en) *	2016-11-03	2020-11-04	The Regents of The University of Michigan	EGFR / PI3K SMALL-MOLECULE DOUBLE INHIBITORS AND THEIR USES
JP2022504905A (ja)	2018-10-16	2022-01-13	ノバルティスアーゲー	標的化療法に対する応答を予測するためのバイオマーカーとしての単独の又は免疫マーカーと組み合わせた腫瘍突然変異負荷
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AU2020326612B2 (en)	2019-08-02	2025-10-23	Onehealthcompany, Inc.	Treatment of canine cancers
KR20220098759A (ko)	2019-11-08	2022-07-12	인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔)	키나제 억제제에 대해 내성을 획득한 암의 치료 방법
EP4073102A4 (en) *	2019-12-12	2024-05-08	Ting Therapeutics LLC	Compositions and methods for the prevention and treatment of hearing loss
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US20230084515A1 (en) *	2020-02-19	2023-03-16	Vanderbilt University	Therapeutic methods and compositions for treating cancer using braf and/or mek inhibitor combination therapy
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2010
- 2010-10-15 HU HUE22189749A patent/HUE067723T2/hu unknown
- 2010-10-15 PL PL19174594.2T patent/PL3560498T3/pl unknown
- 2010-10-15 SI SI201031933T patent/SI2488033T1/sl unknown
- 2010-10-15 BR BR112012008854A patent/BR112012008854B8/pt active IP Right Grant
- 2010-10-15 KR KR1020127012649A patent/KR101729116B1/ko active Active
- 2010-10-15 PL PL22189749.9T patent/PL4159217T3/pl unknown
- 2010-10-15 HR HRP20221304TT patent/HRP20221304T1/hr unknown
- 2010-10-15 MX MX2012004413A patent/MX2012004413A/es active IP Right Grant
- 2010-10-15 CN CN201080046640.6A patent/CN102655753B/zh active Active
- 2010-10-15 DK DK10824148.0T patent/DK2488033T3/da active
- 2010-10-15 LT LTEP19174594.2T patent/LT3560498T/lt unknown
- 2010-10-15 RS RS20220984A patent/RS63702B1/sr unknown
- 2010-10-15 PE PE2012000502A patent/PE20121093A1/es active IP Right Grant
- 2010-10-15 RS RS20240873A patent/RS65800B1/sr unknown
- 2010-10-15 LT LTEP22189749.9T patent/LT4159217T/lt unknown
- 2010-10-15 DK DK22189749.9T patent/DK4159217T3/da active
- 2010-10-15 PT PT10824148T patent/PT2488033T/pt unknown
- 2010-10-15 EP EP22189749.9A patent/EP4159217B1/en not_active Revoked
- 2010-10-15 PT PT221897499T patent/PT4159217T/pt unknown
- 2010-10-15 CA CA2775803A patent/CA2775803C/en active Active
- 2010-10-15 HR HRP20191617 patent/HRP20191617T1/hr unknown
- 2010-10-15 EA EA201290149A patent/EA020589B1/ru not_active IP Right Cessation
- 2010-10-15 PT PT191745942T patent/PT3560498T/pt unknown
- 2010-10-15 ES ES22189749T patent/ES2986037T3/es active Active
- 2010-10-15 LT LTEP10824148.0T patent/LT2488033T/lt unknown
- 2010-10-15 RS RSP20191095 patent/RS59181B1/sr unknown
- 2010-10-15 HU HUE10824148A patent/HUE046139T2/hu unknown
- 2010-10-15 JP JP2012534386A patent/JP5718929B2/ja active Active
- 2010-10-15 EP EP10824148.0A patent/EP2488033B1/en active Active
- 2010-10-15 NZ NZ598913A patent/NZ598913A/xx unknown
- 2010-10-15 ES ES19174594T patent/ES2930157T3/es active Active
- 2010-10-15 PL PL10824148T patent/PL2488033T3/pl unknown
- 2010-10-15 ES ES10824148T patent/ES2745479T3/es active Active
- 2010-10-15 HU HUE19174594A patent/HUE060206T2/hu unknown
- 2010-10-15 EP EP19174594.2A patent/EP3560498B1/en not_active Revoked
- 2010-10-15 FI FIEP22189749.9T patent/FI4159217T3/fi active
- 2010-10-15 EP EP24175377.1A patent/EP4397376B1/en active Active
- 2010-10-15 MY MYPI2012001680A patent/MY174759A/en unknown
- 2010-10-15 DK DK19174594.2T patent/DK3560498T3/da active
- 2010-10-15 UA UAA201204675A patent/UA105064C2/uk unknown
- 2010-10-15 SI SI201032148T patent/SI4159217T1/sl unknown
- 2010-10-15 WO PCT/US2010/052808 patent/WO2011047238A1/en not_active Ceased
- 2010-10-15 ME MEP-2019-236A patent/ME03497B/me unknown
- 2010-10-15 AU AU2010306653A patent/AU2010306653B2/en active Active
- 2010-10-15 PH PH1/2012/500742A patent/PH12012500742A1/en unknown
- 2010-10-15 US US13/499,779 patent/US8703781B2/en active Active
2012
- 2012-03-27 CR CR20120155A patent/CR20120155A/es unknown
- 2012-04-03 DO DO2012000091A patent/DOP2012000091A/es unknown
- 2012-04-05 IL IL219073A patent/IL219073A/en active IP Right Grant
- 2012-04-11 ZA ZA2012/02612A patent/ZA201202612B/en unknown
- 2012-04-16 CL CL2012000964A patent/CL2012000964A1/es unknown
- 2012-04-27 CO CO12069732A patent/CO6531498A2/es active IP Right Grant
- 2012-05-11 MA MA34863A patent/MA33746B1/fr unknown
2014
- 2014-03-05 US US14/197,421 patent/US8952018B2/en active Active
- 2014-12-22 US US14/578,804 patent/US20150111904A1/en not_active Abandoned
2019
- 2019-09-09 CY CY20191100943T patent/CY1122013T1/el unknown

Also Published As

Publication number	Publication date
EP2488033A1 (en)	2012-08-22
CL2012000964A1 (es)	2012-08-31
NZ598913A (en)	2013-11-29
DK4159217T3 (da)	2024-08-12
LT4159217T (lt)	2024-08-26
EP3560498A1 (en)	2019-10-30
EP2488033B1 (en)	2019-06-12
ES2930157T3 (es)	2022-12-07
CO6531498A2 (es)	2012-09-28
CA2775803A1 (en)	2011-04-21
PL2488033T3 (pl)	2019-12-31
RS65800B1 (sr)	2024-08-30
PH12012500742A1 (en)	2015-12-11
AU2010306653B2 (en)	2013-10-24
US8703781B2 (en)	2014-04-22
ZA201202612B (en)	2013-09-25
US20120196879A1 (en)	2012-08-02
MY174759A (en)	2020-05-13
EP4159217B1 (en)	2024-05-22
RS63702B1 (sr)	2022-11-30
JP5718929B2 (ja)	2015-05-13
CN102655753A (zh)	2012-09-05
BR112012008854B1 (pt)	2020-12-29
WO2011047238A1 (en)	2011-04-21
PT4159217T (pt)	2024-08-12
MX2012004413A (es)	2012-05-08
ME03497B (me)	2020-04-20
HRP20221304T1 (hr)	2022-12-23
EA201290149A1 (ru)	2012-11-30
PL4159217T3 (pl)	2024-09-30
DK2488033T3 (da)	2019-09-02
HUE060206T2 (hu)	2023-02-28
KR101729116B1 (ko)	2017-05-02
KR20120104547A (ko)	2012-09-21
DOP2012000091A (es)	2013-09-15
