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EA200601868A1 - 3- или 4-монозамещённые производные фенола и тиофенола, полезные в качестве н-лигандов - Google Patents

3- или 4-монозамещённые производные фенола и тиофенола, полезные в качестве н-лигандов

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Publication number
EA200601868A1
EA200601868A1 EA200601868A EA200601868A EA200601868A1 EA 200601868 A1 EA200601868 A1 EA 200601868A1 EA 200601868 A EA200601868 A EA 200601868A EA 200601868 A EA200601868 A EA 200601868A EA 200601868 A1 EA200601868 A1 EA 200601868A1
Authority
EA
Eurasian Patent Office
Prior art keywords
thiophenol
phenol
derivatives
ligands
useful
Prior art date
Application number
EA200601868A
Other languages
English (en)
Other versions
EA011161B1 (ru
Inventor
Патрик Бернарделли
Эндрю Майкл Кронин
Алексис Дени
Стефен Мартин Дентон
Генри Джакобелли
Марк Ян Кемп
Эдвиж Лортиуа
Фиона Руссо
Дельфин Серрадель-Сиви
Фабрис Вернь
Original Assignee
Уорнер-Ламберт Компани Ллс
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP04291187A external-priority patent/EP1593679A1/en
Priority claimed from GB0504564A external-priority patent/GB0504564D0/en
Application filed by Уорнер-Ламберт Компани Ллс filed Critical Уорнер-Ламберт Компани Ллс
Publication of EA200601868A1 publication Critical patent/EA200601868A1/ru
Publication of EA011161B1 publication Critical patent/EA011161B1/ru

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    • C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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Abstract

Изобретение относится к 3- или 4-монозамещенным производным фенола и тиофенола формулы (1) и к способам получения таких производных, используемым для их получения промежуточным продуктам, содержащим такие производные композициям и применению таких производных. Указанные 3- или 4-замещенные производные фенола и тиофенола являются Н-лигандами и полезны в случае многочисленных заболеваний, нарушений и состояний, в частности воспалительных, аллергических и респираторных заболеваний, нарушений и состояний.
EA200601868A 2004-05-07 2005-04-19 3- или 4-монозамещённые производные фенола и тиофенола, полезные в качестве h-лигандов EA011161B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04291187A EP1593679A1 (en) 2004-05-07 2004-05-07 3- Or 4-monosubstituted phenol derivatives useful as H3 ligands
GB0504564A GB0504564D0 (en) 2005-03-04 2005-03-04 New compounds
PCT/IB2005/001114 WO2005108384A1 (en) 2004-05-07 2005-04-19 3- or 4-monosubstituted phenol and thiophenol derivatives useful as h3 ligands

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EA200601868A1 true EA200601868A1 (ru) 2007-04-27
EA011161B1 EA011161B1 (ru) 2009-02-27

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Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY150088A (en) 2003-05-19 2013-11-29 Irm Llc Immunosuppressant compounds and compositions
AU2004312530A1 (en) 2003-12-29 2005-07-21 Sepracor Inc. Pyrrole and pyrazole DAAO inhibitors
JP2006213674A (ja) * 2005-02-07 2006-08-17 Ube Ind Ltd ４−ホルミルテトラヒドロピラン化合物の製法
WO2007006003A2 (en) 2005-07-06 2007-01-11 Sepracor Inc. Combinations of eszopiclone and trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-n-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders
WO2007045989A1 (en) * 2005-10-20 2007-04-26 Pfizer Limited Pyridyl derivatives useful as h3 ligands
ES2566479T3 (es) 2006-01-06 2016-04-13 Sunovion Pharmaceuticals Inc. Inhibidores de reabsorción de monoamina con base en tetralona
KR101294014B1 (ko) * 2006-01-06 2013-08-09 선오비온 파마슈티컬스 인코포레이티드 모노아민 재흡수 저해제로서의 시클로알킬아민
EP2816024B8 (en) 2006-03-31 2018-04-04 Sunovion Pharmaceuticals Inc. Chiral amines
US7888351B2 (en) 2006-04-11 2011-02-15 Novartis Ag Organic compounds
MX2008016343A (es) 2006-06-23 2009-01-19 Abbott Lab Derivados ciclopropil amina como moduladores del receptro de histamina h3.
US9108948B2 (en) 2006-06-23 2015-08-18 Abbvie Inc. Cyclopropyl amine derivatives
US7884124B2 (en) 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
EP2124913A1 (en) * 2006-12-22 2009-12-02 Novartis AG 1-aminomethyl- l- phenyl- cyclohexane derivatives as ddp-iv inhibitors
US7902252B2 (en) 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
CN101686672A (zh) 2007-05-31 2010-03-31 塞普拉柯公司 苯基取代的环烷胺作为一元胺再摄取抑制剂
TW201039822A (en) 2009-02-06 2010-11-16 Taisho Pharmaceutical Co Ltd Dihydroquinolinone derivatives
US9186353B2 (en) 2009-04-27 2015-11-17 Abbvie Inc. Treatment of osteoarthritis pain
SG186885A1 (en) 2010-06-04 2013-02-28 Albany Molecular Res Inc Glycine transporter-1 inhibitors, methods of making them, and uses thereof
US8853390B2 (en) 2010-09-16 2014-10-07 Abbvie Inc. Processes for preparing 1,2-substituted cyclopropyl derivatives
MD20140037A2 (ru) * 2011-10-26 2014-08-31 Pfizer Limited Производные (4-фенилимидазол-2-ил)этиламина полезные в качестве модулляторов натриевого канала
WO2014095534A1 (en) * 2012-12-19 2014-06-26 Basf Se New substituted triazoles and imidazoles and their use as fungicides
ES2886914T3 (es) * 2013-01-09 2021-12-21 Arena Pharm Inc Acido (R)-3-(4'-(2-(2-metilpirrolidin-1-il)etil)-bifenil-4-il)propanoico como moduladores del receptor de histamina H3 para el tratamiento de trastornos cognitivos
US9067914B1 (en) 2013-12-10 2015-06-30 Genzyme Corporation Tropomyosin-related kinase (TRK) inhibitors
CN110950862B (zh) 2014-12-18 2024-01-05 建新公司 原肌球蛋白相关激酶(trk)抑制剂的药物制剂
CN113336715B (zh) * 2021-08-04 2021-11-23 山东海利尔化工有限公司 一种含二氧戊环的三唑类化合物及其中间体的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3024836A1 (de) * 1980-07-01 1982-01-28 A. Nattermann & Cie GmbH, 5000 Köln (3-alkylamino-2-hydroxy-propoxy)-benzylnitrile, verfahren zu deren herstellung und diese als wirkstof enthaltende arzneimittel
DK368687A (da) * 1986-11-21 1988-05-22 Cheminova As Aminoalkylerede hydroxyforbindelser og deres anvendelse som fungicider
MXPA02012851A (es) * 2000-07-13 2003-09-05 Abbott Lab Pirrolidinas 1,3-disustituidas y 1,3,3-trisustituidas como ligandos del receptor de histamina-3 y sus aplicaciones terapeuticas.
KR100852362B1 (ko) * 2000-08-08 2008-08-14 오르토-맥네일 파마슈티칼, 인코퍼레이티드 비-이미다졸 아릴옥시피페리딘
WO2002076925A2 (en) * 2001-03-23 2002-10-03 Eli Lilly And Company Non-imidazole aryl alkylamines compounds as histamine h3 receptor antagonists, preparation and therapeutic uses

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