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DK1315750T3 - Cykliske peptider med melanocortin-4-receptoragonistaktivitet - Google Patents

Cykliske peptider med melanocortin-4-receptoragonistaktivitet

Info

Publication number
DK1315750T3
DK1315750T3 DK01962958T DK01962958T DK1315750T3 DK 1315750 T3 DK1315750 T3 DK 1315750T3 DK 01962958 T DK01962958 T DK 01962958T DK 01962958 T DK01962958 T DK 01962958T DK 1315750 T3 DK1315750 T3 DK 1315750T3
Authority
DK
Denmark
Prior art keywords
melanocortin
receptor agonist
agonist activity
cyclic peptides
peptides
Prior art date
Application number
DK01962958T
Other languages
English (en)
Inventor
Li Chen
Adrian Wai-Hing Cheung
Xin-Jie Chu
Waleed Danho
Joseph Swistok
Yao Wang
Keith Alan Yagaloff
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DK1315750T3 publication Critical patent/DK1315750T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/68—Melanocyte-stimulating hormone [MSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK01962958T 2000-08-30 2001-08-21 Cykliske peptider med melanocortin-4-receptoragonistaktivitet DK1315750T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22918400P 2000-08-30 2000-08-30
PCT/EP2001/009630 WO2002018437A2 (en) 2000-08-30 2001-08-21 Cyclic peptides having melanocortin-4 receptor agonist activity

Publications (1)

Publication Number Publication Date
DK1315750T3 true DK1315750T3 (da) 2007-06-11

Family

ID=22860145

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01962958T DK1315750T3 (da) 2000-08-30 2001-08-21 Cykliske peptider med melanocortin-4-receptoragonistaktivitet

Country Status (35)

Country Link
US (1) US7045591B2 (da)
EP (1) EP1315750B1 (da)
JP (1) JP4217069B2 (da)
KR (1) KR100483300B1 (da)
CN (1) CN100491396C (da)
AR (2) AR030504A1 (da)
AT (1) ATE353918T1 (da)
AU (2) AU2001284026B2 (da)
BR (1) BR0113637A (da)
CA (1) CA2420058C (da)
CY (1) CY1106562T1 (da)
CZ (1) CZ2003584A3 (da)
DE (1) DE60126624T2 (da)
DK (1) DK1315750T3 (da)
EC (1) ECSP034503A (da)
ES (1) ES2280393T3 (da)
HR (1) HRP20030126B1 (da)
HU (1) HUP0303078A3 (da)
IL (2) IL154575A0 (da)
JO (1) JO2454B1 (da)
MA (1) MA27681A1 (da)
MX (1) MXPA03001721A (da)
MY (1) MY137457A (da)
NO (1) NO20030916L (da)
NZ (1) NZ523989A (da)
PA (1) PA8527201A1 (da)
PE (1) PE20020483A1 (da)
PL (1) PL366630A1 (da)
PT (1) PT1315750E (da)
RU (1) RU2239642C1 (da)
SI (1) SI1315750T1 (da)
TW (1) TWI248941B (da)
WO (1) WO2002018437A2 (da)
YU (1) YU15603A (da)
ZA (1) ZA200301015B (da)

