PE20030231A1 - DERIVADOS DE 7-(4-terc-BUTIL-CICLOHEXIL)-IMIDAZOTRIAZINONAS COMO INHIBIDORES DE FOSFODIESTERASA 4 - Google Patents
DERIVADOS DE 7-(4-terc-BUTIL-CICLOHEXIL)-IMIDAZOTRIAZINONAS COMO INHIBIDORES DE FOSFODIESTERASA 4Info
- Publication number
- PE20030231A1 PE20030231A1 PE2002000464A PE2002000464A PE20030231A1 PE 20030231 A1 PE20030231 A1 PE 20030231A1 PE 2002000464 A PE2002000464 A PE 2002000464A PE 2002000464 A PE2002000464 A PE 2002000464A PE 20030231 A1 PE20030231 A1 PE 20030231A1
- Authority
- PE
- Peru
- Prior art keywords
- butyl
- tert
- imidazotriazinones
- phosphodiesterase
- inhibitors
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- MSYGAHOHLUJIKV-UHFFFAOYSA-N 3,5-dimethyl-1-(3-nitrophenyl)-1h-pyrazole-4-carboxylic acid ethyl ester Chemical compound CC1=C(C(=O)OCC)C(C)=NN1C1=CC=CC([N+]([O-])=O)=C1 MSYGAHOHLUJIKV-UHFFFAOYSA-N 0.000 title 1
- 102000011017 Type 4 Cyclic Nucleotide Phosphodiesterases Human genes 0.000 title 1
- 108010037584 Type 4 Cyclic Nucleotide Phosphodiesterases Proteins 0.000 title 1
- -1 4-tert-BUTYL-CYCLOHEXYL Chemical class 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 abstract 2
- 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 abstract 2
- FTFZJGRXFCKEIU-UHFFFAOYSA-N 2-(3-bromophenyl)-7-(4-tert-butylcyclohexyl)-5-ethyl-1h-imidazo[5,1-f][1,2,4]triazin-4-one Chemical compound N12N=C(C=3C=C(Br)C=CC=3)NC(=O)C2=C(CC)N=C1C1CCC(C(C)(C)C)CC1 FTFZJGRXFCKEIU-UHFFFAOYSA-N 0.000 abstract 1
- WZKSXHQDXQKIQJ-UHFFFAOYSA-N F[C](F)F Chemical class F[C](F)F WZKSXHQDXQKIQJ-UHFFFAOYSA-N 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical class O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- OCBFFGCSTGGPSQ-UHFFFAOYSA-N [CH2]CC Chemical compound [CH2]CC OCBFFGCSTGGPSQ-UHFFFAOYSA-N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- DLFVBJFMPXGRIB-UHFFFAOYSA-N thioacetamide Natural products CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE REFIERE A 7-(4-terc-BUTIL-CICLOHEXIL)-IMIDAZOTRIAZINONAS DE FORMULA I DONDE R1 ES ARILO C6-C10 CON HALOGENO, ALQUILO C1-C4, TRIFLUOROMETILO, CIANO, NITRO, TRIFLUOROMETOXI, ENTRE OTROS; R2 ES 4-TERC-BUTIL-CICLOHEX-1-ILO Y SUS SALES, HIDRATOS O SOLVATOS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO PARA LA PREPARACION Y COMPUESTOS INTERMEDIOS. SON COMPUESTOS PREFERIDOS N-{1-[3-(3-BROMOFENIL)-5-OXO-4,5-DIHIDRO-1,2,4-TRIAZIN-6-IL]PROPIL}ACETAMIDA, 2-(3-BROMOFENIL)-7-(4-terc-BUTILCICLOHEXIL)-5-ETILIMIDAZO[5,1-f][1,2,4]TRIAZIN-4(3H)-ONA. LOS COMPUESTOS MENCIONADOS SON INHIBIDORES DE LA FOSFODIESTERASA (PDE) Y SON UTILES PARA EL TRATAMIENTO DE PROCESOS INFLAMATORIOS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0113344.6A GB0113344D0 (en) | 2001-06-01 | 2001-06-01 | Novel heterocycles 3 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20030231A1 true PE20030231A1 (es) | 2003-05-16 |
Family
ID=9915717
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2002000464A PE20030231A1 (es) | 2001-06-01 | 2002-05-31 | DERIVADOS DE 7-(4-terc-BUTIL-CICLOHEXIL)-IMIDAZOTRIAZINONAS COMO INHIBIDORES DE FOSFODIESTERASA 4 |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US7115602B2 (es) |
| EP (1) | EP1399447A1 (es) |
| JP (1) | JP2004536078A (es) |
| KR (1) | KR20040023605A (es) |
| CN (1) | CN1512993A (es) |
| BG (1) | BG108381A (es) |
| BR (1) | BR0210910A (es) |
| CA (1) | CA2449095A1 (es) |
| CO (1) | CO5540381A2 (es) |
| CZ (1) | CZ295609B6 (es) |
| EC (1) | ECSP034872A (es) |
| EE (1) | EE200300570A (es) |
| GB (1) | GB0113344D0 (es) |
| GT (1) | GT200200099A (es) |
| HR (1) | HRP20031090A2 (es) |
| HU (1) | HUP0400773A3 (es) |
| MX (1) | MXPA03010985A (es) |
| NO (1) | NO20035324L (es) |
| NZ (1) | NZ529848A (es) |
| PE (1) | PE20030231A1 (es) |
| PL (1) | PL366906A1 (es) |
| RU (1) | RU2003138078A (es) |
| SK (1) | SK14672003A3 (es) |
| SV (1) | SV2003001061A (es) |
| UA (1) | UA75149C2 (es) |
| UY (1) | UY27312A1 (es) |
| WO (1) | WO2002098879A1 (es) |
| ZA (1) | ZA200309111B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2388111A (en) * | 2002-05-01 | 2003-11-05 | Bayer Ag | Novel imidazotriazinone compounds |
| GB2388594A (en) * | 2002-05-16 | 2003-11-19 | Bayer Ag | Imidazo-triazine PDE 4 inhibitors |
| FR2850653A1 (fr) * | 2003-02-04 | 2004-08-06 | Univ Pasteur | Derives de pyrazolotriazine, procede de preparation et utilisations |
| JP2006219374A (ja) | 2003-06-13 | 2006-08-24 | Daiichi Asubio Pharma Co Ltd | Ｐｄｅ７阻害作用を有するイミダゾトリアジノン誘導体 |
| TW200745106A (en) * | 2005-10-03 | 2007-12-16 | Astrazeneca Ab | Chemical compounds |
| US20140038967A1 (en) * | 2011-03-17 | 2014-02-06 | Algiax Pharmaceuticals Gmbh | Novel use for imidazotriazinones |
| WO2013156231A1 (en) * | 2012-04-16 | 2013-10-24 | Algiax Pharmaceuticals Gmbh | Use of imidazotriazinones in neuropathic pain |
| CA2942446A1 (en) * | 2014-03-28 | 2015-10-01 | Algiax Pharmaceuticals Gmbh | Treatment of cognitive disorders |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE791025A (fr) * | 1971-11-19 | 1973-05-07 | Allen & Hanburys Ltd | Composes heterocycliques |
| GB1457873A (en) | 1973-01-04 | 1976-12-08 | Allen & Hanburys Ltd | Imidazotriazines |
| DK109578A (da) * | 1977-03-25 | 1978-09-26 | Allen & Hanburys Ltd | Fremgangsmaade til fremstilling af heterocycliske forbindelser |
| WO1999024433A1 (de) * | 1997-11-12 | 1999-05-20 | Bayer Aktiengesellschaft | 2-phenyl-substituierte imidazotriazinone als phosphodiesterase inhibitoren |
| DE19827640A1 (de) * | 1998-06-20 | 1999-12-23 | Bayer Ag | 7-Alkyl- und Cycloalkyl-substituierte Imidazotriazinone |
| US6503908B1 (en) * | 1999-10-11 | 2003-01-07 | Pfizer Inc | Pharmaceutically active compounds |
-
2001
- 2001-06-01 GB GBGB0113344.6A patent/GB0113344D0/en not_active Ceased
-
2002
- 2002-05-17 EP EP02743040A patent/EP1399447A1/en not_active Withdrawn
- 2002-05-17 SK SK1467-2003A patent/SK14672003A3/sk unknown
- 2002-05-17 PL PL02366906A patent/PL366906A1/xx not_active Application Discontinuation
- 2002-05-17 UA UA20031213199A patent/UA75149C2/uk unknown
- 2002-05-17 HR HR20031090A patent/HRP20031090A2/hr not_active Application Discontinuation
- 2002-05-17 NZ NZ529848A patent/NZ529848A/en unknown
- 2002-05-17 MX MXPA03010985A patent/MXPA03010985A/es unknown
- 2002-05-17 WO PCT/EP2002/005436 patent/WO2002098879A1/en not_active Ceased
- 2002-05-17 JP JP2003502000A patent/JP2004536078A/ja active Pending
- 2002-05-17 HU HU0400773A patent/HUP0400773A3/hu unknown
- 2002-05-17 EE EEP200300570A patent/EE200300570A/xx unknown
- 2002-05-17 CZ CZ20033275A patent/CZ295609B6/cs not_active IP Right Cessation
- 2002-05-17 CN CNA028110528A patent/CN1512993A/zh active Pending
- 2002-05-17 RU RU2003138078/04A patent/RU2003138078A/ru not_active Application Discontinuation
- 2002-05-17 KR KR10-2003-7015526A patent/KR20040023605A/ko not_active Withdrawn
- 2002-05-17 BR BR0210910-7A patent/BR0210910A/pt not_active IP Right Cessation
- 2002-05-17 CA CA002449095A patent/CA2449095A1/en not_active Abandoned
- 2002-05-28 UY UY27312A patent/UY27312A1/es not_active Application Discontinuation
- 2002-05-29 GT GT200200099A patent/GT200200099A/es unknown
- 2002-05-30 US US10/160,352 patent/US7115602B2/en not_active Expired - Fee Related
- 2002-05-31 PE PE2002000464A patent/PE20030231A1/es not_active Application Discontinuation
- 2002-05-31 SV SV2002001061A patent/SV2003001061A/es not_active Application Discontinuation
-
2003
- 2003-11-24 ZA ZA200309111A patent/ZA200309111B/en unknown
- 2003-11-24 BG BG108381A patent/BG108381A/bg unknown
- 2003-11-28 NO NO20035324A patent/NO20035324L/no not_active Application Discontinuation
- 2003-12-01 EC EC2003004872A patent/ECSP034872A/es unknown
- 2003-12-10 CO CO03108302A patent/CO5540381A2/es not_active Application Discontinuation
-
2004
- 2004-10-12 US US10/964,380 patent/US20050065153A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| KR20040023605A (ko) | 2004-03-18 |
| PL366906A1 (en) | 2005-02-07 |
| UA75149C2 (en) | 2006-03-15 |
| JP2004536078A (ja) | 2004-12-02 |
| EP1399447A1 (en) | 2004-03-24 |
| CZ295609B6 (cs) | 2005-08-17 |
| RU2003138078A (ru) | 2005-05-27 |
| US20050065153A1 (en) | 2005-03-24 |
| EE200300570A (et) | 2004-04-15 |
| UY27312A1 (es) | 2003-02-28 |
| GT200200099A (es) | 2003-02-13 |
| MXPA03010985A (es) | 2004-10-28 |
| NO20035324D0 (no) | 2003-11-28 |
| CN1512993A (zh) | 2004-07-14 |
| ZA200309111B (en) | 2004-11-24 |
| NZ529848A (en) | 2006-02-24 |
| WO2002098879A1 (en) | 2002-12-12 |
| NO20035324L (no) | 2003-11-28 |
| SV2003001061A (es) | 2003-03-18 |
| BG108381A (bg) | 2004-11-30 |
| SK14672003A3 (sk) | 2004-08-03 |
| ECSP034872A (es) | 2004-01-28 |
| US20030139415A1 (en) | 2003-07-24 |
| GB0113344D0 (en) | 2001-07-25 |
| CZ20033275A3 (en) | 2004-03-17 |
| BR0210910A (pt) | 2004-06-08 |
| HRP20031090A2 (en) | 2005-08-31 |
| CO5540381A2 (es) | 2005-07-29 |
| CA2449095A1 (en) | 2002-12-12 |
| US7115602B2 (en) | 2006-10-03 |
| HUP0400773A2 (hu) | 2004-07-28 |
| HUP0400773A3 (en) | 2007-09-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |