UA95766C2 - Производные терфенила для лечения болезни альцгеймера - Google Patents

Производные терфенила для лечения болезни альцгеймера

Info

Publication number: UA95766C2
Authority: UA; Ukraine
Prior art keywords: alzheimer; disease; treatment; terphenyl derivatives; compounds
Prior art date: 2006-04-21

Application number

UAA200813475A

Other languages

English (en)

Ukrainian (uk)

Inventor

Френсис Вильсон

Элисон Рид

Валери Ридер

Ричард Джон Херрисон

Михиро Сунозе

Ремедиос Эрнадес-Перни

Джереми Мейджор

Сирилл Буссар

Катрин Смелт

Джесс Тейлор

Аделин Леформал

Эндрю Кенсфилд

Свеня Бурккхардт

Чих Юнг Хо

Ян Жанг

Original Assignee

Орто-Макнил-Дженссен Фармасьютикалз, Инк.

Целльзом Лтд.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-04-21

Filing date

2007-04-19

Publication date

2011-08-25

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36293499&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA95766(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2007-04-19 Application filed by Орто-Макнил-Дженссен Фармасьютикалз, Инк., Целльзом Лтд. filed Critical Орто-Макнил-Дженссен Фармасьютикалз, Инк.

2011-08-25 Publication of UA95766C2 publication Critical patent/UA95766C2/ru

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
- C07C57/38—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
- C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
- C07C63/33—Polycyclic acids
- C07C63/331—Polycyclic acids with all carboxyl groups bound to non-condensed rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/62—Halogen-containing esters
- C07C69/65—Halogen-containing esters of unsaturated acids

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Medicinal Chemistry (AREA)
Neurosurgery (AREA)
Oil, Petroleum & Natural Gas (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Plural Heterocyclic Compounds (AREA)

UAA200813475A 2006-04-21 2007-04-19 Производные терфенила для лечения болезни альцгеймера UA95766C2 (ru)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP06112934A EP1847524B1 (en)	2006-04-21	2006-04-21	Terphenyl derivatives for treatment of Alzheimer's disease

Publications (1)

Publication Number	Publication Date
UA95766C2 true UA95766C2 (ru)	2011-08-25

Family

ID=36293499

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UAA200813475A UA95766C2 (ru)	2006-04-21	2007-04-19	Производные терфенила для лечения болезни альцгеймера

Country Status (34)

Country	Link
US (1)	US8106236B2 (ru)
EP (2)	EP1847524B1 (ru)
JP (1)	JP5422827B2 (ru)
KR (1)	KR101494906B1 (ru)
CN (1)	CN101484410B (ru)
AR (1)	AR060621A1 (ru)
AT (1)	ATE445586T1 (ru)
AU (1)	AU2007240382B2 (ru)
BR (1)	BRPI0710632A2 (ru)
CA (1)	CA2649845C (ru)
CR (2)	CR10376A (ru)
CY (1)	CY1109729T1 (ru)
DE (1)	DE602006009764D1 (ru)
DK (1)	DK1847524T3 (ru)
EA (1)	EA016908B1 (ru)
ES (2)	ES2333539T3 (ru)
GE (1)	GEP20115211B (ru)
IL (2)	IL194789A0 (ru)
MA (1)	MA30420B1 (ru)
MX (1)	MX2008013447A (ru)
MY (1)	MY148988A (ru)
NO (1)	NO20084516L (ru)
NZ (1)	NZ572999A (ru)
PE (1)	PE20080267A1 (ru)
PL (1)	PL1847524T3 (ru)
PT (1)	PT1847524E (ru)
SI (1)	SI1847524T1 (ru)
SM (1)	SMP200800062B (ru)
TN (1)	TNSN08414A1 (ru)
TW (1)	TWI435720B (ru)
UA (1)	UA95766C2 (ru)
UY (1)	UY30300A1 (ru)
WO (1)	WO2007124351A1 (ru)
ZA (1)	ZA200809857B (ru)

Families Citing this family (16)

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DE602006009764D1 (de)	2006-04-21	2009-11-26	Cellzome Ltd	Terphenylderivate zur Alzheimerbehandlung
AU2008312355B2 (en)	2007-10-19	2013-07-04	Janssen Pharmaceutica, N.V.	Carbon linked modulators of y-secretase
ES2378594T3 (es)	2007-10-19	2012-04-16	Janssen Pharmaceutica, N.V.	Moduladores de piperidinilo y piperazinilo de la y-secretasa
WO2009052341A1 (en) *	2007-10-19	2009-04-23	Janssen Pharmaceutica, N.V.	Gsm intermediates
CN101903335A (zh)	2007-10-19	2010-12-01	詹森药业有限公司	连接有胺的γ-分泌酶调节剂
US20110092554A1 (en) *	2007-11-19	2011-04-21	Richard Chesworth	1,3,5 tri-subtituted benzenes for treatment of alzheimer's disease and other disorders
CA2707492A1 (en) *	2007-12-13	2009-06-18	Amgen Inc.	Gamma secretase modulators
US8217064B2 (en)	2007-12-20	2012-07-10	Envivo Pharmaceuticals, Inc.	Tetrasubstituted benzenes
BRPI0908837A2 (pt) *	2008-03-11	2015-07-21	Neurosearch As	Derivado de triarila, composição farmacêutica, uso de um derivado de triarila, e, método para tratar, prevenir ou para o alívio de uma doença, um distúrbio ou uma condição de um corpo de animal vivo
US7968725B2 (en) *	2008-07-22	2011-06-28	Janssen Pharmaceutica N.V.	Pyridinyl modulators of γ-secretase
EP2681208B1 (en) *	2011-03-03	2016-05-18	Denovamed Inc.	Antimicrobial/adjuvant compounds
CN103012200B (zh) *	2011-09-20	2014-12-17	北京大学	具有β-分泌酶抑制功能的化合物及其制备方法与应用
WO2015109109A1 (en)	2014-01-15	2015-07-23	Forum Pharmaceuticals Inc.	Fused morpholinopyrimidines and methods of use thereof
US9802927B2 (en)	2015-06-10	2017-10-31	Denali Therapeutics, Inc.	Oxadiazine compounds and methods of use thereof
IL287843B2 (en) *	2019-05-15	2025-05-01	Chemocentryx Inc	Triaryl compounds for the treatment of PD-L1 diseases
WO2022114105A1 (ja) *	2020-11-27	2022-06-02	ミライラボバイオサイエンス株式会社	高純度βニコチンアミドモノヌクレオチド（ＮＭＮ）及びその製造方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH08325182A (ja) *	1995-05-31	1996-12-10	Fuji Yakuhin Kogyo Kk	置換テルフェニル誘導体とそれらを含有する抗血栓剤
FR2767525B1 (fr) *	1997-08-21	1999-11-12	Cird Galderma	Derives biphenyliques substitues par un radical aromatique ou heteroaromatique et compositions pharmaceutiques et cosmetiques les contenant
JP2002544258A (ja)	1999-05-12	2002-12-24	ニューロサーチ、アクティーゼルスカブ	イオンチャネル調節剤
AU2001257022B2 (en)	2000-04-13	2005-02-03	Mayo Foundation For Medical Education And Research	Abeta 42 lowering agents
CA2405170A1 (en)	2000-04-24	2001-11-01	Merck Frosst Canada & Co.	Method of treatment using phenyl and biaryl derivatives as prostaglandin e inhibitors and compounds useful therefore
WO2002066552A1 (en) *	2001-02-20	2002-08-29	Isis Innovation Limited	Metal-containing dendrimers
FR2838439B1 (fr) *	2002-04-11	2005-05-20	Sanofi Synthelabo	Derives de terphenyle, leur preparation, les compositions pharmaceutqiues en contenant
CA2506114A1 (en) *	2002-12-05	2004-06-24	Axys Pharmaceuticals, Inc.	Cyanomethyl derivatives as cysteine protease inhibitors
GB0305918D0 (en)	2003-03-14	2003-04-23	Glaxo Group Ltd	Novel compounds
AU2004234190A1 (en) *	2003-04-30	2004-11-11	Merck Frosst Canada Ltd	8-(3-biaryl)phenylquinoline phosphodiesterase-4-inhibitors
WO2005110963A1 (en)	2004-05-19	2005-11-24	Cellzome Ag	(biphenyl-3-yl)-carboxylic acids and derivatives thereof and their use in therapy
GB0416508D0 (en)	2004-07-23	2004-08-25	Merck Sharp & Dohme	Therapeutic agents
ES2376642T3 (es) *	2005-08-15	2012-03-15	F. Hoffmann-La Roche Ag	Derivados de piperidina y de piperazina como antagonistas del p2x3.
EP1937632A1 (en)	2005-10-06	2008-07-02	Astra Zeneca AB	Novel compounds
DE602006009764D1 (de)	2006-04-21	2009-11-26	Cellzome Ltd	Terphenylderivate zur Alzheimerbehandlung

