PE68699A1 - Pirazolopirimidonas para disfuncion sexual - Google Patents
Pirazolopirimidonas para disfuncion sexualInfo
- Publication number
- PE68699A1 PE68699A1 PE1998000312A PE00031298A PE68699A1 PE 68699 A1 PE68699 A1 PE 68699A1 PE 1998000312 A PE1998000312 A PE 1998000312A PE 00031298 A PE00031298 A PE 00031298A PE 68699 A1 PE68699 A1 PE 68699A1
- Authority
- PE
- Peru
- Prior art keywords
- alcoxy
- optionally replaced
- alkyl optionally
- alkyl
- dysfunction
- Prior art date
Links
- 201000001880 Sexual dysfunction Diseases 0.000 title 1
- 231100000872 sexual dysfunction Toxicity 0.000 title 1
- -1 IMIDAZOLYL Chemical class 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 230000004064 dysfunction Effects 0.000 abstract 2
- ZOOGRGPOEVQQDX-UUOKFMHZSA-N 3',5'-cyclic GMP Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=C(NC2=O)N)=C2N=C1 ZOOGRGPOEVQQDX-UUOKFMHZSA-N 0.000 abstract 1
- 101100189582 Dictyostelium discoideum pdeD gene Proteins 0.000 abstract 1
- 208000005171 Dysmenorrhea Diseases 0.000 abstract 1
- 206010013935 Dysmenorrhoea Diseases 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- NYHBQMYGNKIUIF-UUOKFMHZSA-N Guanosine Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O NYHBQMYGNKIUIF-UUOKFMHZSA-N 0.000 abstract 1
- 101150098694 PDE5A gene Proteins 0.000 abstract 1
- 208000006399 Premature Obstetric Labor Diseases 0.000 abstract 1
- 206010036600 Premature labour Diseases 0.000 abstract 1
- 102100029175 cGMP-specific 3',5'-cyclic phosphodiesterase Human genes 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 208000026440 premature labor Diseases 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- C07D231/40—Acylated on said nitrogen atom
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Reproductive Health (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A COMPUESTOS DE FORMULA (IA) o (IB), SUS SALES O SOLVATOS; DONDE: R1 ES ALQUILO C1-C3 SUSTITUIDO CON CICLOALQUILO C3-C6, CONR5R6, HETEROCICLO UNIDO A TRAVES DE UN N, COMO PIRAZOLILO, IMIDAZOLILO, ENTRE OTROS; R2 ES ALQUILO C1-C6; R3 ES ALQUILO C1-C6 OPCIONALMENTE SUSTITUIDO CON ALCOXI C1-C4; R4 ES SO2NR7R8; R5 Y R6 ES H Y ALQUILO C1-C4 OPCIONALMENTE SUSTITUIDO CON ALCOXI C1-C4 O JUNTO CON N FORMAN PIRROLIDINILO, PIPERIDINILO, ENTRE OTROS; R7 Y R8 JUNTO A N FORMAN 4-R10-PIPERAZINILO; R10 ES ALQUILO C1-C4 OPCIONALMENTE SUSTITUIDO CON OH, ALCOXI C1-C4 o CONH2. UN COMPUESTO PREFERIDO ES 5-{5-[4-(2-HIDROXIETIL)PIPERAZIN-1-ILSULFONIL]-2-n-PROPOXIFENIL}-3-n-PROPIL-1-(PIRIDIN-2-IL)METIL-1,6-DIHIDRO-7H-PIRAZOLO[4,3-d]PIRIMIDIN-7-ONA, ENTRE OTROS. TAMBIEN SE REFIERE A PROCEDIMIENTOS PARA LA PREPARACION. LOS COMPUESTOS DE FORMULA (IA) o (IB) SON INHIBIDORES DE LA ENZIMA FOSFODIESTERASA DEL GUANOSIN 3`,5'-MONOFOSFATO CICLICO (cGMP PDE5), QUE PUEDEN SER UTIL PARA EL TRATAMIENTO CURATIVO O PROFILACTICO DE LA DISFUNCION ERECTIL MASCULINA, DISFUNCION SEXUAL FEMENINA, PARTO PREMATURO, DISMENORREA
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9708406.5A GB9708406D0 (en) | 1997-04-25 | 1997-04-25 | Therapeutic agents |
