PE20020483A1 - Peptidos ciclicos selectivos como agonistas de los receptores de melanocortina 4 - Google Patents
Peptidos ciclicos selectivos como agonistas de los receptores de melanocortina 4Info
- Publication number
- PE20020483A1 PE20020483A1 PE2001000859A PE2001000859A PE20020483A1 PE 20020483 A1 PE20020483 A1 PE 20020483A1 PE 2001000859 A PE2001000859 A PE 2001000859A PE 2001000859 A PE2001000859 A PE 2001000859A PE 20020483 A1 PE20020483 A1 PE 20020483A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- lys
- asp
- melanocortin
- agonists
- Prior art date
Links
- 102000001189 Cyclic Peptides Human genes 0.000 title 1
- 108010069514 Cyclic Peptides Proteins 0.000 title 1
- 102000001796 Melanocortin 4 receptors Human genes 0.000 title 1
- 108050009019 Melanocortin 4 receptors Proteins 0.000 title 1
- 239000000556 agonist Substances 0.000 title 1
- OAMLVOVXNKILLQ-BQBZGAKWSA-N Asp-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@@H](N)CC(O)=O OAMLVOVXNKILLQ-BQBZGAKWSA-N 0.000 abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- 108010092854 aspartyllysine Proteins 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000008589 Obesity Diseases 0.000 abstract 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- KHUXNRRPPZOJPT-UHFFFAOYSA-N phenoxy radical Chemical class O=C1C=C[CH]C=C1 KHUXNRRPPZOJPT-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- C07K14/68—Melanocyte-stimulating hormone [MSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Child & Adolescent Psychology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
SE REFIERE A HEPTAPEPTIDOS CICLICOS DE FORMULA I DONDE R1, R12, X E Y FORMAN FENILO; X E Y SON C; R1 ES H, R2-(NH)n-C(=O)-NH-; R2-C(=O)-NH-CH(R14)-C(=O)-NH-; R12 ES H; R2 ES ALQUILO C1-C5, ALQUENILO C2-C5, ALQUINILO C2-C5; R14 ES ALQUILO C1-C5; n ES 0-1; Q ES GRUPO a, b, C(R11)(R13); R3, R4, R5 SON H, HALO, ALQUILO C1-C4, OH, ALCOXILO C1-C4; CUANDO R4 NO ES H; R3 Y R5 SON H; R6 ES H, ALQUILO C1-C3, ALCOXILO C1-C3, FENOXILO, HALO; R11 Y R13 SON H, ALQUILO C3-C4, CICLOALQUILO C5-C6 O SON AMBOS FENILO; R7 ES O, NH; R8 y R10 SON H, METILO; R9 ES GRUPO c, d; p ES 0-1; m ES 0-3; Z ES CONH; S-S; R17 ES H, ALQUILO. SON COMPUESTOS PREFERIDOS PENTACICLO (ASP-LYS)-ASP-APC-(D)-PHE-ARG-TRP-LYS-NH2; PENTACICLO (ASP-LYS)-ASP-4-MEAPC-(D)-PHE-ARG-TRP-LYS-NH2: ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. LOS COMPUESTOS SON INHIBIDORES DEL RECEPTOR DE MELANOCORTINA 4 Y PUEDE SER UTIL PARA EL TRATAMIENTO DE OBESIDAD
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22918400P | 2000-08-30 | 2000-08-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20020483A1 true PE20020483A1 (es) | 2002-06-06 |
Family
ID=22860145
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2001000859A PE20020483A1 (es) | 2000-08-30 | 2001-08-28 | Peptidos ciclicos selectivos como agonistas de los receptores de melanocortina 4 |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US7045591B2 (es) |
| EP (1) | EP1315750B1 (es) |
| JP (1) | JP4217069B2 (es) |
| KR (1) | KR100483300B1 (es) |
| CN (1) | CN100491396C (es) |
| AR (2) | AR030504A1 (es) |
