PH12012500742A1 - Combination - Google Patents
CombinationInfo
- Publication number
- PH12012500742A1 PH12012500742A1 PH1/2012/500742A PH12012500742A PH12012500742A1 PH 12012500742 A1 PH12012500742 A1 PH 12012500742A1 PH 12012500742 A PH12012500742 A PH 12012500742A PH 12012500742 A1 PH12012500742 A1 PH 12012500742A1
- Authority
- PH
- Philippines
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- raf
- mek
- inhibitor
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
A novel combination comprising the MEK inhibitor N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)6,8-dimethyl;-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide, or a pharmaceutically acceptable salt or solvate thereof, with a B-Raf inhibitor, particularly N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising the same and methods of using such combinations and compositions in the treatment of conditions in which the inhibition of MEK and/or B-Raf is beneficial, eg. cancer.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25221309P | 2009-10-16 | 2009-10-16 | |
| PCT/US2010/052808 WO2011047238A1 (en) | 2009-10-16 | 2010-10-15 | Combination |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH12012500742A1 true PH12012500742A1 (en) | 2015-12-11 |
Family
ID=43876568
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH1/2012/500742A PH12012500742A1 (en) | 2009-10-16 | 2010-10-15 | Combination |
Country Status (35)
| Country | Link |
|---|---|
| US (3) | US8703781B2 (en) |
| EP (4) | EP4159217B1 (en) |
| JP (1) | JP5718929B2 (en) |
| KR (1) | KR101729116B1 (en) |
| CN (1) | CN102655753B (en) |
| AU (1) | AU2010306653B2 (en) |
| BR (1) | BR112012008854B8 (en) |
| CA (1) | CA2775803C (en) |
| CL (1) | CL2012000964A1 (en) |
| CO (1) | CO6531498A2 (en) |
| CR (1) | CR20120155A (en) |
| CY (1) | CY1122013T1 (en) |
| DK (3) | DK2488033T3 (en) |
| DO (1) | DOP2012000091A (en) |
| EA (1) | EA020589B1 (en) |
| ES (3) | ES2986037T3 (en) |
| FI (1) | FI4159217T3 (en) |
| HR (2) | HRP20221304T1 (en) |
| HU (3) | HUE067723T2 (en) |
| IL (1) | IL219073A (en) |
| LT (3) | LT3560498T (en) |
| MA (1) | MA33746B1 (en) |
| ME (1) | ME03497B (en) |
| MX (1) | MX2012004413A (en) |
| MY (1) | MY174759A (en) |
| NZ (1) | NZ598913A (en) |
| PE (1) | PE20121093A1 (en) |
| PH (1) | PH12012500742A1 (en) |
| PL (3) | PL3560498T3 (en) |
| PT (3) | PT2488033T (en) |
| RS (3) | RS63702B1 (en) |
| SI (2) | SI2488033T1 (en) |
| UA (1) | UA105064C2 (en) |
| WO (1) | WO2011047238A1 (en) |
| ZA (1) | ZA201202612B (en) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9029408B2 (en) | 2008-06-16 | 2015-05-12 | Gtx, Inc. | Compounds for treatment of cancer |
| US9447049B2 (en) | 2010-03-01 | 2016-09-20 | University Of Tennessee Research Foundation | Compounds for treatment of cancer |
| HUE060249T2 (en) | 2008-06-16 | 2023-02-28 | Univ Tennessee Res Found | Compounds for treatment of cancer |
| US11084811B2 (en) | 2010-03-01 | 2021-08-10 | Oncternal Therapeutics, Inc. | Compounds for treatment of cancer |
| AU2011224410B2 (en) * | 2010-03-09 | 2015-05-28 | Dana-Farber Cancer Institute, Inc. | Methods of diagnosing and treating cancer in patients having or developing resistance to a first cancer therapy |
| US20130217710A1 (en) * | 2010-11-05 | 2013-08-22 | Glaxosmithkline Intellectual Property (No.2) Limited | Methods for treating cancer |
| TWI505828B (en) | 2010-12-20 | 2015-11-01 | 葛蘭素史克智慧財產（第二）有限公司 | Novel pharmaceutical composition |
