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ES8101589A1 - Un procedimiento para la preparacion de nuevos compuestos iminicos heterociclicos. - Google Patents

Un procedimiento para la preparacion de nuevos compuestos iminicos heterociclicos.

Info

Publication number
ES8101589A1
ES8101589A1 ES79486422A ES486422A ES8101589A1 ES 8101589 A1 ES8101589 A1 ES 8101589A1 ES 79486422 A ES79486422 A ES 79486422A ES 486422 A ES486422 A ES 486422A ES 8101589 A1 ES8101589 A1 ES 8101589A1
Authority
ES
Spain
Prior art keywords
alkyl
phenyl
optionally substituted
alkoxy
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES79486422A
Other languages
English (en)
Other versions
ES486422A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES8101589A1 publication Critical patent/ES8101589A1/es
Publication of ES486422A0 publication Critical patent/ES486422A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/06—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings
    • C07D265/08—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/28—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/18—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
    • C07D279/06—1,3-Thiazines; Hydrogenated 1,3-thiazines not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE COMPUESTOS IMINICOS HETEROCICLICOS. CONSTA DE LAS SIGUIENTES OPERACIONES: 1) REACCION DE UN COMPUESTO DE FORMULA GENERAL (I) O UNA SAL DEL MISMO, CON UNA AMINA, DE FORMULA R ELEVADO A 4 R ELEVADO A 5 NH. *FORMULA* 2) CON VERSION DE LA BASE LIBRE OBTENIDA (II) EN UNA SAL FARMACEUTICAMENTE ACEPTABLE. LA REACCION SE EFECTUA EN UN DISOLVENTE POLAR QUE FORME UNA SOLUCION HOMOGENEA DEL REACTIVO Y QUE SEA INERTE AL REACTIVO Y AL PRODUCTO, LA TEMPERATURA ES APROXIMADAMENTE LA DE REFLUJO DEL DISOLVENTE. EL TIEMPO DE REACCION DEPENDE DE LAS SUSTANCIAS DE PARTIDA EMPLEADAS. TRATAMIENTO DE DIABETES.
ES79486422A 1978-11-29 1979-11-28 Un procedimiento para la preparacion de nuevos compuestos iminicos heterociclicos. Granted ES486422A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7846531 1978-11-29
GB7915737 1979-05-05

Publications (2)

Publication Number Publication Date
ES8101589A1 true ES8101589A1 (es) 1980-12-16
ES486422A0 ES486422A0 (es) 1980-12-16

Family

ID=26269786

Family Applications (2)

Application Number Title Priority Date Filing Date
ES79486422A Granted ES486422A0 (es) 1978-11-29 1979-11-28 Un procedimiento para la preparacion de nuevos compuestos iminicos heterociclicos.
ES493859A Expired ES8200669A1 (es) 1978-11-29 1980-07-30 Un procedimiento para la preparacion de nuevos compuestos iminicos heterociclicos

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES493859A Expired ES8200669A1 (es) 1978-11-29 1980-07-30 Un procedimiento para la preparacion de nuevos compuestos iminicos heterociclicos

Country Status (7)

Country Link
US (2) US4250173A (es)
EP (1) EP0011963B1 (es)
AU (1) AU5263779A (es)
DE (1) DE2963350D1 (es)
DK (1) DK485979A (es)
ES (2) ES486422A0 (es)
IL (1) IL58681A0 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4414211A (en) * 1978-09-18 1983-11-08 Mcneilab, Inc. Heterocyclic derivatives of guanidine
ATE2075T1 (de) * 1979-04-20 1983-01-15 Beecham Group Plc Oxazolin- und thiazolin-derivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen.
US4342764A (en) * 1979-05-29 1982-08-03 Ciba-Geigy Corporation Guanidine compounds, pharmaceutical compositions and use
EP0028883A3 (en) * 1979-11-10 1981-06-03 Beecham Group Plc Benzimidazoline derivatives, processes for their preparation and pharmaceutical compositions containing them
US4421748A (en) * 1982-07-13 1983-12-20 Trager Seymour F Artificial tear aid
US4704389A (en) * 1986-03-05 1987-11-03 Merrell Dow Pharmaceuticals Inc. Aromatic omega-alkyl-imino-tetrahydro-6H-1,3-thiazin-6-one derivatives
GB8903592D0 (en) * 1989-02-16 1989-04-05 Boots Co Plc Therapeutic agents
IT1277486B1 (it) * 1994-12-14 1997-11-10 Japan Tobacco Inc Derivati di tiazina o di tiazepina
JP2001261652A (ja) 2000-03-21 2001-09-26 Suntory Ltd 二置換イミノヘテロサイクリック化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1247318B (de) * 1960-10-13 1967-08-17 Albert Ag Chem Werke Verfahren zur Herstellung von N-[5-Chlormethyloxazolinyl-(2)]-thioharnstoffderivaten
US3758491A (en) * 1972-01-07 1973-09-11 Parke Davis & Co Novel anti infective agents and means of producing the same
DE2205744A1 (de) * 1972-02-08 1973-08-09 Thomae Gmbh Dr K Neue durch einen guanidinylidenrest substituierte heterocyclen und verfahren zu ihrer herstellung
CS225804B2 (cs) * 1976-03-19 1984-02-13 Mcneilab Inc Způsob výroby heterocyklických derivátů guanidinu

Also Published As

Publication number Publication date
IL58681A0 (en) 1980-02-29
ES493859A0 (es) 1981-11-16
DK485979A (da) 1980-05-30
EP0011963B1 (en) 1982-07-14
ES8200669A1 (es) 1981-11-16
ES486422A0 (es) 1980-12-16
US4250173A (en) 1981-02-10
DE2963350D1 (en) 1982-09-02
US4282356A (en) 1981-08-04
EP0011963A1 (en) 1980-06-11
AU5263779A (en) 1980-05-29

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