| AT (1) | ATE353918T1 (es) |
| AU (2) | AU2001284026B2 (es) |
| BR (1) | BR0113637A (es) |
| CA (1) | CA2420058C (es) |
| CY (1) | CY1106562T1 (es) |
| CZ (1) | CZ2003584A3 (es) |
| DE (1) | DE60126624T2 (es) |
| DK (1) | DK1315750T3 (es) |
| EC (1) | ECSP034503A (es) |
| ES (1) | ES2280393T3 (es) |
| HR (1) | HRP20030126B1 (es) |
| HU (1) | HUP0303078A3 (es) |
| IL (2) | IL154575A0 (es) |
| JO (1) | JO2454B1 (es) |
| MA (1) | MA27681A1 (es) |
| MX (1) | MXPA03001721A (es) |
| MY (1) | MY137457A (es) |
| NO (1) | NO20030916L (es) |
| NZ (1) | NZ523989A (es) |
| PA (1) | PA8527201A1 (es) |
| PE (1) | PE20020483A1 (es) |
| PL (1) | PL366630A1 (es) |
| PT (1) | PT1315750E (es) |
| RU (1) | RU2239642C1 (es) |
| SI (1) | SI1315750T1 (es) |
| TW (1) | TWI248941B (es) |
| WO (1) | WO2002018437A2 (es) |
| YU (1) | YU15603A (es) |
| ZA (1) | ZA200301015B (es) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6960646B2 (en) * | 2001-07-12 | 2005-11-01 | Merck & Co., Inc. | Cyclic peptides as potent and selective melanocortin-4 receptors agonists |
| WO2003013571A1 (en) | 2001-08-10 | 2003-02-20 | Palatin Technologies, Inc. | Peptidomimetics of biologically active metallopeptides |
| US7655658B2 (en) | 2001-08-10 | 2010-02-02 | Palatin Technologies, Inc. | Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds |
| US7354923B2 (en) | 2001-08-10 | 2008-04-08 | Palatin Technologies, Inc. | Piperazine melanocortin-specific compounds |
| US7456184B2 (en) | 2003-05-01 | 2008-11-25 | Palatin Technologies Inc. | Melanocortin receptor-specific compounds |
| US7732451B2 (en) | 2001-08-10 | 2010-06-08 | Palatin Technologies, Inc. | Naphthalene-containing melanocortin receptor-specific small molecule |
| US7718802B2 (en) | 2001-08-10 | 2010-05-18 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific piperazine compounds |
| BR0305628A (pt) | 2002-07-09 | 2004-09-08 | Palatin Technologies Inc | Composição farmacêutica para tratar disfunção sexual num mamìfero compreendendo peptìdeo e seu uso |
| US7727990B2 (en) | 2003-05-01 | 2010-06-01 | Palatin Technologies, Inc. | Melanocortin receptor-specific piperazine and keto-piperazine compounds |
| US7968548B2 (en) | 2003-05-01 | 2011-06-28 | Palatin Technologies, Inc. | Melanocortin receptor-specific piperazine compounds with diamine groups |
| US7727991B2 (en) | 2003-05-01 | 2010-06-01 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific single acyl piperazine compounds |
| KR20060026011A (ko) | 2003-05-09 | 2006-03-22 | 노보 노르디스크 에이/에스 | 비만 치료용 펩티드 |
| AU2004235872A1 (en) * | 2003-05-09 | 2004-11-18 | Novo Nordisk A/S | Peptides for use in treating obesity |
| EA200600055A1 (ru) * | 2003-06-19 | 2006-08-25 | Эли Лилли Энд Компани | Агонисты рецептора меланокортина 4 (мк4 ) и их применение |
| EP1644022A1 (en) * | 2003-06-19 | 2006-04-12 | Eli Lilly And Company | Uses of melanocortin-3 receptor (mc3r) agonist peptides |
| US7084111B2 (en) | 2003-06-23 | 2006-08-01 | University Of Florida Research Foundation, Inc. | Melanocortin receptor templates, peptides, and use thereof |
| BRPI0414890A (pt) | 2003-09-30 | 2006-12-12 | Novo Nordisk As | composto, métodos de retardar a progressão de igt para diabete tipo 2, e de diabete tipo 2 para diabete que requer insulina, de tratar a obesidade ou prevenir o excesso de peso, de regular o apetite, de induzir saciedade, de impedir o ganho de peso, de aumentar o gasto de energia, e de tratar uma doença ou estado, composição farmacêutica, e, uso de um composto |
| US7550602B1 (en) * | 2004-01-14 | 2009-06-23 | Palatin Technologies, Inc. | Small molecule compositions for sexual dysfunction |
| US6974187B2 (en) * | 2004-01-28 | 2005-12-13 | Tachi-S Co., Ltd. | Vehicle seat structure |
| CA2557739A1 (en) * | 2004-03-29 | 2005-11-03 | Eli Lilly And Company | Uses of melanocortin-4 receptor (mc4r) agonist peptides administered by continuous infusion |
| JP4793265B2 (ja) * | 2004-04-08 | 2011-10-12 | アステラス製薬株式会社 | 化合物ｗｓ７２７７１３ |
| US7709484B1 (en) | 2004-04-19 | 2010-05-04 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific piperazine compounds |
| JP2008519008A (ja) * | 2004-11-04 | 2008-06-05 | ノボ ノルディスク アクティーゼルスカブ | 肥満症の治療に使用するためのペプチド |
| US20080280820A1 (en) * | 2004-11-04 | 2008-11-13 | Ulrich Sensfuss | Novel Peptides for Use in the Treatment of Obesity |
| CN101052647A (zh) * | 2004-11-04 | 2007-10-10 | 诺和诺德公司 | 用于治疗肥胖的新的肽类 |
| JP2008519006A (ja) * | 2004-11-04 | 2008-06-05 | ノボ ノルディスク アクティーゼルスカブ | 肥満症の治療に使用するためのペプチド |
| KR20080027246A (ko) * | 2005-05-31 | 2008-03-26 | 이섬 리서치 디벨러프먼트 컴파니 오브 더 히브루 유니버시티 오브 예루살렘 | 기본구조에 고리가 형성된 멜라노코르틴 자극 호르몬유사체 |
| EP1893240A2 (en) * | 2005-06-13 | 2008-03-05 | Nastech Pharmaceutical Company Inc. | Transmucosal delivery of peptide derivatives |
| US7795332B2 (en) * | 2005-07-15 | 2010-09-14 | 3M Innovative Properties Company | Method of removing fluorinated carboxylic acid from aqueous liquid |
| US20080015304A1 (en) | 2006-07-13 | 2008-01-17 | Klaus Hintzer | Aqueous emulsion polymerization process for producing fluoropolymers |
| GB2430437A (en) * | 2005-09-27 | 2007-03-28 | 3M Innovative Properties Co | Method of making a fluoropolymer |
| US7834017B2 (en) | 2006-08-11 | 2010-11-16 | Palatin Technologies, Inc. | Diamine-containing, tetra-substituted piperazine compounds having identical 1- and 4-substituents |
| CN101573371A (zh) * | 2006-12-29 | 2009-11-04 | 弗·哈夫曼-拉罗切有限公司 | 环肽类化合物的合成方法 |
| CN101605728B (zh) * | 2007-02-16 | 2013-07-24 | 3M创新有限公司 | 用于从水中去除含氟化合物的系统和方法 |
| US20080264864A1 (en) * | 2007-04-27 | 2008-10-30 | 3M Innovative Properties Company | PROCESS FOR REMOVING FLUORINATED EMULSIFIER FROM FLUOROPOLMER DISPERSIONS USING AN ANION-EXCHANGE RESIN AND A pH-DEPENDENT SURFACTANT AND FLUOROPOLYMER DISPERSIONS CONTAINING A pH-DEPENDENT SURFACTANT |
| US8563000B2 (en) | 2007-05-25 | 2013-10-22 | Ipsen Pharma S.A.S. | Melanocortin receptor ligands modified with hydantoin |
| WO2009011261A1 (ja) * | 2007-07-19 | 2009-01-22 | Tokuyama Corporation | ヒダントイン環を有する化合物及びその製造方法 |
| EP2280941B1 (de) * | 2008-03-27 | 2015-05-06 | Grünenthal GmbH | (hetero-)aryl-cyclohexan-derivate |
| RU2532545C2 (ru) | 2008-03-27 | 2014-11-10 | Грюненталь Гмбх | Замещенные производные 4-аминоциклогексана |
| EA018630B1 (ru) | 2008-06-09 | 2013-09-30 | Палатин Текнолоджиз, Инк. | Специфичные к меланокортиновым рецепторам пептиды для лечения сексуальной дисфункции |
| TW201002340A (en) * | 2008-06-09 | 2010-01-16 | Palatin Technologies Inc | Melanocortin receptor-specific peptides for treatment of obesity |
| CN105037502A (zh) | 2009-06-08 | 2015-11-11 | 帕拉丁科技公司 | 黑皮质素受体特异性肽 |
| EP2440572B1 (en) | 2009-06-08 | 2017-04-05 | Palatin Technologies, Inc. | Lactam-bridged melanocortin receptor-specific peptides |
| UY32690A (es) | 2009-06-08 | 2011-01-31 | Astrazeneca Ab | Péptidos específicos para receptores de melanocortina |
| WO2011063367A1 (en) | 2009-11-23 | 2011-05-26 | Palatin Technologies, Inc. | Melanocortin-1 receptor-specific linear peptides |
| AU2010321738B2 (en) | 2009-11-23 | 2016-07-14 | Palatin Technologies, Inc. | Melanocortin-1 receptor-specific cyclic peptides |
| AU2014227712B2 (en) | 2013-03-15 | 2018-08-02 | Rhythm Pharmaceuticals, Inc. | Peptide compositions |
| GB201416352D0 (en) | 2014-09-16 | 2014-10-29 | Shire Internat Gmbh | Spirocyclic derivatives |
| GB201416351D0 (en) | 2014-09-16 | 2014-10-29 | Shire Internat Gmbh | Heterocyclic derivatives |
| CR20170110A (es) * | 2014-09-26 | 2017-05-08 | Bayer Pharma AG | Derivados estabilizados de adrenomedulina y uso de los mismos |
| US11542302B2 (en) | 2015-10-15 | 2023-01-03 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Modulators of melanocortin receptors for the treatment of depression and anxiety |
| WO2017066754A1 (en) | 2015-10-15 | 2017-04-20 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Compositions and methods for the treatment of depression and anxiety |
| US10899793B2 (en) | 2016-05-27 | 2021-01-26 | Regents Of The University Of Minnesota | Melanocortin ligands and methods of use thereof |
| US20190255142A1 (en) * | 2016-10-17 | 2019-08-22 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Novel modulators of melanocortin receptors for the treatment of depression and anxiety |
| US11124541B2 (en) | 2016-10-18 | 2021-09-21 | Regents Of The University Of Minnesota | Chimeric melanocortin ligands and methods of use thereof |
| CN106496008A (zh) * | 2016-10-20 | 2017-03-15 | 上海毕得医药科技有限公司 | 一种合成4‑(4‑氯苯基)环己酮的方法 |
| CN106496005B (zh) * | 2016-10-20 | 2019-04-09 | 上海毕得医药科技有限公司 | 一种4-(4-氯苯基)环己酮的合成方法 |
| US10745444B2 (en) * | 2017-04-17 | 2020-08-18 | National Tsing Hua University | Cyclopeptide, pharmaceutical or cosmetic composition comprising the same and method for preparing the same |
| US11332499B2 (en) | 2018-08-16 | 2022-05-17 | Regents Of The University Of Minnesota | Cyclic peptides and methods of use thereof |
| CN118530294B (zh) * | 2024-05-10 | 2025-02-14 | 浙江大学 | 一种芳基二胺固载连接子、其前体以及制备方法和应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4237456A1 (de) * | 1992-11-06 | 1994-05-11 | Merck Patent Gmbh | Cyclopeptide |
| US5811391A (en) | 1994-08-25 | 1998-09-22 | Cytel Corporation | Cyclic CS-1 peptidomimetics, compositions and methods of using same |
| US5731408A (en) * | 1995-04-10 | 1998-03-24 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Peptides having potent antagonist and agonist bioactivities at melanocortin receptors |
| US5858972A (en) | 1996-01-11 | 1999-01-12 | La Jolla Cancer Research Foundation | Antithrombotic agents and methods of use |
| SE9700620D0 (sv) * | 1997-02-21 | 1997-02-21 | Wapharm Ab | Cykliska peptider med selektivitet för MSH-receptor subtyper |
| IL145406A0 (en) | 1999-03-29 | 2002-06-30 | Procter & Gamble | Melanocortin receptor ligands |
-
2001
- 2001-08-21 HU HU0303078A patent/HUP0303078A3/hu unknown
- 2001-08-21 ES ES01962958T patent/ES2280393T3/es not_active Expired - Lifetime
- 2001-08-21 KR KR10-2003-7002931A patent/KR100483300B1/ko not_active Expired - Fee Related
- 2001-08-21 AU AU2001284026A patent/AU2001284026B2/en not_active Ceased
- 2001-08-21 DE DE60126624T patent/DE60126624T2/de not_active Expired - Lifetime
- 2001-08-21 CZ CZ2003584A patent/CZ2003584A3/cs unknown
- 2001-08-21 RU RU2003107921/04A patent/RU2239642C1/ru not_active IP Right Cessation
- 2001-08-21 PT PT01962958T patent/PT1315750E/pt unknown
- 2001-08-21 NZ NZ523989A patent/NZ523989A/en unknown
- 2001-08-21 EP EP01962958A patent/EP1315750B1/en not_active Expired - Lifetime
- 2001-08-21 IL IL15457501A patent/IL154575A0/xx unknown
- 2001-08-21 BR BR0113637-2A patent/BR0113637A/pt not_active IP Right Cessation
- 2001-08-21 JP JP2002523951A patent/JP4217069B2/ja not_active Expired - Fee Related
- 2001-08-21 YU YU15603A patent/YU15603A/sh unknown
- 2001-08-21 PL PL01366630A patent/PL366630A1/xx not_active Application Discontinuation
- 2001-08-21 WO PCT/EP2001/009630 patent/WO2002018437A2/en not_active Ceased
- 2001-08-21 AT AT01962958T patent/ATE353918T1/de active
- 2001-08-21 SI SI200130703T patent/SI1315750T1/sl unknown
- 2001-08-21 CN CNB018150284A patent/CN100491396C/zh not_active Expired - Fee Related
- 2001-08-21 CA CA002420058A patent/CA2420058C/en not_active Expired - Fee Related
- 2001-08-21 DK DK01962958T patent/DK1315750T3/da active
- 2001-08-21 MX MXPA03001721A patent/MXPA03001721A/es active IP Right Grant
- 2001-08-21 AU AU8402601A patent/AU8402601A/xx active Pending
- 2001-08-21 HR HR20030126A patent/HRP20030126B1/xx not_active IP Right Cessation
- 2001-08-23 JO JO2001138A patent/JO2454B1/en active
- 2001-08-27 US US09/939,966 patent/US7045591B2/en not_active Expired - Fee Related
- 2001-08-28 PE PE2001000859A patent/PE20020483A1/es not_active Application Discontinuation
- 2001-08-28 MY MYPI20014025A patent/MY137457A/en unknown
- 2001-08-28 PA PA20018527201A patent/PA8527201A1/es unknown
- 2001-08-28 AR ARP010104096A patent/AR030504A1/es active IP Right Grant
- 2001-08-30 TW TW090121400A patent/TWI248941B/zh not_active IP Right Cessation
-
2003
- 2003-02-05 ZA ZA200301015A patent/ZA200301015B/en unknown
- 2003-02-20 IL IL154575A patent/IL154575A/en not_active IP Right Cessation
- 2003-02-27 NO NO20030916A patent/NO20030916L/no not_active Application Discontinuation
- 2003-02-27 MA MA27059A patent/MA27681A1/fr unknown
- 2003-03-06 EC EC2003004503A patent/ECSP034503A/es unknown
-
2007
- 2007-05-07 CY CY20071100594T patent/CY1106562T1/el unknown
- 2007-05-30 AR ARP070102336A patent/AR061422A2/es unknown
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