PE20030319A1 - Compuestos de 1-aril-but-3-enilamina y 1-aril-but-2-enilamina sustituidos - Google Patents
Compuestos de 1-aril-but-3-enilamina y 1-aril-but-2-enilamina sustituidosInfo
- Publication number
- PE20030319A1 PE20030319A1 PE2002000600A PE2002000600A PE20030319A1 PE 20030319 A1 PE20030319 A1 PE 20030319A1 PE 2002000600 A PE2002000600 A PE 2002000600A PE 2002000600 A PE2002000600 A PE 2002000600A PE 20030319 A1 PE20030319 A1 PE 20030319A1
- Authority
- PE
- Peru
- Prior art keywords
- enylamine
- phenyl
- compounds
- aril
- aryl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical class [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000020401 Depressive disease Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 208000001953 Hypotension Diseases 0.000 abstract 1
- -1 PHENETHYL Chemical class 0.000 abstract 1
- 206010039966 Senile dementia Diseases 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- GEAXLHPORCRESC-UHFFFAOYSA-N chlorocyclohexatriene Chemical class ClC1=CC=C=C[CH]1 GEAXLHPORCRESC-UHFFFAOYSA-N 0.000 abstract 1
- 230000036543 hypotension Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- AUFHTKFKIWXXGO-UHFFFAOYSA-N n,n-dimethyl-1-phenyl-1-(2-phenylcyclohexen-1-yl)methanamine Chemical compound C=1C=CC=CC=1C(N(C)C)C(CCCC1)=C1C1=CC=CC=C1 AUFHTKFKIWXXGO-UHFFFAOYSA-N 0.000 abstract 1
- 150000003254 radicals Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/28—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by unsaturated carbon chains
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/29—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
SE REFIERE A COMPUESTOS DE 1-ARIL-BUT-3-ENILAMINA Y 1-ARIL-BUT-2-ENILAMINA SUSTITUIDOS DE FORMULA I DONDE R1 Y R2 SON ALQUILO C1-C6 O JUNTOS FORMAN UN CICLO (CH2)2-6 QUE TAMBIEN PUEDE ESTAR SUSTITUIDO CON A MENOS UN RADICAL ARILO O HETEROARILO, ENTRE OTROS; R3 ES ALQUILO C3-C6, CICLOALQUILO C3-C7, ARILO, HETEROARILO, ENTRE OTROS; R4 Y R5 SON ALQUILO C1-C6, CICLOALQUILO C3-C7, FENILO, BENCILO, FENETILO ENTRE OTROS; X e Y, Y y Z EN CONJUNTO REPRESENTAN UN ENLACE; A ES ARILO, HETEROARILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS DIMETIL-[FENIL-(2-FENIL-CICLOHEX-1-ENIL)-METIL]-AMINA, {[2-(4-CLORO-FENIL)-CICLOHEX-1-ENIL]-FENIL-METIL]-DIMETIL-AMINA, {[2-BENCIL-CICLOHEX-1-ENIL)-FENIL-METIL]-DIMETIL-AMINA, ENTRE OTROS. SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION Y COMPUESTOS INTERMEDIOS. LOS COMPUESTOS DE FORMULA I SON UTILES PARA EL TRATAMIENTO DE DEPRESION, HIPOTENSION, HIPERTENSION, DEMENCIA SENIL
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10132747A DE10132747A1 (de) | 2001-07-05 | 2001-07-05 | Substituierte 1-Aryl-but-3-enylamin- und 1-Aryl-but-2-enylaminverbindungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20030319A1 true PE20030319A1 (es) | 2003-04-26 |
Family
ID=7690809
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2002000600A PE20030319A1 (es) | 2001-07-05 | 2002-07-04 | Compuestos de 1-aril-but-3-enilamina y 1-aril-but-2-enilamina sustituidos |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7064236B2 (es) |
| EP (1) | EP1406857B1 (es) |
| AR (1) | AR037997A1 (es) |
| AT (1) | ATE354561T1 (es) |
| DE (2) | DE10132747A1 (es) |
| ES (1) | ES2282440T3 (es) |
| PE (1) | PE20030319A1 (es) |
| WO (1) | WO2003004452A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102004034619A1 (de) * | 2004-07-16 | 2006-02-23 | Grünenthal GmbH | Substituierte Aminoverbindungen als 5-HT/NA Uptakehemmer |
| DE102006055838A1 (de) * | 2005-12-02 | 2007-06-06 | Simon S.A. | Flächenbündiger Multifunktions-Elektromechanismus |
| CN103936605B (zh) * | 2007-05-31 | 2017-09-01 | 赛诺维信制药公司 | 苯基取代的环烷胺作为一元胺再摄取抑制剂 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE963424C (de) * | 1954-09-24 | 1957-05-09 | Thomae Gmbh Dr K | Verfahren zur Herstellung von therapeutisch wirksamen tertiaeren Aminen |
| DE1518663A1 (de) * | 1965-08-02 | 1969-12-18 | Gruenenthal Chemie | Basisch substituierte Cycloalken-derivate und Verfahren zu ihrer Herstellung |
| DE19609847A1 (de) * | 1996-03-13 | 1997-09-18 | Gruenenthal Gmbh | Dimethyl-(3-aryl-but-3-enyl)-aminverbindungen als pharmazeutische Wirkstoffe |
| DE19915601A1 (de) * | 1999-04-07 | 2000-10-19 | Gruenenthal Gmbh | 3-Amino-3-arylpropan-1-ol-Derivate, deren Herstellung und Verwendung |
-
2001
- 2001-07-05 DE DE10132747A patent/DE10132747A1/de not_active Withdrawn
-
2002
- 2002-07-03 EP EP02754818A patent/EP1406857B1/de not_active Expired - Lifetime
- 2002-07-03 DE DE50209548T patent/DE50209548D1/de not_active Expired - Lifetime
- 2002-07-03 WO PCT/EP2002/007381 patent/WO2003004452A1/de not_active Ceased
- 2002-07-03 ES ES02754818T patent/ES2282440T3/es not_active Expired - Lifetime
- 2002-07-03 AT AT02754818T patent/ATE354561T1/de active
- 2002-07-04 PE PE2002000600A patent/PE20030319A1/es not_active Application Discontinuation
- 2002-07-05 AR ARP020102524A patent/AR037997A1/es not_active Application Discontinuation
-
2004
- 2004-01-05 US US10/751,585 patent/US7064236B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ATE354561T1 (de) | 2007-03-15 |
| ES2282440T3 (es) | 2007-10-16 |
| EP1406857A1 (de) | 2004-04-14 |
| DE10132747A1 (de) | 2003-01-23 |
| AR037997A1 (es) | 2004-12-22 |
| US20040171615A1 (en) | 2004-09-02 |
| US7064236B2 (en) | 2006-06-20 |
| DE50209548D1 (de) | 2007-04-05 |
| WO2003004452A1 (de) | 2003-01-16 |
| EP1406857B1 (de) | 2007-02-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |