PT1828125E - Derivados de arilpiperazina e sua utilização como ligantes selectivos do receptor d3 da dopamina - Google Patents
Derivados de arilpiperazina e sua utilização como ligantes selectivos do receptor d3 da dopamina Download PDFInfo
- Publication number
- PT1828125E PT1828125E PT05822892T PT05822892T PT1828125E PT 1828125 E PT1828125 E PT 1828125E PT 05822892 T PT05822892 T PT 05822892T PT 05822892 T PT05822892 T PT 05822892T PT 1828125 E PT1828125 E PT 1828125E
- Authority
- PT
- Portugal
- Prior art keywords
- nrr
- alkylene
- polyfluoro
- alkyl
- dopamine
- Prior art date
Links
- 102000004073 Dopamine D3 Receptors Human genes 0.000 title abstract 3
- 108090000525 Dopamine D3 Receptors Proteins 0.000 title abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- 125000003709 fluoroalkyl group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- KOAGTIYEJARZPM-UHFFFAOYSA-N 1-(5-methoxy-1,3-dihydroisoindol-2-yl)-6-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]hexan-1-one Chemical compound C1C2=CC(OC)=CC=C2CN1C(=O)CCCCCN(CC1)CCN1C1=CC=CC(C(F)(F)F)=C1 KOAGTIYEJARZPM-UHFFFAOYSA-N 0.000 abstract 1
- 230000002075 anti-alcohol Effects 0.000 abstract 1
- 230000001430 anti-depressive effect Effects 0.000 abstract 1
- 230000000648 anti-parkinson Effects 0.000 abstract 1
- 230000002738 anti-smoking effect Effects 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- 239000000729 antidote Substances 0.000 abstract 1
- 239000000939 antiparkinson agent Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 210000005260 human cell Anatomy 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000003176 neuroleptic agent Substances 0.000 abstract 1
- 230000000701 neuroleptic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Psychology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0412763A FR2878524B1 (fr) | 2004-12-01 | 2004-12-01 | Nouveaux derives d'arylpiperazine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1828125E true PT1828125E (pt) | 2008-08-22 |
Family
ID=34951009
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT05822892T PT1828125E (pt) | 2004-12-01 | 2005-11-29 | Derivados de arilpiperazina e sua utilização como ligantes selectivos do receptor d3 da dopamina |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20080214542A1 (pt) |
| EP (1) | EP1828125B1 (pt) |
| AT (1) | ATE391711T1 (pt) |
| DE (1) | DE602005006018T2 (pt) |
| DK (1) | DK1828125T3 (pt) |
| ES (1) | ES2302254T3 (pt) |
| FR (1) | FR2878524B1 (pt) |
| HR (1) | HRP20080187T3 (pt) |
| PL (1) | PL1828125T3 (pt) |
| PT (1) | PT1828125E (pt) |
| SI (1) | SI1828125T1 (pt) |
| WO (1) | WO2006058993A1 (pt) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2593266A1 (en) * | 2005-01-03 | 2006-07-13 | Universita Degli Studi Di Siena | Aryl piperazine derivatives for the treatment of neuropsychiatric disorders |
| EP1870405A1 (en) * | 2006-06-22 | 2007-12-26 | Bioprojet | Carbonylated (Aza)cyclohexanes as dopamine D3 receptor ligands |
| EP2238125A1 (en) * | 2008-02-01 | 2010-10-13 | NeuroSearch A/S | Novel aryl piperazine derivatives useful as modulators of dopamine and serotonin receptors |
| EP2257531A1 (en) * | 2008-03-14 | 2010-12-08 | NeuroSearch A/S | Novel quinolinylamide derivatives useful as modulators of dopamine and serotonin receptors |
| WO2010040274A1 (zh) | 2008-10-10 | 2010-04-15 | 中国人民解放军军事医学科学院毒物药物研究所 | 新型多巴胺d3受体配体，其制备方法及其医药用途 |
| US9227944B2 (en) | 2008-10-10 | 2016-01-05 | Institute Of Pharmacology And Toxicology Academy Of Military Science P.L.A. China | Dopamine D3 receptor ligands and preparation and medical uses of the same |
| WO2014079504A1 (en) * | 2012-11-22 | 2014-05-30 | Biofordrug S.R.L. | Polycyclic ligands of 5-ht7 receptor and use thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5523299A (en) * | 1992-08-06 | 1996-06-04 | Smithkline Beecham Plc | 5-(2-oxyphenyl)-pyrrole derivatives as dopamine D3 receptor antagonists |
| US5523229A (en) * | 1994-03-22 | 1996-06-04 | Trustees Of The University Of Pennsylvania | Antibodies specific for oncofetal fibronectin |
| PL355502A1 (en) * | 1999-12-30 | 2004-05-04 | H.Lundbeck A/S | 4-phenyl-1-piperazinyl, -piperidinyl and -tetrahydropyridyl derivatives |
| AU2003215558A1 (en) * | 2002-02-13 | 2003-09-04 | Glaxo Group Limited | Benzenesulfonamide derivatives as antipsychotic agents |
| US20040204422A1 (en) * | 2003-04-14 | 2004-10-14 | Abbott Gmbh & Co. Kg. | N-[(Piperazinyl)hetaryl]arylsulfonamide compounds |
-
2004
- 2004-12-01 FR FR0412763A patent/FR2878524B1/fr not_active Expired - Fee Related
-
2005
- 2005-11-29 DE DE602005006018T patent/DE602005006018T2/de not_active Expired - Fee Related
- 2005-11-29 AT AT05822892T patent/ATE391711T1/de not_active IP Right Cessation
- 2005-11-29 DK DK05822892T patent/DK1828125T3/da active
- 2005-11-29 ES ES05822892T patent/ES2302254T3/es not_active Expired - Lifetime
- 2005-11-29 PT PT05822892T patent/PT1828125E/pt unknown
- 2005-11-29 EP EP05822892A patent/EP1828125B1/fr not_active Expired - Lifetime
- 2005-11-29 PL PL05822892T patent/PL1828125T3/pl unknown
- 2005-11-29 WO PCT/FR2005/002964 patent/WO2006058993A1/fr not_active Ceased
- 2005-11-29 HR HR20080187T patent/HRP20080187T3/xx unknown
- 2005-11-29 SI SI200530267T patent/SI1828125T1/sl unknown
- 2005-11-29 US US11/720,526 patent/US20080214542A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ES2302254T3 (es) | 2008-07-01 |
| US20080214542A1 (en) | 2008-09-04 |
| DE602005006018T2 (de) | 2008-07-10 |
| EP1828125A1 (fr) | 2007-09-05 |
| FR2878524A1 (fr) | 2006-06-02 |
| WO2006058993A1 (fr) | 2006-06-08 |
| DE602005006018D1 (de) | 2008-05-21 |
| EP1828125B1 (fr) | 2008-04-09 |
| HRP20080187T3 (hr) | 2008-05-31 |
| DK1828125T3 (da) | 2008-08-04 |
| ATE391711T1 (de) | 2008-04-15 |
| FR2878524B1 (fr) | 2007-01-19 |
| SI1828125T1 (sl) | 2008-08-31 |
| PL1828125T3 (pl) | 2008-09-30 |
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