PE20121093A1 (es)	2012-09-04
EA020589B1 (ru)	2014-12-30
CA2775803C (en)	2017-11-21
SI4159217T1 (sl)	2024-09-30
EP4397376B1 (en)	2025-11-26
US20140187566A1 (en)	2014-07-03
IL219073A0 (en)	2012-06-28
US8952018B2 (en)	2015-02-10
HRP20191617T1 (hr)	2019-12-13
UA105064C2 (uk)	2014-04-10
JP2013508294A (ja)	2013-03-07
ES2745479T3 (es)	2020-03-02
US20150111904A1 (en)	2015-04-23
EP4159217A1 (en)	2023-04-05
LT2488033T (lt)	2019-09-10
PL3560498T3 (pl)	2022-12-12
BR112012008854B8 (pt)	2021-05-25
CY1122013T1 (el)	2020-10-14
PT2488033T (pt)	2019-09-10
MA33746B1 (fr)	2012-11-01
ES2986037T3 (es)	2024-11-08
CN102655753B (zh)	2015-11-25
HUE067723T2 (hu)	2024-11-28
LT3560498T (lt)	2022-11-25
EP3560498B1 (en)	2022-08-17
FI4159217T3 (fi)	2024-08-15
IL219073A (en)	2016-05-31
HUE046139T2 (hu)	2020-02-28
AU2010306653A1 (en)	2012-05-10
EP2488033A4 (en)	2014-04-30
EP4397376A2 (en)	2024-07-10
BR112012008854A2 (pt)	2015-09-22
EP4397376A3 (en)	2024-10-30
DK3560498T3 (da)	2022-11-14
RS59181B1 (sr)	2019-10-31
PT3560498T (pt)	2022-11-03
CR20120155A (es)	2012-07-05

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SI2488033T1 (sl)	2019-10-30	Kombinacija, ki vsebuje inhibitor MEK in inhibitor B-RAF
NL300891I2 (nl)	2017-11-21	Lotilaner en zouten daarvan
BRPI0907231A2 (pt)	2019-09-24	pirrolpirimidinas e pirrolpiridinas
DK3569256T3 (da)	2022-08-15	Stabiliserede fibronectin-domænesammensætninger, fremgangsmåder og anvendelser
AP3856A (en)	2016-10-31	Improvements in feedwells.
HRP20160737T1 (hr)	2016-07-15	Anti-her3-protutijela i njihove uporabe
BR112012001172A2 (pt)	2017-01-31	artigo, e, método
GB2469720B (en)	2015-03-04	Join-us call-log and call-answer messages
BRPI0913227A2 (pt)	2016-01-19	método, e objeto
BR112012002877A2 (pt)	2017-02-14	dilatador e conjunto.
GB0917044D0 (en)	2009-11-18	Agents, uses and methods
GB0917054D0 (en)	2009-11-11	Agents, uses and methods
BRPI1006030A2 (pt)	2016-05-10	reclinador de banco, e, banco
BRPI0908115A2 (pt)	2015-10-06	torneira
BRPI0919184A2 (pt)	2015-12-15	armazenamento e recuperação de mensagem.
EP2318697A4 (en)	2013-04-10	WAVE POWER UNIT AND USE THEREFOR
GB0808575D0 (en)	2008-06-18	Compilign and linking
IT1395580B1 (it)	2012-10-16	Dispositivo pelatore e macchina pelatrice
EP2247601A4 (en)	2011-01-19	THIAZOPYRIMIDINONE AND APPLICATIONS THEREOF
EP2339499A4 (en)	2012-05-09	MEMORY DEVICE, INFORMATION PROCESSING DEVICE AND PROGRAM
NL2001444A1 (nl)	2008-11-25	Stroomverwerkingsinrichting en opslaginrichting.
BR112012003860A2 (pt)	2015-09-01	Combinação, e, composição nutricional
IT1395488B1 (it)	2012-09-28	Contenitore, relativo sbozzato e metodo per realizzare detto contenitore.
PL2376479T3 (pl)	2016-09-30	Podstawione furanokarboksyamidy i ich zastosowanie
FR2935896B1 (fr)	2011-11-25	Prothese discale en polyetherethercetone.