| GB9715380A GB9715380D0 (en) | 1997-07-22 | 1997-07-22 | Therapeutic agents |
| GBGB9722954.6A GB9722954D0 (en) | 1997-10-30 | 1997-10-30 | Therapeutic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE68699A1 true PE68699A1 (es) | 1999-07-10 |
Family
ID=27268823
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1998000312A PE68699A1 (es) | 1997-04-25 | 1998-04-24 | Pirazolopirimidonas para disfuncion sexual |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US6723719B1 (es) |
| EP (1) | EP0977756A1 (es) |
| JP (2) | JP3563078B2 (es) |
| KR (2) | KR100390612B1 (es) |
| CN (2) | CN1281588C (es) |
| AP (1) | AP1002A (es) |
| AR (1) | AR015595A1 (es) |
| AU (1) | AU730670B2 (es) |
| BG (1) | BG103828A (es) |
| BR (1) | BR9810233A (es) |
| CA (1) | CA2288910C (es) |
| CO (1) | CO4940472A1 (es) |
| CZ (1) | CZ299633B6 (es) |
| DZ (1) | DZ2465A1 (es) |
| EA (2) | EA004315B1 (es) |
| HR (1) | HRP980222B1 (es) |
| ID (1) | ID22834A (es) |
| IL (5) | IL132276A0 (es) |
| IS (1) | IS5200A (es) |
| MA (1) | MA24529A1 (es) |
| NO (1) | NO314585B1 (es) |
| NZ (1) | NZ338075A (es) |
| OA (1) | OA11168A (es) |
| PA (1) | PA8450401A1 (es) |
| PE (1) | PE68699A1 (es) |
| PL (1) | PL336586A1 (es) |
| RS (1) | RS50118B (es) |
| SK (1) | SK285991B6 (es) |
| TN (1) | TNSN98053A1 (es) |
| TR (1) | TR199902646T2 (es) |
| WO (1) | WO1998049166A1 (es) |
Families Citing this family (140)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9423910D0 (en) * | 1994-11-26 | 1995-01-11 | Pfizer Ltd | Therapeutic agents |
| IL120266A (en) | 1996-02-28 | 2005-05-17 | Pfizer | Use of estrogen antagonists and estrogen agonists in the preparation of medicaments for inhibiting pathological conditions |
| GB9612514D0 (en) * | 1996-06-14 | 1996-08-14 | Pfizer Ltd | Novel process |
| US6331543B1 (en) | 1996-11-01 | 2001-12-18 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use |
| CN1281588C (zh) | 1997-04-25 | 2006-10-25 | çŸćœèŸçæéć Źćž | ć¶ć€ćĄććč¶ć§ć¶é źç±»ććç©çæ°ćäžéŽäœ |
| GB9722520D0 (en) | 1997-10-24 | 1997-12-24 | Pfizer Ltd | Compounds |
| PT1073658E (pt) | 1998-04-20 | 2003-12-31 | Pfizer | Inibidores de ogmp pdes de pirazolopirimidinona para o tratamento da disfuncao sexual |
| DE19827640A1 (de) | 1998-06-20 | 1999-12-23 | Bayer Ag | 7-Alkyl- und Cycloalkyl-substituierte Imidazotriazinone |
| GB9822238D0 (en) * | 1998-10-12 | 1998-12-09 | Pfizer Ltd | Process for preparation of pyrazolo[4,3-D]pyrimidin-7-ones and intermediates thereof |
| GB9823101D0 (en) | 1998-10-23 | 1998-12-16 | Pfizer Ltd | Pharmaceutically active compounds |
| GB9823102D0 (en) | 1998-10-23 | 1998-12-16 | Pfizer Ltd | Pharmaceutically active compounds |
| GB9823103D0 (en) * | 1998-10-23 | 1998-12-16 | Pfizer Ltd | Pharmaceutically active compounds |
| RU2220145C2 (ru) * | 1998-11-11 | 2003-12-27 | ĐĐŸĐœĐł РЀаŃĐŒ. ĐĐŸ., ĐŃĐŽ. | ĐŃĐŸĐžĐ·ĐČĐŸĐŽĐœŃĐ” пОŃĐ°Đ·ĐŸĐ»ĐŸĐżĐžŃĐžĐŒĐžĐŽĐžĐœĐŸĐœĐ° ĐŽĐ»Ń Đ»Đ”ŃĐ”ĐœĐžŃ ĐžĐŒĐżĐŸŃĐ”ĐœŃОО Đž ŃĐżĐŸŃĐŸĐ± ĐžŃ ĐżĐŸĐ»ŃŃĐ”ĐœĐžŃ |
