CO4650040A1 - Antagonistas oxadiazol y tiadiazol del receptor muscarinico - Google Patents
Antagonistas oxadiazol y tiadiazol del receptor muscarinicoInfo
- Publication number
- CO4650040A1 CO4650040A1 CO97007550A CO97007550A CO4650040A1 CO 4650040 A1 CO4650040 A1 CO 4650040A1 CO 97007550 A CO97007550 A CO 97007550A CO 97007550 A CO97007550 A CO 97007550A CO 4650040 A1 CO4650040 A1 CO 4650040A1
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- muscarinic receptor
- heteroaryl
- alkynyl
- aryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Un compuesto de fómula (I) en la que R1 es alquilo C1 -C6 ,halo-(alquilo C1 -C6 ), cicloalquilo C3 -C7 , alquinilo C2 -C6 , hidroxi-(alquinilo C2 -C6 ), (alcoxi C1 -C4 )- (alquinilo C2 -C6 ), arilo, aril-(alquilo C1 -C4 ), heteroarilo o heteroarilo-(alquilo C1 -C4 ); R2 es H o alquilo C1 -C4 ; R3 es arilo, heteroarilo, 2,3-dihidrobenzofuranilo o cicloalquilo C4 -C7 ; X es O o S; e Y es un enlace directo, -CH2 -, -(CH2 )2 - o -CH2 O-; y sus sales farmacéuticamente aceptables. Los compuestos son antoagonistas del receptor muscarínico, útiles para el tratamiento de, por ejemplo, el síndrome del intestino irritable y la incontinencia urinaria.Los compuestos también son útiles como reforzadores de la cognición.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9603755.1A GB9603755D0 (en) | 1996-02-22 | 1996-02-22 | Therapeutic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO4650040A1 true CO4650040A1 (es) | 1998-09-03 |
Family
ID=10789217
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO97007550A CO4650040A1 (es) | 1996-02-22 | 1997-02-13 | Antagonistas oxadiazol y tiadiazol del receptor muscarinico |
Country Status (42)
| Country | Link |
|---|---|
| US (1) | US5977142A (es) |
| EP (1) | EP0885218B1 (es) |
| JP (1) | JP3148252B2 (es) |
| KR (1) | KR100315934B1 (es) |
| CN (1) | CN1089340C (es) |
| AP (1) | AP751A (es) |
| AR (1) | AR005916A1 (es) |
| AT (1) | ATE200899T1 (es) |
| AU (1) | AU712230B2 (es) |
| BG (2) | BG102699A (es) |
| BR (1) | BR9707733A (es) |
| CA (1) | CA2247164C (es) |
| CO (1) | CO4650040A1 (es) |
| CZ (1) | CZ292650B6 (es) |
| DE (1) | DE69704701T2 (es) |
| DK (1) | DK0885218T3 (es) |
| DZ (1) | DZ2181A1 (es) |
| ES (1) | ES2156357T3 (es) |
| GB (1) | GB9603755D0 (es) |
| GR (1) | GR3036032T3 (es) |
| HN (1) | HN1997000020A (es) |
| HR (1) | HRP970098B1 (es) |
| HU (1) | HUP9900501A3 (es) |
| ID (1) | ID16642A (es) |
| IL (1) | IL125413A (es) |
| IS (1) | IS4803A (es) |
| MY (1) | MY129729A (es) |
| NO (1) | NO313414B1 (es) |
| NZ (1) | NZ331039A (es) |
| OA (1) | OA10838A (es) |
| PE (1) | PE42798A1 (es) |
| PL (1) | PL186879B1 (es) |
| PT (1) | PT885218E (es) |
| RU (1) | RU2162848C2 (es) |
| SK (1) | SK283461B6 (es) |
| TN (1) | TNSN97039A1 (es) |
| TR (1) | TR199801644T2 (es) |
| TW (1) | TW492961B (es) |
| UA (1) | UA61068C2 (es) |
| WO (1) | WO1997030994A1 (es) |
| YU (1) | YU35698A (es) |
| ZA (1) | ZA971513B (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6107313A (en) * | 1998-10-02 | 2000-08-22 | Combichem, Inc. | Dopamine receptor antagonists |
| IL157491A0 (en) * | 2001-02-21 | 2004-03-28 | Nps Pharmeceuticals Inc | Heteropolycyclic compounds and pharmaceutical compositions containing the same |
| GB0510139D0 (en) * | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B1 |
| GB0510141D0 (en) * | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B3 |
| GB0516313D0 (en) * | 2005-08-08 | 2005-09-14 | Argenta Discovery Ltd | Azole derivatives and their uses |
| WO2008017827A2 (en) * | 2006-08-08 | 2008-02-14 | Argenta Discovery Limited | Azole and thiazole derivatives and their uses |
| JP2010501533A (ja) * | 2006-08-21 | 2010-01-21 | アージェンタ ディスカバリー リミテッド | Ｍ３レセプター調節物質として有用な窒素含有複素環化合物 |
| WO2008096093A1 (en) * | 2007-02-06 | 2008-08-14 | Argenta Discovery Ltd. | Oxazole and thiazole derivatives and their uses |
| GB0702414D0 (en) * | 2007-02-07 | 2007-03-21 | Argenta Discovery Ltd | Oxazole and thiazole derivatives and their uses 2 |
| GB0702382D0 (en) * | 2007-02-07 | 2007-03-21 | Argenta Discovery Ltd | New salt |
| GB0702385D0 (en) * | 2007-02-07 | 2007-03-21 | Argenta Discovery Ltd | New combination |
| NZ578475A (en) * | 2007-02-07 | 2011-05-27 | Pulmagen Therapeutics Synergy | Napadisylate salt of a muscarinic m3 antagonist |
| GB0702416D0 (en) * | 2007-02-07 | 2007-03-21 | Argenta Discovery Ltd | New combination |
| JP2010519193A (ja) * | 2007-02-15 | 2010-06-03 | アージェンタ ディスカバリー リミテッド | Ｍ３ムスカリン受容体としての複素環式誘導体 |
| WO2009098453A1 (en) * | 2008-02-06 | 2009-08-13 | Astrazeneca Ab | Azonia bicycloalkanes as m3 muscarinic acetylcholin receptor antagonists |
| US8263623B2 (en) | 2008-07-11 | 2012-09-11 | Pfizer Inc. | Triazol derivatives useful for the treatment of diseases |
| WO2010018352A1 (en) * | 2008-08-12 | 2010-02-18 | Argenta Discovery Limited | Heterocyclic compounds used in the treatment of diseases where enhanced m3 receptor activation is implicated |
| JP2014065387A (ja) * | 2012-09-25 | 2014-04-17 | Showa Corp | 自動二輪車の車高調整装置 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ219646A (en) * | 1986-03-27 | 1990-10-26 | Merck Sharp & Dohme | Oxadiazole derivatives of azacyclics for treating cns disorders |
| IL88846A0 (en) * | 1988-01-08 | 1989-07-31 | Merck Sharp & Dohme | Lipophilic oxadiazoles,their preparation and pharmaceutical compositions containing them |
| US5043345A (en) * | 1989-02-22 | 1991-08-27 | Novo Nordisk A/S | Piperidine compounds and their preparation and use |
| US5622976A (en) * | 1991-12-31 | 1997-04-22 | Fujisawa Pharmaceutical Co., Ltd. | Oxadiazole derivatives having acetylcholinesterase-inhibitory and muscarinic agonist activity |
| TW360653B (en) * | 1995-03-01 | 1999-06-11 | Janssen Pharmaceutica Nv | A oxadiazole compound having colon motility stimulating properties, its preparation process and its pharmaceutical composition |
-
1996
- 1996-02-22 GB GBGB9603755.1A patent/GB9603755D0/en active Pending
-
1997
- 1997-01-21 TW TW086100642A patent/TW492961B/zh not_active IP Right Cessation
- 1997-02-03 HN HN1997000020A patent/HN1997000020A/es unknown
- 1997-02-04 DK DK97902337T patent/DK0885218T3/da active
- 1997-02-04 PT PT97902337T patent/PT885218E/pt unknown
- 1997-02-04 SK SK1123-98A patent/SK283461B6/sk unknown
- 1997-02-04 KR KR1019980706534A patent/KR100315934B1/ko not_active Expired - Fee Related
- 1997-02-04 ES ES97902337T patent/ES2156357T3/es not_active Expired - Lifetime
- 1997-02-04 CZ CZ19982678A patent/CZ292650B6/cs not_active IP Right Cessation
- 1997-02-04 DE DE69704701T patent/DE69704701T2/de not_active Expired - Fee Related
- 1997-02-04 CN CN97192486A patent/CN1089340C/zh not_active Expired - Fee Related
- 1997-02-04 EP EP97902337A patent/EP0885218B1/en not_active Expired - Lifetime
- 1997-02-04 CA CA002247164A patent/CA2247164C/en not_active Expired - Fee Related
- 1997-02-04 HU HU9900501A patent/HUP9900501A3/hu unknown
- 1997-02-04 IL IL12541397A patent/IL125413A/en not_active IP Right Cessation
- 1997-02-04 US US09/117,556 patent/US5977142A/en not_active Expired - Fee Related
- 1997-02-04 TR TR1998/01644T patent/TR199801644T2/xx unknown
- 1997-02-04 BR BR9707733A patent/BR9707733A/pt not_active Application Discontinuation
- 1997-02-04 JP JP52974197A patent/JP3148252B2/ja not_active Expired - Fee Related
- 1997-02-04 RU RU98117457/04A patent/RU2162848C2/ru not_active IP Right Cessation
- 1997-02-04 WO PCT/EP1997/000525 patent/WO1997030994A1/en not_active Ceased
- 1997-02-04 PL PL97328633A patent/PL186879B1/pl not_active IP Right Cessation
- 1997-02-04 AU AU16014/97A patent/AU712230B2/en not_active Ceased
- 1997-02-04 AT AT97902337T patent/ATE200899T1/de not_active IP Right Cessation
- 1997-02-04 NZ NZ331039A patent/NZ331039A/en unknown
- 1997-02-13 CO CO97007550A patent/CO4650040A1/es unknown
- 1997-02-14 PE PE1997000104A patent/PE42798A1/es not_active Application Discontinuation
- 1997-02-19 DZ DZ970027A patent/DZ2181A1/fr active
- 1997-02-19 TN TNTNSN97039A patent/TNSN97039A1/fr unknown
- 1997-02-20 AR ARP970100667A patent/AR005916A1/es unknown
- 1997-02-20 HR HR970098A patent/HRP970098B1/xx not_active IP Right Cessation
- 1997-02-20 AP APAP/P/1997/000930A patent/AP751A/en active
- 1997-02-21 MY MYPI97000654A patent/MY129729A/en unknown
- 1997-02-21 ID IDP970521A patent/ID16642A/id unknown
- 1997-02-21 ZA ZA971513A patent/ZA971513B/xx unknown
- 1997-04-02 UA UA98094939A patent/UA61068C2/uk unknown
-
1998
- 1998-07-21 IS IS4803A patent/IS4803A/is unknown
- 1998-08-14 OA OA9800143A patent/OA10838A/en unknown
- 1998-08-19 BG BG102699A patent/BG102699A/xx unknown
- 1998-08-19 BG BG102699A patent/BG63971B1/bg unknown
- 1998-08-21 YU YU35698A patent/YU35698A/sh unknown
- 1998-08-21 NO NO19983871A patent/NO313414B1/no not_active IP Right Cessation
-
2001
- 2001-06-13 GR GR20010400885T patent/GR3036032T3/el not_active IP Right Cessation
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