PE20599A1 - Pirazoles como inhibidores de fosfolipasa secretora no pancreatica humana a2 - Google Patents
Pirazoles como inhibidores de fosfolipasa secretora no pancreatica humana a2Info
- Publication number
- PE20599A1 PE20599A1 PE1997001083A PE00108397A PE20599A1 PE 20599 A1 PE20599 A1 PE 20599A1 PE 1997001083 A PE1997001083 A PE 1997001083A PE 00108397 A PE00108397 A PE 00108397A PE 20599 A1 PE20599 A1 PE 20599A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- pancreatic
- optionally substituted
- phenyl
- compounds
- Prior art date
Links
- 230000003248 secreting effect Effects 0.000 title abstract 2
- 239000003428 phospholipase inhibitor Substances 0.000 title 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical group C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- RPYMTSUCKIJOAK-UHFFFAOYSA-N 2-chloro-6-methylbenzenesulfonamide Chemical compound CC1=CC=CC(Cl)=C1S(N)(=O)=O RPYMTSUCKIJOAK-UHFFFAOYSA-N 0.000 abstract 1
- WGNUNYPERJMVRM-UHFFFAOYSA-N 3-pyridylacetic acid Chemical compound OC(=O)CC1=CC=CN=C1 WGNUNYPERJMVRM-UHFFFAOYSA-N 0.000 abstract 1
- -1 QUINOLINYL Chemical class 0.000 abstract 1
- 102000005473 Secretory Phospholipases A2 Human genes 0.000 abstract 1
- 108010031873 Secretory Phospholipases A2 Proteins 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- 150000004665 fatty acids Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000035939 shock Effects 0.000 abstract 1
- 229930192474 thiophene Natural products 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/44—Oxygen and nitrogen or sulfur and nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
SE REFIEREN A COMPUESTOS DE FORMULA (I), EN DONDE: R1 ES FENILO, ISOQUINOLIN-3-ILO, PIRAZINILO, PIRIDIN-2-ILO OPCIONALMENTE SUSTITUIDO EN LA POSICION 4 CON ALQUILO C1-C4, ALCOXILO C1-C4, CN, (CH2)nCONH2, EN DONDE n ES 0-2; R2 ES NAFTILO, TIOFENO OPCIONALMENTE SUSTITUIDO CON 1 A 3 HALOGENOS o FENILO OPCIONALMENTE SUSTITUIDO CON 1 A 3 RADICALES ALQUILO C1-C4, CN, HALOGENO, NO2, CO2-ALQUILO C1-C4, CF3; R3 ES H, FENILO OPCIONALMENTE SUSTITUIDO, PIRIDILO, NAFTILO, QUINOLINILO, ALQUILO C1-C4-TIAZOLILO; SON COMPUESTOS (I) PREFERIDOS 3-(2-CLORO-6-METILFENILSULFONILAMINO)-4-(2-(4-ACETAMIDO)PIRIDIL)-5-(3-(4-FLUOROFENOXI)BENCILTIO)-(1H)-PIRAZOL Y 3-(2,6-DICLOROFENILSULFONILAMINO)-4-(2-(4-ACETAMIDO)PIRIDIL)-5-(3-(4-FLUOROFENOXI)BENCILTIO)-(1H)-PIRAZOL. TAMBIEN SE REFIERE AL PROCEDIMIENTO DE PREPARACION. LOS COMPUESTOS DE FORMULA (I) ACTUAN INHIBIENDO LA LIBERACION DE ACIDOS GRASOS PRODUCIDOS POR LA FOSFOLIPASA SECRETORA NO PANCREATICA HUMANA A2 (sPLA2), SIENDO UTILES EN EL TRATAMIENTO DEL SHOCK SEPTICO, SINDROME DE DIFICULTAD RESPIRATORIA EN ADULTOS, ENTRE OTROS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3321696P | 1996-12-04 | 1996-12-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20599A1 true PE20599A1 (es) | 1999-03-05 |
Family
ID=21869147
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1997001083A PE20599A1 (es) | 1996-12-04 | 1997-12-01 | Pirazoles como inhibidores de fosfolipasa secretora no pancreatica humana a2 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5972972A (es) |
| EP (1) | EP0846687B1 (es) |
| JP (1) | JP2002515053A (es) |
| KR (1) | KR20000057366A (es) |
| AR (1) | AR010743A1 (es) |
| AT (1) | ATE203985T1 (es) |
| AU (1) | AU5365598A (es) |
| BR (1) | BR9713993A (es) |
| CA (1) | CA2274048A1 (es) |
| CO (1) | CO4910169A1 (es) |
| DE (1) | DE69706027T2 (es) |
| DK (1) | DK0846687T3 (es) |
| ES (1) | ES2160897T3 (es) |
| HU (1) | HUP0000292A3 (es) |
| ID (1) | ID18983A (es) |
| IL (1) | IL130202A0 (es) |
| PE (1) | PE20599A1 (es) |
| PT (1) | PT846687E (es) |
| TW (1) | TW432051B (es) |
| WO (1) | WO1998024437A1 (es) |
| ZA (1) | ZA9710878B (es) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6514977B1 (en) | 1997-05-22 | 2003-02-04 | G.D. Searle & Company | Substituted pyrazoles as p38 kinase inhibitors |
| US6979686B1 (en) | 2001-12-07 | 2005-12-27 | Pharmacia Corporation | Substituted pyrazoles as p38 kinase inhibitors |
| CA2288787A1 (en) | 1997-05-22 | 1998-11-26 | G.D. Searle And Co. | Pyrazole derivatives as p38 kinase inhibitors |
| AU3054399A (en) | 1998-03-31 | 1999-10-25 | Shionogi & Co., Ltd. | Pyrrolo(1,2-a)pyrazine sPLA2 inhibitor |
| WO1999059999A1 (en) | 1998-05-21 | 1999-11-25 | Shionogi & Co., Ltd. | PYRROLO[1,2-b]PYRIDAZINE DERIVATIVES HAVING sPLA2 INHIBITORY EFFECT |
| AU6004799A (en) | 1998-10-14 | 2000-05-01 | Shionogi & Co., Ltd. | Remedies or preventives for ischemic reflow failure |
| AU6015600A (en) | 1999-07-19 | 2001-02-05 | Shionogi & Co., Ltd. | Tricyclic compounds having spla2-inhibitory activities |
| AU6023200A (en) | 1999-08-02 | 2001-02-19 | Shionogi & Co., Ltd. | Tricyclic compounds having spla2-inhibitory activities |
| US6787545B1 (en) | 1999-08-23 | 2004-09-07 | Shiongi & Co., Ltd. | Pyrrolotriazine derivatives having spla2-inhibitory activities |
| ES2171116B1 (es) * | 2000-04-14 | 2003-08-01 | Esteve Quimica Sa | Procedimiento para la obtencion de derivados de (((piridil sustituido)metil)tio)bencimidazol. |
| AU2001267825A1 (en) | 2000-06-29 | 2002-01-08 | Shionogi And Co., Ltd. | Remedies for cirrhosis |
| WO2002000621A1 (en) | 2000-06-29 | 2002-01-03 | Shionogi & Co., Ltd. | Compounds exhibiting x-type spla2 inhibiting effect |
| TWI314457B (es) | 2001-03-19 | 2009-09-11 | Shionogi & Co | |
| US7076539B2 (en) * | 2001-07-30 | 2006-07-11 | Hewlett-Packard Development Company, L.P. | Network connectivity establishment at user log-in |
| AU2003237397A1 (en) * | 2002-06-04 | 2003-12-19 | Sequenom, Inc. | Diagnosing predisposition to fat deposition and therapeutic methods for reducing fat deposition and treatment of associated conditions |
| AUPS282602A0 (en) | 2002-06-07 | 2002-06-27 | Garvan Institute Of Medical Research | Method of inhibiting cell proliferation |
| JP2006508642A (ja) * | 2002-06-27 | 2006-03-16 | ハークネス ファーマシューティカルズ，インコーポレイティド | 脂肪の蓄積を減少させる方法と、関連疾患を治療するための方法 |
| US20050239077A1 (en) * | 2002-06-27 | 2005-10-27 | Adam Gail I R | Diagnosing predisposition to fat deposition and associated conditions |
| JP2011510033A (ja) * | 2008-01-25 | 2011-03-31 | シンジェンタ パーティシペーションズ アクチェンゲゼルシャフト | 化合物 |
| MX2011011517A (es) | 2009-04-29 | 2012-06-19 | Amarin Corp Plc | Composiciones farmaceuticas que comprenden epa y un agente cardiovascular y metodos para utilizar el mismo. |
| CN105017134A (zh) * | 2015-07-26 | 2015-11-04 | 陈吉美 | 一种4-吡啶丙烯酸的制备方法 |
| SI3752510T1 (sl) | 2018-02-15 | 2023-03-31 | Vertex Pharmaceuticals Incorporated | Makrocikli kot modulatorji regulatorja transmembranske prevodnosti pri cistični fibrozi, farmacevtski sestavki iz le-teh, njihova uporaba pri zdravljenju cistične fibroze in postopek za njihovo proizvodnjo |
| US12479816B2 (en) | 2019-02-08 | 2025-11-25 | University of Pittsburgh—of the Commonwealth System of Higher Education | 20-HETE formation inhibitors |
| AR118555A1 (es) | 2019-04-03 | 2021-10-20 | Vertex Pharma | Agentes moduladores del regulador de la conductancia transmembrana de la fibrosis quística |
| CA3150162A1 (en) | 2019-08-14 | 2021-02-18 | Vertex Pharmaceuticals Incorporated | Crystalline forms of cftr modulators |
| SI4013741T1 (sl) | 2019-08-14 | 2024-06-28 | Vertex Pharmaceuticals Incorporated | Postopek za izdelavo cftr-modulatorjev |
| TWI867024B (zh) | 2019-08-14 | 2024-12-21 | 美商維泰克斯製藥公司 | 囊腫纖維化跨膜傳導調節蛋白之調節劑 |