| WO2013087911A1 (en) | 2011-12-16 | 2013-06-20 | Synthon Biopharmaceuticals B.V. | Compounds and methods for treating inflammatory diseases |
| US20150147350A1 (en) * | 2011-12-22 | 2015-05-28 | Glaxosmithkline Llc | Method Of Treating Cancer With MEGEA3 Immunotherapeutic With BRAF Inhibitor And/Or MEK Inhibitor |
| WO2013144923A1 (en) * | 2012-03-30 | 2013-10-03 | Takeda Pharmaceutical Company Limited | Administration of a raf inhibitor and a mek inhibitor in the treatment of melanoma |
| CN104582706A (en) * | 2012-09-04 | 2015-04-29 | 葛兰素史克有限责任公司 | Ways to Adjuvant Cancer Treatment |
| JP2016503399A (en) * | 2012-10-25 | 2016-02-04 | ノバルティス アーゲー | combination |
| IL300664A (en) * | 2012-11-30 | 2023-04-01 | Novartis Ag | Novel pharmaceutical composition |
| CN103965170A (en) * | 2013-01-24 | 2014-08-06 | 通化济达医药有限公司 | Benzene sulfonamide pyrazole kinase inhibitor |
| CA2904338C (en) * | 2013-03-05 | 2022-07-05 | University Of Tennessee Research Foundation | Use of imidazole derivatives in combination with a braf inhibitor or mek inhibitor in the treatment of cancer |
| ES2822665T3 (en) | 2013-05-31 | 2021-05-04 | Merck Sharp & Dohme | Combination therapies for cancer |
| KR20160013049A (en) * | 2013-06-03 | 2016-02-03 | 노파르티스 아게 | Combinations of an anti-pd-l1 antibody and a mek inhibitor and/or a braf inhibitor |
| WO2015003571A1 (en) * | 2013-07-08 | 2015-01-15 | 杭州普晒医药科技有限公司 | Novel crystal form of dabrafenib mesylate and preparation method thereof |
| WO2015059677A1 (en) * | 2013-10-26 | 2015-04-30 | Glaxosmithkline Intellectual Property (No.2) Limited | Methods of treating cancer |
| CN103588767B (en) * | 2013-11-20 | 2016-01-20 | 苏州明锐医药科技有限公司 | The preparation method of Da Lafeini |
| WO2015087279A1 (en) * | 2013-12-12 | 2015-06-18 | Glaxosmithkline Intellectual Property (No.2) Limited | Combinations of trametinib, panitumumab and dabrafenib for the treatment of cancer |
| EP3378952B1 (en) | 2013-12-28 | 2020-02-05 | Guardant Health, Inc. | Methods and systems for detecting genetic variants |
| WO2015105822A1 (en) * | 2014-01-07 | 2015-07-16 | Glaxosmithkline Llc | Cancer treatment method |
| KR20170013891A (en) | 2014-05-06 | 2017-02-07 | 지티엑스, 인코포레이티드 | Compounds for treatment of cancer |
| KR101629184B1 (en) | 2014-12-10 | 2016-06-13 | 현대오트론 주식회사 | Method for calling periodic function to enhance process speed of EEPROM in AUTOSAR |
| WO2017033113A1 (en) | 2015-08-21 | 2017-03-02 | Acerta Pharma B.V. | Therapeutic combinations of a mek inhibitor and a btk inhibitor |
| EP3534905A4 (en) * | 2016-11-03 | 2020-11-04 | The Regents of The University of Michigan | SMALL MOLECULAR DUAL INHIBITORS OF EGFR / PI3K AND USES THEREOF |
| JP2022504905A (en) | 2018-10-16 | 2022-01-13 | ノバルティス アーゲー | Tumor mutation loading alone or in combination with immune markers as a biomarker to predict response to targeted therapy |
| AU2020242287A1 (en) | 2019-03-21 | 2021-09-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A Dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| CN112294965B (en) * | 2019-07-26 | 2023-03-14 | 苏州亚盛药业有限公司 | Pharmaceutical composition of MDM2 inhibitor and its use in preventing and/or treating diseases |
| AU2020326612B2 (en) | 2019-08-02 | 2025-10-23 | Onehealthcompany, Inc. | Treatment of canine cancers |