2006
- 2006-04-21 DE DE602006009764T patent/DE602006009764D1/de active Active
- 2006-04-21 EP EP06112934A patent/EP1847524B1/en not_active Not-in-force
- 2006-04-21 ES ES06112934T patent/ES2333539T3/es active Active
- 2006-04-21 SI SI200630509T patent/SI1847524T1/sl unknown
- 2006-04-21 PL PL06112934T patent/PL1847524T3/pl unknown
- 2006-04-21 AT AT06112934T patent/ATE445586T1/de active
- 2006-04-21 PT PT06112934T patent/PT1847524E/pt unknown
- 2006-04-21 DK DK06112934T patent/DK1847524T3/da active
2007
- 2007-04-19 MX MX2008013447A patent/MX2008013447A/es active IP Right Grant
- 2007-04-19 KR KR1020087028470A patent/KR101494906B1/ko not_active Expired - Fee Related
- 2007-04-19 JP JP2009506772A patent/JP5422827B2/ja not_active Expired - Fee Related
- 2007-04-19 US US11/737,475 patent/US8106236B2/en not_active Expired - Fee Related
- 2007-04-19 BR BRPI0710632-7A patent/BRPI0710632A2/pt not_active IP Right Cessation
- 2007-04-19 WO PCT/US2007/066951 patent/WO2007124351A1/en not_active Ceased
- 2007-04-19 GE GEAP200710984A patent/GEP20115211B/en unknown
- 2007-04-19 CA CA2649845A patent/CA2649845C/en not_active Expired - Fee Related
- 2007-04-19 CN CN2007800184982A patent/CN101484410B/zh not_active Expired - Fee Related
- 2007-04-19 MY MYPI20084202A patent/MY148988A/en unknown
- 2007-04-19 NZ NZ572999A patent/NZ572999A/en not_active IP Right Cessation
- 2007-04-19 UA UAA200813475A patent/UA95766C2/ru unknown
- 2007-04-19 ES ES07760900T patent/ES2392352T3/es active Active
- 2007-04-19 EA EA200802173A patent/EA016908B1/ru not_active IP Right Cessation
- 2007-04-19 SM SM200800062T patent/SMP200800062B/it unknown
- 2007-04-19 EP EP07760900A patent/EP2016039B1/en active Active
- 2007-04-19 AU AU2007240382A patent/AU2007240382B2/en not_active Ceased
- 2007-04-20 PE PE2007000497A patent/PE20080267A1/es not_active Application Discontinuation
- 2007-04-20 AR ARP070101724A patent/AR060621A1/es not_active Application Discontinuation
- 2007-04-20 UY UY30300A patent/UY30300A1/es unknown
- 2007-04-20 TW TW096114164A patent/TWI435720B/zh not_active IP Right Cessation
2008
- 2008-10-17 TN TNP2008000414A patent/TNSN08414A1/en unknown
- 2008-10-17 CR CR10376A patent/CR10376A/es not_active Application Discontinuation
- 2008-10-22 IL IL194789A patent/IL194789A0/en not_active IP Right Cessation
- 2008-10-22 IL IL194853A patent/IL194853A0/en unknown
- 2008-10-27 NO NO20084516A patent/NO20084516L/no not_active Application Discontinuation
- 2008-11-19 ZA ZA200809857A patent/ZA200809857B/xx unknown
- 2008-11-20 MA MA31394A patent/MA30420B1/fr unknown
- 2008-11-21 CR CR10452A patent/CR10452A/es unknown
2010
- 2010-01-14 CY CY20101100039T patent/CY1109729T1/el unknown

Also Published As

Publication number	Publication date
UY30300A1 (es)	2007-08-31
DE602006009764D1 (de)	2009-11-26
EP1847524B1 (en)	2009-10-14
JP2009538275A (ja)	2009-11-05
DK1847524T3 (da)	2010-01-11
MA30420B1 (fr)	2009-05-04
IL194853A0 (en)	2009-08-03
ES2333539T3 (es)	2010-02-23
KR20090024678A (ko)	2009-03-09
NO20084516L (no)	2009-01-13
ES2392352T3 (es)	2012-12-10
CN101484410B (zh)	2013-08-21
TWI435720B (zh)	2014-05-01
TW200810746A (en)	2008-03-01
US20070254957A1 (en)	2007-11-01
WO2007124351A1 (en)	2007-11-01
CA2649845A1 (en)	2007-11-01
SMAP200800062A (it)	2008-11-19
EP1847524A1 (en)	2007-10-24
PT1847524E (pt)	2009-12-18
CR10452A (es)	2009-02-23
IL194789A0 (en)	2009-08-03
PL1847524T3 (pl)	2010-03-31
EA200802173A1 (ru)	2009-06-30
SMP200800062B (it)	2009-07-14
MX2008013447A (es)	2009-03-10
SI1847524T1 (sl)	2010-01-29
AR060621A1 (es)	2008-07-02
CN101484410A (zh)	2009-07-15
CY1109729T1 (el)	2014-09-10
AU2007240382B2 (en)	2013-05-02
KR101494906B1 (ko)	2015-02-24
HK1134923A1 (en)	2010-05-20
CA2649845C (en)	2014-09-16
CR10376A (es)	2009-02-26
JP5422827B2 (ja)	2014-02-19
EP2016039A1 (en)	2009-01-21
AU2007240382A1 (en)	2007-11-01
ZA200809857B (en)	2009-08-26
BRPI0710632A2 (pt)	2011-08-23
EA016908B1 (ru)	2012-08-30
ATE445586T1 (de)	2009-10-15
US8106236B2 (en)	2012-01-31
GEP20115211B (en)	2011-04-26
EP2016039B1 (en)	2012-08-01
PE20080267A1 (es)	2008-05-16
TNSN08414A1 (en)	2010-04-14
MY148988A (en)	2013-06-28
NZ572999A (en)	2012-06-29

Publication	Publication Date	Title
UA95766C2 (ru)	2011-08-25	Производные терфенила для лечения болезни альцгеймера
TNSN07148A1 (en)	2008-11-21	(biphenyl) carboxylic acids and derivatives thereof
TW200728307A (en)	2007-08-01	Novel spirochromanone derivatives
EA016129B9 (ru)	2012-06-29	Замещенные бифенилкарбоновые кислоты и их производные
TW200734311A (en)	2007-09-16	New compounds
MX2009006742A (es)	2009-08-24	Inhibidores acilaminopirazoles como fgfr.
UA102251C2 (ru)	2013-06-25	Производные аминодигидротиазина как ингибиторы васе для лечения болезни альцгеймера
PT1940839E (pt)	2013-10-10	Inibidores de piridopirimidinona pi3k alfa
ECSP099755A (es)	2009-12-28	Derivados de pirrolopiridina y su uso como inhibidores de bace
GEP20156216B (en)	2015-01-12	Heterocyclic compound and usage thereof
TW200736233A (en)	2007-10-01	Cyclohexyl piperazinyl methanone derivatives
MX2010002938A (es)	2010-04-01	Derivados de (3-hidroxi-4-amino-butan-2-il)-3-(2-tiazol-2-il-pirro lidin-1-carbonil)benzamida y compuestos relacionados como inhibidores de beta-secretasa para tratar enfermedad de alzheimer.
MX2008013196A (es)	2008-10-22	5-amido-2-carboxiamida-indoles.
UA83691C2 (ru)	2008-08-11	Применение замещенных 2-аминотетралинов для упреждающего лечения болезни паркинсона
MX2008002061A (es)	2008-04-16	Derivados de tiazolil piperidina utiles como moduladores del receptor h3.
IL195016A0 (en)	2009-08-03	1h-indol-5-yl-piperazin-1-yl-methanone derivatives
TW200716547A (en)	2007-05-01	Piperidin-4-yl-amide derivatives
ATE467632T1 (de)	2010-05-15	Pyrroloä2,3-büpyridinderivate als modulatoren des h3-rezeptors
UA106200C2 (ru)	2014-08-11	Замещенные производные оксиндола и их применение для лечения заболеваний, зависимых от вазопресина
DE602006010738D1 (de)	2010-01-07	Pyrroloä2,3-cüpyridinderivate
TW200637817A (en)	2006-11-01	5-aminoindole derivatives
WO2007119004A3 (fr)	2008-03-13	Methode de diagnostic in vitro ou ex vivo de desordres psychiatriques et/ou de dysbioses intestinales
MX2009005242A (es)	2009-08-19	Derivados de 3-(hetero)arilisoquinolinamida sustituida en posición 5, 6 o 7 y uso terapeutico del mismo.
ATE466007T1 (de)	2010-05-15	5-substituierte indol-2-carbonsäureamidderivate
MX2010004261A (es)	2010-04-30	Acidos carboxilicos bifenil y derivados de los mismos.