ES8305340A1 - "metodo mejorado de obtencion de derivados 5-bromoecilaminometilixoxaxolicos". - Google Patents
"metodo mejorado de obtencion de derivados 5-bromoecilaminometilixoxaxolicos".Info
- Publication number
- ES8305340A1 ES8305340A1 ES511895A ES511895A ES8305340A1 ES 8305340 A1 ES8305340 A1 ES 8305340A1 ES 511895 A ES511895 A ES 511895A ES 511895 A ES511895 A ES 511895A ES 8305340 A1 ES8305340 A1 ES 8305340A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- alkyl
- oxy
- stands
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000002545 isoxazoles Chemical class 0.000 title abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- -1 carbamoylamino-oxy Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002861 (C1-C4) alkanoyl group Chemical group 0.000 abstract 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- 208000001953 Hypotension Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000002344 aminooxy group Chemical group [H]N([H])O[*] 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000001754 anti-pyretic effect Effects 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 208000021822 hypotensive Diseases 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS 5-BROMOETILAMINOMETILISOXAZOLICOS, DE FORMULA (I), EN LA QUE R<I ES ALQUILO C <- O FENILO; Y R I ES HALOGENO O ALCAXICARBONILO C <- . CONSISTE EN LA REACCION DE UN DERIVADO ISOXAZOLICO DE FORMULA (II), EN LA QUE R<I Y R<I TIENEN LOS MISMOS SIGNIFICADOS QUE EN LA FORMULA (I), CON ETILENIMINA. LA REACCION SE LLEVA A CABO EN ACETONA, AÑADIENDO LA ETILENIMINA A UNA TEMPERATURA ENTRE -5 C Y -10 C Y POSTERIOR CALENTAMIENTO HASTA LA TEMPERATURA DE EBULLICION DE LA MEZCLA DE REACCION. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SUS EFECTOS HIPOTENSOR, ANTIFLOGISTICO Y ANTIPIRETICO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU8080637A HU180567B (en) | 1980-03-19 | 1980-03-19 | Method for producing derivatives of isooxazole |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8305340A1 true ES8305340A1 (es) | 1983-05-01 |
| ES511895A0 ES511895A0 (es) | 1983-05-01 |
Family
ID=10950573
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES501095A Granted ES501095A0 (es) | 1980-03-19 | 1981-03-18 | Procedimiento de preparar derivado 5-aminoximetilisoxazolicos. |
| ES511894A Granted ES511894A0 (es) | 1980-03-19 | 1982-04-16 | "metodo de preparar derivados isoxazol-5-il-metilenoxiguanidinicos". |
| ES511895A Granted ES511895A0 (es) | 1980-03-19 | 1982-04-16 | "metodo mejorado de obtencion de derivados 5-bromoecilaminometilixoxaxolicos". |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES501095A Granted ES501095A0 (es) | 1980-03-19 | 1981-03-18 | Procedimiento de preparar derivado 5-aminoximetilisoxazolicos. |
| ES511894A Granted ES511894A0 (es) | 1980-03-19 | 1982-04-16 | "metodo de preparar derivados isoxazol-5-il-metilenoxiguanidinicos". |
Country Status (15)
| Country | Link |
|---|---|
| JP (1) | JPS56158774A (es) |
| BE (1) | BE887954A (es) |
| CA (1) | CA1163631A (es) |
| CH (1) | CH646157A5 (es) |
| DE (1) | DE3110817A1 (es) |
| DK (3) | DK151012C (es) |
| ES (3) | ES501095A0 (es) |
| FI (1) | FI70011C (es) |
| FR (1) | FR2478634A1 (es) |
| GB (1) | GB2075009B (es) |
| HU (1) | HU180567B (es) |