| KR20220098759A (en) | 2019-11-08 | 2022-07-12 | 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) | A method of treating cancer that has acquired resistance to a kinase inhibitor |
| EP4073102A4 (en) * | 2019-12-12 | 2024-05-08 | Ting Therapeutics LLC | COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF HEARING LOSS |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| US20230084515A1 (en) * | 2020-02-19 | 2023-03-16 | Vanderbilt University | Therapeutic methods and compositions for treating cancer using braf and/or mek inhibitor combination therapy |
| US12014835B2 (en) | 2020-02-19 | 2024-06-18 | Vanderbilt University | Methods for evaluating therapeutic benefit of combination therapies |
| WO2022195551A1 (en) | 2021-03-18 | 2022-09-22 | Novartis Ag | Biomarkers for cancer and methods of use thereof |
| AU2022381730A1 (en) * | 2021-11-02 | 2024-05-02 | Verastem, Inc. | Methods of treating abnormal cell growth |
| US20250032494A1 (en) | 2021-12-06 | 2025-01-30 | My Personal Therapeutics Ltd | A combination treatment for cancer |
| US11873296B2 (en) | 2022-06-07 | 2024-01-16 | Verastem, Inc. | Solid forms of a dual RAF/MEK inhibitor |
| TW202508595A (en) | 2023-05-04 | 2025-03-01 | 美商銳新醫藥公司 | Combination therapy for a ras related disease or disorder |
| WO2025034702A1 (en) | 2023-08-07 | 2025-02-13 | Revolution Medicines, Inc. | Rmc-6291 for use in the treatment of ras protein-related disease or disorder |
| WO2025073765A1 (en) | 2023-10-03 | 2025-04-10 | Institut National de la Santé et de la Recherche Médicale | Methods of prognosis and treatment of patients suffering from melanoma |
| WO2025080946A2 (en) | 2023-10-12 | 2025-04-17 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025240847A1 (en) | 2024-05-17 | 2025-11-20 | Revolution Medicines, Inc. | Ras inhibitors |
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| US5681835A (en) | 1994-04-25 | 1997-10-28 | Glaxo Wellcome Inc. | Non-steroidal ligands for the estrogen receptor |
| GB9716557D0 (en) | 1997-08-06 | 1997-10-08 | Glaxo Group Ltd | Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity |
| IL149150A0 (en) * | 1999-11-22 | 2002-12-01 | Smithkline Beecham Plc | 2-(4-(6-methoxy-naphthalene-2-yl)-5-pyridin-4-yl-1h-imidazole-2-yl)-2-methyl-derivatives, pharmaceutical compositions comprising them and use thereof as tie2 receptor kinase inhibitors |
| DE102004018198A1 (en) * | 2004-04-15 | 2005-11-03 | Merck Patent Gmbh | sulfonamides |
| US7378423B2 (en) | 2004-06-11 | 2008-05-27 | Japan Tobacco Inc. | Pyrimidine compound and medical use thereof |
| PT1761528E (en) * | 2004-06-11 | 2008-04-15 | Japan Tobacco Inc | 5-amino-2,4,7-trioxo-3,4,7,8-tetrahydro-2h-pyrido[2,3-d]pyrimidine derivatives and related compounds for the treatment of cancer |
| WO2008120004A1 (en) | 2007-04-02 | 2008-10-09 | Astrazeneca Ab | Combination of a mek- inhibitor and a b-raf inhibitor for the treatment of cancer |
| CA2694646C (en) | 2007-07-30 | 2017-09-05 | Ardea Biosciences, Inc. | Combinations of mek inhibitors and raf kinase inhibitors and uses thereof |
| UA103319C2 (en) | 2008-05-06 | 2013-10-10 | Глаксосмитклайн Ллк | Thiazole- and oxazole-benzene sulfonamide compounds |
-
2010
- 2010-10-15 HU HUE22189749A patent/HUE067723T2/en unknown
- 2010-10-15 PL PL19174594.2T patent/PL3560498T3/en unknown
- 2010-10-15 SI SI201031933T patent/SI2488033T1/en unknown
- 2010-10-15 BR BR112012008854A patent/BR112012008854B8/en active IP Right Grant
- 2010-10-15 KR KR1020127012649A patent/KR101729116B1/en active Active