| KR100353014B1 (ko) * | 1998-11-11 | 2002-09-18 | ëìì ìœ ìŁŒìíìŹ | ë°êž°ë¶ì ìčëŁì íšêłŒë„Œ ê°ë íŒëŒìĄžëĄíŒëŠŹëŻžëë Œ íí©ëŹŒ |
| US6225315B1 (en) | 1998-11-30 | 2001-05-01 | Pfizer Inc | Method of treating nitrate-induced tolerance |
| MXPA00003997A (es) * | 1999-04-30 | 2002-03-08 | Lilly Icos Llc | Articulos de fabricacion. |
| EP1173167A4 (en) * | 1999-04-30 | 2004-07-14 | Lilly Icos Llc | TREATMENT OF FEMALE SEXUAL STIMULATION DISORDERS |
| JP3145364B2 (ja) | 1999-06-04 | 2001-03-12 | ă¶ă»ăšă«ăăăąăłă»ăăąăŒăă·ăŠăŒăă€ă«ă«ă»ăšă ă»ăšăă»ăžăŒă»ăąăłăă»ăĄăă€ă«ă«ă»ă€ăŻă€ăăăĄăłăă»ă«ăłăăăŒă»ăȘăăăă | æ°èŠććç©ćăłè©Čććç©ăć«æăăć»èŹç”æç© |
| EP1057829B1 (en) * | 1999-06-04 | 2002-11-20 | The Jordanian Pharmaceutical Manufacturing and Medical Equipment Co.Ltd. | Novel compounds and pharmaceutical compositions containing the same |
| ES2166270B1 (es) | 1999-07-27 | 2003-04-01 | Almirall Prodesfarma Sa | Derivados de 8-fenil-6,9-dihidro-(1,2,4,)triazolo(3,4-i)purin-5-ona. |
| DE19942474A1 (de) | 1999-09-06 | 2001-03-15 | Merck Patent Gmbh | Pyrazolo[4,3-d]pyrimidine |
| GB9923968D0 (en) * | 1999-10-11 | 1999-12-15 | Pfizer Ltd | Therapeutic agents |
| US6350751B1 (en) | 1999-10-11 | 2002-02-26 | Pfizer Inc. | Therapeutic agents |
| TWI265925B (en) * | 1999-10-11 | 2006-11-11 | Pfizer | Pyrazolo[4,3-d]pyrimidin-7-ones useful in inhibiting type 5 cyclic guanosine 3',5'-monophosphate phosphodiesterases(cGMP PDE5), process and intermediates for their preparation, their uses and composition comprising them |
| YU59100A (sh) * | 1999-10-11 | 2003-10-31 | Pfizer Inc. | Postupak za dobijanje pirazolo (4,3-d) pirimidin-7-ona-3-piridilsulfonil jedinjenja i njihova intermedijera |
| EP1222190A1 (en) | 1999-10-11 | 2002-07-17 | Pfizer Limited | 5-(2-substituted-5-heterocyclylsulphonylpyrid-3-yl)-dihydropyrazolo[4,3-d]pyrimidin-7-ones as phosphodiesterase inhibitors |
| TW200400821A (en) * | 1999-11-02 | 2004-01-16 | Pfizer | Pharmaceutical composition (II) useful for treating or preventing pulmonary hypertension in a patient |
| US6683081B2 (en) | 1999-12-24 | 2004-01-27 | Bayer Aktiengesellschaft | Triazolotriazinones and the use thereof |
| IL150022A0 (en) | 1999-12-24 | 2002-12-01 | Bayer Ag | Imidazo [1,3,5] triazinones and the use thereof |
| KR100358083B1 (ko) * | 2000-02-17 | 2002-10-25 | ìì€ìŒìŽìŒëŻžìčŒìŁŒìíìŹ | íŒëĄ€ëĄíŒëŠŹëŻžëë Œ ì ëìČŽì ìŽì ì ìĄ°ë°©ëČ, ê·žëŠŹêł ìŽìì©ë |
| WO2001087888A1 (en) * | 2000-05-17 | 2001-11-22 | Sk Chemicals Co., Ltd. | Pyrazolopyrimidinone derivatives, process for their preparation and their use |
| KR100377782B1 (ko) * | 2000-06-23 | 2003-03-29 | ëìì ìœ ìŁŒìíìŹ | ë°êž°ë¶ì ìčëŁì íšêłŒë„Œ ê°ë íŒëŒìĄžëĄíŒëŠŹëŻžëë Œíí©ëŹŒì ì ìĄ°ë°©ëČ |
| US6407259B1 (en) | 2000-07-28 | 2002-06-18 | Pfizer Inc. | Process for the preparation of pyrazoles |
| EP1176142A1 (en) * | 2000-07-28 | 2002-01-30 | Pfizer Inc. | Process for the preparation of pyrazoles |
| CN1446084A (zh) * | 2000-08-11 | 2003-10-01 | èŸç性èŻć | è°ćČçŽ ææ§ç»ŒćççæČ»ç |