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EP1425029A4 (en) 2001-08-10 2006-06-07 Palatin Technologies Inc PEPTIDOMIMETICS OF BIOLOGICALLY ACTIVE METALLOPEPTIDES
US7655658B2 (en) 2001-08-10 2010-02-02 Palatin Technologies, Inc. Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds
US7456184B2 (en) 2003-05-01 2008-11-25 Palatin Technologies Inc. Melanocortin receptor-specific compounds
US7354923B2 (en) 2001-08-10 2008-04-08 Palatin Technologies, Inc. Piperazine melanocortin-specific compounds
US7732451B2 (en) 2001-08-10 2010-06-08 Palatin Technologies, Inc. Naphthalene-containing melanocortin receptor-specific small molecule
US7718802B2 (en) 2001-08-10 2010-05-18 Palatin Technologies, Inc. Substituted melanocortin receptor-specific piperazine compounds
WO2004005324A2 (en) 2002-07-09 2004-01-15 Palatin Technologies, Inc. Peptide composition for treatment of sexual dysfunction
US7968548B2 (en) 2003-05-01 2011-06-28 Palatin Technologies, Inc. Melanocortin receptor-specific piperazine compounds with diamine groups
US7727990B2 (en) 2003-05-01 2010-06-01 Palatin Technologies, Inc. Melanocortin receptor-specific piperazine and keto-piperazine compounds
US7727991B2 (en) 2003-05-01 2010-06-01 Palatin Technologies, Inc. Substituted melanocortin receptor-specific single acyl piperazine compounds
MXPA05011830A (es) 2003-05-09 2006-01-26 Novo Nordisk As Peptidos para uso en el tratamiento de la obesidad.
JP2007524584A (ja) * 2003-05-09 2007-08-30 ノボ　ノルディスク　アクティーゼルスカブ 肥満の治療に使用するペプチド
JP2006527772A (ja) * 2003-06-19 2006-12-07 イーライ リリー アンド カンパニー メラノコルチン３受容体（ｍｃ３ｒ）作用薬ペプチドの用途
CA2530024A1 (en) * 2003-06-19 2005-01-06 Eli Lilly And Company Melanocortin receptor 4(mc4) agonists and their uses
US7084111B2 (en) 2003-06-23 2006-08-01 University Of Florida Research Foundation, Inc. Melanocortin receptor templates, peptides, and use thereof
KR20060089874A (ko) 2003-09-30 2006-08-09 노보 노르디스크 에이/에스 신규 멜라노코르틴 수용체 작용제
US7550602B1 (en) 2004-01-14 2009-06-23 Palatin Technologies, Inc. Small molecule compositions for sexual dysfunction
US6974187B2 (en) * 2004-01-28 2005-12-13 Tachi-S Co., Ltd. Vehicle seat structure
EP1732586A1 (en) * 2004-03-29 2006-12-20 Eli Lilly And Company Uses of melanocortin-4 receptor (mc4r) agonist peptides administered by continunous infusion
KR20100118615A (ko) * 2004-04-08 2010-11-05 아스테라스 세이야쿠 가부시키가이샤 화합물 ｗｓ727713
US7709484B1 (en) 2004-04-19 2010-05-04 Palatin Technologies, Inc. Substituted melanocortin receptor-specific piperazine compounds
WO2006048449A2 (en) * 2004-11-04 2006-05-11 Novo Nordisk A/S Mc4r selective peptides and their use in the treatment of obesity
JP2008519009A (ja) * 2004-11-04 2008-06-05 ノボ ノルディスク アクティーゼルスカブ 肥満症の治療に使用するためのペプチド
CN101052649A (zh) * 2004-11-04 2007-10-10 诺和诺德公司 用于治疗肥胖的肽类
US20110098213A1 (en) * 2004-11-04 2011-04-28 Novo Nordisk A/S Novel peptides for use in the treatment of obesity
EP1885743A1 (en) * 2005-05-31 2008-02-13 Yissum Research Development Company, of The Hebrew University of Jerusalem BACKBONE CYCLIZED MELANOCORTIN STIMULATING HORMONE ( alpha S ) ANALOGS
AU2006257792A1 (en) * 2005-06-13 2006-12-21 Mdrna, Inc. Transmucosal delivery of peptide derivatives
US7795332B2 (en) * 2005-07-15 2010-09-14 3M Innovative Properties Company Method of removing fluorinated carboxylic acid from aqueous liquid
US20080015304A1 (en) 2006-07-13 2008-01-17 Klaus Hintzer Aqueous emulsion polymerization process for producing fluoropolymers
GB2430437A (en) * 2005-09-27 2007-03-28 3M Innovative Properties Co Method of making a fluoropolymer
US7834017B2 (en) 2006-08-11 2010-11-16 Palatin Technologies, Inc. Diamine-containing, tetra-substituted piperazine compounds having identical 1- and 4-substituents
CN101573371A (zh) * 2006-12-29 2009-11-04 弗·哈夫曼-拉罗切有限公司 环肽类化合物的合成方法
WO2008101137A1 (en) * 2007-02-16 2008-08-21 3M Innovative Properties Company System and process for the removal of fluorochemicals from water
US20080264864A1 (en) * 2007-04-27 2008-10-30 3M Innovative Properties Company PROCESS FOR REMOVING FLUORINATED EMULSIFIER FROM FLUOROPOLMER DISPERSIONS USING AN ANION-EXCHANGE RESIN AND A pH-DEPENDENT SURFACTANT AND FLUOROPOLYMER DISPERSIONS CONTAINING A pH-DEPENDENT SURFACTANT
RU2450017C2 (ru) 2007-05-25 2012-05-10 Ипсен Фарма С.А.С. Лиганды меланокортиновых рецепторов, модифицированные гидантоином
US8258313B2 (en) 2007-07-19 2012-09-04 Tokuyama Corporation Compound having hydantoin ring and method of producing the same
AR071066A1 (es) * 2008-03-27 2010-05-26 Gruenenthal Chemie Derivados de (hetero) aril-ciclohexano
RU2532545C2 (ru) 2008-03-27 2014-11-10 Грюненталь Гмбх Замещенные производные 4-аминоциклогексана
AR072072A1 (es) * 2008-06-09 2010-08-04 Palatin Technologies Inc Peptidos especificos del receptor de melanocortina para el tratamiento de la obesidad / 669
CA2727317C (en) 2008-06-09 2015-02-17 Palatin Technologies, Inc. Melanocortin receptor-specific peptides for treatment of sexual dysfunction
EP2440572B1 (en) 2009-06-08 2017-04-05 Palatin Technologies, Inc. Lactam-bridged melanocortin receptor-specific peptides
UY32690A (es) 2009-06-08 2011-01-31 Astrazeneca Ab Péptidos específicos para receptores de melanocortina
CA2761607C (en) 2009-06-08 2018-09-04 Yi-Qun Shi Melanocortin receptor-specific peptides
AU2010321738B2 (en) 2009-11-23 2016-07-14 Palatin Technologies, Inc. Melanocortin-1 receptor-specific cyclic peptides
BR112012011780A2 (pt) 2009-11-23 2019-09-24 Palatin Technologies, Inc peptídeo linear,composição farmacêutica,métodopara tratamento de umadoença,indicação,condição ou sídrome mediadsa por receptor de melanocortina emum mamífero humano ou não humano e método para tratamento de uma condição responsiva ás alterações em função de receptor de melanocortina em um mamifero humano ou não humano
AU2014227712B2 (en) 2013-03-15 2018-08-02 Rhythm Pharmaceuticals, Inc. Peptide compositions
GB201416351D0 (en) * 2014-09-16 2014-10-29 Shire Internat Gmbh Heterocyclic derivatives
GB201416352D0 (en) * 2014-09-16 2014-10-29 Shire Internat Gmbh Spirocyclic derivatives
SG11201701803XA (en) * 2014-09-26 2017-04-27 Bayer Pharma AG Stabilized adrenomedullin derivatives and use thereof
US10653743B2 (en) 2015-10-15 2020-05-19 Arizona Board Of Regents On Behalf Of The University Of Arizona Methods for the treatment of depression and anxiety by a melanocortin 5 receptor antagonist, PG-20N
US11542302B2 (en) 2015-10-15 2023-01-03 Arizona Board Of Regents On Behalf Of The University Of Arizona Modulators of melanocortin receptors for the treatment of depression and anxiety
US10899793B2 (en) 2016-05-27 2021-01-26 Regents Of The University Of Minnesota Melanocortin ligands and methods of use thereof
US20190255142A1 (en) * 2016-10-17 2019-08-22 Arizona Board Of Regents On Behalf Of The University Of Arizona Novel modulators of melanocortin receptors for the treatment of depression and anxiety
US11124541B2 (en) 2016-10-18 2021-09-21 Regents Of The University Of Minnesota Chimeric melanocortin ligands and methods of use thereof
CN106496008A (zh) * 2016-10-20 2017-03-15 上海毕得医药科技有限公司 一种合成4‑(4‑氯苯基)环己酮的方法
CN106496005B (zh) * 2016-10-20 2019-04-09 上海毕得医药科技有限公司 一种4-(4-氯苯基)环己酮的合成方法
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CN118530294B (zh) * 2024-05-10 2025-02-14 浙江大学 一种芳基二胺固载连接子、其前体以及制备方法和应用