| IT (1) | IT1211010B (es) |
| SE (1) | SE454695B (es) |
| SU (3) | SU1053750A3 (es) |
| YU (1) | YU42560B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100512087B1 (ko) * | 1997-04-21 | 2005-09-05 | 스미또모 세이야꾸 가부시키가이샤 | 이속사졸 유도체 |
| US6100260A (en) * | 1997-04-21 | 2000-08-08 | Sumitomo Pharmaceutical Company, Limited | Isoxazole derivatives |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL302496A (es) * | 1962-12-22 | |||
| US3808221A (en) * | 1971-04-14 | 1974-04-30 | Hoffmann La Roche | Antiandrogenic n-(3,5-dilower alkyl-4-heterocyclic)methyl)phthalimides |
-
1980
- 1980-03-19 HU HU8080637A patent/HU180567B/hu not_active IP Right Cessation
-
1981
- 1981-03-16 BE BE1/10179A patent/BE887954A/fr not_active IP Right Cessation
- 1981-03-17 SE SE8101703A patent/SE454695B/sv not_active IP Right Cessation
- 1981-03-17 YU YU689/81A patent/YU42560B/xx unknown
- 1981-03-18 ES ES501095A patent/ES501095A0/es active Granted
- 1981-03-18 CH CH182981A patent/CH646157A5/de not_active IP Right Cessation
- 1981-03-18 IT IT8120395A patent/IT1211010B/it active
- 1981-03-18 DK DK122581A patent/DK151012C/da not_active IP Right Cessation
- 1981-03-18 FI FI810838A patent/FI70011C/fi not_active IP Right Cessation
- 1981-03-18 FR FR8105378A patent/FR2478634A1/fr active Granted
- 1981-03-18 GB GB8108545A patent/GB2075009B/en not_active Expired
- 1981-03-19 JP JP4023281A patent/JPS56158774A/ja active Pending
- 1981-03-19 DE DE19813110817 patent/DE3110817A1/de not_active Withdrawn
- 1981-03-19 CA CA000373380A patent/CA1163631A/en not_active Expired
- 1981-03-19 SU SU813261940A patent/SU1053750A3/ru active
-
1982
- 1982-04-01 SU SU823414099A patent/SU1152518A3/ru active
- 1982-04-01 SU SU823416146A patent/SU1158044A3/ru active
- 1982-04-16 ES ES511894A patent/ES511894A0/es active Granted
- 1982-04-16 ES ES511895A patent/ES511895A0/es active Granted
-
1987
- 1987-01-16 DK DK023187A patent/DK153549C/da not_active IP Right Cessation
- 1987-01-16 DK DK023087A patent/DK151959C/da not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| FI70011B (fi) | 1986-01-31 |
| SU1053750A3 (ru) | 1983-11-07 |
| BE887954A (fr) | 1981-09-16 |
| GB2075009B (en) | 1983-11-30 |
| DK151959C (da) | 1988-07-11 |
| JPS56158774A (en) | 1981-12-07 |
| ES8302674A1 (es) | 1983-02-16 |
| DK153549B (da) | 1988-07-25 |
| FI70011C (fi) | 1986-09-12 |
| FR2478634B1 (es) | 1983-11-10 |
| YU42560B (en) | 1988-10-31 |
| CH646157A5 (en) | 1984-11-15 |
| ES501095A0 (es) | 1983-02-16 |
| DK153549C (da) | 1988-12-05 |
| HU180567B (en) | 1983-03-28 |
| DK151012C (da) | 1988-07-04 |
| CA1163631A (en) | 1984-03-13 |
| SU1158044A3 (ru) | 1985-05-23 |
| DK151959B (da) | 1988-01-18 |
| IT1211010B (it) | 1989-09-29 |
| ES8401758A1 (es) | 1984-01-01 |
| YU68981A (en) | 1983-10-31 |
| SU1152518A3 (ru) | 1985-04-23 |
| IT8120395A0 (it) | 1981-03-18 |
| DK23087A (da) | 1987-01-16 |
| DK122581A (da) | 1981-09-20 |
| DE3110817A1 (de) | 1982-03-04 |
| ES511894A0 (es) | 1984-01-01 |
| GB2075009A (en) | 1981-11-11 |
| DK151012B (da) | 1987-10-12 |
| DK23187A (da) | 1987-01-16 |
| FR2478634A1 (fr) | 1981-09-25 |
| SE454695B (sv) | 1988-05-24 |
| ES511895A0 (es) | 1983-05-01 |
| FI810838L (fi) | 1981-09-20 |
| SE8101703L (sv) | 1981-09-20 |
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