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PE20110944A1 - DERIVADOS DE PIRAZOLO[3,4-d]PIRIMIDINA COMO INHIBIDORES PDE1 - Google Patents

DERIVADOS DE PIRAZOLO[3,4-d]PIRIMIDINA COMO INHIBIDORES PDE1

Info

Publication number
PE20110944A1
PE20110944A1 PE2011001165A PE2011001165A PE20110944A1 PE 20110944 A1 PE20110944 A1 PE 20110944A1 PE 2011001165 A PE2011001165 A PE 2011001165A PE 2011001165 A PE2011001165 A PE 2011001165A PE 20110944 A1 PE20110944 A1 PE 20110944A1
Authority
PE
Peru
Prior art keywords
alkyl
pyrazolo
phenylamine
pyrimidin
dihydro
Prior art date
Application number
PE2011001165A
Other languages
English (en)
Inventor
Peng Li
Lawrence P Wennogle
Jun Zhao
Hailin Zeng
Original Assignee
Intra Cellular Therapies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42233537&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20110944(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Intra Cellular Therapies Inc filed Critical Intra Cellular Therapies Inc
Publication of PE20110944A1 publication Critical patent/PE20110944A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings

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  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Rheumatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Pregnancy & Childbirth (AREA)
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  • Pain & Pain Management (AREA)
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Abstract

REFERIDA A UN COMPUESTOS DERIVADO DE PIRAZOL DE FORMULA (II), DONDE Q ES C(=S), C(=N(R6)) O C(R14)(R15); R1 ES H O ALQUILO C1-C6; R2 ES H, ALQUILO C1-C6, HALOALQUILO C1-C6, ENTRE OTROS; R3 ES D-E-F-, HETEROALQUILO DE 1 A 6 ATOMOS DE CARBONO SUSTITUIDO CON HALOALQUILO C1-C6, ENTRE OTROS; D ES UN ENLACE O ALQUILENO C1-C6; E ES UN ENLACE, ALQUILENO C1-C4, AMINO, ENTRE OTROS; F ES H, HALO, ALQUILO C1-C6, FENILO, ENTRE OTROS; R4 Y R5 SON H, ALQUILO C1-C6, FENILO, CICLOALQUILO C3-C8, ENTRE OTROS; R6 ES H, ALQUILO C1-C6 O CICLOALQUILO C3-C8. SON COMPUESTOS PREFERIDOS: 7-ISOBUTIL-5-METIL-3-(FENILAMINO)-2-(4-(PIRIDIN-2-IL)BENCIL)-4-TIOXO-4,5-DIHIDRO-2H-PIRAZOLO[3,4-d]PIRIMIDIN-6(7H)-ONA, 7-ISOBUTIL-5-METIL-4-(METILIMINO)-3-(FENILAMINO)-2-(4-(PIRIDIN-2-IL)BENCIL)-4,5-DIHIDRO-2H-PIRAZOLO[3,4-d]PIRIMIDIN-6(7H)-ONA, 2-(4-(1H-1,2,4-TRIAZOL-1-IL)BENCIL)-5-METIL-7-NEOPENTIL-3-(FENILAMINO)-4-TIOXO-4,5-DIHIDRO-2H-PIRAZOLO[3,4-d]PIRIMIDIN-6(7H)-ONA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE FOSFODIESTERASA 1 (PDE1) Y SON UTILES EN EL TRATAMIENTO DE LA ENFERMEDAD DE PARKINSON, NARCOLEPSIA, ESQUIZOFRENIA, ENTRE OTRAS
PE2011001165A 2008-12-06 2009-12-07 DERIVADOS DE PIRAZOLO[3,4-d]PIRIMIDINA COMO INHIBIDORES PDE1 PE20110944A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12043808P 2008-12-06 2008-12-06

Publications (1)

Publication Number Publication Date
PE20110944A1 true PE20110944A1 (es) 2012-01-25

Family

ID=42233537

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2011001165A PE20110944A1 (es) 2008-12-06 2009-12-07 DERIVADOS DE PIRAZOLO[3,4-d]PIRIMIDINA COMO INHIBIDORES PDE1

Country Status (22)

Country Link
US (2) US8697710B2 (es)
EP (1) EP2367431B1 (es)
JP (1) JP5710493B2 (es)
KR (1) KR20110098732A (es)
CN (1) CN102223799A (es)
AU (1) AU2009322905A1 (es)
BR (1) BRPI0922700A2 (es)
CA (1) CA2740398A1 (es)
CO (1) CO6390079A2 (es)
CR (1) CR20110310A (es)
DO (1) DOP2011000174A (es)
EA (1) EA201170773A1 (es)
EC (1) ECSP11011180A (es)
ES (1) ES2551325T3 (es)
GE (1) GEP20146029B (es)
IL (1) IL213311A0 (es)
MA (1) MA32940B1 (es)
MX (1) MX2011005932A (es)
PE (1) PE20110944A1 (es)
TN (1) TN2011000249A1 (es)
WO (1) WO2010065153A1 (es)
ZA (1) ZA201103634B (es)

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AU2006255028B2 (en) 2005-06-06 2012-04-19 Intra-Cellular Therapies, Inc. Organic compounds
CA2651519A1 (en) 2006-06-06 2007-12-13 Intra-Cellular Therapies, Inc. Organic compounds
ES2411604T3 (es) * 2006-11-13 2013-07-05 Intra-Cellular Therapies, Inc. Compuestos orgánicos
JP5837278B2 (ja) 2006-12-05 2015-12-24 イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． 新規使用
SI2240490T1 (sl) 2007-12-06 2014-02-28 Takeda Pharmaceutical Company Limited Organske spojine
US8846693B2 (en) * 2007-12-06 2014-09-30 Intra-Cellular Therapies, Inc. Optionally substituted pyrazolo[3,4-d]pyrimidine-4,6-diones
CA2740385A1 (en) 2008-12-06 2010-06-10 Intra-Cellular Therapies, Inc. Organic compounds
PE20110995A1 (es) * 2008-12-06 2012-02-06 Intra Cellular Therapies Inc DERIVADOS DE PIRROLO[3,4-e]PIRIMIDINA COMO INHIBIDORES DE PDE1
JP5989993B2 (ja) 2008-12-06 2016-09-07 イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． 有機化合物
AU2009322901A1 (en) 2008-12-06 2010-06-10 Intra-Cellular Therapies, Inc. Organic compounds
WO2010065152A1 (en) 2008-12-06 2010-06-10 Intra-Cellular Therapies, Inc. Organic compounds
US11464781B2 (en) 2009-02-25 2022-10-11 Intra-Cellular Therapies, Inc. PDE1 inhibitors for ophthalmic disorders
EP2434895A4 (en) 2009-05-13 2013-08-07 Intra Cellular Therapies Inc ORGANIC CONNECTIONS
JP2013507360A (ja) 2009-10-08 2013-03-04 イントラ−セルラー・セラピーズ・インコーポレイテッド ホスホジエステラーゼ１−標的トレーサーおよび方法
JP5911854B2 (ja) 2010-05-31 2016-04-27 イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． 有機化合物
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TW201206937A (en) 2010-05-31 2012-02-16 Intra Cellular Therapies Inc Organic compounds
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