- 2010-10-15 PL PL22189749.9T patent/PL4159217T3/en unknown
- 2010-10-15 HR HRP20221304TT patent/HRP20221304T1/en unknown
- 2010-10-15 MX MX2012004413A patent/MX2012004413A/en active IP Right Grant
- 2010-10-15 CN CN201080046640.6A patent/CN102655753B/en active Active
- 2010-10-15 DK DK10824148.0T patent/DK2488033T3/en active
- 2010-10-15 LT LTEP19174594.2T patent/LT3560498T/en unknown
- 2010-10-15 RS RS20220984A patent/RS63702B1/en unknown
- 2010-10-15 PE PE2012000502A patent/PE20121093A1/en active IP Right Grant
- 2010-10-15 RS RS20240873A patent/RS65800B1/en unknown
- 2010-10-15 LT LTEP22189749.9T patent/LT4159217T/en unknown
- 2010-10-15 DK DK22189749.9T patent/DK4159217T3/en active
- 2010-10-15 PT PT10824148T patent/PT2488033T/en unknown
- 2010-10-15 EP EP22189749.9A patent/EP4159217B1/en not_active Revoked
- 2010-10-15 PT PT221897499T patent/PT4159217T/en unknown
- 2010-10-15 CA CA2775803A patent/CA2775803C/en active Active
- 2010-10-15 HR HRP20191617 patent/HRP20191617T1/en unknown
- 2010-10-15 EA EA201290149A patent/EA020589B1/en not_active IP Right Cessation
- 2010-10-15 PT PT191745942T patent/PT3560498T/en unknown
- 2010-10-15 ES ES22189749T patent/ES2986037T3/en active Active
- 2010-10-15 LT LTEP10824148.0T patent/LT2488033T/en unknown
- 2010-10-15 RS RSP20191095 patent/RS59181B1/en unknown
- 2010-10-15 HU HUE10824148A patent/HUE046139T2/en unknown
- 2010-10-15 JP JP2012534386A patent/JP5718929B2/en active Active
- 2010-10-15 EP EP10824148.0A patent/EP2488033B1/en active Active
- 2010-10-15 NZ NZ598913A patent/NZ598913A/en unknown
- 2010-10-15 ES ES19174594T patent/ES2930157T3/en active Active
- 2010-10-15 PL PL10824148T patent/PL2488033T3/en unknown
- 2010-10-15 ES ES10824148T patent/ES2745479T3/en active Active
- 2010-10-15 HU HUE19174594A patent/HUE060206T2/en unknown
- 2010-10-15 EP EP19174594.2A patent/EP3560498B1/en not_active Revoked
- 2010-10-15 FI FIEP22189749.9T patent/FI4159217T3/en active
- 2010-10-15 EP EP24175377.1A patent/EP4397376B1/en active Active
- 2010-10-15 MY MYPI2012001680A patent/MY174759A/en unknown
- 2010-10-15 DK DK19174594.2T patent/DK3560498T3/en active
- 2010-10-15 UA UAA201204675A patent/UA105064C2/en unknown
- 2010-10-15 SI SI201032148T patent/SI4159217T1/en unknown
- 2010-10-15 WO PCT/US2010/052808 patent/WO2011047238A1/en not_active Ceased
- 2010-10-15 ME MEP-2019-236A patent/ME03497B/en unknown
- 2010-10-15 AU AU2010306653A patent/AU2010306653B2/en active Active
- 2010-10-15 PH PH1/2012/500742A patent/PH12012500742A1/en unknown
- 2010-10-15 US US13/499,779 patent/US8703781B2/en active Active
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2012
- 2012-03-27 CR CR20120155A patent/CR20120155A/en unknown
- 2012-04-03 DO DO2012000091A patent/DOP2012000091A/en unknown
- 2012-04-05 IL IL219073A patent/IL219073A/en active IP Right Grant
- 2012-04-11 ZA ZA2012/02612A patent/ZA201202612B/en unknown
- 2012-04-16 CL CL2012000964A patent/CL2012000964A1/en unknown
- 2012-04-27 CO CO12069732A patent/CO6531498A2/en active IP Right Grant
- 2012-05-11 MA MA34863A patent/MA33746B1/en unknown
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2014
- 2014-03-05 US US14/197,421 patent/US8952018B2/en active Active
- 2014-12-22 US US14/578,804 patent/US20150111904A1/en not_active Abandoned
-
2019
- 2019-09-09 CY CY20191100943T patent/CY1122013T1/en unknown
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