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PE20061351A1 - COMPUESTOS 8H-PIRIDO[2,3-d]PIRIMIDIN-7-ONA 2,4,8-TRISUSTITUIDOS COMO INHIBIDORES DE LA QUINASA CSBP/RK/p38 - Google Patents

COMPUESTOS 8H-PIRIDO[2,3-d]PIRIMIDIN-7-ONA 2,4,8-TRISUSTITUIDOS COMO INHIBIDORES DE LA QUINASA CSBP/RK/p38

Info

Publication number
PE20061351A1
PE20061351A1 PE2006000330A PE2006000330A PE20061351A1 PE 20061351 A1 PE20061351 A1 PE 20061351A1 PE 2006000330 A PE2006000330 A PE 2006000330A PE 2006000330 A PE2006000330 A PE 2006000330A PE 20061351 A1 PE20061351 A1 PE 20061351A1
Authority
PE
Peru
Prior art keywords
alkyl
pyrimidin
compounds
trisustituted
csbp
Prior art date
Application number
PE2006000330A
Other languages
English (en)
Inventor
Jeffrey C Boehm
James Francis Callahan
Stefano Livia
Zehong Wan
Beth A Norton
Neysa Nevins
Anthony William James Cooper
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PE20061351A1 publication Critical patent/PE20061351A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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Abstract

SE REFIERE A COMPUESTOS 8H-PIRIDO[2,3-d]PIRIMIDIN-7-ONA 2,4,8-TRISUSTITUIDA, DE FORMULA (I)o Y (Ia) DONDE G1 Y G2 SON INDEPENDIENTEMENTE N; G3 ES CH2; G4 ES CH; R1 ES C(Z)N(R10')(CR10R20)vRb, N(R10')C(Z)(CR10R20)vRb, ENTRE OTROS, DONDE Z ES O O S; R10' ES H O ALQUILO(C1-C4); R10 Y R20 SON H O ALQUILO(C1-C4); Rb ES H, ALQUILO(C1-C10), CICLOALQUILO(C3-C7), ENTRE OTROS; v ES DE 0 A 2; R1' ES HALOGENO, ALQUILO(C1-C4), HALO-ALQUILO(C1-C4), ENTRE OTROS; X ES R2, OR2, S(O)mR2, (CH2)n'NR4R14, (CH2)N(R2')(R2"), ENTRE OTROS, DONDE R2 ES H, ALQUILO(C1-C10), CICLOALQUILO(C3-C7), ENTRE OTROS; m ES DE 0 A 2; R3 ES ALQUILO(C1-C10), CICLOALQUILO(C3-C7), ARILO, ENTRE OTROS; OPCIONALMENTE SUSTITUIDO; g ES DE 0 A 4. SON COMPUESTOS PREFERIDOS: N-(CICLOPROPILMETIL)-3-(8-(2,6-DIFLUOROFENIL)-2-{[2-HIDROXI-1-(HIDROXIMETIL)ETIL]AMINO}-7-OXO-7,8-DIHIDROPIRIDO[2,3-d]PIRIMIDIN-4-IL)-4-METILBENZAMIDA, N-(CICLOPROPILMETIL)-3-[8-(2,6-DIFLUOROFENIL)-7-OXO-2-(4-PIPERIDINILAMINO)-7,8-DIHIDROPIRIDO[2,3-d]PIRIMIDIN-4-IL]-4-METILBENZAMIDA, N-(CICLOPROPILMETIL)-3-{8-(2,6-DIFLUOROFENIL)-7-OXO-2-[(2,2,6,6-TETRAMETIL-4-PIPERIDINIL)AMINO]-7,8-DIHIDROPIRIDO[2,3-d]PIRIMIDIN-4-IL}-4-METILBENZAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA QUINASA CSBP/RK/p38 SIENDO UTILES EN EL TRATAMIENTO DE ARTRITIS PSORIASICA, ARTRITIS REUMATOIDE, GOTA, ESPONDILITIS REUMATOIDE
PE2006000330A 2005-03-25 2006-03-23 COMPUESTOS 8H-PIRIDO[2,3-d]PIRIMIDIN-7-ONA 2,4,8-TRISUSTITUIDOS COMO INHIBIDORES DE LA QUINASA CSBP/RK/p38 PE20061351A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US66531505P 2005-03-25 2005-03-25

Publications (1)

Publication Number Publication Date
PE20061351A1 true PE20061351A1 (es) 2007-01-14

Family

ID=37053943

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2010000197A PE20100737A1 (es) 2005-03-25 2006-03-23 Nuevos compuestos
PE2006000330A PE20061351A1 (es) 2005-03-25 2006-03-23 COMPUESTOS 8H-PIRIDO[2,3-d]PIRIMIDIN-7-ONA 2,4,8-TRISUSTITUIDOS COMO INHIBIDORES DE LA QUINASA CSBP/RK/p38

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PE2010000197A PE20100737A1 (es) 2005-03-25 2006-03-23 Nuevos compuestos

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US (3) US7678801B2 (es)
EP (3) EP2436686A1 (es)
JP (1) JP5037487B2 (es)
KR (1) KR101235497B1 (es)
CN (4) CN102746299A (es)
AR (1) AR053346A1 (es)
AU (1) AU2006229993B2 (es)
BR (1) BRPI0609437A2 (es)
CA (1) CA2602553C (es)
EA (1) EA012875B1 (es)
ES (2) ES2426251T3 (es)
IL (1) IL185870A (es)
MA (1) MA29341B1 (es)
MX (1) MX2007011856A (es)
MY (2) MY145343A (es)
NO (1) NO20075275L (es)
NZ (1) NZ561237A (es)
PE (2) PE20100737A1 (es)
SG (1) SG166771A1 (es)
TW (1) TWI389690B (es)
UA (1) UA95444C2 (es)
UY (1) UY29440A1 (es)
WO (1) WO2006104915A2 (es)
ZA (1) ZA200707564B (es)

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US20090137550A1 (en) * 2005-03-25 2009-05-28 Glaxo Group Limited Novel Compounds
AR053346A1 (es) * 2005-03-25 2007-05-02 Glaxo Group Ltd Compuesto derivado de 8h -pirido (2,3-d) pirimidin -7 ona 2,4,8- trisustituida composicion farmaceutica y uso para preparar una composicion para tratamiento y profilxis de una enfermedad mediada por la quinasa csbp/ rk/p38
AR053450A1 (es) * 2005-03-25 2007-05-09 Glaxo Group Ltd Derivados de 3,4-dihidro-pirimido(4,5-d)pirimidin-2-(1h)-ona 1,5,7 trisustituidos como inhibidores de la quinasa p38
EP2032142A4 (en) * 2006-06-16 2010-07-21 Glaxo Group Ltd NOVEL CONNECTIONS
US20100144755A1 (en) * 2006-06-16 2010-06-10 Glaxo Group Limited Novel Compounds
GB0621830D0 (en) * 2006-11-02 2006-12-13 Chroma Therapeutics Ltd Inhibitors of p38 mitogen-activated protein kinase
EP1992344A1 (en) 2007-05-18 2008-11-19 Institut Curie P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation
WO2012158197A2 (en) * 2010-11-11 2012-11-22 Lyndor Biosciences L.L.C. Compounds useful as akt/pkb modulators and uses thereof
US9416124B2 (en) * 2011-08-25 2016-08-16 St. Jude Children's Research Hospital Substituted 2-alkyl-1-OXO-N-phenyl-3-heteroaryl-1,2,3,4-tetrahydroisoquinoline-4-carboxamides for antimalarial therapies
CN111601593B (zh) 2017-10-05 2022-04-15 弗尔康医疗公司 P38激酶抑制剂降低dux4和下游基因表达以用于治疗fshd
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