TW200634008A - Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition - Google Patents
Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibitionInfo
- Publication number
- TW200634008A TW200634008A TW094142937A TW94142937A TW200634008A TW 200634008 A TW200634008 A TW 200634008A TW 094142937 A TW094142937 A TW 094142937A TW 94142937 A TW94142937 A TW 94142937A TW 200634008 A TW200634008 A TW 200634008A
- Authority
- TW
- Taiwan
- Prior art keywords
- serotonin reuptake
- combination
- reuptake inhibition
- phenylpiperazine derivatives
- receptor agonism
- Prior art date
Links
- 230000005764 inhibitory process Effects 0.000 title abstract 2
- YZTJYBJCZXZGCT-UHFFFAOYSA-N phenylpiperazine Chemical class C1CNCCN1C1=CC=CC=C1 YZTJYBJCZXZGCT-UHFFFAOYSA-N 0.000 title abstract 2
- 230000000697 serotonin reuptake Effects 0.000 title abstract 2
- 102000004980 Dopamine D2 Receptors Human genes 0.000 title 1
- 108090001111 Dopamine D2 Receptors Proteins 0.000 title 1
- 230000008484 agonism Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000001204 N-oxides Chemical class 0.000 abstract 2
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000009977 dual effect Effects 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to a group of novel phenylpiperazine derivatives with a dual mode of action: serotonin reuptake inhibition and partial agonismondopamine-D2 receptors. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. The compounds have the general formula (1): wherein the symbols have the meanings given in the specification, and tautomers, stereoisomers and N-oxides thereof, as well as pharmacologically acceptable salts, hydrates and solvates of said compounds of formula (1) and its tautomers, stereoisomers and N-oxides.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04106394 | 2004-12-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW200634008A true TW200634008A (en) | 2006-10-01 |
Family
ID=34930019
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW094142952A TW200628457A (en) | 2004-12-08 | 2005-12-06 | Aryloxyethylamine and phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition |
| TW094142936A TW200626565A (en) | 2004-12-08 | 2005-12-06 | Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition |
| TW094142941A TW200634009A (en) | 2004-12-08 | 2005-12-06 | Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition |
| TW094142937A TW200634008A (en) | 2004-12-08 | 2005-12-06 | Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW094142952A TW200628457A (en) | 2004-12-08 | 2005-12-06 | Aryloxyethylamine and phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition |
| TW094142936A TW200626565A (en) | 2004-12-08 | 2005-12-06 | Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition |
| TW094142941A TW200634009A (en) | 2004-12-08 | 2005-12-06 | Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition |
Country Status (7)
| Country | Link |
|---|---|
| CN (4) | CN101072558A (en) |
| AR (4) | AR052261A1 (en) |
| BR (3) | BRPI0518621A2 (en) |
| MX (4) | MX2007006818A (en) |
| SA (2) | SA05260391B1 (en) |
| TW (4) | TW200628457A (en) |
| ZA (2) | ZA200704217B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103360342B (en) * | 2012-04-09 | 2015-12-16 | 江苏恩华药业股份有限公司 | 3-cyano-aniline alkylaryl bridged piperazine derivatives and preparing the application in medicine |
| CN103073524B (en) * | 2013-01-25 | 2015-06-10 | 宁波市微循环与莨菪类药研究所 | 4-[4-(substituted phenyl) piperazine piperazinyl-1]-butylcarbamic acid substituted aromatic ester derivative and preparation method thereof |
-
2005
- 2005-12-06 MX MX2007006818A patent/MX2007006818A/en not_active Application Discontinuation
- 2005-12-06 MX MX2007006815A patent/MX2007006815A/en active IP Right Grant
- 2005-12-06 SA SA05260391A patent/SA05260391B1/en unknown
- 2005-12-06 CN CNA2005800421758A patent/CN101072558A/en active Pending
- 2005-12-06 MX MX2007006816A patent/MX2007006816A/en not_active Application Discontinuation
- 2005-12-06 AR ARP050105093A patent/AR052261A1/en not_active Application Discontinuation
- 2005-12-06 BR BRPI0518621-8A patent/BRPI0518621A2/en not_active IP Right Cessation
- 2005-12-06 TW TW094142952A patent/TW200628457A/en unknown
- 2005-12-06 MX MX2007006817A patent/MX2007006817A/en active IP Right Grant
- 2005-12-06 BR BRPI0518620-0A patent/BRPI0518620A2/en not_active IP Right Cessation
- 2005-12-06 BR BRPI0518862-8A patent/BRPI0518862A2/en not_active IP Right Cessation
- 2005-12-06 SA SA05260387A patent/SA05260387B1/en unknown
- 2005-12-06 CN CNA2005800422248A patent/CN101119722A/en active Pending
- 2005-12-06 TW TW094142936A patent/TW200626565A/en unknown
- 2005-12-06 CN CNA2005800422159A patent/CN101072559A/en active Pending
- 2005-12-06 CN CNA2005800422214A patent/CN101072560A/en active Pending
- 2005-12-06 AR ARP050105092A patent/AR052260A1/en not_active Application Discontinuation
- 2005-12-06 AR ARP050105091A patent/AR052259A1/en not_active Application Discontinuation
- 2005-12-06 TW TW094142941A patent/TW200634009A/en unknown
- 2005-12-06 TW TW094142937A patent/TW200634008A/en unknown
- 2005-12-06 AR ARP050105094A patent/AR052147A1/en not_active Application Discontinuation
-
2007
- 2007-05-23 ZA ZA200704217A patent/ZA200704217B/en unknown
- 2007-05-23 ZA ZA200704219A patent/ZA200704219B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0518621A2 (en) | 2008-12-02 |
| TW200634009A (en) | 2006-10-01 |
| MX2007006818A (en) | 2007-11-09 |
| ZA200704219B (en) | 2008-05-28 |
| AR052259A1 (en) | 2007-03-07 |
| MX2007006816A (en) | 2007-07-24 |
| BRPI0518862A2 (en) | 2008-12-09 |
| AR052147A1 (en) | 2007-03-07 |
| MX2007006817A (en) | 2007-07-24 |
| AR052261A1 (en) | 2007-03-07 |
| CN101072558A (en) | 2007-11-14 |
| TW200628457A (en) | 2006-08-16 |
| CN101072560A (en) | 2007-11-14 |
| SA05260391B1 (en) | 2009-04-01 |
| CN101072559A (en) | 2007-11-14 |
| MX2007006815A (en) | 2007-11-09 |
| ZA200704217B (en) | 2008-12-31 |
| SA05260387B1 (en) | 2009-07-29 |
| TW200626565A (en) | 2006-08-01 |
| CN101119722A (en) | 2008-02-06 |
| BRPI0518620A2 (en) | 2008-12-02 |
| AR052260A1 (en) | 2007-03-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL183064A0 (en) | Phenylpiperazine derivatives with a combination of partial dopamine-d2 receptor agonism and serotonin reuptake inhibition | |
| MX2009004900A (en) | Thiazole and oxazole-substituted arylamides. | |
| TW200732313A (en) | Oxazolidinone compounds and their use as metabotropic glutamate receptor potentiators | |
| HRP20130614T1 (en) | Novel pyrazole-substituted arylamides | |
| TW200531694A (en) | Acetylinic piperazine compounds and their use as metabotropic glutamate receptor antagonists | |
| TNSN07006A1 (en) | Novel heterocyclic compounds | |
| DE60317333D1 (en) | TETRACYCLIC ARYLSULFONYLINDOLE WITH AFFINITY TO THE SEROTONIN RECEPTOR | |
| PL1831152T3 (en) | Tetralin and indane derivatives and uses thereof as 5-ht antagonists | |
| WO2007017728A3 (en) | Novel heterocyclic compounds | |
| TW200704633A (en) | Process for the preparation of sulfonamide derivatives | |
| TW200639177A (en) | Dihydroimidazothiazole derivatives | |
| TW200634008A (en) | Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition | |
| TW200631952A (en) | Benzdioxan piperazine derivatives with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites | |
| TW200633987A (en) | Phenylpiperazines with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites | |
| WO2007004041A3 (en) | New compounds and their pharmaceutical use | |
| WO2006109146A3 (en) | Novel heterocyclic derivatives | |
| WO2007007161A3 (en) | Novel bio-active derivatives | |
| WO2006126074A3 (en) | Heterocyclic derivatives | |
| TW200626575A (en) | Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites | |
| IL206763A0 (en) | Novel imidazolinylmethyl aryl sulfonamides | |
| NO20073390L (en) | Phenylpiperazines with a combination of affinity for dopamine D2 receptors and serotonin reuptake sites | |
| NO20073387L (en) | Benz dioxane piperazine derivatives with a combination of affinity for dopamine D2 receptors and serotonin reuptake sites | |
| NO20073389L (en) | Tetrahydropyridin-4-ylndoles with a combination of affinity for dopamine D2 receptors and serotonin reuptake sites |