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Also Published As

Publication number Publication date
NO20030916D0 (no) 2003-02-27
YU15603A (sh) 2006-05-25
AR061422A2 (es) 2008-08-27
RU2239642C1 (ru) 2004-11-10
DE60126624T2 (de) 2007-11-22
ECSP034503A (es) 2003-04-25
CN100491396C (zh) 2009-05-27
IL154575A (en) 2008-12-29
EP1315750B1 (en) 2007-02-14
HRP20030126B1 (en) 2009-01-31
AU8402601A (en) 2002-03-13
JP4217069B2 (ja) 2009-01-28
CN1451017A (zh) 2003-10-22
US20020143141A1 (en) 2002-10-03
PA8527201A1 (es) 2002-04-25
KR100483300B1 (ko) 2005-04-15
NO20030916L (no) 2003-02-27
HUP0303078A2 (hu) 2003-12-29
CA2420058C (en) 2009-04-07
EP1315750A2 (en) 2003-06-04
JO2454B1 (en) 2008-10-09
MA27681A1 (fr) 2006-01-02
WO2002018437A2 (en) 2002-03-07
MXPA03001721A (es) 2003-05-27
DE60126624D1 (de) 2007-03-29
TWI248941B (en) 2006-02-11
NZ523989A (en) 2004-08-27
MY137457A (en) 2009-01-30
WO2002018437A3 (en) 2002-06-06
SI1315750T1 (sl) 2007-06-30
JP2004507558A (ja) 2004-03-11
IL154575A0 (en) 2003-09-17
ATE353918T1 (de) 2007-03-15
AR030504A1 (es) 2003-08-20
PE20020483A1 (es) 2002-06-06
HUP0303078A3 (en) 2012-02-28
US7045591B2 (en) 2006-05-16
CY1106562T1 (el) 2012-01-25
AU2001284026B2 (en) 2007-03-01
BR0113637A (pt) 2004-02-25
CZ2003584A3 (cs) 2003-08-13
CA2420058A1 (en) 2002-03-07
PL366630A1 (en) 2005-02-07
HRP20030126A2 (en) 2005-10-31
ES2280393T3 (es) 2007-09-16
ZA200301015B (en) 2004-05-05
PT1315750E (pt) 2007-05-31
KR20030061788A (ko) 2003-07-22

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