| EP4225737A1 (en) * | 2020-10-07 | 2023-08-16 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
| EP4259139A1 (en) | 2020-12-10 | 2023-10-18 | Vertex Pharmaceuticals Incorporated | Methods of treatment for cystic fibrosis |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3616681A1 (de) * | 1986-05-16 | 1987-11-19 | Bayer Ag | 1-aralkylpyrazole |
| JPH02229169A (ja) * | 1989-03-01 | 1990-09-11 | Takeda Chem Ind Ltd | ピラゾロン誘導体 |
| JPH02229168A (ja) * | 1989-03-01 | 1990-09-11 | Takeda Chem Ind Ltd | ピラゾロン誘導体 |
| DK0465913T3 (da) * | 1990-07-10 | 1997-10-20 | Ishihara Sangyo Kaisha | Diaminotrifluormethylpyridinderivater, fremgangsmåder til fremstilling deraf og phospholipase-A2-inhibitor indeholdende samme |
| EP0539034A1 (en) * | 1991-10-22 | 1993-04-28 | Konica Corporation | A novel photographic cyan coupler |
| US5541213A (en) * | 1993-06-24 | 1996-07-30 | Eisai Co., Ltd. | Propenoic acid derivatives diazole propenoic acid compounds which have useful pharmaceutical utility |
| US5466823A (en) * | 1993-11-30 | 1995-11-14 | G.D. Searle & Co. | Substituted pyrazolyl benzenesulfonamides |
| US5500439A (en) * | 1993-12-09 | 1996-03-19 | Alteon Inc. | Aminopyrazoles |
| US5559137A (en) * | 1994-05-16 | 1996-09-24 | Smithkline Beecham Corp. | Compounds |
| US5486534A (en) * | 1994-07-21 | 1996-01-23 | G. D. Searle & Co. | 3,4-substituted pyrazoles for the treatment of inflammation |
-
1997
- 1997-11-27 ID IDP973793A patent/ID18983A/id unknown
- 1997-12-01 KR KR1019990704898A patent/KR20000057366A/ko not_active Withdrawn
- 1997-12-01 WO PCT/US1997/021795 patent/WO1998024437A1/en not_active Ceased
- 1997-12-01 PE PE1997001083A patent/PE20599A1/es not_active Application Discontinuation
- 1997-12-01 HU HU0000292A patent/HUP0000292A3/hu unknown
- 1997-12-01 CA CA002274048A patent/CA2274048A1/en not_active Abandoned
- 1997-12-01 IL IL13020297A patent/IL130202A0/xx unknown
- 1997-12-01 BR BR9713993-9A patent/BR9713993A/pt unknown
- 1997-12-01 AU AU53655/98A patent/AU5365598A/en not_active Abandoned
- 1997-12-01 JP JP52568198A patent/JP2002515053A/ja not_active Withdrawn
- 1997-12-02 AT AT97309701T patent/ATE203985T1/de not_active IP Right Cessation
- 1997-12-02 EP EP97309701A patent/EP0846687B1/en not_active Expired - Lifetime
- 1997-12-02 PT PT97309701T patent/PT846687E/pt unknown
- 1997-12-02 CO CO97070453A patent/CO4910169A1/es unknown
- 1997-12-02 DE DE69706027T patent/DE69706027T2/de not_active Expired - Fee Related
- 1997-12-02 ES ES97309701T patent/ES2160897T3/es not_active Expired - Lifetime
- 1997-12-02 DK DK97309701T patent/DK0846687T3/da active
- 1997-12-03 AR ARP970105678A patent/AR010743A1/es unknown
- 1997-12-03 US US08/984,261 patent/US5972972A/en not_active Expired - Fee Related
- 1997-12-03 ZA ZA9710878A patent/ZA9710878B/xx unknown
- 1997-12-05 TW TW086118237A patent/TW432051B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0846687A1 (en) | 1998-06-10 |
| ES2160897T3 (es) | 2001-11-16 |
| PT846687E (pt) | 2001-12-28 |
| KR20000057366A (ko) | 2000-09-15 |
| EP0846687B1 (en) | 2001-08-08 |
| HUP0000292A2 (hu) | 2001-04-28 |
| US5972972A (en) | 1999-10-26 |
| ZA9710878B (en) | 1999-06-03 |
| AU5365598A (en) | 1998-06-29 |
| ID18983A (id) | 1998-05-28 |
| AR010743A1 (es) | 2000-07-12 |
| IL130202A0 (en) | 2000-06-01 |
| DE69706027D1 (de) | 2001-09-13 |
| CO4910169A1 (es) | 2000-04-24 |
| DE69706027T2 (de) | 2002-03-14 |
| DK0846687T3 (da) | 2001-10-08 |
| JP2002515053A (ja) | 2002-05-21 |
| BR9713993A (pt) | 2000-02-08 |
| CA2274048A1 (en) | 1998-06-11 |
| HUP0000292A3 (en) | 2002-01-28 |
| WO1998024437A1 (en) | 1998-06-11 |
| ATE203985T1 (de) | 2001-08-15 |
| TW432051B (en) | 2001-05-01 |
| HK1011865A1 (en) | 1999-07-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |