DK0465913T3 - Diaminotrifluormethylpyridinderivater, fremgangsmåder til fremstilling deraf og phospholipase-A2-inhibitor indeholdende samme - Google Patents
Diaminotrifluormethylpyridinderivater, fremgangsmåder til fremstilling deraf og phospholipase-A2-inhibitor indeholdende sammeInfo
- Publication number
- DK0465913T3 DK0465913T3 DK91110421.4T DK91110421T DK0465913T3 DK 0465913 T3 DK0465913 T3 DK 0465913T3 DK 91110421 T DK91110421 T DK 91110421T DK 0465913 T3 DK0465913 T3 DK 0465913T3
- Authority
- DK
- Denmark
- Prior art keywords
- substituted
- alkyl
- independent
- another
- phenyl
- Prior art date
Links
- UVPXDGMMAFWHMJ-UHFFFAOYSA-N 2-(trifluoromethyl)pyridine-3,4-diamine Chemical class NC1=CC=NC(C(F)(F)F)=C1N UVPXDGMMAFWHMJ-UHFFFAOYSA-N 0.000 title abstract 2
- 108010014865 PLIalpha Proteins 0.000 title 1
- 229940123898 Phospholipase A2 inhibitor Drugs 0.000 title 1
- 239000003358 phospholipase A2 inhibitor Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000001188 haloalkyl group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000002911 monocyclic heterocycle group Chemical group 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
- 125000003367 polycyclic group Chemical group 0.000 abstract 1
- 125000004585 polycyclic heterocycle group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP18199990 | 1990-07-10 | ||
| JP3222530A JPH05170742A (ja) | 1991-05-24 | 1991-05-24 | ジアミノトリフルオロメチルピリジン誘導体、それらの製造方法及びそれらを含有するホスホリパーゼ▲ａ２▼阻害剤 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0465913T3 true DK0465913T3 (da) | 1997-10-20 |
Family
ID=26500966
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK91110421.4T DK0465913T3 (da) | 1990-07-10 | 1991-06-24 | Diaminotrifluormethylpyridinderivater, fremgangsmåder til fremstilling deraf og phospholipase-A2-inhibitor indeholdende samme |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0465913B1 (da) |
| JP (3) | JP3078896B2 (da) |
| KR (1) | KR0173311B1 (da) |
| CN (1) | CN1032534C (da) |
| AT (1) | ATE157969T1 (da) |
| AU (1) | AU642267B2 (da) |
| CA (1) | CA2045857C (da) |
| DE (1) | DE69127595T2 (da) |
| DK (1) | DK0465913T3 (da) |
| ES (1) | ES2107434T3 (da) |
| GR (1) | GR3025455T3 (da) |
| IL (1) | IL98762A (da) |
| NZ (1) | NZ238752A (da) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0465913T3 (da) | 1990-07-10 | 1997-10-20 | Ishihara Sangyo Kaisha | Diaminotrifluormethylpyridinderivater, fremgangsmåder til fremstilling deraf og phospholipase-A2-inhibitor indeholdende samme |
| GB9403333D0 (en) * | 1994-02-22 | 1994-04-13 | Zeneca Ltd | Compound and use |
| FR2720396B1 (fr) * | 1994-05-27 | 1996-06-28 | Adir | Nouveaux N-pyridyl carboxamides et dérivés leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
| ID18983A (id) * | 1996-12-04 | 1998-05-28 | Lilly Co Eli | Pirazola sebagai inhibitor sekresi fosfolipase a2 non-pankreas pada manusia |
| ZA981430B (en) * | 1997-02-28 | 1998-08-24 | Ishihara Sangyo Kaisha | Anticancer composition |
| JP4848091B2 (ja) * | 2000-01-31 | 2011-12-28 | 石原産業株式会社 | ジアミノトリフルオロメチルピリジン誘導体を含有する消化器疾患治療剤又は予防剤 |
| JP2001288089A (ja) * | 2000-02-01 | 2001-10-16 | Ishihara Sangyo Kaisha Ltd | ジアミノトリフルオロメチルピリジン誘導体を含有する肝疾患の治療剤又は予防剤 |
| JP4848092B2 (ja) * | 2000-02-01 | 2011-12-28 | 石原産業株式会社 | ジアミノトリフルオロメチルピリジン誘導体を含有する肺不全の治療剤又は予防剤 |
| EP1252891B1 (en) * | 2000-02-01 | 2005-10-05 | Ishihara Sangyo Kaisha, Ltd. | Use of DIAMINOTRIFLUOROMETHYLPYRIDINE DERIVATIVES FOR the prevention and treatment of LIVER DISEASES |
| AU2003277537A1 (en) * | 2002-10-30 | 2004-05-25 | Ishihara Sangyo Kaisha, Ltd. | REGULATION OF INTERACTION BETWEEN RAPL AND Rap1 |
| JP5584518B2 (ja) | 2009-05-28 | 2014-09-03 | 石原産業株式会社 | ジアミノトリフルオロメチルピリジン誘導体を含有する抗ショック剤 |
| EP2923710A1 (en) | 2014-03-27 | 2015-09-30 | Universitätsklinikum Heidelberg | Bacterial phospholipase inhibitors as modulator of colonic bacterial flora |
| US20200289481A1 (en) | 2017-11-02 | 2020-09-17 | Ishihara Sangyo Kaisha, Ltd. | Sustained-release pharmaceutical composition |
| MX2020008992A (es) * | 2018-03-01 | 2020-09-28 | Ishihara Sangyo Kaisha | Composicion farmaceutica con excelente estabilidad en almacenamiento. |
| US12473259B2 (en) | 2019-05-15 | 2025-11-18 | Ishihara Sangyo Kaisha, Ltd. | Anhydrous crystal of monosodium n-(2-ethylsulfonylamino-5-trifluoromethyl-3-pyridyl)cyclohexane carboxamide |
| KR102188659B1 (ko) | 2019-12-10 | 2020-12-08 | 박영식 | 핸드 파렛트 트럭용 전도방지장치 |
| WO2022071233A1 (ja) * | 2020-09-29 | 2022-04-07 | 石原産業株式会社 | 優れた保存効力を示す液状医薬組成物 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3962263A (en) | 1970-03-20 | 1976-06-08 | Eli Lilly And Company | N-(2,2-difluoroalkanoyl)-2,3-pyridinediamine compounds |
| FR2124163A1 (en) * | 1971-02-10 | 1972-09-22 | Ferlux | 2-amino-3-hydroxypyridine derivs - cardiovascular active |
| US3963660A (en) * | 1973-10-04 | 1976-06-15 | The Upjohn Company | Pyridine dioxamic acids and esters |
| US3961063A (en) | 1975-04-03 | 1976-06-01 | Smithkline Corporation | 2,3-Bis-(3-acyl-2-thioureido)-pyridines |
| DK0465913T3 (da) * | 1990-07-10 | 1997-10-20 | Ishihara Sangyo Kaisha | Diaminotrifluormethylpyridinderivater, fremgangsmåder til fremstilling deraf og phospholipase-A2-inhibitor indeholdende samme |
-
1991
- 1991-06-24 DK DK91110421.4T patent/DK0465913T3/da active
- 1991-06-24 DE DE69127595T patent/DE69127595T2/de not_active Expired - Lifetime
- 1991-06-24 AT AT91110421T patent/ATE157969T1/de not_active IP Right Cessation
- 1991-06-24 ES ES91110421T patent/ES2107434T3/es not_active Expired - Lifetime
- 1991-06-24 EP EP91110421A patent/EP0465913B1/en not_active Expired - Lifetime
- 1991-06-27 CA CA002045857A patent/CA2045857C/en not_active Expired - Lifetime
- 1991-06-27 NZ NZ238752A patent/NZ238752A/xx not_active IP Right Cessation
- 1991-06-29 CN CN91104523A patent/CN1032534C/zh not_active Expired - Lifetime
- 1991-07-02 AU AU79497/91A patent/AU642267B2/en not_active Expired
- 1991-07-08 IL IL9876291A patent/IL98762A/en not_active IP Right Cessation
- 1991-07-09 KR KR1019910011613A patent/KR0173311B1/ko not_active Expired - Lifetime
- 1991-07-10 JP JP03264234A patent/JP3078896B2/ja not_active Expired - Lifetime
- 1991-07-10 JP JP3264235A patent/JP2762323B2/ja not_active Expired - Lifetime
-
1997
- 1997-11-24 GR GR970403100T patent/GR3025455T3/el unknown
-
1998
- 1998-01-05 JP JP10010019A patent/JP3048344B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2045857A1 (en) | 1992-01-11 |
| DE69127595D1 (de) | 1997-10-16 |
| HK1001839A1 (en) | 1998-07-10 |
| GR3025455T3 (en) | 1998-02-27 |
| IL98762A0 (en) | 1992-07-15 |
| CN1058396A (zh) | 1992-02-05 |
| KR920002546A (ko) | 1992-02-28 |
| ES2107434T3 (es) | 1997-12-01 |
| AU642267B2 (en) | 1993-10-14 |
| JP3078896B2 (ja) | 2000-08-21 |
| EP0465913A3 (en) | 1992-04-15 |
| JP3048344B2 (ja) | 2000-06-05 |
| JPH06263735A (ja) | 1994-09-20 |
| JPH06247934A (ja) | 1994-09-06 |
| IL98762A (en) | 1995-05-26 |
| CA2045857C (en) | 1997-09-23 |
| EP0465913A2 (en) | 1992-01-15 |
| DE69127595T2 (de) | 1998-01-22 |
| JPH10152473A (ja) | 1998-06-09 |
| KR0173311B1 (ko) | 1999-02-01 |
| CN1032534C (zh) | 1996-08-14 |
| NZ238752A (en) | 1993-06-25 |
| AU7949791A (en) | 1992-01-16 |
| JP2762323B2 (ja) | 1998-06-04 |
| EP0465913B1 (en) | 1997-09-10 |
| ATE157969T1 (de) | 1997-09-15 |
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