PE20050141A1 - DERIVADOS DE 2-ALQUINIL-Y 2-ALQUENIL-PIRAZOLO-[4,3-e]-1,2,4-TRIAZOLO-[1,5-c]-PIRIDINA COMO ANTAGONISTAS DEL RECEPTOR A2a ADENOSINA - Google Patents
DERIVADOS DE 2-ALQUINIL-Y 2-ALQUENIL-PIRAZOLO-[4,3-e]-1,2,4-TRIAZOLO-[1,5-c]-PIRIDINA COMO ANTAGONISTAS DEL RECEPTOR A2a ADENOSINAInfo
- Publication number
- PE20050141A1 PE20050141A1 PE2004000392A PE2004000392A PE20050141A1 PE 20050141 A1 PE20050141 A1 PE 20050141A1 PE 2004000392 A PE2004000392 A PE 2004000392A PE 2004000392 A PE2004000392 A PE 2004000392A PE 20050141 A1 PE20050141 A1 PE 20050141A1
- Authority
- PE
- Peru
- Prior art keywords
- alkenyl
- alkyl
- alkinyl
- triazolo
- antagonists
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 title abstract 2
- 101150051188 Adora2a gene Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- VUWZPRWSIVNGKG-UHFFFAOYSA-N fluoromethane Chemical compound F[CH2] VUWZPRWSIVNGKG-UHFFFAOYSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE 2-ALQUINIL-Y 2-ALQUENIL-PIRAZOLO-[4,3-e]-1,2,4-TRIAZOLO-[1,5-c]-PIRIDINA DE FORMULA I INCLUYENDO SUS SALES FARMACEUTICAMENTE ACEPTABLES, DONDE R ES a; R1, R2, R3, R4 Y R5 SON H, ALQUILO o ALCOXIALQUILO; R6 ES H, ALQUILO, HIDROXIALQUILO o CH2F; R7, R8 Y R9 SON H, ALQUILOALCOXI, ALQUILTIO, ALCOXIALQUILO, HALO o CF3; Z ES R10-ARILO, R10-HETEROARILO, ENTRE OTROS; R10 ES 1-5 SUSTITUYENTES SELECCIONADOS DE H, ALQUILO, ALQUENILO, HIDROXI, ALCOXI, HIDROXIALQUILO, ENTRE OTROS. UN COMPUESTO PREFERIDO ES LA FORMULA II, ENTRE OTROS . TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. ESTOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR A2a Y SON UTILES PARA TRATAR ENFERMEDADES DEL SISTEMA NERVIOSO CENTRAL, EN PARTICULAR LA ENFERMEDAD DE PARKINSON
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46484003P | 2003-04-23 | 2003-04-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20050141A1 true PE20050141A1 (es) | 2005-04-01 |
Family
ID=33310963
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2004000392A PE20050141A1 (es) | 2003-04-23 | 2004-04-21 | DERIVADOS DE 2-ALQUINIL-Y 2-ALQUENIL-PIRAZOLO-[4,3-e]-1,2,4-TRIAZOLO-[1,5-c]-PIRIDINA COMO ANTAGONISTAS DEL RECEPTOR A2a ADENOSINA |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US6897217B2 (es) |
| EP (1) | EP1622912B1 (es) |
| JP (2) | JP4527712B2 (es) |
| KR (1) | KR100831107B1 (es) |
| CN (1) | CN100503609C (es) |
| AR (1) | AR044041A1 (es) |
| AT (1) | ATE432282T1 (es) |
| AU (1) | AU2004233334B2 (es) |
| BR (1) | BRPI0409787B8 (es) |
| CA (1) | CA2522813C (es) |
| CL (1) | CL2004000847A1 (es) |
| CO (1) | CO5700766A2 (es) |
| CY (1) | CY1109263T1 (es) |
| DE (1) | DE602004021250D1 (es) |
| DK (1) | DK1622912T3 (es) |
| EC (1) | ECSP056115A (es) |
| ES (1) | ES2326270T3 (es) |
| HR (1) | HRP20090394T1 (es) |
| IL (1) | IL171567A (es) |
| MX (1) | MXPA05011366A (es) |
| MY (1) | MY139344A (es) |
| NO (1) | NO332182B1 (es) |
| NZ (1) | NZ542823A (es) |
| PE (1) | PE20050141A1 (es) |
| PL (2) | PL1622912T3 (es) |
| PT (1) | PT1622912E (es) |
| RU (1) | RU2373210C2 (es) |
| SI (1) | SI1622912T1 (es) |
| TW (2) | TWI375677B (es) |
| WO (1) | WO2004094431A2 (es) |
| ZA (1) | ZA200508489B (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7313588B1 (en) * | 2000-07-13 | 2007-12-25 | Biap Systems, Inc. | Locally executing software agent for retrieving remote content and method for creation and use of the agent |
| HUP0402018A3 (en) * | 2001-11-30 | 2008-06-30 | Schering Corp | 5-amino-7h-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives, their use and pharmaceutical compositions containing them |
| US20060128694A1 (en) * | 2002-12-19 | 2006-06-15 | Michael Grzelak | Adenosine A2a receptor antagonists for the treatment of extra-pyramidal syndrome and other movement disorders |
| DE60335294D1 (de) * | 2002-12-19 | 2011-01-20 | Schering Corp | Dlung des extrapyramidalen syndroms |
| TWI375677B (en) * | 2003-04-23 | 2012-11-01 | Schering Corp | 2-alkynyl-and 2-alkenyl-pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidine adenosine a2a receptor antagonists |
| PE20060185A1 (es) * | 2004-04-21 | 2006-03-20 | Schering Corp | ANTAGONISTA DEL RECEPTOR A2A DE LA ADENOSINA CON ESTRUCTURA DE PIRAZOLO--[4,3-e]-1,2,4-TRIAZOLO-[1,5-c]-PIRIMIDINA |
| JPWO2006132275A1 (ja) | 2005-06-07 | 2009-01-08 | 協和醗酵工業株式会社 | 運動障害の予防および／または治療剤 |
| EP1934227B1 (en) * | 2005-09-19 | 2011-12-21 | Schering Corporation | 2-HETEROARYL-PYRAZOLO-[4, 3-e]-1, 2, 4-TRIAZOLO-[1,5-c]-PYRIMIDINE AS ADENOSINE A2a RECEPTOR ANTAGONISTS |
| AR056080A1 (es) * | 2005-09-23 | 2007-09-19 | Schering Corp | 7-[2-[4-(6-fluoro-3-metil-1,2-benciosoxazol-5-il)-1-piperazinil]etil]-2-(1-propinil)-7h-pirazol-[4,3-e]-[1,2,4]-triazol-[1,5-c] -pirimidin-5-amine |
| ES2273599B1 (es) | 2005-10-14 | 2008-06-01 | Universidad De Barcelona | Compuestos para el tratamiento de la fibrilacion auricular. |
| US7691869B2 (en) * | 2007-03-30 | 2010-04-06 | King Pharmaceuticals Research And Development, Inc. | Pyrrolotriazolopyrimidine derivatives, pharmaceutical compositions containing them and methods of treating conditions and diseases mediated by the adenosine A2A receptor activity |
| CA2717172A1 (en) * | 2008-03-04 | 2009-09-11 | Schering Corporation | 1,2,4-triazolo[4,3-c]pyrimidin-3-one and pyrazolo [4,3-e] -1,2,4-triazolo [4,3-c] pyrimidin-3-one compounds for use as adenosine a2a receptor antagonists |
| US8501997B2 (en) * | 2008-08-25 | 2013-08-06 | Air Products And Chemicals, Inc. | Curing agent for low temperature cure applications |
| US8512594B2 (en) * | 2008-08-25 | 2013-08-20 | Air Products And Chemicals, Inc. | Curing agent of N,N′-dimethyl-meta-xylylenediamine and multifunctional amin(s) |
| ES2487616T3 (es) | 2009-03-10 | 2014-08-22 | Takeda Pharmaceutical Company Limited | Derivados de benzofurano |
| EP2462144B1 (en) | 2009-08-07 | 2017-09-20 | Merck Sharp & Dohme Corp. | PROCESS FOR PREPARING A 2-ALKYNYL SUBSTITUTED 5-AMINO-PYRAZOLO-[4,3-e]-1,2,4-TRIAZOLO[1,5-c]PYRIMIDINE |
| US8420661B2 (en) * | 2010-04-13 | 2013-04-16 | Hoffmann-La Roche Inc. | Arylethynyl derivatives |
| MX353024B (es) * | 2011-12-27 | 2017-12-18 | Bio Pharm Solutions Co Ltd | Compuestos de fenil carbamato para uso en la prevencion o tratamiento de epilepsia. |
| WO2014101120A1 (en) | 2012-12-28 | 2014-07-03 | Merck Sharp & Dohme Corp. | Heterobicyclo-substituted-7-methoxy-[1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds with a2a antagonist properties |
| NZ711202A (en) * | 2013-03-14 | 2019-04-26 | Galapagos Nv | Compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders |
| EP3723754A4 (en) | 2017-12-13 | 2021-05-19 | Merck Sharp & Dohme Corp. | IMIDAZO [1,2-C] QUINAZOLINE-5-AMINE COMPOUNDS WITH PROPERTIES OF A2A ANTAGONIST |
| US20230024108A1 (en) * | 2019-07-17 | 2023-01-26 | Teon Therapeutics, Inc. | Adenosine a2a receptor antagonists |
| CN115160120B (zh) * | 2022-08-02 | 2024-08-27 | 乐威医药（江苏）股份有限公司 | 一种多烷氧基芳香酮的合成方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US785906A (en) * | 1904-12-06 | 1905-03-28 | Albert P Mcbride | Casing packer and shoe for gas or oil wells. |
| MX16165A (es) * | 1988-05-25 | 1994-02-28 | Dow Chemical Co | Alcoxi-1,2,4-triazolo[1,5-c]pirimidin-2-sulfonamidas, procedimiento para su preparacion e intermediarios. |
| IT1264901B1 (it) | 1993-06-29 | 1996-10-17 | Schering Plough S P A | Analoghi eterociclici di 1,2,4-triazolo(15-c)pirimidine ad attivita' antagonista per il recettore a2 dell'adenosina |
| ES2165393T3 (es) * | 1993-07-27 | 2002-03-16 | Kyowa Hakko Kogyo Kk | Remedio contra la enfermedad de parkinson. |
| IT1277392B1 (it) | 1995-07-28 | 1997-11-10 | Schering Plough S P A | Analoghi eterociclici di 1,2,4-triazolo(1,5-c]pirimidine ad attivita' antagonista per il recettore a2a dell'adenosina |
| IT1291372B1 (it) | 1997-05-21 | 1999-01-07 | Schering Plough S P A | Uso di analoghi eterociclici di 1,2,4-triazolo (1,5-c) pirimidine per la preparazione di medicamenti utili per il trattamento delle malattie |
| DE19826843A1 (de) * | 1998-06-16 | 1999-12-23 | Boehringer Ingelheim Pharma | Neue Imidazotriazolopyrimidine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| ES2237576T3 (es) * | 2000-05-26 | 2005-08-01 | Schering Corporation | Antagonistas del receptor a2a de adenosina. |
| GB0100624D0 (en) | 2001-01-10 | 2001-02-21 | Vernalis Res Ltd | Chemical compounds VII |
| KR20030076633A (ko) * | 2001-02-05 | 2003-09-26 | 가부시키 가이샤 오오쯔카 세이야쿠 고우죠우 | 트리아조로퀴나졸린 및 피라졸로 트리아조로피리미딘유도체, 의약조성물,아데노신 에이3 수용체 친화제,안압저하제, 녹내장의 예방 및 치료를 위한 제제 및안압저하 방법 |
| JP4545437B2 (ja) | 2001-10-15 | 2010-09-15 | シェーリング コーポレイション | アデノシンａ２ａ受容体アンタゴニストとしてのイミダゾ（４，３−ｅ）−１，２，４−トリアゾロ（１，５−ｃ）ピリミジン |
| DE60335294D1 (de) | 2002-12-19 | 2011-01-20 | Schering Corp | Dlung des extrapyramidalen syndroms |
| TWI375677B (en) * | 2003-04-23 | 2012-11-01 | Schering Corp | 2-alkynyl-and 2-alkenyl-pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidine adenosine a2a receptor antagonists |
-
2004
- 2004-04-21 TW TW100131963A patent/TWI375677B/zh not_active IP Right Cessation
- 2004-04-21 AR ARP040101344A patent/AR044041A1/es not_active Application Discontinuation
- 2004-04-21 PL PL04760128T patent/PL1622912T3/pl unknown
- 2004-04-21 AT AT04760128T patent/ATE432282T1/de active
- 2004-04-21 AU AU2004233334A patent/AU2004233334B2/en not_active Ceased
- 2004-04-21 EP EP04760128A patent/EP1622912B1/en not_active Expired - Lifetime
- 2004-04-21 CL CL200400847A patent/CL2004000847A1/es unknown
- 2004-04-21 CN CNB2004800107535A patent/CN100503609C/zh not_active Expired - Fee Related
- 2004-04-21 US US10/829,416 patent/US6897217B2/en not_active Expired - Lifetime
- 2004-04-21 JP JP2006501291A patent/JP4527712B2/ja not_active Expired - Fee Related
- 2004-04-21 BR BRPI0409787-4 patent/BRPI0409787B8/pt not_active IP Right Cessation
- 2004-04-21 TW TW093111142A patent/TWI355381B/zh not_active IP Right Cessation
- 2004-04-21 WO PCT/US2004/012471 patent/WO2004094431A2/en not_active Ceased
- 2004-04-21 SI SI200431189T patent/SI1622912T1/sl unknown
- 2004-04-21 RU RU2005136166/04A patent/RU2373210C2/ru not_active IP Right Cessation
- 2004-04-21 ES ES04760128T patent/ES2326270T3/es not_active Expired - Lifetime
- 2004-04-21 PE PE2004000392A patent/PE20050141A1/es not_active Application Discontinuation
- 2004-04-21 HR HR20090394T patent/HRP20090394T1/xx unknown
- 2004-04-21 KR KR1020057019891A patent/KR100831107B1/ko not_active Expired - Fee Related
- 2004-04-21 MY MYPI20041463A patent/MY139344A/en unknown
- 2004-04-21 NZ NZ542823A patent/NZ542823A/en not_active IP Right Cessation
- 2004-04-21 PT PT04760128T patent/PT1622912E/pt unknown
- 2004-04-21 DE DE602004021250T patent/DE602004021250D1/de not_active Expired - Lifetime
- 2004-04-21 PL PL378867A patent/PL378867A1/pl unknown
- 2004-04-21 MX MXPA05011366A patent/MXPA05011366A/es active IP Right Grant
- 2004-04-21 CA CA002522813A patent/CA2522813C/en not_active Expired - Fee Related
- 2004-04-21 DK DK04760128T patent/DK1622912T3/da active
-
2005
- 2005-05-23 US US11/135,261 patent/US7368449B2/en not_active Expired - Lifetime
- 2005-10-19 ZA ZA200508489A patent/ZA200508489B/en unknown
- 2005-10-21 CO CO05107374A patent/CO5700766A2/es active IP Right Grant
- 2005-10-21 EC EC2005006115A patent/ECSP056115A/es unknown
- 2005-10-26 IL IL171567A patent/IL171567A/en active IP Right Grant
- 2005-11-22 NO NO20055510A patent/NO332182B1/no not_active IP Right Cessation
-
2009
- 2009-08-04 CY CY20091100821T patent/CY1109263T1/el unknown
- 2009-11-04 JP JP2009253549A patent/JP2010059178A/ja not_active Withdrawn
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