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PE20091492A1 - Compuestos y composiciones como inhibidores de c-kit y de la cinasa pdgfr - Google Patents

Compuestos y composiciones como inhibidores de c-kit y de la cinasa pdgfr

Info

Publication number
PE20091492A1
PE20091492A1 PE2009000257A PE2009000257A PE20091492A1 PE 20091492 A1 PE20091492 A1 PE 20091492A1 PE 2009000257 A PE2009000257 A PE 2009000257A PE 2009000257 A PE2009000257 A PE 2009000257A PE 20091492 A1 PE20091492 A1 PE 20091492A1
Authority
PE
Peru
Prior art keywords
compounds
kit
inhibitors
compositions
ona
Prior art date
Application number
PE2009000257A
Other languages
English (en)
Inventor
Xiaolin Li
Xiaodong Liu
Jon C Lauren
Valentina Molteni
Juliet Nabakka
Vince Yeh
Donatella Chianelli
Original Assignee
Irm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40577860&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20091492(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Irm Llc filed Critical Irm Llc
Publication of PE20091492A1 publication Critical patent/PE20091492A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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  • Veterinary Medicine (AREA)
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  • Psychiatry (AREA)
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  • Tropical Medicine & Parasitology (AREA)
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  • Oncology (AREA)
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  • Cardiology (AREA)
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Abstract

REFERIDA A UN COMPUESTO DE FORMULA I, DONDE R1 ES HALOGENO, ALQUILO C1-C6, CICLOALQUILO C3-C12, HETEROCICLOALQUILO C3-C8, ARILO C6-C10, ENTRE OTROS; A ES ANILLO INSATURADO DE 5 MIEMBROS CONTENIENDO 2-3 HETEROATOMOS O GURPOS SELECCIONADOS DE =N, -O-, S(O)0-2, -NR4-; R4 ES H, ALQUILO C1-C4, CICLOALQUILO C3-C8. SON COMPUESTOS PREFERIDOS: 1,7-DIMETIL-3-(2-METIL-5-(5-(PIRIDIN-2-IL)-1,2,4-OXADIAZOL-3-ILAMINO)FENIL)-1,6-NAFTIRIDIN-2(1H)-ONA; 3-{5-[(5-CICLOPROPIL-1,2,4-OXADIAZOL-3-IL)AMINO]-2-METILFENIL}-1,7-DIMETIL-1,2-DIHIDRO-1,6-NAFTIRIDIN-2-ONA; ENTRE OTROS. DICHOS COMPUESTOS SON INHIBIDORES DE CINASA PDGFR Y C-KIT UTILES EN EL TRATAMIENTO DE TRASTORNOS PROLIFERATIVOS, ARTRITIS REUMATOIDE, OSTEOARTRITIS, ENTRE OTROS
PE2009000257A 2008-02-22 2009-02-20 Compuestos y composiciones como inhibidores de c-kit y de la cinasa pdgfr PE20091492A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3091208P 2008-02-22 2008-02-22

Publications (1)

Publication Number Publication Date
PE20091492A1 true PE20091492A1 (es) 2009-10-22

Family

ID=40577860

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2009000257A PE20091492A1 (es) 2008-02-22 2009-02-20 Compuestos y composiciones como inhibidores de c-kit y de la cinasa pdgfr

Country Status (17)

Country Link
US (1) US8278452B2 (es)
EP (1) EP2252612B1 (es)
JP (1) JP5230755B2 (es)
KR (1) KR101216323B1 (es)
CN (1) CN102083828B (es)
AR (1) AR070469A1 (es)
AT (1) ATE551342T1 (es)
AU (1) AU2009217356B2 (es)
BR (1) BRPI0908849A2 (es)
CA (1) CA2714700C (es)
CL (1) CL2009000400A1 (es)
EA (1) EA018551B1 (es)
ES (1) ES2383331T3 (es)
MX (1) MX2010009207A (es)
PE (1) PE20091492A1 (es)
TW (1) TW200940538A (es)
WO (1) WO2009105712A1 (es)

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