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TNSN97039A1 - Derives d'oxadiazole et de thiadiazole antagonistes des recepteurs muscariniques. - Google Patents

Derives d'oxadiazole et de thiadiazole antagonistes des recepteurs muscariniques.

Info

Publication number
TNSN97039A1
TNSN97039A1 TNTNSN97039A TNSN97039A TNSN97039A1 TN SN97039 A1 TNSN97039 A1 TN SN97039A1 TN TNSN97039 A TNTNSN97039 A TN TNSN97039A TN SN97039 A TNSN97039 A TN SN97039A TN SN97039 A1 TNSN97039 A1 TN SN97039A1
Authority
TN
Tunisia
Prior art keywords
antagonists
muscarinic receptors
thiadiazole
oxadiazole
derivatives
Prior art date
Application number
TNTNSN97039A
Other languages
English (en)
Inventor
Roderick Mackenzie Alexander
Wood Anthony
John Bass Robert
Original Assignee
Pfizer Res And Dev Company Nv S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Res And Dev Company Nv S A filed Critical Pfizer Res And Dev Company Nv S A
Publication of TNSN97039A1 publication Critical patent/TNSN97039A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

L'INVENTION CONCERNE UN COMPOSE DE FORMULE I : DANS LAQUELLE R1 ET R3 REPRESENTENT DES RADICAUX ORGANIQUES. R2 REPRESENTE H OU UN RADICAL ORGANIQUE , X REPRESENTE O OU S ET Y REPRESENTE UNE LIAISON DIRECTE OU UN RADICAL ORGANIQUE, ET SES SELS PHARMACEUTIQUEMENT ACCEPTABLES. ELLE CONCERNE EGALEMENT UN PROCEDE POUR LA PREPARATION D'UN TEL COMPOSE ET UNE COMPOSITION PHARMACEUTIQUE COMPRENANT CE COMPOSE. UTILISATION DES COMPOSES COMME ANTAGONISTES DES RECEPTEURS MUSCARINIQUES DANS LE TRAITEMENT DE DIVERSES MALADIES.
TNTNSN97039A 1996-02-22 1997-02-19 Derives d'oxadiazole et de thiadiazole antagonistes des recepteurs muscariniques. TNSN97039A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9603755.1A GB9603755D0 (en) 1996-02-22 1996-02-22 Therapeutic agents

Publications (1)

Publication Number Publication Date
TNSN97039A1 true TNSN97039A1 (fr) 2005-03-15

Family

ID=10789217

Family Applications (1)

Application Number Title Priority Date Filing Date
TNTNSN97039A TNSN97039A1 (fr) 1996-02-22 1997-02-19 Derives d'oxadiazole et de thiadiazole antagonistes des recepteurs muscariniques.

Country Status (42)

Country Link
US (1) US5977142A (fr)
EP (1) EP0885218B1 (fr)
JP (1) JP3148252B2 (fr)
KR (1) KR100315934B1 (fr)
CN (1) CN1089340C (fr)
AP (1) AP751A (fr)
AR (1) AR005916A1 (fr)
AT (1) ATE200899T1 (fr)
AU (1) AU712230B2 (fr)
BG (2) BG102699A (fr)
BR (1) BR9707733A (fr)
CA (1) CA2247164C (fr)
CO (1) CO4650040A1 (fr)
CZ (1) CZ292650B6 (fr)
DE (1) DE69704701T2 (fr)
DK (1) DK0885218T3 (fr)
DZ (1) DZ2181A1 (fr)
ES (1) ES2156357T3 (fr)
GB (1) GB9603755D0 (fr)
GR (1) GR3036032T3 (fr)
HN (1) HN1997000020A (fr)
HR (1) HRP970098B1 (fr)
HU (1) HUP9900501A3 (fr)
ID (1) ID16642A (fr)
IL (1) IL125413A (fr)
IS (1) IS4803A (fr)
MY (1) MY129729A (fr)
NO (1) NO313414B1 (fr)
NZ (1) NZ331039A (fr)
OA (1) OA10838A (fr)
PE (1) PE42798A1 (fr)
PL (1) PL186879B1 (fr)
PT (1) PT885218E (fr)
RU (1) RU2162848C2 (fr)
SK (1) SK283461B6 (fr)
TN (1) TNSN97039A1 (fr)
TR (1) TR199801644T2 (fr)
TW (1) TW492961B (fr)
UA (1) UA61068C2 (fr)
WO (1) WO1997030994A1 (fr)
YU (1) YU35698A (fr)
ZA (1) ZA971513B (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6107313A (en) * 1998-10-02 2000-08-22 Combichem, Inc. Dopamine receptor antagonists
DE60222872T2 (de) * 2001-02-21 2008-07-24 Astrazeneca Ab Heteropolycyclische verbindungen und deren verwendung als metabotrope glutamatrezeptorantagonisten
GB0510139D0 (en) * 2005-05-18 2005-06-22 Addex Pharmaceuticals Sa Novel compounds B1
GB0510141D0 (en) * 2005-05-18 2005-06-22 Addex Pharmaceuticals Sa Novel compounds B3
GB0516313D0 (en) * 2005-08-08 2005-09-14 Argenta Discovery Ltd Azole derivatives and their uses
WO2008017827A2 (fr) * 2006-08-08 2008-02-14 Argenta Discovery Limited Composés chimiques
WO2008023157A1 (fr) * 2006-08-21 2008-02-28 Argenta Discovery Limited Composés et leur utilisation
WO2008096093A1 (fr) * 2007-02-06 2008-08-14 Argenta Discovery Ltd. Dérivés d'oxazole et de thiazole et leurs utilisations
GB0702385D0 (en) * 2007-02-07 2007-03-21 Argenta Discovery Ltd New combination
GB0702414D0 (en) * 2007-02-07 2007-03-21 Argenta Discovery Ltd Oxazole and thiazole derivatives and their uses 2
GB0702416D0 (en) * 2007-02-07 2007-03-21 Argenta Discovery Ltd New combination
MX2009008364A (es) * 2007-02-07 2009-08-20 Astrazeneca Ab Sal de napadisilato de un antagonista m3 muscarinico.
GB0702382D0 (en) * 2007-02-07 2007-03-21 Argenta Discovery Ltd New salt
UY30916A1 (es) * 2007-02-15 2008-09-30 Argenta Discovery Ltd Derivados del 1-[sustituido]--3-[sustituido]-1-azona-biciclo[2,2,2]octano y sus enantiomeros
WO2009098453A1 (fr) * 2008-02-06 2009-08-13 Astrazeneca Ab Azonia bicycloalcanes comme antagonistes du récepteur d'acétylcholine muscarinique m3
US8263623B2 (en) 2008-07-11 2012-09-11 Pfizer Inc. Triazol derivatives useful for the treatment of diseases
WO2010018352A1 (fr) * 2008-08-12 2010-02-18 Argenta Discovery Limited Composés hétérocycliques utilisés dans le traitement de maladies impliquant l’activation améliorée du récepteur m3
JP2014065387A (ja) * 2012-09-25 2014-04-17 Showa Corp 自動二輪車の車高調整装置

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ219646A (en) * 1986-03-27 1990-10-26 Merck Sharp & Dohme Oxadiazole derivatives of azacyclics for treating cns disorders
IL88846A0 (en) * 1988-01-08 1989-07-31 Merck Sharp & Dohme Lipophilic oxadiazoles,their preparation and pharmaceutical compositions containing them
US5043345A (en) * 1989-02-22 1991-08-27 Novo Nordisk A/S Piperidine compounds and their preparation and use
CA2126976A1 (fr) * 1991-12-31 1993-07-08 Hisashi Takasugi Derives d'oxadiazole inhibiteurs de l'activite de l'acetylcholinesterase et agonistes muscariniques
TW360653B (en) * 1995-03-01 1999-06-11 Janssen Pharmaceutica Nv A oxadiazole compound having colon motility stimulating properties, its preparation process and its pharmaceutical composition

Also Published As

Publication number Publication date
BG63971B1 (bg) 2003-08-29
AU1601497A (en) 1997-09-10
HRP970098B1 (en) 2001-12-31
ZA971513B (en) 1998-08-21
YU35698A (sh) 1999-07-28
WO1997030994A1 (fr) 1997-08-28
CO4650040A1 (es) 1998-09-03
ID16642A (id) 1997-10-23
MY129729A (en) 2007-04-30
OA10838A (en) 2001-08-13
UA61068C2 (en) 2003-11-17
JPH11504051A (ja) 1999-04-06
PL186879B1 (pl) 2004-03-31
CA2247164C (fr) 2004-11-16
BR9707733A (pt) 1999-07-27
BG102699A (en) 1999-09-30
IL125413A (en) 2002-09-12
AU712230B2 (en) 1999-11-04
EP0885218B1 (fr) 2001-05-02
NO983871D0 (no) 1998-08-21
GR3036032T3 (en) 2001-09-28
PT885218E (pt) 2001-08-30
IL125413A0 (en) 1999-03-12
US5977142A (en) 1999-11-02
RU2162848C2 (ru) 2001-02-10
HRP970098A2 (en) 1999-04-30
HUP9900501A2 (hu) 1999-06-28
AP751A (en) 1999-07-12
HN1997000020A (es) 1997-06-05
NO313414B1 (no) 2002-09-30
NO983871L (no) 1998-08-21
CZ267898A3 (cs) 1999-08-11
GB9603755D0 (en) 1996-04-24
SK112398A3 (en) 2000-04-10
DK0885218T3 (da) 2001-05-28
DE69704701T2 (de) 2001-08-16
PE42798A1 (es) 1998-08-18
CZ292650B6 (cs) 2003-11-12
KR19990087143A (ko) 1999-12-15
ATE200899T1 (de) 2001-05-15
TR199801644T2 (xx) 1998-11-23
HUP9900501A3 (en) 2001-02-28
HK1018274A1 (en) 1999-12-17
AR005916A1 (es) 1999-07-21
ES2156357T3 (es) 2001-06-16
AP9700930A0 (en) 1997-04-30
IS4803A (is) 1998-07-21
NZ331039A (en) 1999-10-28
DZ2181A1 (fr) 2002-12-01
CN1089340C (zh) 2002-08-21
PL328633A1 (en) 1999-02-15
TW492961B (en) 2002-07-01
CN1211981A (zh) 1999-03-24
SK283461B6 (sk) 2003-08-05
KR100315934B1 (ko) 2002-03-21
JP3148252B2 (ja) 2001-03-19
EP0885218A1 (fr) 1998-12-23
DE69704701D1 (de) 2001-06-07
CA2247164A1 (fr) 1997-08-28

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