| PE20020394A1 (es) | 2000-08-18 | 2002-06-21 | Agouron Pharma | Compuestos de pirazol y composiciones farmaceuticas que los contienen, que modulan y/o inhiben la actividad de erab/hadh2 |
| WO2002016364A1 (en) * | 2000-08-23 | 2002-02-28 | Lg Life Sciences Ltd. | Polyethoxylated pyrazolo pyrimidinone derivatives, process for preparation thereof and pharmaceutical compositions comprising the same for the treatment of impotence |
| US6821978B2 (en) | 2000-09-19 | 2004-11-23 | Schering Corporation | Xanthine phosphodiesterase V inhibitors |
| US6548508B2 (en) | 2000-10-20 | 2003-04-15 | Pfizer, Inc. | Use of PDE V inhibitors for improved fecundity in mammals |
| GB0025782D0 (en) * | 2000-10-20 | 2000-12-06 | Pfizer Ltd | Use of inhibitors |
| SE0004780D0 (sv) | 2000-12-22 | 2000-12-22 | Jordanian Pharmaceutical Mfg & | Novel compunds |
| US6943171B2 (en) | 2001-11-09 | 2005-09-13 | Schering Corporation | Polycyclic guanine derivative phosphodiesterase V inhibitors |
| GB0129274D0 (en) * | 2001-12-06 | 2002-01-23 | Pfizer Ltd | Novel kit |
| DE60237425D1 (de) | 2002-03-28 | 2010-10-07 | Univerzita Palackeho V Olomouc | PyrazoloĂ4,3-dĂpyrimidine, Verfahren zu ihrer Herstellung und therapeutische Anwendung |
| GB0219961D0 (en) | 2002-08-28 | 2002-10-02 | Pfizer Ltd | Oxytocin inhibitors |
| US7323462B2 (en) | 2002-12-10 | 2008-01-29 | Pfizer Inc. | Morpholine dopamine agonists |
| NZ539972A (en) | 2002-12-13 | 2008-05-30 | Warner Lambert Co | Alpha-2-delta ligand to treat lower urinary tract symptoms |
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- 1998-04-10 EP EP98924132A patent/EP0977756A1/en not_active Withdrawn
- 1998-04-20 PA PA19988450401A patent/PA8450401A1/es unknown
- 1998-04-22 TN TNTNSN98053A patent/TNSN98053A1/fr unknown
- 1998-04-22 DZ DZ980076A patent/DZ2465A1/xx active
- 1998-04-22 MA MA25040A patent/MA24529A1/fr unknown
- 1998-04-23 AP APAP/P/1998/001228A patent/AP1002A/en active
- 1998-04-23 AR ARP980101889A patent/AR015595A1/es unknown
- 1998-04-23 CO CO98022516A patent/CO4940472A1/es unknown
- 1998-04-24 HR HR980222A patent/HRP980222B1/xx not_active IP Right Cessation
- 1998-04-24 PE PE1998000312A patent/PE68699A1/es not_active Application Discontinuation
-
1999
- 1999-09-28 IS IS5200A patent/IS5200A/is unknown
- 1999-10-07 IL IL132276A patent/IL132276A/en not_active IP Right Cessation
- 1999-10-22 OA OA9900234A patent/OA11168A/en unknown
- 1999-10-22 BG BG103828A patent/BG103828A/xx unknown
- 1999-10-25 NO NO19995211A patent/NO314585B1/no not_active IP Right Cessation
-
2003
- 2003-08-28 IL IL157645A patent/IL157645A/en not_active IP Right Cessation
- 2003-08-28 IL IL157647A patent/IL157647A/en not_active IP Right Cessation
- 2003-08-28 IL IL157646A patent/IL157646A/en not_active IP Right Cessation
-
2004
- 2004-03-03 JP JP2004059879A patent/JP4036836B2/ja not_active Expired - Fee Related
- 2004-03-23 US US10/808,027 patent/US6916927B2/en not_active Expired - Fee Related
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