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PE20060237A1 - Derivados de fenol y tiofenol 3- o 4-monosustituidos como ligandos de h3 - Google Patents

Derivados de fenol y tiofenol 3- o 4-monosustituidos como ligandos de h3

Info

Publication number
PE20060237A1
PE20060237A1 PE2005000505A PE2005000505A PE20060237A1 PE 20060237 A1 PE20060237 A1 PE 20060237A1 PE 2005000505 A PE2005000505 A PE 2005000505A PE 2005000505 A PE2005000505 A PE 2005000505A PE 20060237 A1 PE20060237 A1 PE 20060237A1
Authority
PE
Peru
Prior art keywords
monosustituted
thiophenol
ligands
phenol
derivatives
Prior art date
Application number
PE2005000505A
Other languages
English (en)
Inventor
Patrick Bernardelli
Andrew Michael Cronin
Stephen Martin Denton
Mark Ian Kemp
Fiona Rousseau
Fabrice Vergne
Delphine Serradeil-Civit
Edwige Lorthiois
Henry Jacobelli
Alexis Denis
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP04291187A external-priority patent/EP1593679A1/en
Priority claimed from GB0504564A external-priority patent/GB0504564D0/en
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of PE20060237A1 publication Critical patent/PE20060237A1/es

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    • C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D309/06—Radicals substituted by oxygen atoms
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Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE EL SUSTITUYENTE -Z-R ESTA EN POSICION META O PARA DEL GRUPO FENILO; X SE SELECCIONA ENTRE -CN, -CH2OH, -CH2-O-(ALQUILOC1-C4), -C(O)OH, ENTRE OTROS; Y ES CH2, CH(OH), O, C=O, N, ENTRE OTROS; Z ES O, S, SO, SO2; m Y p SON CADA UNO 1-3, CON LA CONDICION DE QUE m+p SEA IGUAL O MENOR QUE 4. SON COMPUESTOS PREFERIDOS: DIMETIL-{4-[3-(3-PIRROLIDIN-1-ILPROPOXI)FENIL]TETRAHIDRO-PIRAN-4-ILMETIL}AMINA; 1-{3-[4-(4-DIMETILAMINOMETIL-TETRAHIDRO-PIRAN-4-IL)-FENOXI]-PROPIL}-PIPERIDIN-4-OL; 2-(1-{3-[4-(4-DIMETILAMINOMETILTETRAHIDROPIRAN-4-IL)FENOXI]PROPIL}PIPERIDIN-4-IL)ETANOL; ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON LIGANDOS DE LOS RECEPTORES DE HISTAMINA H3 UTIELS EN EL TRATAMIENTO DE TRASTORNOS DEL SISTEMA NERVIOSO CENTRAL Y TRASTORNOS INFLAMATORIOS
PE2005000505A 2004-05-07 2005-05-04 Derivados de fenol y tiofenol 3- o 4-monosustituidos como ligandos de h3 PE20060237A1 (es)

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Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY150088A (en) 2003-05-19 2013-11-29 Irm Llc Immunosuppressant compounds and compositions
JP2007517056A (ja) 2003-12-29 2007-06-28 セプラコア インコーポレーテッド ピロール及びピラゾールｄａａｏ阻害剤
JP2006213674A (ja) * 2005-02-07 2006-08-17 Ube Ind Ltd ４−ホルミルテトラヒドロピラン化合物の製法
EP1904066B1 (en) 2005-07-06 2018-05-23 Sunovion Pharmaceuticals Inc. COMBINATIONS OF ESZOPICLONE AND TRANS 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-N-METHYL-1-NAPTHALENAMINE OR TRANS 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-1-NAPTHALENAMINE, for treating MENOPAUSE, perimenopause AND COGNITIVE DISORDERS
WO2007045989A1 (en) * 2005-10-20 2007-04-26 Pfizer Limited Pyridyl derivatives useful as h3 ligands
CN101426372A (zh) 2006-01-06 2009-05-06 塞普拉柯公司 基于四氢萘酮的单胺再摄取抑制剂
RU2430913C2 (ru) 2006-01-06 2011-10-10 Сепракор Инк. Циклоалкиламины в качестве ингибиторов повторного поглощения моноамина
PT2013835E (pt) 2006-03-31 2016-01-06 Sunovion Pharmaceuticals Inc Preparação de amidas and aminas quirais
CL2007001006A1 (es) 2006-04-11 2008-07-11 Novartis Ag Compuestos derivados de piperidina u 8-aza-biciclo[3.2.1]octano sustituidos; formulacion farmaceutica; producto; y uso para el tratamiento o prevencion de enfermedades tales como diabetes mellitus no insulino dependiente, artritis, obesidad, dislipid
TW200808773A (en) * 2006-06-23 2008-02-16 Abbott Lab Cyclopropyl amine derivatives
US9108948B2 (en) 2006-06-23 2015-08-18 Abbvie Inc. Cyclopropyl amine derivatives
US7884124B2 (en) 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
CN101610761A (zh) * 2006-12-22 2009-12-23 诺瓦提斯公司 作为ddp-iv抑制剂的1-氨基甲基-l-苯基-环己烷衍生物
US7902252B2 (en) 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
KR101581289B1 (ko) 2007-05-31 2015-12-31 세프라코 아이엔시. 모노아민 재흡수 억제제로서 페닐 치환된 시클로알킬아민
TW201039822A (en) 2009-02-06 2010-11-16 Taisho Pharmaceutical Co Ltd Dihydroquinolinone derivatives
US9186353B2 (en) 2009-04-27 2015-11-17 Abbvie Inc. Treatment of osteoarthritis pain
EP2575815A4 (en) 2010-06-04 2013-12-25 Albany Molecular Res Inc GLYCIN TRANSPORTER 1 INHIBITORS, METHODS OF MAKING THE SAME, AND USES THEREOF
WO2012037258A1 (en) 2010-09-16 2012-03-22 Abbott Laboratories Processes for preparing 1,2-substituted cyclopropyl derivatives
PH12014500919A1 (en) * 2011-10-26 2014-06-09 Pfizer Ltd (4-phenylimidazol-2-yl) ethylamine derivatives useful as sodium channel modulators
WO2014095534A1 (en) * 2012-12-19 2014-06-26 Basf Se New substituted triazoles and imidazoles and their use as fungicides
US9365511B2 (en) * 2013-01-09 2016-06-14 Arena Pharmaceuticals, Inc. Biphenyl-ethyl-pyrrolidine derivatives as histamine H3 receptor modulators for the treatment of cognitive disorders
TWI731317B (zh) 2013-12-10 2021-06-21 美商健臻公司 原肌球蛋白相關之激酶（ｔｒｋ）抑制劑
BR112017012566B1 (pt) 2014-12-18 2024-01-30 Genzyme Corporation Forma cristalina monohidratada, composição e formulações farmacêuticas de inibidores de cinases relacionadas à tropomiosina (trk)
CN113336715B (zh) * 2021-08-04 2021-11-23 山东海利尔化工有限公司 一种含二氧戊环的三唑类化合物及其中间体的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3024836A1 (de) * 1980-07-01 1982-01-28 A. Nattermann & Cie GmbH, 5000 Köln (3-alkylamino-2-hydroxy-propoxy)-benzylnitrile, verfahren zu deren herstellung und diese als wirkstof enthaltende arzneimittel
DK368687A (da) * 1986-11-21 1988-05-22 Cheminova As Aminoalkylerede hydroxyforbindelser og deres anvendelse som fungicider
MXPA02012851A (es) * 2000-07-13 2003-09-05 Abbott Lab Pirrolidinas 1,3-disustituidas y 1,3,3-trisustituidas como ligandos del receptor de histamina-3 y sus aplicaciones terapeuticas.
US7071191B2 (en) * 2000-08-08 2006-07-04 Ortho-Mcneil Pharmaceutical, Inc. Non-imidazole aryloxypiperidines
AU2002254114A1 (en) * 2001-03-23 2002-10-08 Eli Lilly And Company Non-imidazole aryl alkylamines compounds as histamine h3 receptor antagonists, preparation and therapeutic uses

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