PE20040593A1 - DERIVADOS DE DIHIDROPIRIMIDO[4,5-d]PIRIMIDONA AMINO SUSTITUIDOS COMO INHIBIDORES DE TIROSINACINASAS DEL GRUPO SRC - Google Patents
DERIVADOS DE DIHIDROPIRIMIDO[4,5-d]PIRIMIDONA AMINO SUSTITUIDOS COMO INHIBIDORES DE TIROSINACINASAS DEL GRUPO SRCInfo
- Publication number
- PE20040593A1 PE20040593A1 PE2003001103A PE2003001103A PE20040593A1 PE 20040593 A1 PE20040593 A1 PE 20040593A1 PE 2003001103 A PE2003001103 A PE 2003001103A PE 2003001103 A PE2003001103 A PE 2003001103A PE 20040593 A1 PE20040593 A1 PE 20040593A1
- Authority
- PE
- Peru
- Prior art keywords
- methyl
- pyrimidin
- dihydro
- bromo
- phenyl
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- -1 2-BROMO-PHENYL Chemical class 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- PUYHFXLCBSPKLN-UHFFFAOYSA-N 4-amino-1-methylpyrimido[4,5-d]pyrimidin-2-one Chemical compound C1=NC=C2C(N)=NC(=O)N(C)C2=N1 PUYHFXLCBSPKLN-UHFFFAOYSA-N 0.000 abstract 1
- 206010005949 Bone cancer Diseases 0.000 abstract 1
- 208000020084 Bone disease Diseases 0.000 abstract 1
- 208000018084 Bone neoplasm Diseases 0.000 abstract 1
- 229910006074 SO2NH2 Inorganic materials 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical group [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- SFDJOSRHYKHMOK-UHFFFAOYSA-N nitramide Chemical compound N[N+]([O-])=O SFDJOSRHYKHMOK-UHFFFAOYSA-N 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
SE REFIERE A COMPUESTOS DE FORMULA (I), DONDE R1 ES H, ALQUILO, CICLOALQUILO, ARILO, HETEROARILO, ARILALQUILO, ARILO, HETEROARILALQUILO, EVENTUALMENTE SUSTITUIDOS; R2 ES HALOGENO, H, CIANO, CF3; R3 ES HALOGENO, HIDROXI, CIANO, NITRO, AMINO, ACILAMINO, -CONH2, -SO2NH2, -S(O)m-ALQUILO, ENTRE OTRAS, EVENTUALMENTE SUSTITUIDOS, R4 ES H, ALQUILO, ALCOXI, CIANO Y A ES DE FORMULA: A-1, A-2, A-3, A-4, A-5 O A-6 DONDE X ES O O S(O)m; n ES 0,1,2 O 3; m ES 0,1,2 O 3. SON COMPUESTOS PREFERIDOS: 3-(2-BROMO-FENIL)-3,4-DIHIDRO-7-(1'-ACETIL-ESPIRO[1,3-BENZO-DIOXOLO-2,4'-PIPERIDINA]-5-IL)AMINO-1-METIL-PIRIMIDO[4,5-d]-PIRIMIDIN-2(1H)-ONA, 3-(2-BROMO-FENIL)-7-(2,3-DIHIDRO-BENZO[1,4]DIOXIN-6-ILAMINO)-1-METIL-3,4-DIHIDRO-1H-PIRIMIDO[4,5-d]PIRIMIDIN-2-ONA, 5-[6-(2-BROMO-FENIL)-8-METIL-7-OXO-5,6,7,8-TETRAHIDRO-PIRIMIDO[4,5-d]PIRIMIDIN-2-ILAMINO]-2-METIL-ISOINDOL-1,3-DIONA, 7-(BENZO[1,3]DIOXOL-5-ILAMINO)-3-(2-BROMO-FENIL)-1-METIL-3,4-DIHIDRO-1H-PIRIMIDO[4,5-d]PIRIMIDIN-2-ONA, ENTRE OTOS. TAMBIEN SE REFIERE A UN PROCESO DE ELABORACION. ESTOS COMPUESTOS SON INHIBIDORES DE PROTEINOCINASAS, EN ESPECIAL DEL GRUPO SRC DE TIROSINACINASAS Y SON UTILES PARA EL TRATAMIENTO DE TRANSTORNOS INFLAMATORIOS, INMUNOLOGICOS, DEL SNC, TRANSTORNOS OSEOS Y TRATAMIENTO DEL CANCER
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02024573 | 2002-11-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20040593A1 true PE20040593A1 (es) | 2004-09-09 |
Family
ID=32116230
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2003001103A PE20040593A1 (es) | 2002-11-04 | 2003-10-31 | DERIVADOS DE DIHIDROPIRIMIDO[4,5-d]PIRIMIDONA AMINO SUSTITUIDOS COMO INHIBIDORES DE TIROSINACINASAS DEL GRUPO SRC |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7091345B2 (es) |
| EP (1) | EP1560831A1 (es) |
| JP (1) | JP2006506408A (es) |
| KR (1) | KR100755770B1 (es) |
| CN (1) | CN1711265A (es) |
| AR (1) | AR041740A1 (es) |
| AU (1) | AU2003287982A1 (es) |
| BR (1) | BR0315988A (es) |
| CA (1) | CA2502477A1 (es) |
| GT (1) | GT200300240A (es) |
| MX (1) | MXPA05004212A (es) |
| PA (1) | PA8587101A1 (es) |
| PE (1) | PE20040593A1 (es) |
| PL (1) | PL377239A1 (es) |
| RU (1) | RU2005117342A (es) |
| TW (1) | TW200413381A (es) |
| UY (1) | UY28059A1 (es) |
| WO (1) | WO2004041823A1 (es) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE521353T1 (de) * | 2000-10-23 | 2011-09-15 | Glaxosmithkline Llc | Neues trisubstitutiertes 8h-pyridoä2,3- düpyrimidin-7-onderivat zur behandlung von durch csbp/p38kinase vermittelten krankheiten |
| JP2007500725A (ja) | 2003-07-29 | 2007-01-18 | アイアールエム・リミテッド・ライアビリティ・カンパニー | プロテインキナーゼ阻害剤としての化合物および組成物 |
| FR2873118B1 (fr) * | 2004-07-15 | 2007-11-23 | Sanofi Synthelabo | Derives de pyrido-pyrimidine, leur application en therapeutique |
| JP2008509964A (ja) * | 2004-08-31 | 2008-04-03 | エフ．ホフマン−ラ ロシュ アーゲー | ７−アミノ−３−フェニル−ジヒドロピリミド［４，５−ｄ］ピリミジノンのアミド誘導体、これらの製造、及びプロテインキナーゼ阻害剤としての使用 |
| RU2007111757A (ru) | 2004-08-31 | 2008-10-10 | Ф.Хоффманн-Ля Рош Аг (Ch) | Амидные производные 3-фенилдигидропиримидо [4,5-d] пиримидинонов, их получение и использованиев качестве фармацевтических агентов |
| AR053346A1 (es) * | 2005-03-25 | 2007-05-02 | Glaxo Group Ltd | Compuesto derivado de 8h -pirido (2,3-d) pirimidin -7 ona 2,4,8- trisustituida composicion farmaceutica y uso para preparar una composicion para tratamiento y profilxis de una enfermedad mediada por la quinasa csbp/ rk/p38 |
| CN101495475A (zh) * | 2005-03-25 | 2009-07-29 | 葛兰素集团有限公司 | 制备吡啶并[2,3-d]嘧啶-7-酮和3,4-二氢嘧啶并[4,5-d]嘧啶-2(1H)-酮衍生物的方法 |
| CA2636981A1 (en) | 2006-01-31 | 2007-08-09 | F. Hoffmann-La Roche Ag | 7h-pyrido[3,4-d]pyrimidin-8-ones, their manufacture and use as protein kinase inhibitors |
| WO2007124355A2 (en) * | 2006-04-20 | 2007-11-01 | Nova Southeastern University | Vascular endothelial receptor specific inhibitors |
| MX2008014618A (es) * | 2006-05-15 | 2008-11-28 | Irm Llc | Composiciones y metodos para inhibidores de cinasas del receptor fgf. |
| CN101784551A (zh) | 2007-06-15 | 2010-07-21 | 万有制药株式会社 | 二环苯胺衍生物 |
| TW200942537A (en) | 2008-02-01 | 2009-10-16 | Irm Llc | Compounds and compositions as kinase inhibitors |
| EP2351743A4 (en) | 2008-10-27 | 2012-05-09 | Takeda Pharmaceutical | BICYCLIC COMPOUND |
| WO2010067888A1 (en) | 2008-12-12 | 2010-06-17 | Banyu Pharmaceutical Co.,Ltd. | Dihydropyrimidopyrimidine derivatives |
| US8507505B2 (en) | 2008-12-12 | 2013-08-13 | Msd K.K. | Dihydropyrazolopyrimidinone derivative |
| WO2011014795A2 (en) | 2009-07-30 | 2011-02-03 | Irm Llc | Compounds and compositions as syk kinase inhibitors |
| WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
| UA125503C2 (uk) | 2012-06-13 | 2022-04-13 | Інсайт Холдинґс Корпорейшн | Заміщені трициклічні сполуки як інгібітори fgfr |
| BR112014032346A2 (pt) | 2012-06-26 | 2017-06-27 | Del Mar Pharmaceuticals | métodos para tratamento de malignidades resistentes ao inibidor de tirosina-quinase em pacientes com polimorfismos genéticos ou desregulações de ahi1 mutações empregando dianidrogalactitol, diacetildianidrogalactitol, dibromodulcitol, ou análogos ou derivados destes |
| WO2014026125A1 (en) | 2012-08-10 | 2014-02-13 | Incyte Corporation | Pyrazine derivatives as fgfr inhibitors |
| CN102816164A (zh) * | 2012-08-31 | 2012-12-12 | 北京理工大学 | 一种合成7-氨基-2,3-二氢嘧啶[4,5-d]嘧啶-4(1H)-酮的方法 |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| NZ711376A (en) | 2013-03-15 | 2020-01-31 | Sanofi Sa | Heteroaryl compounds and uses thereof |
| MX374558B (es) | 2013-03-15 | 2025-03-06 | Sanofi Sa | Compuestos de heteroarilo y sus usos. |
| AR095464A1 (es) | 2013-03-15 | 2015-10-21 | Celgene Avilomics Res Inc | Compuestos de heteroarilo y usos de los mismos |
| WO2014172644A2 (en) | 2013-04-19 | 2014-10-23 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| UA121669C2 (uk) | 2015-02-20 | 2020-07-10 | Інсайт Корпорейшн | Біциклічні гетероцикли як інгібітори fgfr |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| US9580423B2 (en) | 2015-02-20 | 2017-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| WO2017156350A1 (en) | 2016-03-09 | 2017-09-14 | K-Gen, Inc. | Methods of cancer treatment |
| CN108815167B (zh) * | 2017-05-24 | 2021-04-13 | 四川晶华生物科技有限公司 | 一种化合物在制备治疗肿瘤的药物中的用途 |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| CN112566912A (zh) | 2018-05-04 | 2021-03-26 | 因赛特公司 | Fgfr抑制剂的盐 |
| SI3788047T1 (sl) | 2018-05-04 | 2024-11-29 | Incyte Corporation | Trdne oblike inhibitorja fgfr in postopki priprave le-teh |
| WO2020185532A1 (en) | 2019-03-08 | 2020-09-17 | Incyte Corporation | Methods of treating cancer with an fgfr inhibitor |
| US11591329B2 (en) | 2019-07-09 | 2023-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| US12122767B2 (en) | 2019-10-01 | 2024-10-22 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| EP4045151A1 (en) | 2019-10-14 | 2022-08-24 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| US11566028B2 (en) | 2019-10-16 | 2023-01-31 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| CA3163875A1 (en) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| EP4069695A1 (en) | 2019-12-04 | 2022-10-12 | Incyte Corporation | Derivatives of an fgfr inhibitor |
| WO2021146424A1 (en) | 2020-01-15 | 2021-07-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| US12065494B2 (en) | 2021-04-12 | 2024-08-20 | Incyte Corporation | Combination therapy comprising an FGFR inhibitor and a Nectin-4 targeting agent |
| WO2022261160A1 (en) | 2021-06-09 | 2022-12-15 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| CA3220155A1 (en) | 2021-06-09 | 2022-12-15 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0085321B1 (de) | 1982-01-27 | 1986-08-27 | Schering Aktiengesellschaft | Diphosphonsäure-Derivate und diese enthaltende pharmazeutische Präparate |
| EP0084822B1 (de) | 1982-01-27 | 1986-01-08 | Schering Aktiengesellschaft | Diphosphonsäure-Derivate und diese enthaltende pharmazeutische Präparate |
| DE3203308A1 (de) * | 1982-01-27 | 1983-07-28 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Diphosphonsaeure-derivate und diese enthaltende pharmazeutische praeparate |
| DE3428524A1 (de) * | 1984-08-02 | 1986-02-13 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| US4687768A (en) | 1984-12-21 | 1987-08-18 | The Procter & Gamble Company | Certain hexahydroindan-2,2-diphosphonic acids useful in treating diseases associated with abnormal calcium and phosphate metabolism |
| IL77243A (en) | 1984-12-21 | 1996-11-14 | Procter & Gamble | Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds |
| WO1994009017A1 (en) | 1992-10-09 | 1994-04-28 | The Upjohn Company | Pyrimidine bisphosphonate esters and (alkoxymethylphosphinyl)alkyl phosphonic acids as anti-inflammatories |
| SE9402001D0 (sv) * | 1994-06-09 | 1994-06-09 | Leiras Oy | Pyridylbisphosphonates for use as a therapeutical agent |
| TR200003429T2 (tr) | 1998-05-26 | 2001-07-23 | Warner-Lambert Company | Hücresel çoğalma inhibitörleri olarak bisiklik pirimidinler ve bisiklik 3,4-dihidropirimidinler. |
| TR200101102T2 (tr) | 1998-10-23 | 2002-01-21 | F.Hoffmann-La Roche Ag | Bisiklik nitrojen heterosikleler |
| IL149100A0 (en) | 1999-10-21 | 2002-11-10 | Hoffmann La Roche | Heteroalkylamino-substituted bicyclic nitrogen heterocycles as inhibitors of p38 protein kinase |
| MXPA02003841A (es) | 1999-10-21 | 2002-09-30 | Hoffmann La Roche | Heterociclos de nitrogeno biciclicos alquilamino substituidos como inhibidores de proteina p38. |
| EP1246829A1 (en) | 1999-12-17 | 2002-10-09 | Ariad Pharmaceuticals, Inc. | Novel heterocycles |
-
2003
- 2003-10-29 TW TW092130056A patent/TW200413381A/zh unknown
- 2003-10-30 US US10/697,543 patent/US7091345B2/en not_active Expired - Fee Related
- 2003-10-30 PA PA20038587101A patent/PA8587101A1/es unknown
- 2003-10-31 UY UY28059A patent/UY28059A1/es not_active Application Discontinuation
- 2003-10-31 PE PE2003001103A patent/PE20040593A1/es not_active Application Discontinuation
- 2003-10-31 AR ARP030104001A patent/AR041740A1/es not_active Application Discontinuation
- 2003-11-03 MX MXPA05004212A patent/MXPA05004212A/es active IP Right Grant
- 2003-11-03 BR BR0315988-4A patent/BR0315988A/pt not_active IP Right Cessation
- 2003-11-03 AU AU2003287982A patent/AU2003287982A1/en not_active Abandoned
- 2003-11-03 RU RU2005117342/04A patent/RU2005117342A/ru not_active Application Discontinuation
- 2003-11-03 PL PL377239A patent/PL377239A1/pl not_active Application Discontinuation
- 2003-11-03 CA CA002502477A patent/CA2502477A1/en not_active Abandoned
- 2003-11-03 JP JP2004548850A patent/JP2006506408A/ja active Pending
- 2003-11-03 KR KR1020057007978A patent/KR100755770B1/ko not_active Expired - Fee Related
- 2003-11-03 GT GT200300240A patent/GT200300240A/es unknown
- 2003-11-03 EP EP03779831A patent/EP1560831A1/en not_active Withdrawn
- 2003-11-03 CN CNA200380102849XA patent/CN1711265A/zh active Pending
- 2003-11-03 WO PCT/EP2003/012203 patent/WO2004041823A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CN1711265A (zh) | 2005-12-21 |
| GT200300240A (es) | 2004-09-02 |
| WO2004041823A1 (en) | 2004-05-21 |
| BR0315988A (pt) | 2005-09-20 |
| PA8587101A1 (es) | 2004-09-16 |
| AR041740A1 (es) | 2005-05-26 |
| JP2006506408A (ja) | 2006-02-23 |
| KR20050067433A (ko) | 2005-07-01 |
| RU2005117342A (ru) | 2006-01-20 |
| UY28059A1 (es) | 2004-04-30 |
| AU2003287982A1 (en) | 2004-06-07 |
| US20040087600A1 (en) | 2004-05-06 |
| EP1560831A1 (en) | 2005-08-10 |
| CA2502477A1 (en) | 2004-05-21 |
| KR100755770B1 (ko) | 2007-09-05 |
| US7091345B2 (en) | 2006-08-15 |
| PL377239A1 (pl) | 2006-01-23 |
| TW200413381A (en) | 2004-08-01 |
| MXPA05004212A (es) | 2005-06-08 |
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