CL2009000400A1 - Compuestos heterociclicos derivados de 3-fenil-1,6- naftiridin-2-ona; moduladores de la actividad cinasa; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como trastornos alergicos, trastornos autoinmunes, neoplasias, rechazo en trasplante de organos, entre otras. - Google Patents
Compuestos heterociclicos derivados de 3-fenil-1,6- naftiridin-2-ona; moduladores de la actividad cinasa; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como trastornos alergicos, trastornos autoinmunes, neoplasias, rechazo en trasplante de organos, entre otras.Info
- Publication number
- CL2009000400A1 CL2009000400A1 CL2009000400A CL2009000400A CL2009000400A1 CL 2009000400 A1 CL2009000400 A1 CL 2009000400A1 CL 2009000400 A CL2009000400 A CL 2009000400A CL 2009000400 A CL2009000400 A CL 2009000400A CL 2009000400 A1 CL2009000400 A1 CL 2009000400A1
- Authority
- CL
- Chile
- Prior art keywords
- naphthyridin
- neoplasms
- diseases
- disorders
- treatment
- Prior art date
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 4
- 208000023275 Autoimmune disease Diseases 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 230000000172 allergic effect Effects 0.000 title abstract 2
- 208000010668 atopic eczema Diseases 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000035475 disorder Diseases 0.000 title abstract 2
- 150000002391 heterocyclic compounds Chemical class 0.000 title abstract 2
- 210000000056 organ Anatomy 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- PEYAYAIIKFYFAB-UHFFFAOYSA-N 3-phenyl-1h-1,6-naphthyridin-2-one Chemical compound O=C1NC2=CC=NC=C2C=C1C1=CC=CC=C1 PEYAYAIIKFYFAB-UHFFFAOYSA-N 0.000 title 1
- 108091000080 Phosphotransferase Proteins 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
- 102000020233 phosphotransferase Human genes 0.000 title 1
- ZQKMVHXJWJNEQG-UHFFFAOYSA-N 1h-1,6-naphthyridin-2-one Chemical compound C1=NC=CC2=NC(O)=CC=C21 ZQKMVHXJWJNEQG-UHFFFAOYSA-N 0.000 abstract 1
- 206010052779 Transplant rejections Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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Abstract
Compuestos heterocíclicos derivados de 1,6- naftiridin-2-ona; composición farmacéutica; y uso en el tratamiento de enfermedades tales como trastornos alérgicos, trastornos autoinmunes, neoplasias, rechazo en trasplante de órganos, entre otras.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3091208P | 2008-02-22 | 2008-02-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2009000400A1 true CL2009000400A1 (es) | 2010-09-10 |
Family
ID=40577860
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2009000400A CL2009000400A1 (es) | 2008-02-22 | 2009-02-20 | Compuestos heterociclicos derivados de 3-fenil-1,6- naftiridin-2-ona; moduladores de la actividad cinasa; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como trastornos alergicos, trastornos autoinmunes, neoplasias, rechazo en trasplante de organos, entre otras. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8278452B2 (es) |
| EP (1) | EP2252612B1 (es) |
| JP (1) | JP5230755B2 (es) |
| KR (1) | KR101216323B1 (es) |
| CN (1) | CN102083828B (es) |
| AR (1) | AR070469A1 (es) |
| AT (1) | ATE551342T1 (es) |
| AU (1) | AU2009217356B2 (es) |
| BR (1) | BRPI0908849A2 (es) |
| CA (1) | CA2714700C (es) |
| CL (1) | CL2009000400A1 (es) |
| EA (1) | EA018551B1 (es) |
| ES (1) | ES2383331T3 (es) |
| MX (1) | MX2010009207A (es) |
| PE (1) | PE20091492A1 (es) |
| TW (1) | TW200940538A (es) |
| WO (1) | WO2009105712A1 (es) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011049625A1 (en) | 2009-10-20 | 2011-04-28 | Mansour Samadpour | Method for aflatoxin screening of products |
| EP3444242A3 (en) | 2009-11-05 | 2019-03-20 | Rhizen Pharmaceuticals S.A. | Novel benzopyran kinase modulators |
| TWI619713B (zh) * | 2010-04-21 | 2018-04-01 | 普雷辛肯公司 | 用於激酶調節的化合物和方法及其適應症 |
| CN103402522A (zh) * | 2011-03-01 | 2013-11-20 | 恩法玛康有限责任公司 | N-(4-甲氧基苯基)-1-苯基-1h-吡唑-3-胺及相关化合物的用途 |
| PT2705029T (pt) | 2011-05-04 | 2019-02-01 | Rhizen Pharmaceuticals S A | Novos compostos como moduladores de proteína quinases |
| US9434753B2 (en) | 2011-09-19 | 2016-09-06 | Gencia Corporation | Modified creatine compounds |
| SMT201800662T1 (it) | 2011-12-22 | 2019-01-11 | Alios Biopharma Inc | Nucleotidi, nucleosidi sostituiti e loro analoghi |
| USRE48171E1 (en) | 2012-03-21 | 2020-08-25 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| US9441007B2 (en) | 2012-03-21 | 2016-09-13 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| PL2861611T3 (pl) | 2012-05-25 | 2017-08-31 | Janssen Sciences Ireland Uc | Nukleozydy uracylowe spirooksetanu |
| US8461179B1 (en) | 2012-06-07 | 2013-06-11 | Deciphera Pharmaceuticals, Llc | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
| AU2012327210B2 (en) * | 2012-06-07 | 2016-07-28 | Deciphera Pharmaceuticals, Llc | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
| HRP20171610T1 (hr) | 2012-07-04 | 2018-03-23 | Rhizen Pharmaceuticals S.A. | Selektivni inhibitori pi3k delta |
| EP3912984A1 (en) | 2012-12-21 | 2021-11-24 | Janssen BioPharma, Inc. | 4'-fluoro-nucleosides, 4'-fluoro-nucleotides and analogs thereof for the treatment of hcv |
| ES2675027T3 (es) | 2013-09-06 | 2018-07-05 | Aurigene Discovery Technologies Limited | Derivados de 1,2,4-oxadiazol como inmunomoduladores |
| CN104458675A (zh) * | 2013-09-12 | 2015-03-25 | 中国药科大学 | 一种筛选干细胞因子受体激酶抑制剂高通量筛选方法 |
| CN104458674A (zh) * | 2013-09-12 | 2015-03-25 | 中国药科大学 | 一种筛选血管内皮生长因子1激酶抑制剂高通量筛选方法 |
| SG10201804835VA (en) | 2013-10-11 | 2018-07-30 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
| SG11201706902SA (en) * | 2015-03-10 | 2017-09-28 | Aurigene Discovery Tech Ltd | 3-substituted-1,2,4-oxadiazole and thiadiazole compounds as immunomodulators |
| CA3220902A1 (en) | 2015-03-10 | 2016-09-15 | Aurigene Discovery Technologies Limited | 1,2,4-oxadiazole and thiadiazole compounds as immunomodulators |
| EP3402792B1 (en) * | 2016-01-11 | 2021-08-25 | Merck Patent GmbH | Quinolin-2-one derivatives |
| WO2019061324A1 (en) | 2017-09-29 | 2019-04-04 | Curis Inc. | CRYSTALLINE FORMS OF IMMUNOMODULATORS |
| BR112020006669A2 (pt) | 2017-10-11 | 2020-09-24 | Aurigene Discovery Technologies Limited | formas cristalinas de 1,2,4-oxadiazol 3-substituído |
| MY206121A (en) | 2017-11-03 | 2024-11-29 | Aurigene Discovery Tech Ltd | Dual inhibitors of tim-3 and pd-1 pathways |
| KR20200084333A (ko) | 2017-11-06 | 2020-07-10 | 오리진 디스커버리 테크놀로지스 리미티드 | 면역조절을 위한 병행 요법 |
| EP3746060A1 (en) | 2018-01-31 | 2020-12-09 | Deciphera Pharmaceuticals, LLC | Combination therapy for the treatment of mastocytosis |
| BR112020015581A2 (pt) | 2018-01-31 | 2021-02-02 | Deciphera Pharmaceuticals, Llc | terapia de combinação para o tratamento de tumores estromais gastrointestinais |
| US11472781B2 (en) | 2018-02-21 | 2022-10-18 | Southern Research Institute | 2-aminoaryl-5-aryloxazole analogs for the treatment of neurodegenerative diseases |
| US11718593B2 (en) | 2018-05-17 | 2023-08-08 | Southern Research Institute | 2,5-aryl-thiazole analogs for the treatment of neurodegenerative diseases |
| JP2022526713A (ja) | 2019-03-21 | 2022-05-26 | オンクセオ | がんの処置のための、キナーゼ阻害剤と組み合わせたDbait分子 |
| CA3138300A1 (en) | 2019-05-03 | 2020-11-12 | Kinnate Biopharma Inc. | Inhibitors of raf kinases |
| KR20220045189A (ko) | 2019-08-12 | 2022-04-12 | 데시페라 파마슈티칼스, 엘엘씨. | 위장관 기질 종양을 치료하는 방법 |
| WO2021030405A1 (en) | 2019-08-12 | 2021-02-18 | Deciphera Pharmaceuticals, Llc | Ripretinib for treating gastrointestinal stromal tumors |
| PH12022550976A1 (en) | 2019-10-24 | 2023-09-25 | Kinnate Biopharma Inc | Inhibitors of raf kinases |
| KR20220098759A (ko) | 2019-11-08 | 2022-07-12 | 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) | 키나제 억제제에 대해 내성을 획득한 암의 치료 방법 |
| CN118948773A (zh) | 2019-12-30 | 2024-11-15 | 德西费拉制药有限责任公司 | 1-(4溴-5-(1乙基-7-(甲氨基)-2侧氧基-1,2-二氢-1,6-萘啶-3基)-2氟苯基)-3-苯基脲的组合物 |
| SMT202300467T1 (it) | 2019-12-30 | 2024-01-10 | Deciphera Pharmaceuticals Llc | Formulazioni di inibitori di chinasi amorfi e loro procedimenti d’uso |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| US11407737B2 (en) | 2020-09-18 | 2022-08-09 | Kinnate Biopharma Inc. | Inhibitors of RAF kinases |
| US11377431B2 (en) | 2020-10-12 | 2022-07-05 | Kinnate Biopharma Inc. | Inhibitors of RAF kinases |
| IL307908A (en) | 2021-04-23 | 2023-12-01 | Kinnate Biopharma Inc | Cancer treatment with a RAF inhibitor |
| CN113662938B (zh) * | 2021-09-26 | 2022-08-16 | 广西科技大学 | 一种胺类衍生物在制备抗肿瘤药物组合物中的应用 |
| US11814384B2 (en) | 2022-02-03 | 2023-11-14 | Kinnate Biopharma Inc. | Inhibtors of Raf kinases |
| US11779572B1 (en) | 2022-09-02 | 2023-10-10 | Deciphera Pharmaceuticals, Llc | Methods of treating gastrointestinal stromal tumors |
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| ZA985870B (en) | 1997-07-15 | 1999-01-27 | Dainippon Pharmaceutical Co | 5-substituted-3-oxadiazolyl-1, 6-naphthyridin-2(1H)-one derivatives |
| WO1999009030A1 (en) | 1997-08-20 | 1999-02-25 | Warner-Lambert Company | Naphthyridinones for inhibiting protein tyrosine kinase and cell cycle kinase mediated cellular proliferation |
| US6822097B1 (en) | 2002-02-07 | 2004-11-23 | Amgen, Inc. | Compounds and methods of uses |
| US7196090B2 (en) | 2002-07-25 | 2007-03-27 | Warner-Lambert Company | Kinase inhibitors |
| CN1863774B (zh) * | 2003-10-08 | 2010-12-15 | Irm责任有限公司 | 用作蛋白激酶抑制剂的化合物和组合物 |
| US20070054916A1 (en) | 2004-10-01 | 2007-03-08 | Amgen Inc. | Aryl nitrogen-containing bicyclic compounds and methods of use |
| GT200500321A (es) * | 2004-11-09 | 2006-09-04 | Compuestos y composiciones como inhibidores de proteina kinase. | |
| AU2005321946B2 (en) * | 2004-12-23 | 2012-08-16 | Deciphera Pharmaceuticals, Llc | Enzyme modulators and treatments |
| US20090312349A1 (en) * | 2004-12-23 | 2009-12-17 | Deciphera Pharmaceuticals, Llc | Anti-inflammatory medicaments |
| ES2351939T3 (es) | 2005-08-09 | 2011-02-14 | Irm Llc | Compuestos y composiciones como inhibidores de proteínas cinasas. |
| RU2436776C2 (ru) | 2005-09-27 | 2011-12-20 | Айрм Ллк | ДИАРИЛАМИН-СОДЕРЖАЩИЕ СОЕДИНЕНИЯ, КОМПОЗИЦИИ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ МОДУЛЯТОРОВ РЕЦЕПТОРОВ с-КIT |
| BRPI0711628A2 (pt) | 2006-05-15 | 2011-12-06 | Irm Llc | composto, composição farmacêutica, uso e processo para preparação do composto |
| US8188113B2 (en) | 2006-09-14 | 2012-05-29 | Deciphera Pharmaceuticals, Inc. | Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
| US7897762B2 (en) * | 2006-09-14 | 2011-03-01 | Deciphera Pharmaceuticals, Llc | Kinase inhibitors useful for the treatment of proliferative diseases |
| EP2076513A1 (en) * | 2006-10-20 | 2009-07-08 | Irm Llc | Compositions and methods for modulating c-kit and pdgfr receptors |
| JP5160637B2 (ja) | 2007-05-04 | 2013-03-13 | アイアールエム・リミテッド・ライアビリティ・カンパニー | c−kitおよびPDGFRキナーゼインヒビターとしての化合物および組成物 |
| BRPI0811617A2 (pt) | 2007-05-04 | 2017-06-06 | Irm Llc | derivados de primidina e composições como inibidores de c-kit e pdgfr quinase. |
-
2009
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- 2009-02-20 JP JP2010547818A patent/JP5230755B2/ja not_active Expired - Fee Related
- 2009-02-20 KR KR1020107021103A patent/KR101216323B1/ko not_active Expired - Fee Related
- 2009-02-20 ES ES09711557T patent/ES2383331T3/es active Active
- 2009-02-20 AT AT09711557T patent/ATE551342T1/de active
- 2009-02-20 US US12/918,801 patent/US8278452B2/en not_active Expired - Fee Related
- 2009-02-20 MX MX2010009207A patent/MX2010009207A/es active IP Right Grant
- 2009-02-20 BR BRPI0908849-0A patent/BRPI0908849A2/pt not_active IP Right Cessation
- 2009-02-20 CL CL2009000400A patent/CL2009000400A1/es unknown
- 2009-02-20 EP EP09711557A patent/EP2252612B1/en not_active Not-in-force
- 2009-02-20 CA CA2714700A patent/CA2714700C/en not_active Expired - Fee Related
- 2009-02-20 PE PE2009000257A patent/PE20091492A1/es not_active Application Discontinuation
- 2009-02-20 WO PCT/US2009/034778 patent/WO2009105712A1/en not_active Ceased
- 2009-02-20 CN CN2009801139589A patent/CN102083828B/zh not_active Expired - Fee Related
- 2009-02-20 EA EA201001331A patent/EA018551B1/ru not_active IP Right Cessation
- 2009-02-23 TW TW098105719A patent/TW200940538A/zh unknown
- 2009-02-24 AR ARP090100626A patent/AR070469A1/es unknown
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|---|---|
| CA2714700A1 (en) | 2009-08-27 |
| PE20091492A1 (es) | 2009-10-22 |
| CN102083828A (zh) | 2011-06-01 |
| WO2009105712A1 (en) | 2009-08-27 |
| EA018551B1 (ru) | 2013-08-30 |
| AU2009217356A1 (en) | 2009-08-27 |
| MX2010009207A (es) | 2011-03-03 |
| TW200940538A (en) | 2009-10-01 |
| JP2011513231A (ja) | 2011-04-28 |
| EP2252612A1 (en) | 2010-11-24 |
| ES2383331T3 (es) | 2012-06-20 |
| KR101216323B1 (ko) | 2012-12-27 |
| AR070469A1 (es) | 2010-04-07 |
| US8278452B2 (en) | 2012-10-02 |
| US20110183997A1 (en) | 2011-07-28 |
| ATE551342T1 (de) | 2012-04-15 |
| EP2252612B1 (en) | 2012-03-28 |
| KR20100115379A (ko) | 2010-10-27 |
| CN102083828B (zh) | 2013-11-13 |
| BRPI0908849A2 (pt) | 2015-08-25 |
| JP5230755B2 (ja) | 2013-07-10 |
| AU2009217356B2 (en) | 2012-05-03 |
| CA2714700C (en) | 2013-07-30 |
| EA201001331A1 (ru) | 2011-04-29 |
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